Lightning Observations and Tropical Cyclogenesis in the Atlantic and East Pacific

It has been hypothesized that deep, intense convective-scale "hot" towers may aid the process of tropical cyclogenesis and intensification through dynamic and thermodynamic feedbacks on the larger meso-to-synoptic scale circulation. In this study, we make use of NCEP Reanalysis data and Tropical Rainfall Measurement Mission (TRMM) lightning imaging sensor (LIS), precipitation radar (PR), and microwave imager (TMI) data to investigate the role that widespread and/or intense lightning-producing convection (i.e., "electrically-hot towers") present in African easterly waves (AEWs) may play in tropical cyclogenesis over the Atlantic, Caribbean, and East Pacific regions. NCEP Reanalysis 700 hPa meridional winds for the months of June to November for the years 2001-2009 were analyzed for the domain of 5degN-20degN and 130degW-20degE in order to partition individual AEWs into northerly, southerly, trough, and ridge phases. Subsequently, information from National Hurricane Center (NHC) storm reports was used to divide the waves into developing and non-developing waves. In addition, information from the NHC reports was used to further divide the developing waves into those waves that spawned storms that only developed to tropical storm strength and those that spawned storms that reached hurricane strength. The developing waves were also divided by the region in which they developed. To assess the evolution of convection associated with the AEWs as they propagated across our analysis domain, the full 130degW-20degE domain was divided into five longitude bands, and waves were analyzed for each band. To help determine the gross nature of the smaller convective scale, composites were created of all developing and non-developing waves as a function of AEW wave phase over the full analysis domain and each longitude band by compositing TRMM PR, TMI, LIS, and IR brightness temperature data extracted from the NASA global-merged infrared brightness temperature dataset. Finally, similar composites were created using various NCEP variables to assess the nature of the larger scale environment and circulation

A Daily Diary Analysis of Preschool Depressive Behaviors: Same Day and Prospective Associations Across 14 Days

Depressive disorders can be observed in early childhood and are associated with significant concurrent and prospective impairment. Although young children demonstrate similar depressive behaviors as older children and adults, certain depressive behaviors, such as sadness and irritability, are more common in early childhood whereas other depressive behaviors, such as loss of pleasure and suicidal ideation, are much less common. However, little is known about day-to-day variations in common depressive behaviors and factors impacting those variations in early childhood. The current study examined the day-to-day variability and co-occurrence of two common depressive behaviors in young children, sadness and irritability, and predictors of their day-to-day change. Participants included 291 parents of preschool-aged children (ages 3-5). Parents completed a baseline questionnaire assessing demographics, current emotional/behavioral problems, and functional impairment, and then completed an electronic daily diary for 14 days assessing the frequency of daily depressive behaviors, sleep quality, and parent-child relationship functioning. Results indicated that irritability and sadness frequently co-occurred during the same day and were concurrently and prospectively associated with parent-child relationship functioning but not sleep quality. Moreover, we observed between-person stability, but within-person variability, in children’s sadness and irritability across 14 days, and that this variability was moderated by several factors. With few exceptions, we observed greater between-person stability in sadness and irritability for older preschoolers, for males, and for children with overall better functioning (e.g., absence of less common depressive symptoms, fewer baseline psychiatric symptoms, lower baseline impairment, better parent-child relationship functioning and sleep quality). Importantly, our findings highlight stability of children’s sadness and irritability relative to peers and variability relative to their own mean sadness and irritability, as well as provide evidence regarding factors predicting the day-to-day stability or variability of these common depressive behaviors. Understanding daily variation in child depressive behaviors and factors predicting variation can identify at-risk children and provide targets for prevention and intervention, which is particularly crucial given that preschool depression predicts later depression and other psychiatric disorders

Stability and Change of Cortisol Reactivity to a Laboratory Stressor from Early to Middle Childhood

This study examined the stability and change of children’s cortisol reactivity to a laboratory stressor from early to middle childhood and moderators of change. Ninety-six children completed stress-inducing laboratory tasks and provided five salivary cortisol samples at preschool age (T1; M = 49.88 months, SD = 9.51 months) and three years later (T2; M = 87.44 months, SD = 11.42 months). At T1, parents completed clinical interviews assessing child and parent psychopathology. Cortisol reactivity patterns significantly changed from decreasing to increasing reactivity from early to middle childhood. Moreover, preschool psychopathology moderated this change. Children with fewer preschool psychiatric symptoms demonstrated more stable reactivity patterns, whereas children with preschool psychiatric comorbidity demonstrated more unstable reactivity patterns across assessments. Findings suggest a developmental shift from decreasing to increasing cortisol reactivity from early to middle childhood, and highlight early preschool psychopathology as a moderator of change in cortisol reactivity

Coordination-driven magnetic-to-nonmagnetic transition in manganese doped silicon clusters

The interaction of a single manganese impurity with silicon is analyzed in a combined experimental and theoretical study of the electronic, magnetic, and structural properties of manganese-doped silicon clusters. The structural transition from exohedral to endohedral doping coincides with a quenching of high-spin states. For all geometric structures investigated, we find a similar dependence of the magnetic moment on the manganese coordination number and nearest neighbor distance. This observation can be generalized to manganese point defects in bulk silicon, whose magnetic moments fall within the observed magnetic-to-nonmagnetic transition, and which therefore react very sensitively to changes in the local geometry. The results indicate that high spin states in manganese-doped silicon could be stabilized by an appropriate lattice expansion

Electrically-Active Convection in Tropical Easterly Waves and Implications for Tropical Cyclogenesis in the Atlantic and East Pacific

In this study, we investigate the characteristics of tropical easterly wave convection and the possible implications of convective structure on tropical cyclogenesis and intensification over the Atlantic Ocean and East Pacific using data from the Tropical Rainfall Measurement Mission Microwave Imager, Precipitation Radar (PR), and Lightning Imaging Sensor as well as infrared (IR) brightness temperature data from the NASA global-merged IR brightness temperature dataset. Easterly waves were partitioned into northerly, southerly, trough, and ridge phases based on the 700-hPa meridional wind from the NCEP-NCAR reanalysis dataset. Waves were subsequently divided according to whether they did or did not develop tropical cyclones (i.e., developing and nondeveloping, respectively), and developing waves were further subdivided according to development location. Finally, composites as a function of wave phase and category were created using the various datasets. Results suggest that the convective characteristics that best distinguish developing from nondeveloping waves vary according to where developing waves spawn tropical cyclones. For waves that developed a cyclone in the Atlantic basin, coverage by IR brightness temperatures .240 K and .210 K provide the best distinction between developing and nondeveloping waves. In contrast, several variables provide a significant distinction between nondeveloping waves and waves that develop cyclones over the East Pacific as these waves near their genesis location including IR threshold coverage, lightning flash rates, and low-level (<4.5 km) PR reflectivity. Results of this study may be used to help develop thresholds to better distinguish developing from nondeveloping waves and serve as another aid for tropical cyclogenesis forecasting

Tuning the bandgap of Cs2AgBiBr6 through dilute tin alloying.

The promise of lead halide hybrid perovskites for optoelectronic applications makes finding less-toxic alternatives a priority. The double perovskite Cs2AgBiBr6 (1) represents one such alternative, offering long carrier lifetimes and greater stability under ambient conditions. However, the large and indirect 1.95 eV bandgap hinders its potential as a solar absorber. Here we report that alloying crystals of 1 with up to 1 atom% Sn results in a bandgap reduction of up to ca. 0.5 eV while maintaining low toxicity. Crystals can be alloyed with up to 1 atom% Sn and the predominant substitution pathway appears to be a ∼2 : 1 substitution of Sn2+ and Sn4+ for Ag+ and Bi3+, respectively, with Ag+ vacancies providing charge compensation. Spincoated films of 1 accommodate a higher Sn loading, up to 4 atom% Sn, where we see mostly Sn2+ substitution for both Ag+ and Bi3+. Density functional theory (DFT) calculations ascribe the bandgap redshift to the introduction of Sn impurity bands below the conduction band minimum of the host lattice. Using optical absorption spectroscopy, photothermal deflection spectroscopy, X-ray absorption spectroscopy, 119Sn NMR, redox titration, single-crystal and powder X-ray diffraction, multiple elemental analysis and imaging techniques, and DFT calculations, we provide a detailed analysis of the Sn content and oxidation state, dominant substitution sites, and charge-compensating defects in Sn-alloyed Cs2AgBiBr6 (1:Sn) crystals and films. An understanding of heterovalent alloying in halide double perovskites opens the door to a wider breadth of potential alloying agents for manipulating their band structures in a predictable manner

Pain Management in Patients with Cancer: Focus on Opioid Analgesics

Cancer pain is generally treated with pharmacological measures, relying on using opioids alone or in combination with adjuvant analgesics. Weak opioids are used for mild-to-moderate pain as monotherapy or in a combination with nonopioids. For patients with moderate-to-severe pain, strong opioids are recommended as initial therapy rather than beginning treatment with weak opioids. Adjunctive therapy plays an important role in the treatment of cancer pain not fully responsive to opioids administered alone (ie, neuropathic, bone, and visceral colicky pain). Supportive drugs should be used wisely to prevent and treat opioids’ adverse effects. Understanding the pharmacokinetics, pharmacodynamics, interactions, and cautions with commonly used opioids can help determine appropriate opioid selection for individual cancer patients

Matrix Metalloproteinase (MMP)-8 and MMP-9 in Cerebrospinal Fluid during Bacterial Meningitis: Association with Blood-Brain Barrier Damage and Neurological Sequelae

To evaluate the spectrum and regulation of matrix metalloproteinases (MMPs) in bacterial meningitis (BM), concentrations of MMP-2, MMP-3, MMP-8, and MMP-9 and endogenous inhibitors of metalloproteinases (TIMP-1 and TIMP-2) were measured in the cerebrospinal fluid (CSF) of 27 children with BM. MMP-8 and MMP-9 were detected in 91% and 97%, respectively, of CSF speci-mens from patients but were not detected in control patients. CSF levels of MMP-9 were higher (P <.05) in 5 patients who developed hearing impairment or secondary epilepsy than in those who recovered without neurological deficits. Levels of MMP-9 correlated with concentrations of TIMP-1 (P <.001) and tumor necrosis factor-α (P =.03). Repeated lumbar punctures showed that levels of MMP-8 and MMP-9 were regulated independently and did not correlate with the CSF cell count. Therefore, MMPs may derive not only from granulocytes infiltrating the CSF space but also from parenchymal cells of the meninges and brain. High concentrations of MMP-9 are a risk factor for the development of postmeningitidal neurological sequela

Delayed Nrf2-regulated antioxidant gene induction in response to silica nanoparticles.

Silica nanoparticles with iron on their surface cause the production of oxidants and stimulate an inflammatory response in macrophages. Nuclear factor erythroid-derived 2 - like factor 2 (Nrf2) signaling and its regulated antioxidant genes play critical roles in maintaining redox homeostasis. In this study we investigated the regulation of four representative Nrf2-regulated antioxidant genes; i.e., glutamate cysteine ligase (GCL) catalytic subunit (GCLC), GCL modifier subunit (GCLM), heme oxygenase 1 (HO-1), and NAD(P)H:quinone oxidoreductase-1 (NQO-1), by iron-coated silica nanoparticles (SiO2-Fe) in human THP-1 macrophages. We found that the expression of these four antioxidant genes was modified by SiO2-Fe in a time-dependent manner. At 6h, their expression was unchanged except for GCLC, which was reduced compared with controls. At 18h, the expression of these antioxidant genes was significantly increased compared with controls. In contrast, the Nrf2 activator sulforaphane induced all antioxidant genes at as early as 3h. The nuclear translocation of Nrf2 occurred later than that for NF-κB p65 protein and the induction of proinflammatory cytokines (TNFα and IL-1β). NF-κB inhibitor SN50 prevented the reduction of GCLC at 6h and abolished the induction of antioxidant genes at 18h by SiO2-Fe, but did not affect the basal and sulforaphane-induced expression of antioxidant genes, suggesting that NF-κB signaling plays a key role in the induction of Nrf2-mediated genes in response to SiO2-Fe. Consistently, SN50 inhibited the nuclear translocation of Nrf2 caused by SiO2-Fe. In addition, Nrf2 silencing decreased the basal and SiO2-induced expression of the four reprehensive antioxidant genes. Taken together, these data indicated that SiO2-Fe induced a delayed response of Nrf2-regulated antioxidant genes, likely through NF-κB-Nrf2 interactions