Low cardiorespiratory fitness in people at risk for type 2 diabetes: early marker for insulin resistance

<p>Abstract</p> <p>Purpose</p> <p>There is a significant association between insulin resistance and low cardiorespiratory fitness in nondiabetic subjects. In a population with risk factors for type 2 diabetes (T2DM), before they are insulin resistant, we investigated low exercise capacity (VO2max) as an early marker of impaired insulin sensitivity in order to determine earlier interventions to prevent development of insulin resistance syndrome (IRS) and T2DM.</p> <p>Methods</p> <p>Cross-sectional analyses of data on 369 (78 men and 291 women) people at risk for IRS and T2DM, aged 45.6 +/- 10 years (20-65 years) old from the Community Diabetes Prevention Project in Minnesota were carried out. The cardiorespiratory fitness (VO2max) by respiratory gas exchange and bicycle ergometer were measured in our at risk non insulin resistant population and compared with a control group living in the same geographic area. Both groups were equally sedentary, matched for age, gender and BMI.</p> <p>Results</p> <p>The most prevalent abnormality in the study population was markedly low VO2max when compared with general work site screening control group, (n = 177; 137F; 40 M, mean age 40 ± 11 years; BMI = 27.8 ± 6.1 kg/m²). Individuals at risk for IRS and T2DM had a VO2max (22 ± 6 ml/kg/min) 15% lower than the control group VO2max (26 ± 9 ml/kg/min) (p < 0.001). It was foun that VO₂max was inversely correlated with HOMA-IR (r = -0.30, p < 0.0001).</p> <p>Conclusions</p> <p>Decreased VO2max is correlated with impaired insulin sensitivity and was the most prevalent abnormality in a population at risk for IRS and T2DM but without overt disease. This raises the possibility that decreased VO2 max is among the earliest indicators of IRS and T2DM therefore, an important risk factor for disease progression.</p

Chitosan improves the durability of resin-dentin interface with etch-and-rinse or self-etch adhesive systems

Degradation of the dentin-resin interface can occur due to hydrolysis of exposed collagen, resulting in reduced bond strength. This study assessed the effect of dentin treatment with chitosan combined with an etch-and-rinse or self-etch adhesive system on improvement of bond strength and preservation of the interface durability. Methodology: Enamel was removed from 80 molars and the teeth were divided into two groups: without chitosan (control) or with 2.5% chitosan gel (1 min). They were further subdivided into two subgroups according to the adhesive system: etch-and-rinse or self-etch. Dentin was restored using a composite resin. Half of the specimens from each restored group were subjected to interface aging and the remaining specimens were used for immediate analysis. The specimens were sectioned and subjected to microtensile bond strength (µTBS) test (n=10), chemical composition testing using Fourier-transform infrared (FTIR) spectroscopy (n=4) and energy-dispersive spectroscopy (EDS) (n=5), and morphological analysis of the adhesive interface using scanning electron microscopy (SEM) (n=5). Data were analyzed using three-way ANOVA. Results: Chitosan improved the µTBS of the adhesive interface when compared with the control group (p=0.004). No significant differences were observed in dentin adhesion between the adhesive systems (p=0.652). Immediate µTBS was not significantly different from that after 6 months (p=0.274). EDS and SEM did not show significant differences in the chemical and structural composition of the specimens. FTIR showed a decrease in the intensity of phosphate and carbonate bands after using chitosan.&nbsp;Conclusions: Dentin treatment with chitosan combined with an etch-and-rinse or self-etch adhesive system improved the immediate and preserved the 6-month bond strength of the adhesive interface

História do papel: panorama evolutivo das técnicas de produção e implicações para sua preservação

Este artigo conta a história do papel em breves linhas, inclusive sobre seu aparecimento no Brasil, traçando um panorama evolutivo das técnicas de produção e das implicações para sua preservação, especialmente no que se refere aos processos de fabricação conhecidos. Apresenta o método das isopermas, uma ferramenta que quantifica o efeito dos fatores ambientais de temperatura e de umidade relativa percentual sobre a expectativa de vida útil prevista para coleções em suporte de papel. Para tal, aborda o monitoramento de acervos e reservas técnicas assim como o monitoramento experimental e ensaios de envelhecimento natural de amostras de papel, demonstrando a importância de se lançar um olhar sobre esse material como testemunho dos processos de modificação técnica e tecnológica, e das influências positivas e negativas que essas alterações provocam em sua permanência. Finaliza a abordagem lembrando que o advento do registro das informações em meio digital aparece como solução para tornar as informações mais acessíveis, mas também requer mudanças específicas na política de preservação dos novos acervos

Perfil do consumidor e oscilações de preços de produtos agroecológicos.

Em todo o mundo, o consumo de alimentos naturais tem aumentado significativamente, e o termo “orgânico” tem se destacado. Em face disto, buscou-se conhecer o perfil do consumidor de alimentos orgânicos, no município de Goiânia (GO), bem como saber quais são as principais dificuldades por ele encontradas, na aquisição destes produtos. Fez-se, também, um levantamento de preços, a fim de serem comparados alimentos orgânicos e convencionais. O principal problema apontado pelos entrevistados, quanto à dificuldade no consumo, foi o fator preço, seguido pela disponibilidade de produtos. Abóbora(Curcubita moschata), berinjela (Solanum melongena), beterraba (Beta vulgaris L.), cenoura (Daucus carota L.), jiló (Solanum gilo Raddi) e pepino (Cucumis sativus) foram os produtos que mais apresentaram variação percentual no preço (convencional x orgânico)

Epidemiological Aspects Of Microcephal Cases And Central Nervous System Changes In Newborn

Objective: To describe the epidemiological situation of cases of microcephaly and / or Central Nervous System changes in newborns in the Northeast region of Brazil. Methods: Epidemiological, descriptive study with secondary data. Epidemiological data were collected in the Notifiable Diseases Information System, with cumulative data from the years 2015 and 2016. They were processed in the statistical software SPSS - version 21 and analyzed from the descriptive statistics. Results: It was evidenced that, in the Northeast region, 6,481 cases of microcephaly and / or central nervous system disorders were reported. Of these, the states of Pernambuco and Bahia stand out with a higher percentage of reported and confirmed cases. About the reported deaths, the states of Pernambuco, Ceará and Bahia prevailed. Of the cases of deaths confirmed, the states of Rio Grande do Norte and Paraíba. Conclusion: it is imperative to carry out an ongoing population awareness campaign on the prevention of ZIKAV and how important it is to follow up the pregnant woman during prenatal care. In addition to the constant updating of health professionals regarding microcephaly and the creation of more services to support the NB and their families. Therefore, it is suggested to carry out more studies to understand the reason for the increase in reported cases of microcephaly, being possible to draw up specific strategies for each locality in order to reduce the cases of this disease. Keywords: Epidemiology; Microcephaly; Central Nervous System; Children

Anthelmintic Activity In Vivo of Epiisopiloturine against Juvenile and Adult Worms of Schistosoma mansoni

Schistosomiasis is a serious disease currently estimated to affect more that 207 million people worldwide. Due to the intensive use of praziquantel, there is increasing concern about the development of drug-resistant strains. Therefore, it is necessary to search for and investigate new potential schistosomicidal compounds. This work reports the in vivo effect of the alkaloid epiisopiloturine (EPI) against adults and juvenile worms of Schistosoma mansoni. EPI was first purified its thermal behavior and theoretical solubility parameters charaterised. In the experiment, mice were treated with EPI over the 21 days post-infection with the doses of 40 and 200 mg/kg, and 45 days post-infection with single doses of 40, 100 and 300 mg/kg. The treatment with EPI at 40 mg/kg was more effective in adult worms when compared with doses of 100 and 300 mg/kg. The treatment with 40 mg/kg in adult worms reduced parasite burden significantly, lead to reduction in hepatosplenomegaly, reduced the egg burden in faeces, and decreased granuloma diameter. Scanning electron microscopy revealed morphological changes to the parasite tegument after treatment, including the loss of important features. Additionally, the in vivo treatment against juvenile with 40 mg/kg showed a reduction of the total worm burden of 50.2%. Histopathological studies were performed on liver, spleen, lung, kidney and brain and EPI was shown to have a DL50 of 8000 mg/kg. Therefore EPI shows potential to be used in schistosomiasis treatment. This is the first time that schistosomicidal in vivo activity of EPI has been reported

Conhecendo os impactos pulmonares ocasionados pelo uso de cigarros eletrônicos

O presente trabalho tem por objetivo a análise dos impactos pulmonares que são ocasionados pelo uso de cigarros eletrônicos. Este trabalho trata-se de uma revisão integrativa, sendo realizada a partir da busca dos seguintes Descritores em Ciências da Saúde (DeCS) na base de dados PubMed: electronic; cigarette; lung; impacts. Dos artigos encontrados, foram selecionados apenas artigos publicados nos anos de 2021 a 2023 até a data de 25/10/2023, sendo escolhidos 18 artigos, em que 10 foram excluídos após a análise de enquadramento ao tema, sendo apenas 8 analisados para a confecção deste estudo. O uso de E-cigarros está relacionado a diversas alterações pulmonares, sendo que em 2019, nos Estados Unidos, foi responsável pelo surto de doença pulmonar associada a cigarros eletrônicos, além disso é capaz de induzir alterações como síndrome respiratória aguda grave, alterações na função e composição do surfactante alterando a hematose, tosse, falta de ar e dentre outras alterações. Com isto, é essencial que se faça um apanhado das principais evidências científicas acerca deste tema para que todas estas problemáticas sejam evidenciadas.&nbsp

Clinical and laboratory indicators predictive of the negative outcome of gastrointestinal emergencies in cattle

This study aimed to identify clinical and laboratory variables that could help predict the negative outcome in cattle affected by gastrointestinal emergencies. A retrospective cohort study was carried out using multivariate logistic regression analysis based on data collected from the clinical records of cattle hospitalized at the Garanhuns Bovine Clinic, UFRPE campus. One hundred and twenty-two cattle met the inclusion criteria established for the study. Among the clinical variables, heart rate (HR) and abdominal distension are associated with the outcome in animals with right displaced abomasum (RDA), and anorexia and 10% dehydration in animals with an obstructive intestinal disorder. Among the laboratory variables, plasma fibrinogen (PF) and total leukocyte count were associated with the outcome in animals with RDA, while PF and plasma L-lactate were associated with animals with an obstructive intestinal disorder. HR and the total leukocyte count remained in the final model of the regression adjusted for animals with RDA. On the other hand, plasma L-lactate and PF remained in the final model in the adjusted model for animals with an obstructive intestinal disorder. Cattle with RDA and HR higher than 90 bpm present an increased chance of having a negative outcome whereas cattle with obstructive intestinal disorder and plasma L-lactate higher than 1.84 mmol/L or PF higher than 850 mg/dL have a higher chance of not survive. Therefore, clinical and laboratory variables such as HR, fibrinogen, and plasma L-lactate are useful to predict the negative outcome in cattle with gastrointestinal emergencies, especially RDA and obstructive intestinal disorders. Keywords: biomarkers; gastrointestinal disease; prognostic factor

Indicadores proteicos, enzimáticos e minerais da toxemia da prenhez clínica e subclínica durante o período de transição de cabras leiteiras

O objetivo deste estudo foi avaliar a influência das formas clínica e subclínica da toxemia da prenhez (TP) na dinâmica dos metabólitos sanguíneos, compondo os perfis proteico, enzimático e mineral das cabras leiteiras durante o período de transição. Foram utilizadas 111 cabras multíparas que eram criadas em sistema intensivo. Grupos experimentais (n=3) foram criados utilizando diferentes concentrações séricas de βHB como ponto de corte, o G1 grupo controle (n=40), G2 grupo subclínico da TP (n=39) estabelecido quando pelo menos um dos momentos experimentais apresentou valores de βHB entre 0,8 mmol/L e 1,6 mmol/L; e o grupo G3, com manifestação clínica da TP (n=32), que em qualquer um dos momentos os valores de βHB foram superiores a 1,6 mmol/L. Os animais foram avaliados aos 30º, 20º e 10º dias antes do parto (dap), no parto e no 10º, 20º e 30º dia pós-parto (dpp). Proteínas totais (PT), albumina, globulina, ureia, creatinina, aspartato aminotransferase (AST), gama glutamiltransferase (GGT), creatina quinase (CK), amilase, fósforo, cloreto e cálcio, sódio e potássio foram mensurados. A análise de variância (Teste F) foi realizada com o objetivo de investigar os efeitos e interações entre os tempos dos grupos. A doença clínica e/ou subclínica resultou num aumento das concentrações de fósforo e potássio (P0,05). A ocorrência da forma subclínica foi maior que a clínica durante o período de transição. As variáveis que compõem o perfil mineral foram as que apresentaram alterações decorrentes da TP, destacando-se, o cálcio ionizado. Chama-se a atenção o impacto que a doença reflete nesses componentes e na saúde do animal. Palavras-chave: caprinos; cetose; final da gestação; lactação; metabólitos sanguíneos