The effects of a background potential in star cluster evolution: a delay in the relaxation time-scale and runaway collision processes

Runaway stellar collisions in dense star clusters are invoked to explain the presence of very massive stars or blue stragglers in the center of those systems. This process has also been explored for the first star clusters in the Universe and shown to yield stars that may collapse at some points into an intermediate mass black hole. Although the early evolution of star clusters requires the explicit modeling of the gas out of which the stars form, these calculations would be extremely time-consuming and often the effects of the gas can be accurately treated by including a background potential to account for the extra gravitational force. We apply this approximation to model the early evolution of the first dense star clusters formed in the Universe by performing $N$-body simulations, our goal is to understand how the additional gravitational force affects the growth of a very massive star through stellar mergers in the central parts of the star cluster. Our results show that the background potential increases the velocities of the stars, causing an overall delay in the evolution of the clusters and in the runaway growth of a massive star at the center. The population of binary stars is lower due to the increased kinetic energy of the stars, initially reducing the number of stellar collisions, and we show that relaxation processes are also affected. Despite these effects, the external potential enhances the mass of the merger product by a factor $\sim$2 if the collisions are maintained for long times.Comment: 16 pages. Accepted for publication in Astronomy and Astrophysic

Exact Integration of the High Energy Scale in Doped Mott Insulators

We expand on our earlier work (cond-mat/0612130, Phys. Rev. Lett. {\bf 99}, 46404 (2007)) in which we constructed the exact low-energy theory of a doped Mott insulator by explicitly integrating (rather than projecting) out the degrees of freedom far away from the chemical potential. The exact low-energy theory contains degrees of freedom that cannot be obtained from projective schemes. In particular a new charge $\pm 2e$ bosonic field emerges at low energies that is not made out of elemental excitations. Such a field accounts for dynamical spectral weight transfer across the Mott gap. At half-filling, we show that two such excitations emerge which play a crucial role in preserving the Luttinger surface along which the single-particle Green function vanishes. In addition, the interactions with the bosonic fields defeat the artificial local SU(2) symmetry that is present in the Heisenberg model. We also apply this method to the Anderson-U impurity and show that in addition to the Kondo interaction, bosonic degrees of freedom appear as well. Finally, we show that as a result of the bosonic degree of freedom, the electron at low energies is in a linear superposition of two excitations--one arising from the standard projection into the low-energy sector and the other from the binding of a hole and the boson.Comment: Published veriso

Fronto-striatal cognitive deficits at different stages of Parkinson's disease

Groups of patients with idiopathic Parkinson's disease, either medicated or unmedicated, were compared with matched groups of normal controls on a computerized battery previously shown to be sensitive to frontal lobe dysfunction, including tests of planning, spatial working memory and attentional set-shifting. In a series of problems based on the 'Tower of London' test, medicated patients with Parkinson's disease were shown to be impaired in the amount of time spent thinking about (planning) the solution to each problem. Additionally, an impairment in terms of the accuracy of the solution produced on this test was only evident in those patients with more severe clinical symptoms and was accompanied by deficits in an associated test of spatial short-term memory. Medicated patients with both mild and severe clinical symptoms were also impaired on a related test of spatial working memory. In contrast, a group of patients who were unmedicated and 'early in the course' of the disease were unimpaired in all three of these tests. However, all three Parkinson's disease groups were impaired in the test of attentional set-shifting ability, although unimpaired in a test of pattern recognition which is insensitive to frontal lobe damage. These data are compared with those previously published from a group of young neurosurgical patients with localized excisions of the frontal lobes and are discussed in terms of the specific nature of the cognitive deficit at different stages of Parkinson's disease

A common cardiac sodium channel variant associated with sudden infant death in African Americans, SCN5A S1103Y.

Thousands die each year from sudden infant death syndrome (SIDS). Neither the cause nor basis for varied prevalence in different populations is understood. While 2 cases have been associated with mutations in type Valpha, cardiac voltage-gated sodium channels (SCN5A), the "Back to Sleep" campaign has decreased SIDS prevalence, consistent with a role for environmental influences in disease pathogenesis. Here we studied SCN5A in African Americans. Three of 133 SIDS cases were homozygous for the variant S1103Y. Among controls, 120 of 1,056 were carriers of the heterozygous genotype, which was previously associated with increased risk for arrhythmia in adults. This suggests that infants with 2 copies of S1103Y have a 24-fold increased risk for SIDS. Variant Y1103 channels were found to operate normally under baseline conditions in vitro. As risk factors for SIDS include apnea and respiratory acidosis, Y1103 and wild-type channels were subjected to lowered intracellular pH. Only Y1103 channels gained abnormal function, demonstrating late reopenings suppressible by the drug mexiletine. The variant appeared to confer susceptibility to acidosis-induced arrhythmia, a gene-environment interaction. Overall, homozygous and rare heterozygous SCN5A missense variants were found in approximately 5% of cases. If our findings are replicated, prospective genetic testing of SIDS cases and screening with counseling for at-risk families warrant consideration

Dynamics of the DBI Spike Soliton

We compare oscillations of a fundamental string ending on a D3-brane in two different settings: (1) a test-string radially threading the horizon of an extremal black D3-brane and (2) the spike soliton of the DBI effective action for a D3-brane. Previous work has shown that overall transverse modes of the test-string appear as l=0 modes of the transverse scalar fields of the DBI system. We identify DBI world-volume degrees of freedom that have dynamics matching those of the test-string relative transverse modes. We show that there is a map, resembling T-duality, between relative and overall transverse modes for the test-string that interchanges Neumann and Dirichlet boundary conditions and implies equality of the absorption coefficients for both modes. We give general solutions to the overall and relative transverse parts of the DBI coupled gauge and scalar system and calculate absorption coefficients for the higher angular momentum modes in the low frequency limit. We find that there is a nonzero amplitude for l>0 modes to travel out to infinity along the spike, demonstrating that the spike remains effectively 3+1-dimensional.Comment: 15 pages, 1 figur

Early childhood lung function is a stronger predictor of adolescent lung function in cystic fibrosis than early Pseudomonas aeruginosa infection

Pseudomonas aeruginosa has been suggested as a major determinant of poor pulmonary outcomes in cystic fibrosis (CF), although other factors play a role. Our objective was to investigate the association of early childhood Pseudomonas infection on differences in lung function in adolescence with CF

Access: Multiple Avenues For Deaf People

The companion to Signs and Voices: Deaf Culture, Identity, Language, and Arts, this volume presents an accomplished group of contributors who address the major technological, institutional, and societal advances in access for deaf people, as well as the remaining hurdles

Efficacy of HIV/STI behavioral interventions for heterosexual African American men in the United States: a meta-analysis

This meta-analysis estimates the overall efficacy of HIV prevention interventions to reduce HIV sexual risk behaviors and sexually transmitted infections (STIs) among heterosexual African American men. A comprehensive search of the literature published during 1988–2008 yielded 44 relevant studies. Interventions significantly reduced HIV sexual risk behaviors and STIs. The stratified analysis for HIV sexual risk behaviors indicated that interventions were efficacious for studies specifically targeting African American men and men with incarceration history. In addition, interventions that had provision/referral of medical services, male facilitators, shorter follow-up periods, or emphasized the importance of protecting family and significant others were associated with reductions in HIV sexual risk behaviors. Meta-regression analyses indicated that the most robust intervention component is the provision/referral of medical services. Findings indicate that HIV interventions for heterosexual African American men might be more efficacious if they incorporated a range of health care services rather than HIV/STI-related services alone

Rehabilitation Therapy in Older Acute Heart Failure Patients (REHAB-HF) trial: Design and rationale.

BACKGROUND: Acute decompensated heart failure (ADHF) is a leading cause of hospitalization in older persons in the United States. Reduced physical function and frailty are major determinants of adverse outcomes in older patients with hospitalized ADHF. However, these are not addressed by current heart failure (HF) management strategies and there has been little study of exercise training in older, frail HF patients with recent ADHF. HYPOTHESIS: Targeting physical frailty with a multi-domain structured physical rehabilitation intervention will improve physical function and reduce adverse outcomes among older patients experiencing a HF hospitalization. STUDY DESIGN: REHAB-HF is a multi-center clinical trial in which 360 patients ≥60 years hospitalized with ADHF will be randomized either to a novel 12-week multi-domain physical rehabilitation intervention or to attention control. The goal of the intervention is to improve balance, mobility, strength and endurance utilizing reproducible, targeted exercises administered by a multi-disciplinary team with specific milestones for progression. The primary study aim is to assess the efficacy of the REHAB-HF intervention on physical function measured by total Short Physical Performance Battery score. The secondary outcome is 6-month all-cause rehospitalization. Additional outcome measures include quality of life and costs. CONCLUSIONS: REHAB-HF is the first randomized trial of a physical function intervention in older patients with hospitalized ADHF designed to determine if addressing deficits in balance, mobility, strength and endurance improves physical function and reduces rehospitalizations. It will address key evidence gaps concerning the role of physical rehabilitation in the care of older patients, those with ADHF, frailty, and multiple comorbidities