Business-education Partnerships as Basis for Effective Socioeconomic Development: Lessons for Kazakhstan

AbstractThe author identifies the challenges faced by Kazakhstani universities and business environment during socioeconomic transformation. The research provides a general overview of the “gaps” between Educational sector and Business sphere in Kazakhstan. Moreover, it reveals the graduate skills differences in Kazakhstan and determine the extent to which the quality of graduates fails to meet the expectation of employers.The main goal of the article is to distinguish the main invocations and opportunities for effective cooperation in the development of Business – Education partnership in Kazakhstan, to evaluate the skills acquired by MBA graduates and to assess the impact made by a business education on socioeconomic development of the state.The selected methodology for this study is a combination of desk research, primary research (through quantitative and qualitative techniques and methods of data collection) that aim to enable triangulation of findings and thus to provide more reliable data for a better understanding of business-education cooperation outcomes

Pattern Transitions in Unstable Viscous Convective Medium

Convection in a thin layer of liquid (gas) with temperature dependent viscosity between poorly heat conducting boundaries is studied within framework of the Proctor-Sivashinsky model. This model is examined in order to study both the flow pattern formation and the second-order structural phase transitions as between patterns with translational invariance as well as between structures with broken translational invariance but keeping a long-range order. The spatial spectrum of arising patterns and estimation of their visual defectiveness are analyzed. The relation between the density of pattern defects and spectral characteristics of the pattern is found. We also discuss the noise effects on the formation of pattern defects. The influence of temperature dependence of viscosity on the process of pattern formation and structure transformations is also discussed. It is shown that the temperature dependence of viscosity inhibits structural transition from regular rolls to square cells

Functionalized Derivatives of 2-azaspiro[3.3]heptane-1-carboxylic Acid and 7-oxa-2-azaspiro[3.5]nonane-1-carboxylic Acid for Drug Design

2-azaspiro[3.3]heptane-1-carboxylic acid and 7-oxa-2-azaspiro[3.5]nonane-1-carboxylic acid, which had been reported as bioisoster of well-known pipecolic acid, were subjected to chemical transformations, resulting in a number of functionalized derivatives. The obtained molecules contained diversified functional groups, allowing their incorporation in bioactive compounds in versatile modes. Described synthetic approaches afforded multigram-scaled synthesis of the desired compounds with good yields, thus being applicable in drug desig

On the nature of the Mossbauer effect

The spectrum of electromagnetic waves emitted by an oscillator trapped in an external potential well is studied. It is assumed that the natural frequency of the oscillator is much greater than the frequency of oscillations in the potential well. We consider the quantum model of emission with regard to the recoil e ect. The highest intensity of the absorption and emission lines is observed on the natural frequency of the oscillator when the recoil energy is equal to the energy of the quantum of low-frequency (LF) oscillations in the potential well. A certain decrease in the amplitude of the emission and absorption lines is noted caused by the oscillations of the potential well due to, for example, the presence of the phonon spectrum. The relaxation times of the oscillator LF motion in the potential well, resulted from the phonon emission, are estimated. It is concluded that these processes have no in uence on the observed features of the emission and absorption of high-frequency photons. This model can be applied to description of the emission and absorption of gamma rays in the crystal structures even in the presence of the phonon spectrum on condition that the relaxation time of the LF movements in the potential well is greater than the lifetime of the HF oscillator

Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria

SummaryMitochondrial uncoupling protein 1 (UCP1) is responsible for nonshivering thermogenesis in brown adipose tissue (BAT). Upon activation by long-chain fatty acids (LCFAs), UCP1 increases the conductance of the inner mitochondrial membrane (IMM) to make BAT mitochondria generate heat rather than ATP. Despite being a member of the family of mitochondrial anion carriers (SLC25), UCP1 is believed to transport H+ by an unusual mechanism that has long remained unresolved. Here, we achieved direct patch-clamp measurements of UCP1 currents from the IMM of BAT mitochondria. We show that UCP1 is an LCFA anion/H+ symporter. However, the LCFA anions cannot dissociate from UCP1 due to hydrophobic interactions established by their hydrophobic tails, and UCP1 effectively operates as an H+ carrier activated by LCFA. A similar LCFA-dependent mechanism of transmembrane H+ transport may be employed by other SLC25 members and be responsible for mitochondrial uncoupling and regulation of metabolic efficiency in various tissues

On the nature of the Mossbauer effect

The spectrum of electromagnetic waves emitted by an oscillator trapped in an external potential well is studied. It is assumed that the natural frequency of the oscillator is much greater than the frequency of oscillations in the potential well. We consider the quantum model of emission with regard to the recoil e ect. The highest intensity of the absorption and emission lines is observed on the natural frequency of the oscillator when the recoil energy is equal to the energy of the quantum of low-frequency (LF) oscillations in the potential well. A certain decrease in the amplitude of the emission and absorption lines is noted caused by the oscillations of the potential well due to, for example, the presence of the phonon spectrum. The relaxation times of the oscillator LF motion in the potential well, resulted from the phonon emission, are estimated. It is concluded that these processes have no in uence on the observed features of the emission and absorption of high-frequency photons. This model can be applied to description of the emission and absorption of gamma rays in the crystal structures even in the presence of the phonon spectrum on condition that the relaxation time of the LF movements in the potential well is greater than the lifetime of the HF oscillator

Mitochondrial Ca2+ Uniporter and CaMKII in heart

The influx of cytosolic Ca2+ into mitochondria is mediated primarily by the mitochondrial calcium uniporter (MCU), a small-conductance, Ca2+-selective channel-. MCU modulates intracellular Ca2+ transients and regulates ATP production and cell death. Recently, Joiner et al. reported that MCU is regulated by mitochondrial CaMKII, and this regulation determines stress response in heart. They reported a very large current putatively mediated by MCU that was about two orders of magnitude greater than the MCU current (IMCU) that we previously measured in heart mitochondria. Also, the current traces presented by Joiner et al. showed unusually high fluctuations incompatible with the low single-channel conductance of MCU. Here we performed patch-clamp recordings from mouse heart mitochondria under the exact conditions used by Joiner et al. We confirmed that IMCU in cardiomyocytes is very small and showed that it is not directly regulated by CaMKII. Thus the currents presented by Joiner et al. do not correspond to MCU, and there is no direct electrophysiological evidence that CaMKII regulates MCU