Effects of microhabitat on recruitment variation in a Gulf of Maine reef fish

Variation in recruitment of larvae can be important in determining temporal and spatial variat~on in adult demersal fish populations. Thls study examines how microhabitat use by newly settled cunner Tautogolabrus adspersus (Pisces. Labrldae) influences small-scale recruitment variation. The microhabitat occupied by cunner recruits was characterized by quantifying 14 attributes of the microhab~tat at 2 sites in Southern Malne, USA. Attributes at randomly selected sites were also recorded. Cunner recruits were distributed nonrandomly anlong microhabitats wlthin sltes. Recruit presence was positively associated with the presence of macrophytes and negabvely associated with microhabitats of low structural complexity. Association with specific microhabitats differed among sites; however, microhabitats available also differed among sites. While presence or absence could be prebcted by attributes of microhabitats, small-scale densities of fish could not. These data suggest that microhabitat use is nonrandom, and that the distribution of microhabitat types may influence small scale spatial patterns of recruitment in this species

Real inequality in Europe since 1500

Introducing a concept of real, as opposed to nominal, inequality of income or wealth suggests some historical reinterpretations, buttressed by a closer look at consumption by the rich. The purchasing powers of different income classes depend on how relative prices move. Relative prices affected real inequality more strongly in earlier centuries than in the twentieth. Between 1500 and about 1800, staple food and fuels became dearer, while luxury goods, especially servants, became cheaper, greatly widening the inequality of lifestyles. Peace, industrialization, and globalization reversed this inegalitarian price effect in the nineteenth century, at least for England

Use and cost of disease-modifying therapies by Sonya Slifka Study participants: has anything really changed since 2000 and 2009?

Background:Disease-modifying therapies benefit individuals with relapsing forms of multiple sclerosis, but their utility remains unclear for those without relapses. Objective:To determine disease-modifying therapy use and costs in 2009, compare use in 2009 and 2000, and examine compliance with evidence-based guidelines. Methods:We determined the extent and characteristics of disease-modifying therapy use by participants in the Sonya Slifka Longitudinal Multiple Sclerosis Study (Slifka) in 2000 (n=2156) and 2009 (n=2361) and estimated out-of-pocket and total (payer) costs for 2009. Two multivariable logistic regressions predicted disease-modifying therapy use. Results:Disease-modifying therapy use increased from 55.3% in 2000 to 61.5% in 2009. In 2009, disease-modifying therapy use was reported by 76.5% of participants with relapsing-remitting multiple sclerosis, 73.2% with progressive-relapsing multiple sclerosis, 62.5% with secondary progressive multiple sclerosis, and 41.8% with primary progressive multiple sclerosis. Use was significantly associated with relapsing-remitting multiple sclerosis, shorter duration of illness, one to two relapses per year, non-ambulatory symptoms, using a cane, younger age, higher family income, and having health insurance. Average annual costs in 2009 were US$939-3101 for patients and US$16,302-18,928 for payers. Conclusion:Use rates were highest for individuals with relapsing-remitting multiple sclerosis, but substantial for those with progressive courses although clinical trials have not demonstrated significant benefits for them

Diffuse reflectance imaging with astronomical applications

Diffuse objects generally tell us little about the surrounding lighting, since the radiance they reflect blurs together incident lighting from many directions. In this paper we discuss how occlusion geometry can help invert diffuse reflectance to recover lighting or surface albedo. Self-occlusion in the scene can be regarded as a form of coding, creating high frequencies that improve the conditioning of diffuse light transport. Our analysis builds on a basic observation that diffuse reflectors with sufficiently detailed geometry can fully resolve the incident lighting. Using a Bayesian framework, we propose a novel reconstruction method based on high-resolution photography, taking advantage of visibility changes near occlusion boundaries. We also explore the limits of single-pixel observations as the diffuse reflector (and potentially the lighting) vary over time. Diffuse reflectance imaging is particularly relevant for astronomy applications, where diffuse reflectors arise naturally but the incident lighting and camera position cannot be controlled. To test our approaches, we first study the feasibility of using the moon as a diffuse reflector to observe the earth as seen from space. Next we present a reconstruction of Mars using historical photometry measurements not previously used for this purpose. As our results suggest, diffuse reflectance imaging expands our notion of what can qualify as a camera.Natural Sciences and Engineering Research Council of Canada (NSERC) (Postdoctoral Fellowship)United States-Israel Binational Science Foundation (Grant 2008155)United States. National Geospatial-Intelligence Agency (NEGI-1582-04-0004)United States. Multidisciplinary University Research Initiative (Grant N00014-06-1-0734

Prices and Real Inequality in Europe since 1500

Introducing a concept of real, as opposed to nominal, inequality of income or wealth suggests some historical reinterpretations, buttressed by a closer look at consumption by the rich. The purchasing powers of different income classes depend on how relative prices move. The influence of relative prices on real inequality was greater in the sixteenth through nineteenth centuries than in the twentieth. Between 1500 and about 1800, staple food and fuels became dearer, while luxury goods, especially servants, became cheaper, greatly widening the inequality of lifestyles. Peace, industrialization, and globalization reversed this inegalitarian price effect in the nineteenth century

Clinical and Economic Outcomes Associated With the Timing of Initiation of Basal Insulin in Patients With Type 2 Diabetes Mellitus Previously Treated With Oral Antidiabetes Drugs

AbstractPurposeIn patients with type 2 diabetes mellitus (T2DM) not achieving glycemic targets using oral antidiabetes drugs (OADs), studies suggest that timely insulin initiation has clinical benefits. Insulin initiation at the early versus late stage of disease progression has not been explored in detail. This retrospective database analysis investigated clinical and economic outcomes associated with the timing of insulin initiation in patients with T2DM treated with ≥1 OAD in a real-world US setting.MethodsThis study linked data from the Truven Health MarketScan® Commercial database, Medicare Supplemental database, and Quintiles Electronic Medical Records database. A total of 1830 patients with T2DM were included. Patients were grouped according to their OAD use before basal insulin initiation (1, 2, or ≥3 OADs) as a proxy for the timing of insulin initiation. Clinical and economic outcomes were evaluated over 1 year of follow-up.FindingsDuring follow-up the 1 OAD group, compared with the 2 and ≥3 OADs groups, had a greater reduction in glycosylated hemoglobin A1c (−1.7% vs −1.0% vs −0.9%, respectively; P < 0.0001), greater achievement of glycemic target (38.2% vs 26.7% vs 19.6%, respectively; P < 0.0001), and a lower incidence of hypoglycemia (2.7% vs 6.6% vs 5.0%, respectively; P = 0.0002), with no difference in total health care costs ($21,167 vs$21,060 vs $20,133, respectively).ImplicationsThis study shows that early insulin initiation (represented by the 1 OAD group) may be clinically beneficial to patients with T2DM not controlled with OADs, without adding to costs. This supports the call for timely initiation of individualized insulin therapy in this population

Stellar dynamical evidence against a cold disc origin for stars in the Galactic Centre

Observations of massive stars within the central parsec of the Galaxy show that, while most stars orbit within a well-defined disc, a significant fraction have large eccentricities and / or inclinations with respect to the disc plane. Here, we investigate whether this dynamically hot component could have arisen via scattering from an initially cold disc -- the expected initial condition if the stars formed from the fragmentation of an accretion disc. Using N-body methods, we evolve a variety of flat, cold, stellar systems, and study the effects of initial disc eccentricity, primordial binaries, very massive stars and intermediate mass black holes. We find, consistent with previous results, that a circular disc does not become eccentric enough unless there is a significant population of undetected 100--1000 Msun objects. However, since fragmentation of an eccentric disc can readily yield eccentric stellar orbits, the strongest constraints come from inclinations. We show that_none_ of our initial conditions yield the observed large inclinations, regardless of the initial disc eccentricity or the presence of massive objects. These results imply that the orbits of the young massive stars in the Galactic Centre are largely primordial, and that the stars are unlikely to have formed as a dynamically cold disc.Comment: 5 pages, 6 colour figures. MNRAS Letters in press. (v2: very minor changes