Maintenance in Railway Rolling Stock Rescheduling for Passenger Railways

This paper addresses the Rolling Stock Rescheduling Problem (RSRP), while taking maintenance appointments into account. After a disruption, the rolling stock of passenger trains has to be rescheduled in order to maintain a feasible rolling stock circulation. A limited number of rolling stock units have a scheduled maintenance appointment during the day: these appointments need to be taken into account while rescheduling. In this paper we propose three different models for this. The Extra Unit Type model extends the known Composition model by adding additional rolling stock types for every rolling stock unit that requires maintenance. The Shadow-Account model keeps track of a shadow account for all units that require maintenance. The Job-Composition model is a combination of the Job model and the Composition model, both known in the literature. Paths are created such that maintenance units are on time for their maintenance appointment. All models are tested on instances of Netherlands Railways. The results show that the models are able to efficiently take maintenance appointments into account

Differential Effects of X-Irradiation and Cyclosporin-A Administration on the Thymus with Respect to the Generation of Cyclosporin-A-Induced Autoimmunity

Cyclosporin A (CsA), a potent inhibitor of T-cell activation, has been shown to have several effects on thymocyte maturation, thymic stromal cells, and the generation of autoreactive T cells. In Lewis rats, the combination of lethal irradiation, syngeneic bone marrow transplantation, and a 4-week course of CsA administration causes the development of an autoimmune disease (CsA-AI) resembling allogeneic graft-versus-host disease. This occurs upon withdrawal of CsA, provided the thymus receives irradiation and is present during CsA treatment. In this study, the separate effects of irradiation or CsA treatment on thymic stromal cells and thymocytes, compared to the combinatory effects, were examined using immunohistochemistry and tricolor flow cytometric analysis

Flexible Connections in PESP Models for Cyclic Passenger Railway Timetabling

In this paper we describe how rolling stock and passenger connections in a cyclic railway timetable can be modeled in a flexible way within the model for the Periodic Event Scheduling Problem (PESP). The PESP model was introduced by Serani and Ukovich (1989). Usually, PESP-models assume that the constraints for rolling stock or passenger connections specify in detail which trains should connect with each other. However, the flexibility described in this paper allows the model to choose which trains should connect with each other in a rolling stock or passenger connection. We express the required number of train compositions in terms of the integer cycle variables of the constraint graph. We also describe an abstract framework, demonstrating that, under certain conditions, the extra flexibility can be modeled purely in terms of PESP constraints. The concept of flexible rolling stock and passenger connections is illustrated by an example based on three intercity lines of Netherlands Railways

A Comparison of Two Exact Methods for Passenger Railway Rolling Stock (Re)Scheduling

The assignment of rolling stock units to timetable services in passenger railways is an important optimization problem that has been addressed by many papers in different forms. Solution approaches have been proposed for different planning phases: strategic, tactical, and also operational planning. In this paper we compare two approaches within two operational planning phases (i.e. the daily and the real time planning). The first exact approach is based on a Mixed Integer Linear Program (MILP) which is solved using CPLEX. The second approach is an extension of a recently introduced column generation approach. In this paper, we benchmark the performance of the methods on networks of two countries (Denmark and The Netherlands). We use the approaches to make daily schedules and we test their real time applicability by performing tests with different disruption scenarios. The computational experiments demonstrate that both models can be used on both networks and are able to find optimal rolling stock circulations in the different planning phase

Application of an iterative framework for real-time railway rescheduling

Since disruptions in railway networks are inevitable, railway operators and infrastructure managers need reliable measures and tools for disruption management. Current literature on railway disruption management focuses most of the time on rescheduling one resource (timetable, rolling stock or crew) at the time. In this research, we describe the application of an iterative framework in which all these three resources are considered. The framework applies existing models and algorithms for rescheduling the individual resources. We extensively test our framework on instances from Netherlands Railways and show that schedules which are feasible for all three resources can be obtained within short computation times. This case study shows that the framework and the existing rescheduling approaches can be of great value in practice

Autologous peripheral retinal pigment epithelium translocation in patients with subfoveal neovascular membranes

AIM: To evaluate the possibility of translocating autologous peripheral retinal pigment epithelial (RPE) cells and enhance their adhesion to improve functional outcome after choroidal neovascular membrane extracti

Orthographic depth and its impact on Universal Predictors of Reading: a cross-language investigation

Alphabetic orthographies differ in the transparency of their letter-sound mappings, with English orthography being less transparent than other alphabetic scripts. The outlier status of English has led scientists to question the generality of findings based on English-language studies. We investigated the role of phonological awareness, memory, vocabulary, rapid naming, and nonverbal intelligence in reading performance across five languages lying at differing positions along a transparency continuum (Finnish, Hungarian, Dutch, Portuguese, and French). Results from a sample of 1,265 children in Grade 2 showed that phonological awareness was the main factor associated with reading performance in each language. However, its impact was modulated by the transparency of the orthography, being stronger in less transparent orthographies. The influence of rapid naming was rather weak and limited to reading and decoding speed. Most predictors of reading performance were relatively universal across these alphabetic languages, although their precise weight varied systematically as a function of script transparenc

Tooth-surface-specific Effects of Xylitol: Randomized Trial Results

The Xylitol for Adult Caries Trial was a three-year, double-blind, multi-center, randomized clinical trial that evaluated the effectiveness of xylitol vs. placebo lozenges in the prevention of dental caries in caries-active adults. The purpose of this secondary analysis was to investigate whether xylitol lozenges had a differential effect on cumulative caries increments on different tooth surfaces. Participants (ages 21-80 yrs) with at least one follow-up visit (n = 620) were examined at baseline, 12, 24, and 33 months. Negative binomial and zero-inflated negative binomial regression models were used to estimate incidence rate ratios (IRR) for xylitol’s differential effect on cumulative caries increments on root and coronal surfaces and, among coronal surfaces, on smooth (buccal and lingual), occlusal, and proximal surfaces. Participants in the xylitol arm developed 40% fewer root caries lesions (0.23 D2FS/year) than those in the placebo arm (0.38 D2FS/year; IRR = 0.60; 95% CI [0.44, 0.81]; p < .001). There was no statistically significant difference between xylitol and control participants in the incidence of smooth-surface caries (p = .100), occlusal-surface caries (p = .408), or proximal-surface caries (p = .159). Among these caries-active adults, xylitol appears to have a caries-preventive effect on root surfaces (ClinicalTrials.gov NCT00393055)

Second-order corrections to neutrino two-flavor oscillation parameters in the wave packet approach

We report about an analytic study involving the {\em intermediate} wave packet formalism for quantifying the physically relevant information which appear in the neutrino two-flavor conversion formula and help us to obtain more precise limits and ranges for neutrino flavor oscillation. By following the sequence of analytic approximations where we assume a strictly peaked momentum distribution and consider the second-order corrections in a power series expansion of the energy, we point out a {\em residual} time-dependent phase which, coupled with the {\em spreading/slippage} effects, can subtly modify the neutrino oscillation parameters and limits. Such second-order effects are usually ignored in the relativistic wave packet treatment, but they present an evident dependence on the propagation regime so that some small modifications to the oscillation pattern, even in the ultra-relativistic limit, can be quantified. These modifications are implemented in the confront with the neutrino oscillation parameter range (mass-squared difference \Delta m^{\2} and the mixing-angle $\theta$) where we assume the same wave packet parameters previously noticed in the literature in a kind of {\em toy model} for some reactor experiments. Generically speaking, our analysis parallels the recent experimental purposes which concern with higher precision parameter measurements. To summarize, we show that the effectiveness of a more accurate determination of \Delta m^{\2} and $\theta$ depends on the wave packet width $a$ and on the averaged propagating energy flux $\bar{E}$ which still correspond to open variables for some classes of experiments. \Comment: 25 pages, 5 figure

Complex lithium ion dynamics in simulated LiPO3 glass studied by means of multi-time correlation functions

Molecular dynamics simulations are performed to study the lithium jumps in LiPO3 glass. In particular, we calculate higher-order correlation functions that probe the positions of single lithium ions at several times. Three-time correlation functions show that the non-exponential relaxation of the lithium ions results from both correlated back-and-forth jumps and the existence of dynamical heterogeneities, i.e., the presence of a broad distribution of jump rates. A quantitative analysis yields that the contribution of the dynamical heterogeneities to the non-exponential depopulation of the lithium sites increases upon cooling. Further, correlated back-and-forth jumps between neighboring sites are observed for the fast ions of the distribution, but not for the slow ions and, hence, the back-jump probability depends on the dynamical state. Four-time correlation functions indicate that an exchange between fast and slow ions takes place on the timescale of the jumps themselves, i.e., the dynamical heterogeneities are short-lived. Hence, sites featuring fast and slow lithium dynamics, respectively, are intimately mixed. In addition, a backward correlation beyond the first neighbor shell for highly mobile ions and the presence of long-range dynamical heterogeneities suggest that fast ion migration occurs along preferential pathways in the glassy matrix. In the melt, we find no evidence for correlated back-and-forth motions and dynamical heterogeneities on the length scale of the next-neighbor distance.Comment: 12 pages, 13 figure