Revealing side effects of quota rules on group cooperation

ArticleThe quota rule in employment is a legal tool to promote gender equality in professions and positions where women are underrepresented. An accompanying assumption is that gender diversity positively affects one of the aspects of team performance in form of group cooperation. However, it is unclear whether this positive effect can be achieved if diversity increases due to a quota rule. In two fully incentivized experiments involving a real-effort task (N1 = 188 and N2 = 268), we examined the impact of quotas as compared to performance-based promotion on group cooperation. We thereby categorized participants either with regard to gender or to an artificial category that was randomly assigned. Cooperation within groups declined when promotion was based on quota compared to performance-based promotion, irrespective of the categorization criterion. Further analyses revealed that this negative effect of quota rules on cooperation is not driven by procedural fairness perceptions or expectations about performance of the promoted group member. Implications of the results for the implementation of equality and diversity initiatives are discussed

The flow direction of interstellar neutral H from SOHO/SWAN

Interstellar neutral hydrogen flows into the heliosphere as a mixture of the primary and secondary populations from two somewhat different directions due to splitting occurring in the magnetized outer heliosheath. The direction of inflow of interstellar neutral H observed in the inner heliosphere, confronted with that of the unperturbed flow of interstellar neutral helium, is important for understanding the geometry of the distortion of the heliosphere from axial symmetry. It is also needed for facilitating remote-sensing studies of the solar wind structure based on observations of the helioglow, such as those presently performed by SOHO/SWAN, and in a near future by IMAP/GLOWS. In the past, the only means to measure the flow direction of interstellar hydrogen were spectroscopic observations of the helioglow. Here, we propose a new method to determine this parameter based on a long series of photometric observations of the helioglow. The method is based on purely geometric considerations and does not depend on any model and absolute calibration of the measurements. We apply this method to sky maps of the helioglow available from the SOHO/SWAN experiment and derive the mean flow longitude of interstellar hydrogen. We obtain 253.1\degr \pm 2.8\degr, which is in perfect agreement with the previously obtained results based on spectroscopic observations.Comment: Accepted for Ap

Local structure and conductivity behaviour in Bi7WO13.5

Total neutron scattering analysis reveals details of cation coordination and vacancy distribution in Bi7WO13.5.</p

Persistent dysregulation of DNA methylation in cells with arsenic-induced genomic instability

The mechanisms by which arsenic-induced genomic instability is initiated and maintained are poorly understood. In previous studies long-term progression of chromosomal instability was typified by increasing aneuploidy in Chinese hamster V79 and human keratinocyte cells treated with arsenite for a 24 hr exposure period followed by growth in arsenic-free medium for 40-120 cell generations. In the current study the role of progressive DNA methylation changes was evaluated in long-term cell cultures after brief arsenite treatments as above. We have found altered genomic methylation patterns in cells that were briefly exposed to arsenic with evidence for widespread dysregulation of CpG methylation that persists for many population doublings after the treatment. In V79 cell populations, progressive aneuploidy increases were notable by 50 cell generations after a 24 hr exposure to 1-10 uM arsenite. Dicentric chromosomes and/or telomeric associations, as well as complex chromosome rearrangements, occurred by 90 cells generations post treatment; and mutator and transformed phenotypes began to appear thereafter. This increasing genomic instability correlated with modifications of global DNA methylation patterns in V79 cells evaluated by 5-methylcytosine antibody binding and MeSAP-PCR. The results show that short-term exposure to arsenite induced an apparent genome hypomethylating effect within a short time after exposure. In identical protocols using human HaCaT keratinocytes exposed to low doses of arsenite (0.05-0.1 M) for 24 hr, genomewide methylation levels were measured by LINE1 pyrosequencing and gene-specific methylation status was assessed by Methylation-Specific-PCR for up to 40 generations post exposure. Global demethylation following treatment was supported by preliminary LINE-1 studies. Moreover, the study of gene-specific MSP and determination of expression levels by RT-PCR of several genes (p16, hMLH1, hMSH2, DNMT1, DNMT3a and DNMT3b) demonstrated that hMSH2 gene was epigenetically regulated by arsenite and that down regulation of DNMT3a and DNMT3b genes occurred in an arsenite dose-dependent manner. The results reported here demonstrate that acute 24 hr arsenic exposure promptly induces genome wide DNA hypomethylation, and support the hypothesis that the cells continue to undergo epigenetic reprogramming both at the gene and genomic levels in the absence of further arsenite treatment; thus likely contributing to long-lasting genomic instability that manifests as aberrant chromosomal, mutator and cell transformation effects