496 research outputs found
Métodos de avaliação da aptidão cardiorrespiratória e composição corporal de adultos com lesão medular: uma revisão sistemática
Objetivo: Identificar quais são as ferramentas de avaliação utilizadas para mensurar as alterações na aptidão cardiorrespiratória (ACR) e composição corporal (CC) provocadas pelo exercício físico em adultos com lesão da medula espinhal (LME). Metodologia: Uma revisão sistemática da literatura científica produzida de janeiro/2017 a abril/2022 nas bases de dados PubMed, Embase, Cochrane Library, Lilacs e Scielo. Resultados: Foram incluídos seis ensaios clínicos randomizados e controlados. A ergoespirometria em cicloergômetro de membros superiores, as medidas antropométricas e a absorciometria de raios-x de dupla energia (DEXA) foram as ferramentas utilizadas para quantificar as adaptações na ACR e CC, respectivamente. Além disso, os estudos observaram aumento da ACR após o exercício físico, no entanto, não foram encontradas mudanças na CC. Conclusão: A ergoespirometria em cicloergômetro de membro superior, a DEXA e as medidas antropométricas parecem ser as principais ferramentas utilizadas na literatura para quantificar as mudanças na ACR e CC em adultos com LME, após o exercício físico. Por fim, o exercício físico pode ser uma intervenção não farmacológica capaz de melhorar a ACR de adultos com LME crônica
Uso de nanobast?es de ouro para o desenvolvimento de aulas pr?ticas de nanotecnologia.
Use of gold
nanoparticles functionalization experiment was conducted in a biotechnology summer course at UFOP as a model for the introduction
of the laboratory practice in nanotechnology for postgraduate courses in the areas of chemistry and biotechnology. The gold
nanorods were synthesized by the seed method and then, functionalized with anti-IL-6 antibodies using the reagents EDAC/NHS
and polyethyleneimine (PEI). This nanocompound was tested against the binding with the specific antigen (IL-6) and changes in the
longitudinal plasmon absorption spectrum showed the coupling efficiency, which was also verified by the decrease in zeta potential.
The experiment was satisfactory, with a positive feedback from participants, and could be implemented in nanotechnology practical
classes from postgraduate courses, as a way for improve education in the emergent area of nanobiotechnology
Cardiomiopatia de Takotsubo: uma breve revisão sistemática: Takotsubo Cardiomiopathy: a brief systematic review
A cardiomiopatia de Takotsubo é uma nova cardiomiopatia que foi noticiada pela primeira vez em 2001. A doença é definida por disfunção reversível do ventrículo esquerdo e manifesta-se normalmente como uma síndrome coronária aguda. Este estudo teve como objetivo discutir as principais características da cardiomiopatia takotsubo. Para isso, foi desenvolvida uma revisão sistemática de literatura, recorrendo-se às bases de dados Scielo, Medline e Lilacs, selecionando-se estudos publicados nos últimos 5 anos. A partir da análise e interpretação dos dados das fontes foi possível concluir que a cardiomiopatia de takotsubo é desencadeada pelo estresse físico e é vista como uma complicação para outras doenças não cardíacas, se apresentando geralmente em mulheres pós-menopausa, acima dos 70 anos de idade. Manifesta-se com início súbito de dor torácica e dispneia, após um evento emocional estressante que precede o início dos sintomas. Com principais consequências, tem-se choque cardiogênico, obstrução da via de saída do ventrículo esquerdo, trombo da parede ventricular esquerda, arritmias ventriculares, ruptura da parede ventricular e paragem cardíaca, registrando-se alguns casos de morte súbita
Dependência psicológica de Benzodiazepínicos: Psychological dependence on Benzodiazepines
O crescente aumento do seu uso no começo do século XXI, os ansiolíticos vêm se tornando a “porta de fuga” para nova e também velha geração. Geração essa, que cada vez mais vem sendo consumida por distúrbios de ansiedade, insônia e quadros depressivos de forma exponencial. (Faculdade de Ciências Farmacêuticas de Ribeirão Preto – 2019). Este trabalho, avalia o uso e possível dependência psicológica dos benzodiazepínicos, a partir de um levantamento bibliográfico de forma sistemática de pesquisas dentro da literatura científica acerca do assunto. 
Multidifferential study of identified charged hadron distributions in -tagged jets in proton-proton collisions at 13 TeV
Jet fragmentation functions are measured for the first time in proton-proton
collisions for charged pions, kaons, and protons within jets recoiling against
a boson. The charged-hadron distributions are studied longitudinally and
transversely to the jet direction for jets with transverse momentum 20 GeV and in the pseudorapidity range . The
data sample was collected with the LHCb experiment at a center-of-mass energy
of 13 TeV, corresponding to an integrated luminosity of 1.64 fb. Triple
differential distributions as a function of the hadron longitudinal momentum
fraction, hadron transverse momentum, and jet transverse momentum are also
measured for the first time. This helps constrain transverse-momentum-dependent
fragmentation functions. Differences in the shapes and magnitudes of the
measured distributions for the different hadron species provide insights into
the hadronization process for jets predominantly initiated by light quarks.Comment: All figures and tables, along with machine-readable versions and any
supplementary material and additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-013.html (LHCb
public pages
Study of the decay
The decay is studied
in proton-proton collisions at a center-of-mass energy of TeV
using data corresponding to an integrated luminosity of 5
collected by the LHCb experiment. In the system, the
state observed at the BaBar and Belle experiments is
resolved into two narrower states, and ,
whose masses and widths are measured to be where the first uncertainties are statistical and the second
systematic. The results are consistent with a previous LHCb measurement using a
prompt sample. Evidence of a new
state is found with a local significance of , whose mass and width
are measured to be and , respectively. In addition, evidence of a new decay mode
is found with a significance of
. The relative branching fraction of with respect to the
decay is measured to be , where the first
uncertainty is statistical, the second systematic and the third originates from
the branching fractions of charm hadron decays.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-028.html (LHCb
public pages
Measurement of the ratios of branching fractions and
The ratios of branching fractions
and are measured, assuming isospin symmetry, using a
sample of proton-proton collision data corresponding to 3.0 fb of
integrated luminosity recorded by the LHCb experiment during 2011 and 2012. The
tau lepton is identified in the decay mode
. The measured values are
and
, where the first uncertainty is
statistical and the second is systematic. The correlation between these
measurements is . Results are consistent with the current average
of these quantities and are at a combined 1.9 standard deviations from the
predictions based on lepton flavor universality in the Standard Model.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-039.html (LHCb
public pages
Genetic ancestry is associated with systolic blood pressure and glucose in Brazilian children and adolescents.
Background: Studies in admixed populations show that the prevalence
of obesity and related diseases, such as type 2 diabetes and hypertension,
may vary by ethnic group. The aim of this study was to
investigate the relationship of genetic ancestry with phenotypes associated
with obesity in a sample of school children and adolescents
from Ouro Preto, Minas Gerais.
Methods: We used data from genetic ancestry of 189 individuals
previously determined by 15 ancestry informative markers (AIMs),
and segregated individuals into three ancestral groups (predominantly
African (PAFR), predominantly mixed (PMIX), and predominantly
European (PEUR)) using the proportion of ancestry. The ancestral
groups were compared with mean values of anthropometric, clinical,
biochemical, and demographic variables. The simple linear regression
analysis was used to test whether differences in mean values of
the dependent variables (blood pressure and glucose) between the ancestral
groups were dependent on the other variables.
Results: Our results show that the proportions of African (F = 144.2,
P < 0.001), Amerindian (F = 15.5, P < 0.001) and European (F =
184.9, P < 0.001) ancestry differed significantly (P < 0.001) among
the three ancestral groups. PAFR individuals had higher mean blood
pressure (P ≤ 0.029) and glucose (P = 0.025) as compared to PEUR.
In the linear regression model, the difference in systolic blood pressure
(SBP) values remained significant in all models tested and independent
of confounding variables (P ≤ 0.041). The difference in
diastolic blood pressure values observed in PAFR and PEUR groups
did not remain significant when the metabolic profile was included
in the tested model (P = 0.097). The difference in glucose values was
significant only between PMIX and PEUR groups and independent of
the settings (P ≤ 0.037).
Conclusion: The positive correlation between genetic ancestry and
SBP and glucose in Brazilian children and adolescents suggests the
need for special care in the subgroups of this population
Genetic composition of a Brazilian population : the footprint of the Gold Cycle.
Ancestry-informative markers (AIMs) are powerful tools for inferring the genetic composition of admixed populations. In this study, we determined the genetic ancestry of the Ouro Preto (Brazil) population and evaluated the association between ancestry and self-reported skin color. The genetic ancestry of 189 children and adolescents was estimated by genotyping 15 AIMs. The estimate of population admixture was determined using the Bayesian Markov Chain Monte Carlo (MCMC) method implemented in two different programs (STRUCTURE and ADMIXMAP). Volunteers self-reported their skin colors. The European ancestry contribution ranged from 0.503 to 0.539, the African contribution ranged from 0.333 to 0.425, and the Amerindian component ranged from 0.04 to 0.164. The relative contributions of African (P < 0.016) and European (P < 0.011) ancestry differed significantly among skin color groups, except between black and dark-brown groups. The population of Ouro Preto has a higher contribution of African ancestry compared to the mean for the southeast region of Brazil. Therefore, extrapolating the African ancestry contribution for southeastern Brazil to the Ouro Preto population would underestimate the actual value for this city. We also showed that self-reported skin color could be appropriate for describing the genetic structure of this particular population
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