Tratamiento de evidencias digitales forenses en dispositivos móviles

En este artículo se presenta la investigación que se viene desarrollando en el Instituto de Investigaciones en Informática y Sistemas de Información de la Universidad Nacional de Santiago del Estero (UNSE) sobre obtención de evidencias digitales de dispositivos móviles. Para ello se considera como marco normativo el Nuevo Sistema Procesal Penal de la Provincia de Santiago del Estero El proceso de adquisición de evidencias digitales debe ser legalmente aceptable, apoyándose en métodos científicos que permitan recolectar, analizar y validar las mismas, recurriendo entonces a la Informática Forense. En este contexto, y en el marco de la investigación, se han desarrollado actividades con el propósito de definir un conjunto de lineamientos a los que se puede recurrir al momento de realizar la obtención de evidencias digitales desde dispositivos móviles. Durante esta etapa, se han estudiado las buenas prácticas tendientes a asegurar la calidad de los procesos aplicados y sus resultados.Eje: Ingeniería en Sistemas Software.Red de Universidades con Carreras en Informátic

Tratamiento de evidencias digitales forenses en dispositivos móviles

En este artículo se presenta la investigación que se viene desarrollando en el Instituto de Investigaciones en Informática y Sistemas de Información de la Universidad Nacional de Santiago del Estero (UNSE) sobre obtención de evidencias digitales de dispositivos móviles. Para ello se considera como marco normativo el Nuevo Sistema Procesal Penal de la Provincia de Santiago del Estero El proceso de adquisición de evidencias digitales debe ser legalmente aceptable, apoyándose en métodos científicos que permitan recolectar, analizar y validar las mismas, recurriendo entonces a la Informática Forense. En este contexto, y en el marco de la investigación, se han desarrollado actividades con el propósito de definir un conjunto de lineamientos a los que se puede recurrir al momento de realizar la obtención de evidencias digitales desde dispositivos móviles. Durante esta etapa, se han estudiado las buenas prácticas tendientes a asegurar la calidad de los procesos aplicados y sus resultados.Eje: Ingeniería en Sistemas Software.Red de Universidades con Carreras en Informátic

Clinical profile of patients with ATP1A3 mutations in alternating hemiplegia of childhood-a study of 155 patients.

BACKGROUND: Mutations in the gene ATP1A3 have recently been identified to be prevalent in patients with alternating hemiplegia of childhood (AHC2). Based on a large series of patients with AHC, we set out to identify the spectrum of different mutations within the ATP1A3 gene and further establish any correlation with phenotype. METHODS: Clinical data from an international cohort of 155 AHC patients (84 females, 71 males; between 3 months and 52 years) were gathered using a specifically formulated questionnaire and analysed relative to the mutational ATP1A3 gene data for each patient. RESULTS: In total, 34 different ATP1A3 mutations were detected in 85 % (132/155) patients, seven of which were novel. In general, mutations were found to cluster into five different regions. The most frequent mutations included: p.Asp801Asn (43 %; 57/132), p.Glu815Lys (16 %; 22/132), and p.Gly947Arg (11 %; 15/132). Of these, p.Glu815Lys was associated with a severe phenotype, with more severe intellectual and motor disability. p.Asp801Asn appeared to confer a milder phenotypic expression, and p.Gly947Arg appeared to correlate with the most favourable prognosis, compared to the other two frequent mutations. Overall, the comparison of the clinical profiles suggested a gradient of severity between the three major mutations with differences in intellectual (p = 0.029) and motor (p = 0.039) disabilities being statistically significant. For patients with epilepsy, age at onset of seizures was earlier for patients with either p.Glu815Lys or p.Gly947Arg mutation, compared to those with p.Asp801Asn mutation (p < 0.001). With regards to the five mutation clusters, some clusters appeared to correlate with certain clinical phenotypes. No statistically significant clinical correlations were found between patients with and without ATP1A3 mutations. CONCLUSIONS: Our results, demonstrate a highly variable clinical phenotype in patients with AHC2 that correlates with certain mutations and possibly clusters within the ATP1A3 gene. Our description of the clinical profile of patients with the most frequent mutations and the clinical picture of those with less common mutations confirms the results from previous studies, and further expands the spectrum of genotype-phenotype correlations. Our results may be useful to confirm diagnosis and may influence decisions to ensure appropriate early medical intervention in patients with AHC. They provide a stronger basis for the constitution of more homogeneous groups to be included in clinical trials

Sentinel Lymph Node Biopsy in Malignant Melanoma of the Head and Neck: A Single Center Experience

Purpose: This study evaluated the characteristics of patients with head and neck (H&N) melanoma who underwent sentinel lymph node biopsy (SNLB) and assessed the clinical course of patients categorizing subjects according to SLNB status and melanoma location (scalp area vs. non-scalp areas). Methods: Patients undergoing SLNB for melanoma of H&N from 2015 to 2021 were prospectively characterized according to sentinel lymph node (SLN) status. SPECT/CT had been previously performed. Patients were followed until the first adverse event to evaluate progression-free survival. Results: 93 patients were enrolled. SLNB was negative in 75 patients. The median Breslow index was higher for patients with positive SLNB compared with patients with negative SLNB. In addition, the Breslow index was higher for melanoma of the scalp compared with non-scalp melanoma. The median follow-up was 24.8 months. Progression occurred at the systemic level in the 62.5% of cases. There was a significant association between positive SLNB and progression (p-value p-value: 0.15). Conclusions: Scalp melanomas are more aggressive than other types of H&N melanomas. Sentinel lymph node status is the strongest prognostic criterion for recurrence

Accuracy of F-18-FDG in Detecting Stage I Lung Adenocarcinomas According to IASLC/ATS/ERS Classification

Background Only a small number of studies have explored the clinicopathological features of pulmonary adenocarcinoma (PA) associated with F-18-fluorodeoxyglucose positron emission tomography (FDG-PET) false-negative (FN) results. Herein, we investigated the FDG-PET diagnostic performance by stratifying PAs according to International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) classification.Methods From January 2002 to December 2016, all consecutive patients who underwent pulmonary resection for stage I PA at six thoracic surgery institutions were retrospectively reviewed. The diagnostic performance of FDG-PET was analysed according to IASLC/ATS/ERS classification and two validated subclassifications. Univariable and multivariable logistic analysis were used to identify predictors of FDG-PET FN results.Results Five hundred and fifty (550) patients with stage I PA were included in the analyses. Most of the patients were male (n=354 [64.4%]) and smokers (n=369 [67.1%]). Ninety-seven (n=97 [17.6%]) FN cases were observed at FDG-PET imaging. On multivariable analysis, a lepidic pattern was found to be independently associated with FDG-PET FN results (odds ratio [OR], 3.20; p&lt;0.001), while a solid pattern more commonly presented with a positive finding (OR, 0.40; p=0.066). According to Nakamura's classification, we observed an independent association between lepidic pattern and FDG-PET FN results (OR, 3.17; p&lt;0.001), while solid/micropapillary patterns were independently related with increased FDG uptake (OR, 0.35; p=0.021). According to Yoshizawa's classification, Intermediate-grade tumours were independently correlated with FN FDG-PET results (OR, 2.78; p=0.005).Conclusions In our cohort, histopathological features were significantly associated with FDG uptake. In particular, some adenocarcinoma subtypes (mostly Lepidic pattern) have a tendency towards FN FDG-PET findings. The correlation between computed tomography findings, clinical characteristics, and FDG uptake is mandatory, in order to tailor the precise diagnostic and therapeutic pathway for each patient

La Petite presse : journal quotidien... / [rédacteur en chef : Balathier Bragelonne]

21 juin 18691869/06/21 (A4,N1159)