Morphology of seismically slow lower-mantle structures

Large low shear velocity provinces (LLSVPs), whose origin and dynamic implication remain enigmatic, dominate the lowermost mantle. For decades, seismologists have created increasingly detailed pictures of the LLSVPs through tomographic models constructed with different modeling methodologies, data sets, parametrizations and regularizations. Here, we extend the cluster analysis methodology of Lekic $\textit{et al.}$, to classify seismic mantle structure in five recent global shear wave speed ($\textit{V}_S$) tomographic models into three groups. By restricting the analysis to moving depth windows of the radial profiles of $\textit{V}_S$, we assess the vertical extent of features. We also show that three clusters are better than two (or four) when representing the entire lower mantle, as the boundaries of the three clusters more closely follow regions of high lateral $\textit{V}_S$ gradients. Qualitatively, we relate the anomalously slow cluster to the LLSVPs, the anomalously fast cluster to slab material entering the lower mantle and the neutral cluster to ‘background’ lower mantle material. We obtain compatible results by repeating the analysis on recent global $\textit{P}$-wave speed ($\textit{V}_P$) models, although we find less agreement across $\textit{V}_P$ models. We systematically show that the clustering results, even in detail, agree remarkably well with a wide range of local waveform studies. This suggests that the two LLSVPs consist of multiple internal anomalies with a wide variety of morphologies, including shallowly to steeply sloping, and even overhanging, boundaries. Additionally, there are indications of previously unrecognized meso-scale features, which, like the Perm anomaly, are separated from the two main LLSVPs beneath the Pacific and Africa. The observed wide variety of structure size and morphology offers a challenge to recreate in geodynamic models; potentially, the variety can result from various degrees of mixing of several compositionally distinct components. Finally, we obtain new, much larger estimates of the volume/mass occupied by LLSVPs— 8.0 per cent ±0.9 ($\mu$ ± 1$\sigma$) of whole mantle volume and 9.1 per cent ±1.0 ($\mu$ ± 1$\sigma$) of whole mantle mass—and discuss implications for associating the LLSVPs with the hidden reservoir enriched in heat producing elements.National Science Foundation (EAR1352214), Packard Foundation, Pembroke College, Cambridge (Drapers’ Company Research Fellowship

Geo-neutrinos and Earth Models

We present the current status of geo-neutrino measurements and their implications for radiogenic heating in the mantle. Earth models predict different levels of radiogenic heating and, therefore, different geo-neutrino fluxes from the mantle. Seismic tomography reveals features in the deep mantle possibly correlated with radiogenic heating and causing spatial variations in the mantle geo-neutrino flux at the Earth surface. An ocean-based observatory offers the greatest sensitivity to the mantle flux and potential for resolving Earth models and mantle features. Refinements to estimates of the geo-neutrino flux from continental crust reduce uncertainty in measurements of the mantle flux, especially measurements from land-based observatories. These refinements enable the resolution of Earth models using the combined measurements from multiple continental observatories.Comment: 9 pages, 4 figures; Contributed paper TAUP 201

Three-dimensional seismic structure of the Mid-Atlantic Ridge (35°N) : evidence for focused melt supply and lower crustal dike injection

Author Posting. © American Geophysical Union, 2005. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research 110 (2005): B09101, doi:10.1029/2004JB003473.We gathered seismic refraction and wide-angle reflection data from several active source experiments that occurred along the Mid-Atlantic Ridge near 35°N and constructed three-dimensional anisotropic tomographic images of the crust and upper mantle velocity structure and crustal thickness. The tomographic images reveal anomalously thick crust (8–9 km) and a low-velocity “bull's-eye”, from 4 to 10 km depth, beneath the center of the ridge segment. The velocity anomaly is indicative of high temperatures and a small amount of melt (up to 5%) and likely represents the current magma plumbing system for melts ascending from the mantle. In addition, at the segment center, seismic anisotropy in the lower crust indicates that the crust is composed of partially molten dikes that are surrounded by regions of hot rock with little or no melt fraction. Our results indicate that mantle melts are focused at mantle depths to the segment center and that melt is delivered to the crust via dikes in the lower crust. Our results also indicate that the segment ends are colder, receive a reduced magma supply, and undergo significantly greater tectonic stretching than the segment center.This research was supported by U.S. National Science Foundation grants OCE-0203228 and OCE-0136793; support for V. Lekic was provided by the IRIS undergraduate internship program

Crotalus atrox venom preconditioning increases plasma fibrinogen and reduces perioperative hemorrhage in a rat model of surgical brain injury.

Perioperative bleeding is a potentially devastating complication in neurosurgical patients, and plasma fibrinogen concentration has been identified as a potential modifiable risk factor for perioperative bleeding. The aim of this study was to evaluate preconditioning with Crotalus atrox venom (Cv-PC) as potential preventive therapy for reducing perioperative hemorrhage in the rodent model of surgical brain injury (SBI). C. atrox venom contains snake venom metalloproteinases that cleave fibrinogen into fibrin split products without inducing clotting. Separately, fibrinogen split products induce fibrinogen production, thereby elevating plasma fibrinogen levels. Thus, the hypothesis was that preconditioning with C. atrox venom will produce fibrinogen spilt products, thereby upregulating fibrinogen levels, ultimately improving perioperative hemostasis during SBI. We observed that Cv-PC SBI animals had significantly reduced intraoperative hemorrhage and postoperative hematoma volumes compared to those of vehicle preconditioned SBI animals. Cv-PC animals were also found to have higher levels of plasma fibrinogen at the time of surgery, with unchanged prothrombin time. Cv-PC studies with fractions of C. atrox venom suggest that snake venom metalloproteinases are largely responsible for the improved hemostasis by Cv-PC. Our findings indicate that Cv-PC increases plasma fibrinogen levels and may provide a promising therapy for reducing perioperative hemorrhage in elective surgeries

Lipid Composition and Antioxidant Activities of the Seed Oil from Three Malvaceae Species

The oil content and fatty acids, unsaponifiable composition and antioxidant activities of the seed oil from three Malvaceae species (Malva sylvestris L., Malva sylvestris L. var. mauritiana and Althaea officinalis L.) from Serbia were determined. The oil yields from the seeds varied from 7.18 to 9.60%. The main fatty acids of the seed oils were linoleic acid (44.14-54.49%), oleic acid (13.00-16.99%) and palmitic acid (11.45-24.29%). A small amount of cyclopropenoid acids, up to 1.85% was also established. The predominant sterol in all seed oils was beta-sitosterol (11.51-17.34 mg/g of oil). The antioxidant potential of all the investigated seed oils was evaluated by radical scavenging activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay

Expression of Msx-1 is suppressed in bisphosphonate associated osteonecrosis related jaw tissue-etiopathology considerations respecting jaw developmental biology-related unique features

<p>Abstract</p> <p>Background</p> <p>Bone-destructive disease treatments include bisphosphonates and antibodies against the osteoclast differentiator, RANKL (aRANKL); however, osteonecrosis of the jaw (ONJ) is a frequent side-effect. Current models fail to explain the restriction of bisphosphonate (BP)-related and denosumab (anti-RANKL antibody)-related ONJ to jaws. Msx-1 is exclusively expressed in craniofacial structures and pivotal to cranial neural crest (CNC)-derived periodontal tissue remodeling. We hypothesised that Msx-1 expression might be impaired in bisphosphonate-related ONJ. The study aim was to elucidate Msx-1 and RANKL-associated signal transduction (BMP-2/4, RANKL) in ONJ-altered and healthy periodontal tissue.</p> <p>Methods</p> <p>Twenty ONJ and twenty non-BP exposed periodontal samples were processed for RT-PCR and immunohistochemistry. An automated staining-based alkaline phosphatase-anti-alkaline phosphatase method was used to measure the stained cells:total cell-number ratio (labelling index, Bonferroni adjustment). Real-time RT-PCR was performed on ONJ-affected and healthy jaw periodontal samples (n = 20 each) to quantitatively compare Msx-1, BMP-2, RANKL, and GAPDH mRNA levels.</p> <p>Results</p> <p>Semi-quantitative assessment of the ratio of stained cells showed decreased Msx-1 and RANKL and increased BMP-2/4 (all p < 0.05) expression in ONJ-adjacent periodontal tissue. ONJ tissue also exhibited decreased relative gene expression for Msx-1 (p < 0.03) and RANKL (p < 0.03) and increased BMP-2/4 expression (p < 0.02) compared to control.</p> <p>Conclusions</p> <p>These results explain the sclerotic and osteopetrotic changes of periodontal tissue following BP application and substantiate clinical findings of BP-related impaired remodeling specific to periodontal tissue. RANKL suppression substantiated the clinical finding of impaired bone remodelling in BP- and aRANKL-induced ONJ-affected bone structures. Msx-1 suppression in ONJ-adjacent periodontal tissue suggested a bisphosphonate-related impairment in cellular differentiation that occurred exclusively jaw remodelling. Further research on developmental biology-related unique features of jaw bone structures will help to elucidate pathologies restricted to maxillofacial tissue.</p