The role of Volatile Anesthetics in Cardioprotection: a systematic review.

This review evaluates the mechanism of volatile anesthetics as cardioprotective agents in both clinical and laboratory research and furthermore assesses possible cardiac side effects upon usage. Cardiac as well as non-cardiac surgery may evoke perioperative adverse events including: ischemia, diverse arrhythmias and reperfusion injury. As volatile anesthetics have cardiovascular effects that can lead to hypotension, clinicians may choose to administer alternative anesthetics to patients with coronary artery disease, particularly if the patient has severe preoperative ischemia or cardiovascular instability. Increasing preclinical evidence demonstrated that administration of inhaled anesthetics - before and during surgery - reduces the degree of ischemia and reperfusion injury to the heart. Recently, this preclinical data has been implemented clinically, and beneficial effects have been found in some studies of patients undergoing coronary artery bypass graft surgery. Administration of volatile anesthetic gases was protective for patients undergoing cardiac surgery through manipulation of the potassium ATP (KATP) channel, mitochondrial permeability transition pore (mPTP), reactive oxygen species (ROS) production, as well as through cytoprotective Akt and extracellular-signal kinases (ERK) pathways. However, as not all studies have demonstrated improved outcomes, the risks for undesirable hemodynamic effects must be weighed against the possible benefits of using volatile anesthetics as a means to provide cardiac protection in patients with coronary artery disease who are undergoing surgery

The role of Volatile Anesthetics in Cardioprotection: a systematic review.

This review evaluates the mechanism of volatile anesthetics as cardioprotective agents in both clinical and laboratory research and furthermore assesses possible cardiac side effects upon usage. Cardiac as well as non-cardiac surgery may evoke perioperative adverse events including: ischemia, diverse arrhythmias and reperfusion injury. As volatile anesthetics have cardiovascular effects that can lead to hypotension, clinicians may choose to administer alternative anesthetics to patients with coronary artery disease, particularly if the patient has severe preoperative ischemia or cardiovascular instability. Increasing preclinical evidence demonstrated that administration of inhaled anesthetics - before and during surgery - reduces the degree of ischemia and reperfusion injury to the heart. Recently, this preclinical data has been implemented clinically, and beneficial effects have been found in some studies of patients undergoing coronary artery bypass graft surgery. Administration of volatile anesthetic gases was protective for patients undergoing cardiac surgery through manipulation of the potassium ATP (KATP) channel, mitochondrial permeability transition pore (mPTP), reactive oxygen species (ROS) production, as well as through cytoprotective Akt and extracellular-signal kinases (ERK) pathways. However, as not all studies have demonstrated improved outcomes, the risks for undesirable hemodynamic effects must be weighed against the possible benefits of using volatile anesthetics as a means to provide cardiac protection in patients with coronary artery disease who are undergoing surgery

Isoflurane Post-Treatment Ameliorates GMH-Induced Brain Injury in Neonatal Rats

Background and purposeThis study investigated whether isoflurane ameliorates neurological sequelae after germinal matrix hemorrhage (GMH) through activation of the cytoprotective sphingosine kinase/sphingosine-1-phosphate receptor/Akt pathway.MethodsGMH was induced in P7 rat pups by intraparenchymal infusion of bacterial collagenase (0.3 U) into the right hemispheric germinal matrix. GMH animals received 2% isoflurane either once 1 hour after surgery or every 12 hours for 3 days. Isoflurane treatment was then combined with sphingosine-1-phosphate receptor-1/2 antagonist VPC23019 or sphingosine kinase 1/2 antagonist N,N-dimethylsphingosine.ResultsBrain protein expression of sphingosine kinase-1 and phosphorylated Akt were significantly increased after isoflurane post-treatment, and cleaved caspase-3 was decreased at 24 hours after surgery, which was reversed by the antagonists. Isoflurane significantly reduced posthemorrhagic ventricular dilation and improved motor, but not cognitive, functions in GMH animals 3 weeks after surgery; no improvements were observed after VPC23019 administration.ConclusionsIsoflurane post-treatment improved the neurological sequelae after GMH possibly by activation of the sphingosine kinase/Akt pathway

Isoflurane Post-Treatment Ameliorates GMH-Induced Brain Injury in Neonatal Rats

BACKGROUND AND PURPOSE: This study investigated whether isoflurane ameliorates neurological sequelae after germinal matrix hemorrhage (GMH) through activation of the cytoprotective sphingosine kinase/sphingosine-1-phosphate receptor/Akt pathway. METHODS: GMH was induced in P7 rat pups by intraparenchymal infusion of bacterial collagenase (0.3U) into the right hemispheric germinal matrix. GMH animals received 2% isoflurane either once 1 hour after surgery, or every 12 hours for 3 days. Isoflurane treatment was then combined with sphingosine-1-phoshate receptor-1/2 antagonist VPC23019 or sphingosine kinase 1/2 antagonist N,N-dimethylsphingosine. RESULTS: Brain protein expression of sphingosine kinase-1 and phosphorylated Akt were significantly increased after isoflurane post-treatment, and cleaved capase-3 was decreased at 24 hours after surgery; which was reversed by the antagonists. Isoflurane significantly reduced post-hemorrhagic ventricular dilation and improved motor, but not cognitive, functions in GMH animals 3 weeks after surgery; no improvements were observed following VPC23019 administration. CONCLUSION: Isoflurane post-treatment improved the neurological sequelae after GMH possibly by activation of the sphingosine kinase/Akt pathway

Proceedings of GAMA days 2022

International audienceBuilding on last year’s success, the GAMA Days 2022 is the 2nd edition of the conference, where users and developers of the GAMA modeling and simulation platform will have an opportunity to meet, present their work, expose their difficulties, propose enhancements and, more generally, exchange and collaborate on exciting topics related to GAMA

Proceedings of GAMA days 2022

Building on last year’s success, the GAMA Days 2022 is the 2nd edition of the conference, where users and developers of the GAMA modeling and simulation platform will have an opportunity to meet, present their work, expose their difficulties, propose enhancements and, more generally, exchange and collaborate on exciting topics related to GAMA

Proceedings of GAMA days 2022

Building on last year’s success, the GAMA Days 2022 is the 2nd edition of the conference, where users and developers of the GAMA modeling and simulation platform will have an opportunity to meet, present their work, expose their difficulties, propose enhancements and, more generally, exchange and collaborate on exciting topics related to GAMA

Proceedings of GAMA days 2022

Building on last year’s success, the GAMA Days 2022 is the 2nd edition of the conference, where users and developers of the GAMA modeling and simulation platform will have an opportunity to meet, present their work, expose their difficulties, propose enhancements and, more generally, exchange and collaborate on exciting topics related to GAMA

Proceedings of GAMA days 2022

Building on last year’s success, the GAMA Days 2022 is the 2nd edition of the conference, where users and developers of the GAMA modeling and simulation platform will have an opportunity to meet, present their work, expose their difficulties, propose enhancements and, more generally, exchange and collaborate on exciting topics related to GAMA