Using of User Micro-Segmentation and Human Resource Management for Supply Chains Approaches to Study Prospective Target Audiences

 Supply chain management can enable economies and companies to overcome disruptions and continually transform them to meet the changing needs and expectations of its customers, shareholders and other stakeholders. Therefore, the objective of this study was to investigate the influence of strategic human resource managing on supply chain resilience in manufacturing firms in Russia. The employed population is more considered to be economically active. Possibilities of consumption of this layer of the population are caused by a tendency of development of theories and practices about a society of consumption. The concept of earning in order to consume allows you to explore not only the possibility of consumption in terms of income of the employed population, but also the thematic direction of consumed economic benefits. Semantic fields that form a community of consumers among the employed population are formed by combining people working in one place. All these elements of one system can be described in the economic interpretation, which will allow to look at the new state of consumption of the employed population of the Russian Federation

Методика выбора мест размещения транспортно-пересадочных узлов на основе оптимизационной математической модели

The article discusses development of a system of transport and interchange hubs (TIH). The need to create TIHs is due to an opportunity to increase efficiency of passenger flows in the urban public transport system, to reduce travel time for passengers, to ensure comfortable and safe conditions for transfer, and to improve quality of service to the population.  The objective of the research is to develop methods that allow solving the problem of optimal selection of TIH locations in any city according to the economic criterion and the criterion of the average travel time using the methods of mathematical modelling. The technique comprises search for optimal travel routes in the city and identification of effective interchange hubs using the developed software product called «Efficient transfers». Efficient transfer hubs with maximum passenger traffic are candidates for TIH locations. The work describes calculations made according the proposed methods and optimal options for location of this in the city of Samara considering limited funds, reduction in travel time and in the number of passengers using these TIHs. The research also resulted in obtaining the dependence of reduction in the average time of an urban trip on the number of TIHs.В статье рассмотрено формирование системы транспортно-пересадочных узлов (ТПУ). Необходимость создания ТПУ обусловлена возможностью повышения эффективности организации пассажиропотоков в системе городского общественного транспорта, сокращения времени поездки пассажиров, обеспечения комфортных, безопасных условий пересадки и улучшения качества обслуживания населения. Цель работы – разработка методики, позволяющей решать задачу оптимального выбора мест размещения ТПУ любого города по экономическому критерию и критерию среднего времени поездки с использованием методов математического моделирования. Методика включает поиск оптимальных маршрутов поездки по городу и определение эффективных пересадочных узлов с помощью разработанного программного продукта «Эффективные пересадки». При этом эффективные пересадочные узлы с максимальной величиной пассажиропотока являются кандидатами на создание в них ТПУ. В работе выполнены расчёты согласно предлагаемой методике и определены оптимальные варианты размещения транспортно-пересадочных узлов в городском округе Самара при ограниченных денежных средствах с учётом величины сокращения времени поездки и количества пассажиров, пользующихся этими пересадочными узлами. Получена зависимость сокращения среднего времени одной поездки по городу от количества транспортно-пересадочных узлов

The Problem of Drug Interactions Between Rosuvastatin and Ticagrelor in the Aspect of the Risk of Rhabdomyolysis: Discussion of the Problem and Description of the Clinical Case

Background. Combination therapy with two antiplatelet agents (ticagrelor or clopidogrel plus acetylsalicylic acid) and a high dose statin is recommended in accordance with clinical guidelines for patients undergoing acute coronary syndrome and coronary intervention. Combined therapeutic regimens have drug-drug interaction potential. Rhabdomyolysis is a known side effect of statin therapy, and there is evidence that co-therapy with ticagrelor increases the risk of this complication.Case description. A 72-year-old female patient was hospitalized with typical signs of rhabdomyolysis: muscle pain, oliguria, weakness, significant increases in creatine kinase (CK), myoglobin and creatinine. One month before that, she was urgently hospitalized with acute recurrent ST-elevation myocardial infarction and underwent endovascular intervention on a critical stenosis of the left anterior descending artery with stent implantation. After that, rosuvastatin 40 mg per day and ticagrelor 90mg 2 times a day were added to her therapy. During the current hospitalization, rosuvastatin, ACE inhibitors and spirolactone were canceled, infusion therapy was carried out, which led to a rapid regression of symptoms, restoration of adequate diuresis, and normalization of CK, myoglobin and creatinine levels. Conclusions. The combined use of ticagrelor with rosuvastatin (especially at a high dose) increases the risk of rhabdomyolysis in elderly patients. Patients taking ticagrelor may require changes in statin therapy, dose adjustments, and possible drug changes to avoid pharmacological interactions and an increased risk of side effects

Transformation of the Structure of Self-Attitude in Early, Middle and Later Adulthood (on the Example of the Ukrainian Sample)

The study intends to trace the dynamics of self-esteem and changes in the structure of self-attitude at different stages of adult life, as well as identify signs of experiencing age-related crises. Self-attitude is considered a multidimensional formation, with its individual components, have different subjective significance in different periods of life. A cross-section was carried out in 507 subjects aged 25-65 years was carried out. Rosenberg Self-Esteem Scale and Self-Attitude Study Methodology by Pantileev were used. Normative data for RSES obtained on a sample of adult Ukrainians (N=488) are presented for the first time. The average interval was 22.70 ±5.43 (with a measuring scale of 0 to 30 points), but the reference point for low self-esteem is different for men and women. Comparison of average results in groups belonging to periods of early, middle, and later adulthood showed that the attitude towards oneself with age becomes more emotionally expressive, concerning both positive and negative components. The indicators of self-blame and inner closedness grow along with the growth of the positive self-attitude (self-confidence, self-management, self-acceptance). The heterogeneous age dynamics of components of self-attitude, pronounced peaks, and dips in different periods are shown. Based on the clustering of empirical data, we described seven types of self-attitude in adulthood: illusory, confident, accepting, crisis, externally oriented, persistently negative, and inexpressive. Markers of experiencing crisis life periods are the ambivalence of self-attitude - the simultaneous manifestation of positive and negative components, which is regarded as a sign of instability. The obtained results demonstrate that there are potential opportunities for personal growth among cases of low self-esteem

Photovoltaic Response of Silicon Wafers Treated in the K2WO4-Na2WO4-WO3Melt

Texturing silicon wafers is one way to increase the performance of solar cells. This work is the first to report on the surface modification of Si wafers by processing in polytungstate melts. Scanning electron microscopy (SEM), atomic force microscopy (AFM), X-ray diffraction analysis (XRD), the Brunauer-Emmett-Teller (BET) method, and photoelectrochemical measurements were used to elucidate the effect of texturing conditions in the Na2WO4 - K2WO4 (1:1) melt containing 35 or 50 mol% WO3 at 973 K in air. As a result of cathodic treatment in the melt containing 50 mol% WO3 at the potential of -0.92 V (vs Pt) for 15 s, upright pyramids were formed on the Si surface. In addition, inverted pyramids appeared at the OTB/Si contact points. The photocurrent density of these samples was several times higher than that for the initial Si wafer or the Si wafer etched in 5 M NaOH solution at 353 K for 20 min. Mechanisms for the formation of upright and inverted pyramids were proposed. Unusual eight-faceted pyramids were formed on the Si surface during cathodic treatment in the melt containing 35 mol% WO3 at -1.19 V for 15 s, but the photocurrent density of such samples was low. © 2021 The Electrochemical Society ("ECS"). Published on behalf of ECS by IOP Publishing Limited.This work is performed in the frame of the State Assignment number 075-03-2020-582/1 dated 18.02.2020 (the theme number 0836-2020-0037). This work has been (partly) done using facilities of the Shared Access Center "Composition of Compounds" (IHTE, UB RAS)

Использование нейронной сети для учёта и анализа показателей работы транспортного предприятия

Recently, the issue of determining actual values of passenger flow processed by urban public and suburban transport on each section of the route in real time has become even more relevant since those values affect planning, organisation of operations and performance of transport enterprises.It is not possible to assess the real volume of passenger flow with the number of tickets issued to passengers due to the large number of unaccounted passengers (the discrepancy between the number of tickets issued to passengers and the real number of passengers transported).The objective of the study which results are described in the article was to develop an intelligent system for calculating and analysing the transport enterprise performance, which allows automatically collecting, processing and analysing information about passenger flows, calculating the passenger rotation ratio on the route, drawing up optimal bus schedules and timetables, adjusting vehicle traffic intervals, determining the need for rolling stock to minimise the likelihood that a passenger is denied boarding, improving the quality of passenger service and reducing the operating costs of a transport enterprise.Real-time calculation of passenger flow values for each vehicle on the route of urban public transport is carried out by a quantitative method based on artificial neural network technology, which allows automatic processing of a large amount of information from CCTV cameras installed in vehicle interiors.The use of theoretical research methods helped to create an intelligent system capable to analyse and compare the number of tickets issued to passengers with the actual number of passengers transported on Samara city public transport route, the results were displayed through a graphical user interface. It was possible to reveal dependences of the number of unaccounted passengers on the route on the amount of passenger flow and the time of day.A possibility of using the proposed intelligent system in commuter trains was noted, provided that the cars are equipped with video surveillance cameras.В последнее время возрастает актуальность вопроса определения фактических значений пассажиропотока на городском общественном и пригородном транспорте на каждом участке маршрута в режиме реального времени, которые оказывают значительное влияние на планирование и организацию, а также на показатели работы транспортного предприятия.Оценить реальные размеры пассажиропотока по числу оформленных пассажирам проездных документов не представляется возможным из-за большого количества неучтённых пассажиров (несоответствия числа оформленных проездных документов реальному значению перевезённых пассажиров).Целью исследования, результаты которого приводятся в статье, является разработка интеллектуальной системы для расчёта и анализа показателей работы транспортного предприятия, которая в автоматическом режиме позволяет собирать, обрабатывать и анализировать информацию о пассажиропотоках, рассчитывать коэффициент сменности пассажиров на маршруте, составлять оптимальные графики и расписание движения автобусов, корректировать интервалы движения транспортных средств, определять потребность в подвижном составе с целью минимизации вероятности отказа пассажиру в посадке, повышения качества обслуживания пассажиров и снижения эксплуатационных расходов транспортного предприятия.Подсчёт значений пассажиропотока в режиме реального времени по каждому транспортному средству на маршруте городского общественного транспорта осуществляется количественным методом, основанным на технологии искусственной нейронной сети, позволяющим в автоматическом режиме обрабатывать большой объём информации с камер видеонаблюдения, которыми оборудуются салоны транспортных средств.С использованием теоретических методов исследования и с помощью интеллектуальной системы выполнены анализ и сравнение числа оформленных проездных документов с фактическим числом перевезённых пассажиров на маршруте городского общественного транспорта Самары с выводом результатов в графический интерфейс пользователя. Получены зависимости числа неучтённых пассажиров на маршруте от величины пассажиропотока и времени суток. Отмечена возможность использования предлагаемой интеллектуальной системы в пригородных электричках при условии оборудования вагонов камерами видеонаблюдения

Project of NNbar Experiment at the WWR-M Reactor

Supersource of ultracold neutrons on the basis of superfluid helium is under construction in PNPI NRC KI. It must provide UCN density 2-3 orders of magnitude higher than existing sources. For the new source we propose an experiment on search for neutron–antineutron oscillations based on the storage of ultracold neutrons in a material trap. The sensitivity of the experiment mostly depends on the trap size and the amount of UCN in it. The results of simulations of the designed experimental scheme show that the sensitivity can be increased by ∼ 10–40 times compared to sensitivity of previous experiment depending on the model of neutron reflection from walls

Comprehensive assessment of specific antibodies on infectious activity of tick-borne encephalitis virus

Vaccines for prophylactic immunization provide the most reliable and effective protection against the vast majority of infectious diseases. Tick-borne encephalitis (TBE) represents a high-priority medical issue at the territory of the Eurasian continent. Of great importance is assessing a role of distinct antibody titers especially low titers, observed quite often in vaccinated individuals, sometimes posing obstacles in determining a threshold of seropositivity as well as the level of specific protection against TBE virus. We aimed at obtaining data to assess antiviral activity of virus-specific antibodies with distinct titer levels based on the in vitro, ex vivo and in vivo experimental studies with a highly virulent Far-Eastern strain of tick-borne encephalitis virus. The in vitro, ex vivo and in vivo comprehensive experimental studies with a highly virulent Far-Eastern strain of tick-borne encephalitis virus (TBEV) were conducted and the dynamics of antiviral activity of virus-specific antibodies at variable titers (1:100–1:3200) was measured (timeframe ranged within 1–96 hours p.i.) to provide a rationale for evaluating the antiviral immune response. It was found that the in vitro experiments demonstrated that the IgG at 1:100 titer exerted a weak anti-TBEV neutralizing effect at all time-points examined. The IgG 1:400 titer caused a 2 log PFU/mL decline in TBEV Dal strain yield at 72 h post-infection, whereas at 1:3200 titer it completely suppressed TBEV replication throughout the observation period. The ex vivo experiments with blood serum obtained from vaccinated subjects demonstrating a range of TBEV antibody titers (sera from vaccinated individuals with varying anti-TBEV antibody titers) and in vivo (outinbred white mice) experiments revealed a delayed virus elimination for antibody titers at 1:100 and 1:200 as well as rapid virus elimination (1–2 days p.i.) for antibody titers greater than 1:400. Thus, antibody titer at 1:400 may be considered as the universal anti-TBEV protection threshold. In order to properly conclude regarding the revaccination schedule it is advised to start with testing blood serum for durability of anti-TBEV immune response. Subjects with TBEV antibody titers at 1:100 and 1:200 should be strongly recommended to undergo a mandatory revaccination. Such an approach is believed to be the most effective way toward enhancing efficacy of vaccine-mediated protection against TBE

Специалистическая модель в условиях непрерывного профессионального образования

Fundamental changes in the Russian economy determined by the increasing role of knowledge, the revolution in information and communication technologies, the formation of the global labor market, as well as political changes, dictate new requirements for professional training. The specialist model, professiogram, qualification characteristic, sociogram of profession, sociogram of professional identity is the view options of the ideal result of students’ training. The key competence is the defining competence because it corresponds to the conditions of implementation, which are neither limited, not too specific, but are to a certain extent universal. The essence of professional competence of a specialist is the integration of knowledge, skills, experience; personal qualities that provide professional development and self-realization of a specialist, i.e. personal opportunities that allow solving professional problems independently and effectively. The perspective direction of improvement of specialists training in professional education system is development of their models giving the chance to study more deeply problems of training and use of experts, to estimate quality of educational institutions work. In recent years, research aimed at developing a specialist model has covered not only the sphere of higher education; they are conducted in the systems of basic and secondary vocational education. One of the main means of rationing and assessing the quality of professional training of students is a competence model that allows getting the clearest information about the composition of competencies that must be formed in the future specialist in the learning process. The analysis of requirements to specialists training, the contents and technologies of educational process, methodology and practice of modern educational activity allows defining a number of principles and methods of formation of specialist model as bases of a component of the Federal State Educational Standard.Los cambios fundamentales en la economía rusa, determinados por el papel cada vez mayor del conocimiento, la revolución en las tecnologías de la información y la comunicación, la formación del mercado laboral mundial, así como los cambios políticos, dictan nuevos requisitos para la formación profesional. El modelo de especialista, el profesiograma, la característica de calificación, el sociograma de la profesión, el sociograma de la identidad profesional son las opciones de visualización del resultado ideal de la formación de los estudiantes. La competencia clave es la competencia definitoria porque corresponde a las condiciones de implementación, que no son limitadas, ni demasiado específicas, pero en cierta medida son universales. La esencia de la competencia profesional de un especialista es la integración de conocimientos, habilidades, experiencia; cualidades personales que proporcionan desarrollo profesional y autorrealización de un especialista, es decir, oportunidades personales que permiten resolver problemas profesionales de manera independiente y efectiva. La dirección de la perspectiva de mejora de la formación de especialistas en el sistema de educación profesional es el desarrollo de sus modelos que brinden la oportunidad de estudiar más profundamente los problemas de formación y uso de expertos, para estimar la calidad del trabajo de las instituciones educativas. En los últimos años, la investigación dirigida a desarrollar un modelo especializado ha cubierto no solo el ámbito de la educación superior; se llevan a cabo en los sistemas de educación vocacional básica y secundaria. Uno de los principales medios para racionar y evaluar la calidad de la formación profesional de los estudiantes es un modelo de competencia que permita obtener la información más clara sobre la composición de las competencias que deben formarse en el futuro especialista en el proceso de aprendizaje. El análisis de los requisitos para la capacitación de especialistas, los contenidos y las tecnologías del proceso educativo, la metodología y la práctica de la actividad educativa moderna permite definir una serie de principios y métodos de formación de modelos especializados como bases de un componente del Estándar Educativo del Estado Federal.Фундаментальные изменения в российской экономике, обусловленные растущей ролью знаний, революцией в информационных и коммуникационных технологиях, формированием мирового рынка труда, а также политическими изменениями, диктуют новые требования к профессиональной подготовке. Модель специалиста, профессиограмма, квалификационная характеристика, социограмма профессии, социограмма профессиональной идентичности - это варианты выбора идеального результата обучения студентов. Ключевой компетенцией является определяющая компетенция, поскольку она соответствует условиям реализации, которые не являются ни ограниченными, ни слишком конкретными, но в определенной степени универсальными. Суть профессиональной компетентности специалиста - интеграция знаний, навыков, опыта; личные качества, которые обеспечивают профессиональное развитие и самореализацию специалиста, то есть личные возможности, позволяющие самостоятельно и эффективно решать профессиональные проблемы. Перспективным направлением совершенствования подготовки специалистов в системе профессионального образования является разработка их моделей, позволяющих глубже изучить проблемы подготовки и использования специалистов, оценить качество работы учебных заведений. В последние годы исследования, направленные на разработку модели специалиста, охватывали не только сферу высшего образования; они ведутся в системах начального и среднего профессионального образования. Одним из основных средств нормирования и оценки качества профессиональной подготовки студентов является модель компетенций, позволяющая получить наиболее четкую информацию о составе компетенций, которые должны быть сформированы у будущего специалиста в процессе обучения. Анализ требований к подготовке специалистов, содержания и технологий учебного процесса, методологии и практики современной образовательной деятельности позволяет определить ряд принципов и методов формирования модели специалиста как основы компонента Федерального государственного образовательного стандарта

Monitoring of the Effectiveness of Public Relations to Optimize the Website of the Ministry of the Russian Federation for Affairs for Civil Defence, Emergencies and Elimination of Consequences of Natural Disasters

Development of websites as an important component of PR-collaboration to achieve their audiences in today's information environment has become one of the defining criteria of perception of the effectiveness of state institutions activities. The study presents the initiation of market research to identify advantageous features, tools, and internet communication technologies in the activities of the five public institutions of Rostov region. Data analysis served as the justification for proposals of the expert group on benchmarking for the website of the Southern Regional Center of the Ministry of the Russian Federation for Civil Defense, Emergencies and Elimination of Consequences of Natural Disasters (SRC MES of Russia). Keywords: expert survey method, website optimization, online communications, public relations JEL Classifications: A10, 010, Z1