Probing conformational states of glutaryl-CoA dehydrogenase by fragment screening

The first crystal structure is reported of a glutaryl-CoA dehydrogenase in the apo state without flavin adenine dinucleotide cofactor bound. Additional structures with small molecules complexed in the catalytic active site were obtained by fragment-based screening

Application of an RF current mirror for MRI transmit coils

Some types of MRI transmit coils (e.g. Helmholtz coils) require equal currents in different coil elements. We present a novel feeding concept based on a passive RF current mirror, which ensures equal currents even if the loading and tuning of individual elements differ. Analytical equations are given for the dimensioning. It is demonstrated by simulations and experiments that the concept is viable, especially for ultra-high field imaging

Fast measurement of B1+ using the NO2RAGE pulse sequence

The knowledge of the spatial distribution of the transmit field of the coil, B1+, is essential in a number of MRI applications, particularly at higher field strength. SA2RAGE is a recently developed technique for B1+ mapping, derived from the MP2RAGE scheme. The sensitivity to B1+ is obtained from a preparation pulse and optimized delays between block gradient acquisitions. Here, we propose a much faster (but otherwise comparable) method, referred to as NO2RAGE, where the B1+ sensitivity is obtained by omitting the preparation, nullifying the delays, and adjusting the other sequence parameters. The technique compares favorably against other in vivo methods