Avaliação toxicológica do bio-óleo utilizando o teste de Allium cepa.

Resumo

Estudo das alterações no metabolismo da soja em decorrência da infecção por Aphelenchoides besseyi.

Título em inglês: Study of changes in soybean metabolism due to infection by Aphelenchoides besseyi

Criptorquidectomia em coelhos: modelo experimental para treinamento laparoscópico

O artigo não apresenta resumo

Endothelin-1 receptor antagonists protect the kidney against the nephrotoxicity induced by cyclosporine-A in normotensive and hypertensive rats

Cyclosporin-A (CsA) is an immunosuppressant associated with acute kidney injury and chronic kidney disease. Nephrotoxicity associated with CsA involves the increase in afferent and efferent arteriole resistance, decreased renal blood flow (RBF) and glomerular filtration. The aim of this study was to evaluate the effect of Endothelin-1 (ET-1) receptor blockade with bosentan (BOS) and macitentan (MAC) antagonists on altered renal function induced by CsA in normotensive and hypertensive animals. Wistar and genetically hypertensive rats (SHR) were separated into control group, CsA group that received intraperitoneal injections of CsA (40 mg/kg) for 15 days, CsA+BOS and CsA+MAC that received CsA and BOS (5 mg/kg) or MAC (25 mg/kg) by gavage for 15 days. Plasma creatinine and urea, mean arterial pressure (MAP), RBF and renal vascular resistance (RVR), and immunohistochemistry for ET-1 in the kidney cortex were measured. CsA decreased renal function, as shown by increased creatinine and urea. There was a decrease in RBF and an increase in MAP and RVR in normotensive and hypertensive animals. These effects were partially reversed by ET-1 antagonists, especially in SHR where increased ET-1 production was observed in the kidney. Most MAC effects were similar to BOS, but BOS seemed to be better at reversing cyclosporine-induced changes in renal function in hypertensive animals. The results of this work suggested the direct participation of ET-1 in renal hemodynamics changes induced by cyclosporin in normotensive and hypertensive rats. The antagonists of ET-1 MAC and BOS reversed part of these effects.Univ Fed Sao Paulo, Disciplina Nefrol, Dept Med, Sao Paulo, SP, BrazilUniv Cruzeiro Sul, Programa Interdisciplinar Ciencias Saude, Inst Ciencias Atividade Fis & Esporte, Sao Paulo, SP, BrazilUniv Sao Paulo, LEMA, Escola Enfermagem, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Dept Enfermagem Clin & Cirurg, Escola Paulista Enfermagem, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Disciplina Nefrol, Dept Med, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Dept Enfermagem Clin & Cirurg, Escola Paulista Enfermagem, Sao Paulo, SP, BrazilWeb of Scienc

Deposition temperature influence on the wear behaviour of carbon-based coatings deposited on hardened steel

An evaluation regarding the influence of substrate material characteristics and deposition parameters on the tribological behaviour of carbon-based is presented. Chromium nitride interlayers and carbon-based thin films were deposited on hardened AISI 5115 case hardening steel, by magnetron sputtering. The physical vapour deposition (PVD) deposition was performed at three different temperatures: 180 °C, 200 °C and 250 °C. The chemical composition of the samples was assessed by Rutherford Backscattering Spectroscopy (RBS), the structure by X-ray Diffraction (XRD), and the surface morphology by Atomic Force Microscopy (AFM). The surface chemistry was analysed by X-ray Photoelectron Spectroscopy (XPS) and Raman Spectroscopy. The coatings are homogeneous, amorphous, with a smooth surface. The mechanical behaviour has been assessed on a pin-on disk rotational tribometer (wear characteristics), on a micro scratch tester (adhesion to the substrate), by ball-cratering (film thickness); by nanoindentation (hardness and the modulus of elasticity). A strong correlation between the substrate characteristics, but more importantly, of the deposition temperature, on one hand, and the mechanical characteristics, on the other hand, has been observed. The fracture toughness is positively influenced by the presence of the ceramic interlayer (chromium nitride). The modulus of elasticity and friction coefficient (both in dry conditions and lubricated) are decreased for higher deposition temperatures, however the higher deposition temperature negatively affects the hardness of the steel substrate.We hereby acknowledge the structural funds project PRO-DD (POSCCE, O.2.2.1., ID 123, SMIS 2637, ctr. no 11/2009) for providing some of the infrastructure used in this work

Melatonin reduces apoptotic cells, SOD2 and HSPB1 and improves the in vitro production and quality of bovine blastocysts.

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