Polo passivo na ação de repetição de indébito ajuizada por servidor público estadual, distrital ou municipal que verse sobre imposto de renda retido na fonte.

TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Jurídicas. Direito.A União é competente para instituir e legislar sobre o imposto sobre a renda e proventos de qualquer natureza. Além disso, por nunca ter delegado capacidade tributária ativa a outro ente da federação, é a União a única legitimada para arrecadar e fiscalizar o recolhimento do aludido imposto. Por outro lado, pertencem aos Estados, Distrito Federal e Municípios a totalidade da arrecadação do imposto de renda retido na fonte, proveniente dos rendimentos pagos aos seus respectivos servidores estaduais, distritais ou municipais. Dessa maneira, no momento em que o servidor público – seja este estadual, municipal ou distrital - pleitear, por meio da ação de repetição de indébito, a restituição do IRRF recolhido indevidamente, é imprescindível a formação de litisconsórcio passivo necessário no pólo passivo da demanda entre a União e o entre o Ente Federado no qual o servidor se vincule. Logo, defende-se o litisconsórcio passivo necessário entre o Estado, Distrito Federal ou Município e a União, em ação de repetição de indébito ajuizada pelo respectivo servidor público, que verse sobre imposto de renda retido na fonte, incidente sobre os rendimentos pagos pelo ente federado em questão

Capacities and Choquet averages of ultrafilters

We show that a normalized capacity ν : P(N) → R is invariant with respect to an ideal I on N if and only if it can be represented as a Choquet average of {0, 1}-valued finitely additive probability measures corresponding to the ultrafilters containing the dual filter of I. This is obtained as a consequence of an abstract analogue in the context of Archimedean Riesz spaces

Bioaccumulation of Trace Elements in the Muscle of the Blackmouth Catshark Galeus melastomus from Mediterranean Waters

Environmental pollution, particularly in the marine environment, has become a significant concern due to the increasing presence of pollutants and their adverse effects on ecosystems and human health. This study focuses on the bioaccumulation of trace elements in the muscle tissue of the blackmouth catshark (Galeus melastomus) from different areas in the Mediterranean Sea. Trace elements are of interest due to their persistence, toxicity, and potential for bioaccumulation. This research aims to assess the distribution and accumulation of trace elements in the muscle tissue of G. melastomus and investigate their potential impact on the deep-sea environment of the Mediterranean. The focused areas include the Ligurian Sea, the northern and central Tyrrhenian Sea, the southern Tyrrhenian Sea, the Ionian Sea, the Pantelleria Waters, and the Gela Waters. Samples were collected following established protocols, and trace element analysis was conducted using inductively coupled plasma mass spectrometry. The study provides data on the concentrations of 17 trace elements, namely aluminum, arsenic, cadmium, cobalt, copper, manganese, molybdenum, nickel, zinc, selenium, strontium, lead, chromium, iron, barium, bismuth, and uranium. The findings contribute to a better understanding of trace element bioaccumulation patterns in elasmobranch species, specifically G. melastomus, and highlight the potential risks associated with chemical contamination in the Mediterranean Sea. This research emphasizes the importance of studying the impacts of pollutants on marine organisms, particularly those occupying key ecological roles, like sharks, to support effective conservation and management strategies

Determinants of frontline tyrosine kinase inhibitor choice for patients with chronic-phase chronic myeloid leukemia: A study from the Registro Italiano LMC and Campus CML

Background: Imatinib, dasatinib, and nilotinib are tyrosine kinase inhibitors (TKIs) approved in Italy for frontline treatment of chronic-phase chronic myeloid leukemia (CP-CML). The choice of TKI is based on a combined evaluation of the patient's and the disease characteristics. The aim of this study was to analyze the use of frontline TKI therapy in an unselected cohort of Italian patients with CP-CML to correlate the choice with the patient's features. Methods: A total of 1967 patients with CP-CML diagnosed between 2012 and 2019 at 36 centers throughout Italy were retrospectively evaluated; 1089 patients (55.4%) received imatinib and 878 patients (44.6%) received a second-generation (2G) TKI. Results: Second-generation TKIs were chosen for most patients aged <45 years (69.2%), whereas imatinib was used in 76.7% of patients aged >65 years (p < .001). There was a predominant use of imatinib in intermediate/high European long-term survival risk patients (60.0%/66.0% vs. 49.7% in low-risk patients) and a limited use of 2G-TKIs in patients with comorbidities such as hypertension, diabetes, chronic obstructive pulmonary disease, previous neoplasms, ischemic heart disease, or stroke and in those with >3 concomitant drugs. We observed a greater use of imatinib (61.1%) in patients diagnosed in 2018-2019 compared to 2012-2017 (53.2%; p = .002). In multivariable analysis, factors correlated with imatinib use were age > 65 years, spleen size, the presence of comorbidities, and ≥3 concomitant medications. Conclusions: This observational study of almost 2000 cases of CML shows that imatinib is the frontline drug of choice in 55% of Italian patients with CP-CML, with 2G-TKIs prevalently used in younger patients and in those with no concomitant clinical conditions. Introduction of the generic formulation in 2018 seems to have fostered imatinib use

Analysis of Early Events during the First Year of Tyrosine Kinase Inhibitor Therapy in Patients with Chronic Phase - Chronic Myeloid Leukemia: A "Campus CML" Study

Tyrosine kinase inhibitors (TKIs) revolutionized treatment of chronic myeloid leukemia (CML). However, the rst months of therapy are crucial, as optimal response is dened as the achievement of molecular milestones at 3, 6 and 12 months (mo.) and as many toxicities, also causing a TKI switch, are more frequent in the 1st yea

La renovación de la palabra en el bicentenario de la Argentina : los colores de la mirada lingüística

El libro reúne trabajos en los que se exponen resultados de investigaciones presentadas por investigadores de Argentina, Chile, Brasil, España, Italia y Alemania en el XII Congreso de la Sociedad Argentina de Lingüística (SAL), Bicentenario: la renovación de la palabra, realizado en Mendoza, Argentina, entre el 6 y el 9 de abril de 2010. Las temáticas abordadas en los 167 capítulos muestran las grandes líneas de investigación que se desarrollan fundamentalmente en nuestro país, pero también en los otros países mencionados arriba, y señalan además las áreas que recién se inician, con poca tradición en nuestro país y que deberían fomentarse. Los trabajos aquí publicados se enmarcan dentro de las siguientes disciplinas y/o campos de investigación: Fonología, Sintaxis, Semántica y Pragmática, Lingüística Cognitiva, Análisis del Discurso, Psicolingüística, Adquisición de la Lengua, Sociolingüística y Dialectología, Didáctica de la lengua, Lingüística Aplicada, Lingüística Computacional, Historia de la Lengua y la Lingüística, Lenguas Aborígenes, Filosofía del Lenguaje, Lexicología y Terminología

Automatic generation and learning of finite-state controllers

We propose a method for generating and learning agent controllers, which combines techniques from automated planning and reinforcement learning. An incomplete description of the domain is first used to generate a non-deterministic automaton able to act (sub-optimally) in the given environment. Such a controller is then refined through experience, by learning choices at non-deterministic points. On the one hand, the incompleteness of the model, which would make a pure-planning approach ineffective, is overcome through learning. On the other hand, the portion of the domain available drives the learning process, that otherwise would be excessively expensive. Our method allows to adapt the behavior of a given planner to the environment, facing the unavoidable discrepancies between the model and the environment. We provide quantitative experiments with a simulator of a mobile robot to assess the performance of the proposed method. © 2012 Springer-Verlag