Determination of Small Strain Modulus and Degradation for in-Situ Weathered Rock and Old Alluvium Deposits

The small strain shear modulus (G0) and the degradation of shear modulus (G/G0) with increasing magnitude of shear strain are important soil properties required for the evaluation of site response due to earthquake effects. While these properties are well established for geologically recent alluvial sand and clay materials, published data on the properties of materials derived from in-situ rock weathering and ancient alluvial deposits are limited. This paper presents the results of laboratory testing on completely decomposed granite and tuff in Hong Kong, and weathered Jurong Siltstone and Old Alluvium in Singapore. The small strain shear modulus (G0) of the materials was determined from bender element tests, while the shear modulus degradation (G/G0) was assessed from cyclic triaxial test with local strain measurement. The results are compared with the published data of similar materials. Apart from the laboratory bender element tests, G0 can also be determined by the in-situ shear wave velocity test. It has been found worldwide that there is generally a reasonable relationship between shear wave velocity and the SPT N value. In this paper, various in-situ shear wave velocity (Vs) testing results obtained from Singapore and Hong Kong have been reviewed and the observed correlations between VS and SPT N values for various soils are presented

A Case of Beare-Stevenson Syndrome with Unusual Manifestations

Case series Patient: - Final Diagnosis: Beare-Stevenson syndrome Symptoms: - Medication: - Clinical Procedure: Genetic analysis Specialty: Pediatrics and Neonatology Objective: Rare disease Background: Beare-Stevenson syndrome (BSS) is an extremely rare genetic disorder, with fewer than 25 cases reported worldwide. This autosomal dominant syndrome has been linked to two mutations in the fibroblast growth factor receptor 2 gene (FGFR2), Tyr375Cys and Ser372Cys, both causing amino acid changes. Case Report: BSS is characterized by a range of morphological features, some more classically associated than others, of which craniosynostosis has been almost uniformly present. Other common features include cutis gyrata, acanthosis nigricans, ear and eye defects, skin/mucosal tissue tags, prominent umbilical stump, and anogenital anomalies. This account reports what we believe to be the 25th case of BSS, and exhibits a constellation of the characteristic features similar to those previously described, including the presence of cutis gyrata, proptosis, a bifid scrotum, and hypospadias. However, craniosynostosis was not detected prenatally by ultrasound or at birth. Prenatal ultrasound may detect some dysmorphic features of BSS. Many of these features have also been associated with other genetic disorders with overlapping phenotypes. Our case presented with the unusual features of a natal tooth and absence of craniosynostosis at birth. At birth, a diagnosis of BSS was suspected based on clinical features despite the absence of craniosynostosis. This was later confirmed with the use of molecular analysis, revealing a Tyr375Cys mutation of exon 9 of the FGFR2 gene. Conclusions: We suggest that a normal antenatal ultrasound scan and the absence of craniosynostosis at birth should not preclude further workup for BSS if this possibility is clinically suspected

DARPA Phoenix Payload Orbital Delivery System: Progress towards Small Satellite Access to GEO

The emerging practice of hosting payloads on commercial geosynchronous Earth orbit (GEO) satellites is gaining traction throughout the space community because of the flight opportunities and budgetary savings that it offers. Using the hosted payload model, the DARPA Phoenix Payload Orbital Delivery (POD) system is meant to enable a higher tempo to GEO for small‐mass hardware items. The POD system proposes a departure from the typical hosted payload. The POD would provide a controlled release of the hosted payload from the commercial host near GEO. The POD standard user\u27s guide developed under the Phoenix program ensures compatibility with most of the approximately 15 commercial launches to GEO each year. By hosting with a standard user’s guide, commercial satellite providers would be capable of bringing hosted payloads quite late into the typical launch integration cycle. The combination of hightempo commercial launches and late integration would create an “express delivery” capability to GEO orbit. This POD capability would continue the paradigm shift of working with the commercial satellite provider directly to leverage the efficiencies of mass to orbit, reducing interactions with the launch provider. Phoenix is completing the design and ground testing of the POD system to help make access to new orbits more affordable and more routine for small‐mass systems

Diet of dingoes and other wild dogs in peri-urban areas of north-eastern Australia

Knowledge of the resource requirements of urban predators can improve our understanding of their ecology and assist town planners and wildlife management agencies in developing management approaches that alleviate human-wildlife conflicts. Here we examine food and dietary items identified in scats of dingoes in peri-urban areas of north-eastern Australia to better understand their resource requirements and the potential for dingoes to threaten locally fragmented populations of native fauna. Our primary aim was to determine what peri-urban dingoes eat, and whether or not this differs between regions. We identified over 40 different food items in dingo scats, almost all of which were mammals. Individual species commonly observed in dingo scats included agile wallabies, northern brown bandicoots and swamp wallabies. Birds were relatively common in some areas but not others, as were invertebrates. Dingoes were identified as a significant potential threat to fragmented populations of koalas. Dietary overlap was typically very high or near-identical between regions, indicating that peri-urban dingoes ate the same types or sizes of prey in different areas. Future studies should seek to quantify actual and perceived impacts of, and human attitudes towards, peri-urban dingoes, and to develop management strategies with a greater chance of reducing human-wildlife conflicts

The mitochondrial phosphate carrier: Role in oxidative metabolism, calcium handling and mitochondrial disease

The mitochondrial phosphate carrier (PiC) is a mitochondrial solute carrier protein, which is encoded by SLC25A3 in humans. PiC delivers phosphate, a key substrate of oxidative phosphorylation, across the inner mitochondrial membrane. This transport activity is also relevant for allowing effective mitochondrial calcium handling. Furthermore, PiC has also been described to affect cell survival mechanisms via interactions with cyclophilin D and the viral mitochondrial-localized inhibitor of apoptosis (vMIA). The significance of PiC has been supported by the recent discovery of a fatal human condition associated with PiC mutations. Here, we present first the early studies that lead to the discovery and molecular characterization of the PiC, then discuss the very recently developed mouse models for PiC and pathological mutations in the human SLC25A3 gene. © 2015

PRN OPINION PAPER: Application of precision medicine across pharmacy specialty areas

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149551/1/jac51107_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149551/2/jac51107.pd

A National Spinal Muscular Atrophy Registry for Real-World Evidence.

BACKGROUND: Spinal muscular atrophy (SMA) is a devastating rare disease that affects individuals regardless of ethnicity, gender, and age. The first-approved disease-modifying therapy for SMA, nusinursen, was approved by Health Canada, as well as by American and European regulatory agencies following positive clinical trial outcomes. The trials were conducted in a narrow pediatric population defined by age, severity, and genotype. Broad approval of therapy necessitates close follow-up of potential rare adverse events and effectiveness in the larger real-world population. METHODS: The Canadian Neuromuscular Disease Registry (CNDR) undertook an iterative multi-stakeholder process to expand the existing SMA dataset to capture items relevant to patient outcomes in a post-marketing environment. The CNDR SMA expanded registry is a longitudinal, prospective, observational study of patients with SMA in Canada designed to evaluate the safety and effectiveness of novel therapies and provide practical information unattainable in trials. RESULTS: The consensus expanded dataset includes items that address therapy effectiveness and safety and is collected in a multicenter, prospective, observational study, including SMA patients regardless of therapeutic status. The expanded dataset is aligned with global datasets to facilitate collaboration. Additionally, consensus dataset development aimed to standardize appropriate outcome measures across the network and broader Canadian community. Prospective outcome studies, data use, and analyses are independent of the funding partner. CONCLUSION: Prospective outcome data collected will provide results on safety and effectiveness in a post-therapy approval era. These data are essential to inform improvements in care and access to therapy for all SMA patients