6,056 research outputs found
Closed-cycle, low-vibration 4 K cryostat for ion traps and other applications
In-vacuo cryogenic environments are ideal for applications requiring both low
temperatures and extremely low particle densities. This enables reaching long
storage and coherence times for example in ion traps, essential requirements
for experiments with highly charged ions, quantum computation, and optical
clocks. We have developed a novel cryostat continuously refrigerated with a
pulse-tube cryocooler and providing the lowest vibration level reported for
such a closed-cycle system with 1 W cooling power for a <5 K experiment. A
decoupling system suppresses vibrations from the cryocooler by three orders of
magnitude down to a level of 10 nm peak amplitudes in the horizontal plane.
Heat loads of about 40 W (at 45 K) and 1 W (at 4 K) are transferred from an
experimental chamber, mounted on an optical table, to the cryocooler through a
vacuum-insulated massive 120 kg inertial copper pendulum. The 1.4 m long
pendulum allows installation of the cryocooler in a separate, acoustically
isolated machine room. In the laser laboratory, we measured the residual
vibrations using an interferometric setup. The positioning of the 4 K elements
is reproduced to better than a few micrometer after a full thermal cycle to
room temperature. Extreme high vacuum on the mbar level is achieved.
In collaboration with the Max-Planck-Intitut f\"ur Kernphysik (MPIK), such a
setup is now in operation at the Physikalisch-Technische Bundesanstalt (PTB)
for a next-generation optical clock experiment using highly charged ions
Modeling meander morphodynamics over self-formed heterogeneous floodplains
This work addresses the signatures embedded in the planform geometry of meandering rivers consequent to the formation of floodplain heterogeneities as the river bends migrate. Two geomorphic features are specifically considered: scroll bars produced by lateral accretion of point bars at convex banks and oxbow lake fills consequent to neck cutoffs. The sedimentary architecture of these geomorphic units depends on the type and amount of sediment, and controls bank erodibility as the river impinges on them, favoring or contrasting the river migration. The geometry of numerically generated planforms obtained for different scenarios of floodplain heterogeneity is compared to that of natural meandering paths. Half meander metrics and spatial distribution of channel curvatures are used to disclose the complexity embedded in meandering geometry. Fourier Analysis, Principal Component Analysis, Singular Spectrum Analysis and Multivariate Singular Spectrum Analysis are used to emphasize the subtle but crucial differences which may emerge between apparently similar configurations. A closer similarity between observed and simulated planforms is attained when fully coupling flow and sediment dynamics (fully-coupled models) and when considering self-formed heterogeneities that are less erodible than the surrounding floodplain
A Deep Learning Approach to Denoise Optical Coherence Tomography Images of the Optic Nerve Head
Purpose: To develop a deep learning approach to de-noise optical coherence
tomography (OCT) B-scans of the optic nerve head (ONH).
Methods: Volume scans consisting of 97 horizontal B-scans were acquired
through the center of the ONH using a commercial OCT device (Spectralis) for
both eyes of 20 subjects. For each eye, single-frame (without signal
averaging), and multi-frame (75x signal averaging) volume scans were obtained.
A custom deep learning network was then designed and trained with 2,328 "clean
B-scans" (multi-frame B-scans), and their corresponding "noisy B-scans" (clean
B-scans + gaussian noise) to de-noise the single-frame B-scans. The performance
of the de-noising algorithm was assessed qualitatively, and quantitatively on
1,552 B-scans using the signal to noise ratio (SNR), contrast to noise ratio
(CNR), and mean structural similarity index metrics (MSSIM).
Results: The proposed algorithm successfully denoised unseen single-frame OCT
B-scans. The denoised B-scans were qualitatively similar to their corresponding
multi-frame B-scans, with enhanced visibility of the ONH tissues. The mean SNR
increased from dB (single-frame) to dB
(denoised). For all the ONH tissues, the mean CNR increased from (single-frame) to (denoised). The MSSIM increased from
(single frame) to (denoised) when compared with
the corresponding multi-frame B-scans.
Conclusions: Our deep learning algorithm can denoise a single-frame OCT
B-scan of the ONH in under 20 ms, thus offering a framework to obtain superior
quality OCT B-scans with reduced scanning times and minimal patient discomfort
Motion-sensitive responses in visual area V4 in the absence of primary visual cortex
Neurons in cortical ventral-stream area V4 are thought to contribute to important aspects of visual processing by integrating information from primary visual cortex (V1). However, how V4 neurons respond to visual stimulation after V1 injury remains unclear: While electrophysiological investigation of V4 neurons during reversible V1 inactivation suggests that virtually all responses are eliminated (Girard et al., 1991), fMRI in humans and monkeys with permanent lesions shows reliable V1-independent activity (Baseler et al., 1999; Goebel et al., 2001; Schmid et al., 2010). To resolve this apparent discrepancy, we longitudinally assessed neuronal functions of macaque area V4 using chronically implanted electrode arrays before and after creating a permanent aspiration lesion in V1. During the month after lesioning, we observed weak yet significant spiking activity in response to stimuli presented to the lesion-affected part of the visual field. These V1-independent responses showed sensitivity for motion and likely reflect the effect of V1-bypassing geniculate input into extrastriate areas
Coherent states for the hydrogen atom
We construct wave packets for the hydrogen atom labelled by the classical
action-angle variables with the following properties. i) The time evolution is
exactly given by classical evolution of the angle variables. (The angle
variable corresponding to the position on the orbit is now non-compact and we
do not get exactly the same state after one period. However the gross features
do not change. In particular the wave packet remains peaked around the labels.)
ii) Resolution of identity using this overcomplete set involves exactly the
classical phase space measure. iii) Semi-classical limit is related to
Bohr-Sommerfield quantization. iv) They are almost minimum uncertainty wave
packets in position and momentum.Comment: 9 pages, 2 figures, minor change in language and journal reference
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Обеспечение точности обобщенной интервальной оценки качества изделий
Разработан метод интервальной оценки качества изделий, отличительной особенностью которого является получение весовых коэффициентов обобщенного показателя с использованием нечетких функций принадлежности гауссового типа. Их использование позволяет повысить точность и достоверность принятия решения при определении категории качества изделий различного целевого назначения в соответствии с вербально-числовой шкалой функции желательности Харрингтона.Розроблено метод інтервальної оцінки якості виробів, відмітною особливістю якого є отримання вагових коефіцієнтів узагальненого показника з використанням нечітких функцій приналежності гауссового типу. Їх використання дозволяє підвищити точність та вірогідність прийняття рішення під час визначення категорії якості виробів різного цільового призначення відповідно до вербально-числової шкали функції бажаності Харрінгтона.The method of interval estimation of the products’ quality, the distinctive feature of which is a receipt of gravimetric coefficients of the generalized index with the use of unclear membership functions of gauss type, is developed. Their usage allows to promote exactness and authenticity of decision-making at determination category of products’ quality of the different target destination in accordance with the verbally-numerical scale of desirability function of Harrington
Multi-Timescale Perceptual History Resolves Visual Ambiguity
When visual input is inconclusive, does previous experience aid the visual system in attaining an accurate perceptual interpretation? Prolonged viewing of a visually ambiguous stimulus causes perception to alternate between conflicting interpretations. When viewed intermittently, however, ambiguous stimuli tend to evoke the same percept on many consecutive presentations. This perceptual stabilization has been suggested to reflect persistence of the most recent percept throughout the blank that separates two presentations. Here we show that the memory trace that causes stabilization reflects not just the latest percept, but perception during a much longer period. That is, the choice between competing percepts at stimulus reappearance is determined by an elaborate history of prior perception. Specifically, we demonstrate a seconds-long influence of the latest percept, as well as a more persistent influence based on the relative proportion of dominance during a preceding period of at least one minute. In case short-term perceptual history and long-term perceptual history are opposed (because perception has recently switched after prolonged stabilization), the long-term influence recovers after the effect of the latest percept has worn off, indicating independence between time scales. We accommodate these results by adding two positive adaptation terms, one with a short time constant and one with a long time constant, to a standard model of perceptual switching
How native state topology affects the folding of Dihydrofolate Reductase and Interleukin-1beta
The overall structure of the transition state and intermediate ensembles
experimentally observed for Dihydrofolate Reductase and Interleukin-1beta can
be obtained utilizing simplified models which have almost no energetic
frustration. The predictive power of these models suggest that, even for these
very large proteins with completely different folding mechanisms and functions,
real protein sequences are sufficiently well designed and much of the
structural heterogeneity observed in the intermediates and the transition state
ensembles is determined by topological effects.Comment: Proc. Natl. Acad. Sci. USA, in press (11 pages, 4 color PS figures)
Higher resolution PS files can be found at
http://www-physics.ucsd.edu/~cecilia/pub_list.htm
The effect of parallel static and microwave electric fields on excited hydrogen atoms
Motivated by recent experiments we analyse the classical dynamics of a
hydrogen atom in parallel static and microwave electric fields. Using an
appropriate representation and averaging approximations we show that resonant
ionisation is controlled by a separatrix, and provide necessary conditions for
a dynamical resonance to affect the ionisation probability.
The position of the dynamical resonance is computed using a high-order
perturbation series, and estimate its radius of convergence. We show that the
position of the dynamical resonance does not coincide precisely with the
ionisation maxima, and that the field switch-on time can dramatically affect
the ionisation signal which, for long switch times, reflects the shape of an
incipient homoclinic. Similarly, the resonance ionisation time can reflect the
time-scale of the separatrix motion, which is therefore longer than
conventional static field Stark ionisation. We explain why these effects should
be observed in the quantum dynamics.
PACs: 32.80.Rm, 33.40.+f, 34.10.+x, 05.45.Ac, 05.45.MtComment: 47 pages, 20 figure
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