The smokeless tobacco habit and DNA damage : a systematic review and meta-analysis

The aim of this systematic review was to evaluate the frequency of micronuclei or other DNA damage in the oral mucosa of adults that have smokeless tobacco habits compared to adults that not have these habits. We searched PubMed, Scopus, Web of Science, LILACS, BBO and Cochrane Library and SIGLE. We also surveyed gray literature. We included only clinical trials that compare the frequency of micronuclei or other DNA damage in the oral mucosa of adults that have smokeless tobacco habits compared to adults that not have these habits. Quality assessments of the selected trials were evaluated by two independent reviewers, using the Effective Public Health Practice Project ? (EPHPP) with modifications. After the database screening and removal of duplicates, 2574 studies were identified. After title screening, 172 studies remained, and this number was reduced to 25 after careful examination of the abstracts. The standardized mean difference of the frequency of micronuclei between groups was 1.88, with a 95% confidence interval of 1.40 to 2.36 (p< 0.00001). In all analyses heterogeneity was detected. Despite the heterogeneity of studies, the frequency of micronuclei was significant bigger in adults who have the smokeless tobacco habit when compared to those not have this habit. The same occurred with the frequency of binucleated cells, karyolisis and karyorrhexis

Orthodontic bracket bonding techniques and adhesion failures : a systematic review and meta-analysis

This systematic review compared the bonding failures of orthodontic brackets bonded by indirect or direct techniques. Data sources: The searched databases were Cochrane Library, LILACS, BBO, PubMed, Scopus, Web of Science. A search for randomized clini

Can Hemophilia Impact on the Oral Health Conditions of Children and Adolescents? A Systematic Review and Metanalysis

Objective: To analyze if the oral health conditions in children and adolescents are associated with hemophilia (PROSPERO-42020168192). Material and Methods: The search strategy was performed in PubMed, Scopus, Lilacs/BBO, Web of Science, Cochrane, and Grey literature databases. Two independent researchers assessed the risk of bias in these studies by the Newcastle-Ottawa Scale. For the meta-analysis, the clinical conditions data were extracted as numerical variables according to their indexes, such as dental caries experience (dmft/DMFT), gingival condition (Modified Gingival Index - IGM), and oral hygiene (Plaque Index - PI). The quality of the evidence of the meta-analysis was evaluated by the GRADE tool (GRADEproGDT). Results: From a total of 431 studies, 27 were included, and 10 were included in the meta-analysis. The studies presented a moderate risk of bias, ranging from 2 to 7 points. The dental caries experience in primary (-0.62; CI95%: -1.68–0.43) and permanent dentitions (-0.05; CI95%: -0.69–0.59), gingival condition (-0.12; CI95%: -0.27–0.03), and oral hygiene (0.36; CI95%: -0.06–0.77) did not differ between the groups. Conclusion: Based on studies with very weak evidence, there were no differences in the oral health conditions of children and adolescents with and without hemophilia

Injection of platelet aggregates in facial rejuvenation: a systematic review

Introduction: This systematic review was conducted to assess whether the use of a platelet aggregate injection with or without associated facial rejuvenation techniques favors facial rejuvenation in adult patients. Methods: Randomized clinical trials that compared the use of techniques for facial rejuvenation alone with the same techniques coupled with the injection of platelet aggregates were searched. The search was performed in indexed databases and in the gray literature. The Cochrane Collaboration bias risk tool was applied to assess the quality of the studies. Results: In total, 7137 articles were identified. Only four studies remained in the qualitative synthesis, and the others were considered as having undefined bias risk in the key domains. Conclusion: There are few studies in the literature that compare the use of platelet aggregates in facial rejuvenation and those that are available have a risk of "undefined" or "high" bias. There is a need for more well-designed clinical studies comparing the use of platelet aggregate injection with or without associated facial rejuvenation techniques

Conhecimento e utilização do diamino fluoreto de prata entre cirurgiões-dentistas do estado do Paraná, Brasil

O diamino fluoreto de prata (DFP) está inserido no contexto da Odontologia minimamente invasiva para controle e tratamento das lesões de cárie. A proposta deste estudo foi identificar o conhecimento e a utilização do DFP entre cirurgiões-dentistas do estado do Paraná, Brasil. Tratou-se de um estudo exploratório com amostragem intencional, com período de coleta entre agosto a outubro de 2021, em que 100 cirurgiões-dentistas receberam questionário via aplicativo de comunicação telefônica, contendo 22 perguntas. Os dados foram tabulados e analisados em SPSS® versão 25.0. Foram aplicados os testes t de Student e de Qui-quadrado, com nível de significância de 5%. Participaram 60 profissionais, em que 27 (45%) afirmaram utilizar o DFP. As mulheres compuseram 91,7% da amostra total e a média de tempo de formação foi de 15,9 (± 11,7) anos. Maior tempo de formação (p = 0,010) e atuação no serviço público (p = 0,020) foram associados ao uso do DFP. Mais de 40% dos respondentes não sabem qual concentração do produto apresenta melhores resultados e 77,8% o indicam apenas para crianças. Ainda, 70,4% removem tecido amolecido antes da aplicação. Quanto às vantagens do DFP, destacaram-se a ação bactericida/bacteriostática (74,1%) e a não necessidade de intervenções mais invasivas (55,6%). Houve unanimidade ao ser mencionada a questão estética como o fator que limita a indicação do DFP. Concluiu-se que o conhecimento em relação ao uso do DFP entre os cirurgiões-dentistas aqui investigados foi limitado, o que reforça a necessidade de ações de educação permanente e o desenvolvimento de protocolos de utilização do material

The influence of tooth brushing supervision on the dental plaque index and toothbrush wear in preschool children

OBJECTIVE: To evaluate the effectiveness of tooth brushing supervision in one or more sessions on dental plaque removal and toothbrush wear. MATERIAL AND METHOD: 3- to 5-year-old children received new toothbrushes and attended a puppet theater about oral health. Forty-nine children were randomly selected and divided into 3 groups (GI=20; GII=14; GIII=14). Fones' brushing method was demonstrated to the GI and GII groups to evaluate the following: the professional direct supervision and tooth brushing training in five sessions (GI), the professional direct supervision and a one-training session (GII) and the puppet theater influence only (GIII-control group). The dental plaque index (IPL) was recorded at baseline (T0), after 24 days (T1) and after 46 days (T2) and toothbrush wear (ID) was recorded on T1 and T2. The Kruskal-Wallis test and the Friedman test (IPL), as well as the one-way ANOVA and the paired Student's t-test (ID) (p<0.05) were employed to analyze the data. RESULT: GI showed a significant difference from the others groups in T1 and T2 (p<0.01).The index of toothbrush wear increased (p<0.0001) from 24 days (0.52±0.35mm) to 46 days (0.90±0.48mm), but there was no significant association between toothbrush wear and plaque index for T1 (r=0.230-p= 0.116) as well as for T2 (r=0.226-p=0.121). CONCLUSION: The multiple sessions of professional supervision were effective to reduce the dental plaque index, which was not influenced by toothbrush wear, showing continuous oral hygiene motivation needs

A expansão rápida de maxila muda a posição natural da cabeça em crianças com constrição maxilar? Uma revisão sistemática e meta-análise

Objective: a systematic review was performed to evaluate the natural head position (NHP) in children with maxillary constriction before and after rapid maxillary expansion (RME). Material and Methods: a comprehensive search was carried out in the MEDLINE via PubMeb, Scopus, Web of Science, LILACS, BBO and Cochrane Library and SIGLE without restrictions. The annual conference of the IADR abstracts (1990–2017) and unpublished and ongoing trials registry were also searched. Dissertations and theses were searched using the ProQuest Dissertations and “Periódicos CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior) Theses Databases”. The studies compared the natural head position in patients submitted rapid maxillary expansion (RME) and untreated patients both with maxillary constriction. Results: a total of 3023 studies were identified, three remained in qualitative study and all these studies were considered at “unclear” risk of bias in the key domains. Only two studies presented similar data to be included in the meta-analysis. Both studies evaluated the natural head position, through the angle between nasion-sella line and true vertical (SN-Ver). The meta-analyses demonstrated that after 12 months follow-up, the SN-Ver angle decreased by 3.39 degrees (95% confidence interval [CI]=0.57 to 6.21; p=0.02). Conclusion: the RME promoted increase in SN-VER angle in child after 12 months for intervention; however, there are few studies in the literature about this topic, and there is a need of further well-designed trials to investigate this alteration.Objetivo: uma revisão sistemática foi realizada para avaliar se a posição natural da cabeça (PNS) muda em crianças com constrição maxilar antes e após expansão rápida da maxila (ERM). Material e método: uma pesquisa foi realizada no MEDLINE via PubMeb, Scopus, Web of Science, LILACS, BBO e Cochrane Library sem restrições. Também foram pesquisadas a conferência anual dos resumos da IADR (1990–2017) e o registro de ensaios não publicados e em andamento. As dissertações e teses foram pesquisadas usando os bancos de dados ProQuest Dissertations e “Periódicos CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior) de Teses”. Os estudos compararam a posição natural da cabeça em pacientes submetidos a expansão rápida da maxila (ERM) e pacientes não tratados, ambos com constrição maxilar. Resultados: um total de 3023 estudos foram identificados, três permaneceram em estudo qualitativo e todos esses estudos foram considerados de risco "pouco claro" de viés nos principais domínios. Apenas dois estudos apresentaram dados semelhantes para serem incluídos na meta-análise. Ambos os estudos avaliaram a posição natural da cabeça, através do ângulo entre a linha násio-sela e a vertical verdadeira (SN-Ver). As meta-análises demonstraram que, após 12 meses de acompanhamento, o ângulo SN-Ver diminuiu 3,39 graus (intervalo de confiança de 95% [IC] = 0,57 a 6,21; p = 0,02). Conclusão: o ERM promoveu aumento do ângulo SN-VER na criança após 12 meses de intervenção; no entanto, existem poucos estudos na literatura sobre esse tópico, e há necessidade de mais estudos bem delineados para investigar essa alteração