Stop as a next-to-lightest supersymmetric particle in constrained MSSM

So far the squarks have not been detected at the LHC indicating that they are heavier than a few hundred GeVs, if they exist. The lighter stop can be considerably lighter than the other squarks. We study the possibility that a supersymmetric partner of the top quark, stop, is the next-to-lightest supersymmetric particle in the constrained supersymmetric standard model. Various constraints, on top of the mass limits, are taken into an account, and the allowed parameter space for this scenario is determined. Observing stop which is the next-to-lightest supersymmetric particle at the LHC may be difficult.Comment: v2: A few references, a plot indicating used parameters, discussion about the role of parameters in determination of the stop NLSP, CCB minima and a comment about (g-2) added. Typos corrected. Version in PR

Prostate cancer risk regions at 8q24 and 17q24 are differentially associated with somatic TMPRSS2:ERG fusion status.

Molecular and epidemiological differences have been described between TMPRSS2:ERG fusion-positive and fusion-negative prostate cancer (PrCa). Assuming two molecularly distinct subtypes, we have examined 27 common PrCa risk variants, previously identified in genome-wide association studies, for subtype specific associations in a total of 1221 TMPRSS2:ERG phenotyped PrCa cases. In meta-analyses of a discovery set of 552 cases with TMPRSS2:ERG data and 7650 unaffected men from five centers we have found support for the hypothesis that several common risk variants are associated with one particular subtype rather than with PrCa in general. Risk variants were analyzed in case-case comparisons (296 TMPRSS2:ERG fusion-positive versus 256 fusion-negative cases) and an independent set of 669 cases with TMPRSS2:ERG data was established to replicate the top five candidates. Significant differences (P < 0.00185) between the two subtypes were observed for rs16901979 (8q24) and rs1859962 (17q24), which were enriched in TMPRSS2:ERG fusion-negative (OR = 0.53, P = 0.0007) and TMPRSS2:ERG fusion-positive PrCa (OR = 1.30, P = 0.0016), respectively. Expression quantitative trait locus analysis was performed to investigate mechanistic links between risk variants, fusion status and target gene mRNA levels. For rs1859962 at 17q24, genotype dependent expression was observed for the candidate target gene SOX9 in TMPRSS2:ERG fusion-positive PrCa, which was not evident in TMPRSS2:ERG negative tumors. The present study established evidence for the first two common PrCa risk variants differentially associated with TMPRSS2:ERG fusion status. TMPRSS2:ERG phenotyping of larger studies is required to determine comprehensive sets of variants with subtype-specific roles in PrCa.RAE acknowledges support from the NIHR to the Biomedical Research Centre at The Institute of Cancer Research and Royal Marsden NHS Foundation Trust. ML was a fellow of the International Graduate School in Molecular Medicine, Ulm. AER was a fellow of the Heinrich Warner Foundation. The GTEx Consortium is acknowledged for the GTEx data (the full acknowledgement is available in the Supplementary Materials). This work was supported by the following grants for the iCOGS infrastructure: European Community's Seventh Framework Programme under grant agreement n° 223175 [HEALTHF2-2009-223175]; Cancer Research UK [C1287/A10118, C1287/A10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692]; the National Institutes of Health [CA128978] and Post-Cancer GWAS initiative [1U19 CA148537, 1U19 CA148065, 1U19 CA148112 - the GAME-ON initiative]; the Department of Defence [W81XWH-10-1-0341]; the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer; Komen Foundation for the Cure; the Breast Cancer Research Foundation; and the Ovarian Cancer Research Fund. The FHCRC, Tampere, UKGPCS and Ulm groups are part of the ICPCG, supported by the National Institutes of Health [U01 CA089600]. The Molecular Prostate Cancer project of Ulm was funded by the Deutsche Krebshilfe. The Berlin and Ulm collaboration was supported by the Berliner Krebsgesellschaft. The FHCRC studies were supported by the U.S. National Cancer Institute, National Institutes of Health [RO1 CA056678, RO1 CA082664, RO1 CA092579]; with additional support from the Fred Hutchinson Cancer Research Center. Genotyping was supported by the Intramural Program of the National Human Genome Research Institute, National Institutes of Health. The Tampere (Finland) study was supported by the Academy of Finland [116437, 251074, 126714]; the Finnish Cancer Organisations; Sigrid Juselius Foundation; and The Medical Research Fund of Tampere University Hospital [# 9L091]. The PSA screening samples were collected by the Finnish part of ERSPC (European Study of Screening for Prostate Cancer)

Intensity and temporal patterns of physical activity and cardiovascular disease risk in midlife

Abstract Physical activity (PA) and sedentary time (SED) are associated with the risk of cardiovascular disease (CVD), but the temporal patterns of these behaviors most beneficial for cardiovascular health remain unknown. We aimed to identify the intensity and temporal patterns of PA and SED measured continuously by an accelerometer and their relationship with CVD risk. At the age of 46 years, 4582 members (1916 men; 2666 women) of the Northern Finland Birth Cohort 1966 study underwent continuous measurement of PA with Polar Active (Polar Electro, Finland) accelerometers for one week. X-means clustering was applied based on 10 min average MET (metabolic equivalent) values during the measurement period. Ten-year risk of CVD was estimated using the Framingham risk model. Most of the participants had low risk for CVD. Four distinct PA clusters were identified that were well differentiable by the intensity and temporal patterns of activity (inactive, evening active, moderately active, very active). A significant difference in 10-year CVD risk across the clusters was found in men (p = 0.028) and women (p &lt; 0.001). Higher levels of HDL cholesterol were found in more active clusters compared to less active clusters (p &lt; 0.001) in both genders. In women total cholesterol was lower in the moderately active cluster compared to the inactive and evening active clusters (p = 0.001). Four distinct PA clusters were recognized based on accelerometer data and X-means clustering. A significant difference in CVD risk across the clusters was found in both genders. These results can be used in developing and promoting CVD prevention strategies

Prolonged bouts of sedentary time and cardiac autonomic function in midlife

Abstract Excessive sedentary time (SED) and long SED bouts are associated with cardiovascular diseases (CVD) and increased mortality. Low heart rate variability (HRV), indicating autonomic dysfunction, increases mortality and CVD morbidity. Information about the association between prolonged SED and HRV is lacking. The aim was to assess the relationship between SED bouts and HRV. Physical activity (PA), SED, HRV, and cardiorespiratory fitness (CRF) were collected from a birth‐cohort sample (n = 4150) at 46 years. PA and SED were measured for 14 days with an activity monitor (Polar Active, Polar Electro, Finland). SED accumulating in bouts of at least 30 and 60 minutes (SED30, SED60) was calculated. Linear regression was used to study the relationship between prolonged SED and HRV accounting for CRF, PA, and health covariates. Higher SED60 and in women SED30 were associated with higher root mean square of differences in R‐R intervals (rMSSD) after adjustments (β = .082‐.104). In women, higher SED60 was associated with lower ratio between low‐ and high‐frequency powers (β = −.060). Sedentary bouts were not associated with resting HR or post‐exercise HR recovery. A positive relationship between SED bouts and rMSSD independent of PA and CRF was found, prolonged SED being positively associated with cardiac parasympathetic activity in midlife

Geography of global change and species richness in the North

Abstract Different components of global change (e.g., climate change, land use, pollution, and introduced species) continue to alter biodiversity worldwide. As northern regions are still relatively undisturbed and will likely face clear increases in temperature in the near-future, we examined the signs of biodiversity change due to anthropogenic stressors using a systematic review of previous studies. Our aim was to map where, in which way, and owing to which stressor biodiversity in northern regions has changed. We made a systematic literature search covering the years between 2000 and 2015 to obtain a comprehensive selection of recent research. As species richness was clearly the most commonly used indicator of biodiversity, we only concentrated on this aspect of biodiversity. We compared different biological groups, regions, and ecosystems. In the majority of the cases, anthropogenic stressors had decreased species richness, or had no effects on it, while increasing or multiple effects of stressors on species richness were less common. Freshwater ecosystems were most sensitive to anthropogenic stressors, as species richness often decreased owing to these stressors. The effects of land use on richness were covered relatively widely in the selected set of articles, but the effects of other components of global change on species richness require further attention. Despite the fact that pollution was not as commonly studied stressor as land use, it was the most harmful stressor type affecting species richness. Geographically, most studies were located in boreal Canada or Fennoscandia, while no studies were executed in vast circumpolar areas where the temperature rise has been greatest and the projected climate change is likely to be fast. Overall, we could find an alarmingly small set of studies that described the effects of actual anthropogenic stressors in real-life circumstances in northern high latitudes

Microseminoprotein-Beta Expression in Different Stages of Prostate Cancer

Microseminoprotein-beta (MSMB, MSMB) is an abundant secretory protein contributed by the prostate, and is implicated as a prostate cancer (PC) biomarker based on observations of its lower expression in cancerous cells compared with benign prostate epithelium. However, as the current literature on MSMB is inconsistent, we assessed the expression of MSMB at the protein and mRNA levels in a comprehensive set of different clinical stages of PC. Immunohistochemistry using monoclonal and polyclonal antibodies against MSMB was used to study protein expression in tissue specimens representing prostatectomies (n = 261) and in diagnostic needle biopsies from patients treated with androgen deprivation therapy (ADT) (n = 100), and in locally recurrent castration-resistant PC (CRPC) (n = 105) and CRPC metastases (n = 113). The transcript levels of MSMB, nuclear receptor co-activator 4 (NCOA4) and MSMB-NCOA4 fusion were examined by qRT-PCR in prostatectomy samples and by RNA-sequencing in benign prostatic hyperplasia, PC, and CRPC samples. We also measured serum MSMB levels and genotyped the single nucleotide polymorphism rs10993994 using DNA from the blood of 369 PC patients and 903 controls. MSMB expression in PC (29% of prostatectomies and 21% of needle biopsies) was more frequent than in CRPC (9% of locally recurrent CRPCs and 9% of CRPC metastases) (p<0.0001). Detection of MSMB protein was inversely correlated with the Gleason score in prostatectomy specimens (p = 0.024). The read-through MSMB-NCOA4 transcript was detected at very low levels in PC. MSMB levels in serum were similar in cases of PC and controls but were significantly associated with PC risk when adjusted for age at diagnosis and levels of free or total PSA (p<0.001). Serum levels of MSMB in both PC patients and controls were significantly associated with the rs10993994 genotype (p<0.0001). In conclusion, decreased expression of MSMB parallels the clinical progression of PC and adjusted serum MSMB levels are associated with PC risk

Comparison of neutralino and sneutrino dark matter in a model with spontaneous CP violation

Contains fulltext : 119349_pub.pdf (publisher's version ) (Open Access) Contains fulltext : 119349_pre.pdf (preprint version ) (Open Access

Metabolomics reveals the metabolic shifts following an intervention with rye bread in postmenopausal women- a randomized control trial

<p>Abstract</p> <p>Background</p> <p>Epidemiological studies have consistently shown that whole grain (WG) cereals can protect against the development of chronic diseases, but the underlying mechanism is not fully understood. Among WG products, WG rye is considered even more potent because of its unique discrepancy in postprandial insulin and glucose responses known as the rye factor. In this study, an NMR-based metabolomics approach was applied to study the metabolic effects of WG rye as a tool to determine the beneficial effects of WG rye on human health.</p> <p>Methods</p> <p>Thirty-three postmenopausal Finnish women with elevated serum total cholesterol (5.0-8.5 mmol/L) and BMI of 20–33 kg/m² consumed a minimum of 20% of their daily energy intake as high fiber WG rye bread (RB) or refined wheat bread (WB) in a randomized, controlled, crossover design with two 8-wk intervention periods separated by an 8-wk washout period. At the end of each intervention period, fasting serum was collected for NMR-based metabolomics and the analysis of cholesterol fractions. Multilevel partial least squares discriminant analysis was used for paired comparisons of multivariate data.</p> <p>Results</p> <p>The metabolomics analysis of serum showed lower leucine and isoleucine and higher betaine and N,N-dimethylglycine levels after RB than WB intake. To further investigate the metabolic effects of RB, the serum cholesterol fractions were measured. Total- and LDL-cholesterol levels were higher after RB intake than after WB (p<0.05).</p> <p>Conclusions</p> <p>This study revealed favorable shifts in branched amino acid and single carbon metabolism and an unfavorable shift in serum cholesterol levels after RB intake in postmenopausal women, which should be considered for evaluating health beneficial effects of rye products.</p