Nîmes – Mas Carbonnel

Date de l'opération : 1992 (SU) ; 1993 (SU) ; 1996 (SU) Inventeur(s) : Petitot Hervé (AFAN) ; Sauvage Laurent (AFAN) ; Poupet Pierre (CNRS) ; Hervé Marie-Laure (AFAN) ; Lemerle Pascale (AFAN) ; Paone Françoise (AFAN) ; Vidal Laurent (AFAN) Plan général des opérations extra muros de Nîmes (Fig. n°2 : Plan général des principales opérations rurales (1991-1998)). La zone d’aménagement concerté (ZAC) du mas Carbonnel, située à 1 km au sud-est de l’enceinte antique de Nîmes et qui s’étend sur 3,4..

CD45RC Expression of Circulating CD8+ T Cells Predicts Acute Allograft Rejection: A Cohort Study of 128 Kidney Transplant Patients

Predictive biomarkers of acute rejection (AR) are lacking. Pre-transplant expression of CD45RC on blood CD8+ T cells has been shown to predict AR in kidney transplant (KT) patients. The objective of the present study was to study CD45RC expression in a large cohort of KT recipients exposed to modern immunosuppressive regimens. CD45RC expression on T cells was analyzed in 128 KT patients, where 31 patients developed AR, of which 24 were found to be T-cell mediated (TCMR). Pre-transplant CD4+ and CD8+ CR45RChigh T cell proportions were significantly higher in patients with AR. The frequency of CD45RChigh T cells was significantly associated with age at transplantation but was not significantly different according to gender, history of transplantation, pre-transplant immunization, and de novo donor specific anti-Human Leucocyte Antigen (HLA) antibody. Survival-free AR was significantly better in patients with CD8+ CD45RChigh T cells below 58.4% (p = 0.0005), but not different according to CD4+ T cells (p = 0.073). According to multivariate analysis, CD8+ CD45RChigh T cells above 58.4% increased the risk of AR 4-fold (HR 3.96, p = 0.003). Thus, pre-transplant CD45RC expression on CD8+ T cells predicted AR, mainly TCMR, in KT patients under modern immunosuppressive therapies. We suggest that CD45RC expression should be evaluated in a prospective study to validate its usefulness to quantify the pre-transplant risk of AR

Recommendations for the development of a carnivore viewing site at a colony of Cape fur seals (Arctocephalus pusillus pusillus) in southern Namibia

This study examined the daily and monthly activity patterns of brown hyenas (Hyaena brunnea) and black-backed jackals (Canis mesomelas) at a Cape fur seal colony in southern Namibia, to provide recommendations for developing a sustainable wildlife viewing site. Observations conducted between November 2020 and October 2022 showed that the carnivores were most active between May and October, with jackals showing peak activity around sunrise and sunset, and brown hyenas mostly visiting around midday. The animals were more active during cloudy and cool weather. With the diurnal activity of carnivores and their predation behaviour on Cape fur seal (Arctocephalus pusillus pusillus) pups, the area has high ecotourism potential. Brown hyenas, however, are sensitive to human disturbance, such as moving vehicles and unknown sounds and smells. Therefore, limiting the number of visitors and creating a fixed viewpoint is recommended to minimise disturbance. This study provides valuable input on how ecotourism activities could be developed at a seal colony without compromising the sensitive wildlife there.The Namibia Nature Foundation.https://www.tandfonline.com/journals/reco202025-07-24hj2024Mammal Research InstituteZoology and EntomologySDG-15:Life on lan

Serum phosphate level and its kinetic as an early marker of acute kidney injury in tumor lysis syndrome

International audienc

Etude de l’association entre l’élévation des chaînes légères libres et les critères clinico-biologiques dans le lupus érythémateux systémique

International audienc

CD45RC Expression of Circulating CD8+ T Cells Predicts Acute Allograft Rejection: A Cohort Study of 128 Kidney Transplant Patients

International audiencePredictive biomarkers of acute rejection (AR) are lacking. Pre-transplant expression of CD45RC on blood CD8 + T cells has been shown to predict AR in kidney transplant (KT) patients. The objective of the present study was to study CD45RC expression in a large cohort of KT recipients exposed to modern immunosuppressive regimens. CD45RC expression on T cells was analyzed in 128 KT patients, where 31 patients developed AR, of which 24 were found to be T-cell mediated (TCMR). Pre-transplant CD4 + and CD8 + CR45RC high T cell proportions were significantly higher in patients with AR. The frequency of CD45RC high T cells was significantly associated with age at transplantation but was not significantly different according to gender, history of transplantation, pre-transplant immunization, and de novo donor specific anti-Human Leucocyte Antigen (HLA) antibody. Survival-free AR was significantly better in patients with CD8 + CD45RC high T cells below 58.4% (p = 0.0005), but not different according to CD4 + T cells (p = 0.073). According to multivariate analysis, CD8 + CD45RC high T cells above 58.4% increased the risk of AR 4-fold (HR 3.96, p = 0.003). Thus, pre-transplant CD45RC expression on CD8 + T cells predicted AR, mainly TCMR, in KT patients under modern immunosuppressive therapies. We suggest that CD45RC expression should be evaluated in a prospective study to validate its usefulness to quantify the pre-transplant risk of AR

Publications

Vaillant André, Vey Marc, Mazon André, Frolow André, Lemerle Paul, Unbegaun Boris O., Philippot Robert, Coquin François-Xavier, Struve Nikita, Scherrer Marie, Granjard Henri, Tapié Victor-Lucien, Fichelle Alfred, Bonnoure Pierre, Decaux Étienne, Backvis Claude, Gieysztor Aleksander, Bernard Roger. Publications. In: Revue des études slaves, tome 37, fascicule 1-4, 1960. pp. 159-338

Publications

Vaillant André, Vey Marc, Mazon André, Frolow André, Lemerle Paul, Unbegaun Boris Ottokar, Philippot Robert, Coquin François-Xavier, Struve Nikita, Scherrer Marie, Granjard Henri, Tapié Victor-Lucien, Fichelle Alfred, Bonnoure Pierre, Decaux Étienne, Backvis Claude, Gieysztor Aleksander, Castellan Georges. Publications. In: Revue des études slaves, tome 39, fascicule 1-4, 1961. pp. 139-376

Publications

Vaillant André, Vey Marc, Mazon André, Frolow André, Lemerle Paul, Unbegaun Boris Ottokar, Philippot Robert, Coquin François-Xavier, Struve Nikita, Scherrer Marie, Granjard Henri, Tapié Victor-Lucien, Fichelle Alfred, Bonnoure Pierre, Decaux Étienne, Backvis Claude, Gieysztor Aleksander, Castellan Georges. Publications. In: Revue des études slaves, tome 39, fascicule 1-4, 1961. pp. 139-376