Réflexions sur l'efficacité internationale des sentences arbitrales

Leurent Bruno. Réflexions sur l'efficacité internationale des sentences arbitrales. In: Droit international privé : travaux du Comité français de droit international privé, 12e année, 1993-1995. 1996. pp. 181-208

Reduced basis output bounds for linear elasticity : application to microtruss structures

Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2001.Includes bibliographical references (p. 95-97).by Thomas B. Leurent.S.M

Éco-conception des ensembles bâtis et des infrastructures, tome 2

International audienc

Eco-design of buildings and infrastructure: Developments in the Period 2016-2020

International audienc

Eco-design of Buildings and Infrastructure

International audienceThe Chair on Ecodesign for buildings and infrastructures was created by ParisTech in partnership with VINCI with the aim of developing evaluation and simulation tools that integrate all ecodesign aspects (e.g. greenhouse gas emissions, impact on biodiversity, depletion of resources, etc.) and provide genuine decision-aid instruments, based on a scientific approach, to all those involved in the urban environment (i.e. designers, builders and users).The present book takes stock of five years of research under the Chair. It starts by presenting some methodological bases of ecodesign, life cycle assessments, impact studies, and methods for planning and transport. Several specific subjects are then covered, i.e. public transport, parking, road traffic, the environmental profile of building materials, building retrofits, energy management, and biodiversity. The last part of the book sets out how the knowledge and tools developed under the Chair were applied to a case study: Cité Descartes in Marne la Vallée (Ile de France).This work is aimed at urban planners, local authorities, contracting clients, architects, engineering firms, contractors, building managers, research lecturers, and anyone interested in the environmental quality of the places we live in

LCA of urban development projects : Coupling LCA and transport simulation tools

International audienc

Certification ISO 9001 d’un système de management qualité dans un centre d’investigation clinique [ISO 9001certification of a quality management system in a clinical investigation center]

International audienceBeyond the application of legal requirements, clinical trials must have a permanent approach of quality control. The clinical investigation centers (CICs) are academic structures of clinical research certified by the French National institute of health and medical research (Inserm) and whose functioning relies on recommendations of good practice. It is important to accompany this standardization of practices by the implementation of a quality management system. This article presents the process that enabled the CIC of Rennes to become certified ISO 9001 by French standards association (Afnor) certification in May, 2016. The application of the fundamental principles of the standard ISO 9001 in the domain of clinical research is approached. The problem of the perimeter for the certification and the related process mapping are exposed. The activities of methodology, management and analysis of clinical studies were chosen for the initial certification of the CIC of Rennes. The perspectives for the extension of the perimeter of certification are also approached at the end of article

Impact of a targeted monitoring on data-quality and data-management workload of randomized controlled trials a prospective comparative study

International audienceAims: Monitoring risk‐based approaches in clinical trials are encouraged by regulatory guidance. However, the impact of a targeted source data verification (SDV) on data‐management (DM) workload and on final data quality needs to be addressed.Methods: MONITORING was a prospective study aiming at comparing full SDV (100% of data verified for all patients) and targeted SDV (only key data verified for all patients) followed by the same DM program (detecting missing data and checking consistency) on final data quality, global workload and staffing costs.Results: In all, 137,008 data including 18,124 key data were collected for 126 patients from six clinical trials. Compared to the final database obtained using the full SDV monitoring process, the final database obtained using the targeted SDV monitoring process had a residual error rate of 1.47% [95% confidence interval, 1.41% to 1.53%] on overall data and 0.78% [95% confidence interval, 0.65% to 0.91%] on key data. There were nearly four times more queries per study with targeted SDV than with full SDV (mean±SD: 132±101 vs 34±26; p=0.03). For a handling time of 15 min per query, the global workload of the targeted SDV monitoring strategy remained below that of the full SDV monitoring strategy. From 25 minutes per query, it was above increasing progressively to represent a 50% increase for 45 minutes per query.Conclusion: Targeted SDV monitoring is accompanied by increased workload for DM, which allows to obtain a small proportion of remaining errors on key data (<1%), but may substantially increase trial costs

Design and preliminary results of FRENSHOCK 2016: A prospective nationwide multicentre registry on cardiogenic shock

International audienceBACKGROUND:Most data on the epidemiology of cardiogenic shock (CS) have come from patients with acute myocardial infarction admitted to intensive cardiac care units (ICCUs). However, CS can have other aetiologies, and could be managed in intensive care units (ICUs), especially the most severe forms of CS.AIM:To gather data on the characteristics, management and outcomes of patients hospitalized in ICCUs and ICUs for CS, whatever the aetiology, in France in 2016.METHODS:We included all adult patients with CS between April and October 2016 in metropolitan France. CS was defined (at admission or during hospitalization) by: low cardiac output, defined by systolic blood pressure90mmHg and/or cardiac index2mmol/L, hepatic insufficiency, renal failure).RESULTS:Over a 6-month period, 772 patients were included in the survey (mean age 65.7±14.9 years; 71.5% men) from 49 participating centres (91.8% were public, and 77.8% of these were university hospitals). Ischaemic trigger was the most common cause (36.3%).CONCLUSIONS:To date, FRENSHOCK is the largest CS survey; it will provide a detailed and comprehensive global description of the spectrum and management of patients with CS in a high-income country