SafetyBench: Evaluating the Safety of Large Language Models with Multiple Choice Questions

With the rapid development of Large Language Models (LLMs), increasing attention has been paid to their safety concerns. Consequently, evaluating the safety of LLMs has become an essential task for facilitating the broad applications of LLMs. Nevertheless, the absence of comprehensive safety evaluation benchmarks poses a significant impediment to effectively assess and enhance the safety of LLMs. In this work, we present SafetyBench, a comprehensive benchmark for evaluating the safety of LLMs, which comprises 11,435 diverse multiple choice questions spanning across 7 distinct categories of safety concerns. Notably, SafetyBench also incorporates both Chinese and English data, facilitating the evaluation in both languages. Our extensive tests over 25 popular Chinese and English LLMs in both zero-shot and few-shot settings reveal a substantial performance advantage for GPT-4 over its counterparts, and there is still significant room for improving the safety of current LLMs. We believe SafetyBench will enable fast and comprehensive evaluation of LLMs' safety, and foster the development of safer LLMs. Data and evaluation guidelines are available at https://github.com/thu-coai/SafetyBench. Submission entrance and leaderboard are available at https://llmbench.ai/safety.Comment: 15 page

A fuel consumption model for mixed traffic flow in multiple connected and autonomous scenarios

Abstract The potential increase/decrease in energy consumption of traffic operation modes is a hot topic in the studies of connected and autonomous vehicles (CAVs), but there are few theoretical studies on the fuel consumption of human driving vehicles (HDVs) and CAV mixed platoon as a result of limited data. Based on the power distribution of light‐duty vehicles, this study developed a fuel consumption model for HDV and CAV mixed platoons by theoretical hypothesis considering the oscillation along with the platoon. Firstly, a vehicle‐specific power (VSP) distribution conforming to normal distribution is constructed with hypothesis‐based VSP standard deviation and constant VSP average value at each speed bin under different platoon arrangement conditions. Then, the fuel factors (mL/km) are calculated by weighted fuel rate (mL/s) according to the VSP distribution. Finally, a library of fuel consumption values for multiple penetration rates, platoon intensities, and speeds was established. In the case, at a speed of 30 km/h, the fuel consumption in the CAV group was reduced by 0.8–5%, 1.9–12.5%, 8.6–12%, and 12.4%, respectively, at the penetration rate of 20%, 50%, 80%, and 100%, compared to the HDV group. The fuel consumption reduction effect of CAV was negatively correlated with the speed

The fat accumulation promotion effects of dihydrxytetraphenylmethane and its underlying mechanisms via transcriptome analysis

Dihydrxytetraphenylmethane, also known as Bisphenol BP (BPBP), has been increasingly used in industrial production and more frequently detected in the environment as an alternative plasticizer of BPA. However, there are no reports about BPBP in food safety or its effects on cellular lipogenesis. The purpose of this research was to investigate the influence and potential mechanisms of BPBP on adipogenesis in 3T3-L1 cells. Cells were treated with 4 concentrations (0.01, 0.1, 1, and 10 μM) of BPBP and the results showed that treatment with at low concentrations (0.01 μM) promoted cell fat differentiation and triglyceride accumulation. RNA-seq data showed that a total of 370 differentially expressed genes between control and the low-dose BPBP-treated group were determined, including 227 upregulated genes and 143 downregulated genes. Some key genes related to adipocyte differentiation and adipogenesis were significantly enriched after BPBP treatment, including PPAR-γ, Adipoq, Nr1h3 and Plin1. Pathway analyses suggest that the activation of PPAR-γ signaling pathway may be key for BPBP to promote adipocyte differentiation and fat accumulation. Our work provides evidence for the potential obesogenic effect of BPBP and may call for further research on the safety of the chemical in food products

Research progress in steel slag-based functional fillers with high added value in non-building materials field

People not only face the increasing depletion of primary resources, but also the difficult disposal of solid waste caused by consumption of primary resources. On the basis of fully investigating properties of steel slag, the steel slag-based functional filler has been researched and developed according to the characteristics of steel slag. It has been used in the fields of rubber, coatings and plastics, hoping to realize the cross-industry ecological chain and high value-added utilization of steel slag, which has great economic value and important practical significance. Steel slag-based functional filler has the characteristics of strong adsorption, small particle size, and good compatibility with organic systems. Therefore, it is potential to be widely used in rubber conveyor belts, steel structure anti-rust coatings, architectural exterior wall coatings, man-made composite panels and other fields. In this paper, the characteristics of steel slag and the preparation principle of steel slag-based functional fillers were firstly briefly introduced, and then, the situation of steel slag-based functional fillers used as rubber fillers, paint pigments, and plastic fillers was specifically analyzed. Secondly, the characteristics of steel slag-based functional fillers used in rubber composite materials, building exterior wall primers, building exterior wall coatings, and PVC micro-foamed sheets were pointed out respectively in detail. Then, the application limitations of current steel slag-based functional fillers were reviewed. Eventually, it was proposed to optimize the performance of steel slag-based functional fillers and develop multi-solid waste-based synergistic composite functional fillers, which will be the main development directions of steel slag-based functional fillers in the future

Transcription Regulation of Cell Cycle Regulatory Genes Mediated by NtrX to Affect <i>Sinorhizobium</i> <i>meliloti</i> Cell Division

The cell division of the alfalfa symbiont, Sinorhizobium meliloti, is dictated by a cell cycle regulatory pathway containing the key transcription factors CtrA, GcrA, and DnaA. In this study, we found that NtrX, one of the regulators of nitrogen metabolism, can directly regulate the expression of ctrA, gcrA, and dnaA from the cell cycle pathway. Three sets of S. meliloti ntrX mutants showed similar cell division defects, such as slow growth, abnormal morphology of some cells, and delayed DNA synthesis. Transcription of ctrA and gcrA was upregulated, whereas the transcription of dnaA and ftsZ1 was downregulated in the insertion mutant and the strain of Sm1021 expressing ntrXD53E. Correspondingly, the inducible transcription of ntrX activates the expression of dnaA and ftsZ1, but represses ctrA and gcrA in the depletion strain. The expression levels of CtrA and GcrA were confirmed by Western blotting. The transcription regulation of these genes requires phosphorylation of the conserved 53rd aspartate in the NtrX protein that binds directly to the promoter regions of ctrA, gcrA, dnaA, and ftsZ1 by recognizing the characteristic sequence CAAN2-5TTG. Our findings suggest that NtrX affects S. meliloti cell division by regulating the transcription of the key cell cycle regulatory genes

DataSheet1_L-carnitine attenuated hyperuricemia-associated left ventricular remodeling through ameliorating cardiomyocytic lipid deposition.docx

Hyperuricemia (HUA) is associated with left ventricular remodeling (LVR) and thereby causes the initiation and development of a large number of cardiovascular diseases. LVR is typically accompanied by cardiomyocyte energy metabolic disorder. The energy supply of cardiomyocytes is provided by glucose and fatty acid (FA) metabolism. Currently, the effect of HUA on cardiomyocytic FA metabolism is unclear. In this study, we demonstrate that UA-induced cardiomyocyte injury is associated with cytoplasmic lipid deposition, which can be ameliorated by the FA metabolism-promoting drug L-carnitine (LC). UA suppresses carnitine palmitoyl transferase 1B (CPT1B), thereby inhibiting FA transport into the mitochondrial inner matrix for elimination. LC intervention can ameliorate HUA-associated left ventricular anterior wall thickening in mice. This study showed that FA transport dysfunction plays is a critical mechanism in both cardiomyocytic injury and HUA-associated LVR and promoting cytoplasmic FA transportation through pharmacological treatment by LC is a valid strategy to attenuate HUA-associated LVR.</p