Eurysémie et typologie des signes linguistiques

Le caractère asymétrique du signe linguistique permet différentes approches –quantitatives et qualitatives– des unités significatives. L’eurysémie est une catégorie lexico-sémantique qualitative, parce qu’elle prend en compte les possibilités dénominatives des mots. Les dimensions qualitatives et quantitatives de ceux-ci ouvrent de réelles perspectives vers une classification plus nuancée des signes de la langue.El carácter asimétrico del signo lingüístico permite distintos enfoques – cualitativos y cuantitativos – de las unidades significativas. La eurisemia es una categoría léxico-semántica cualitativa, puesto que toma en consideración el potencial denominativo de las palabras. Las dimensiones cualitativas y cuantitativas de éstas abren perspectivas reales para una clasificación más matizada de los signos lingüísticos

Feasibility of using microbeads with holographic barcodes to track DNA specimens in the clinical molecular laboratory

We demonstrate the feasibility of using glass microbeads with a holographic barcode identifier to track DNA specimens in the molecular pathology laboratory. These beads can be added to peripheral blood specimens and are carried through automated DNA extraction protocols that use magnetic glass particles. We found that an adequate number of microbeads are consistently carried over during genomic DNA extraction to allow specimen identification, that the beads do not interfere with the performance of several different molecular assays, and that the beads and genomic DNA remain stable when stored together under regular storage conditions in the molecular pathology laboratory. The beads function as an internal, easily readable specimen barcode. This approach may be useful for identifying DNA specimens and reducing errors associated with molecular laboratory testing

Total synthesis and absolute configuration assignment of MRSA active garcinol and isogarcinol

A short total synthesis of (±)-garcinol and (±)-isogarcinol, two endo-type B PPAPs with reported activity against methiciline resistant Staphylococcus aureus (MRSA), is presented. The separation of framework-constructing from framework-decorating steps and the application of two highly regio- and stereoselective Pd-catalysed allylations, that is, the Pd-catalysed decarboxylative Tsuji-Trost allylation and the diastereoselective Pd-catalysed allyl-allyl cross-coupling, are key elements that allowed the total synthesis to be accomplished within 13 steps starting from acetylacetone. After separation of the enantiomers the absolute configurations of the four natural products (i.e., (-)-garcinol, (+)-guttiferone E (i.e., ent-garcinol), (-)-isogarcinol, and (+)-isoxanthochymol (i.e., ent-isogarcinol)) were assigned based on ECD spectroscopy.Fil: Socolsky, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Quimica del Noroeste; Argentina. Universidad Nacional de Tucumán; ArgentinaFil: Plietker, Bernd . Universität Stuttgart. Institut für Organische Chemie; Alemani