Effects of Socioeconomic Status, Parent–Child Relationship, and Learning Motivation on Reading Ability

Against the background of Chinese culture, we investigated the relationship between family socioeconomic status (SES) and children’s reading ability. Participants included 2294 middle-school students in grade 8. SES was measured by parents’ education level, parents’ occupational prestige, and family property, and children’s reading ability was estimated with item response theory. In addition, we adopted an 8-item parent–child relationship scale and a 22-item learning motivation scale that included four dimensions. We examined whether the parent–child relationship mediated the relationship between family SES and reading ability and whether this was moderated by learning motivation. The results indicated that the parent–child relationship played a mediating role in the relationship between SES and reading ability. This relationship was moderated by students’ learning motivation. The direct effects of SES on reading ability at high, medium, and low levels of learning motivation were 0.24, 0.32, and 0.40, respectively

Study on the interlayer bonding state of an asphalt pavement based on the stacking peak ratio method

The interlayer bonding of an asphalt pavement significantly influences the mechanical properties and long-term durability of the pavement structure. In order to develop a rapid and comprehensive evaluation method for assessing the interlayer condition of asphalt pavements using 3D GPR, we propose the stacking peak ratio (SPR) method. This method involves stacking the ratio between the amplitude peak of the interlayer and that of surface reflection to evaluate the interlayer state. Comparative analysis with direct shear tests and field measurements leads us to draw several conclusions: the optimal test parameters for the SPR method are a stacking peak ratio at 35 ns with a residence time of 1 us; the SPR method is compatible with various bonding materials and pollution layers, demonstrating its ability to effectively assess the bonding state of asphalt pavements; field tests further validate that the SPR approach can identify insufficient layer bonding and predict potential flaws in advance. Through our test findings and data analysis, it is evident that this SPR approach provides theoretical support and technological assistance for promptly evaluating the bonding status in asphalt pavements

Regenerative Futures: From Global to Local Development in 2032

The ‘Regenerative Futures: From Global to Local Development in 2032’ project was jointly conceived by the Innovation School at Glasgow School of Art and the School of Cancer Sciences at the University of Glasgow. The project partnership involved a community of experts working across both organisations including the University of Glasgow’s Mazumdar-Shaw Advanced Research Centre (ARC). Regenerative Design is about designing for people and the planet from a socio-ecological perspective. It seeks not merely to do less harm, but rather catalyses a positive force that restores, renews or revitalises products, services and systems to foster resilient and equitable futures for people and the planet. The Regenerative Futures project asked the final year BDes Product Design cohort to consider what happens in this landscape ten years from now, where Global Development has evolved to the extent that new forms of regenerative experiences of health, economies and citizenship transform how we interact with each other, with local and global communities, and the world around us. Working with an expert community of practice from the University of Glasgow’s Advanced Research Centre (the project’s partner) and a wider expert group of academic and professional stakeholders, the students, faculty, and experts co-researched, explored and designed speculative future worlds and experiences of regenerative global and local communities and systems leading towards equitable health, economies and citizenship in ten year’s time. In the first part of the project, the student cohort work in six groups to collectively research the brief, exploring the domains of Health, Economies and Citizenship from a Globally-Centred or Locally-Centred perspective. In-depth insights from the first stage fuel individual design work in Part Two. The second part of the project saw individual students select an aspect of their Future World research to develop as a design direction, which they then prototyped and produced as products, services, and/or systems. These are designed for specific communities, contexts or scenarios of use defined by the students to communicate a future experience. The output from this project is curated and presented as a public exhibition. The exhibition resulting from this research project includes products, services and experiences designed for the people who might live and work within these future contexts. Each ‘future world’ is situated within a discrete design domain: Health (Global + Local), Economies (Global + Local) and Citizenship (Global + Local). Exhibition dates: Tuesday 7th to Friday 10th February, 2023 Venue: Advanced Research Centre, University of Glasgow The deposited materials are arranged as follows: 1 - Regenerative Futures Project Brief. The Project Brief is developed as rationale, context and a guide to the project. 2 - Regenerative Futures Project Exhibition Guide. The Guide catalogues and describes the exhibits presented in the show. It takes you through each ‘Future World’ experience created by the students. It complements the videos and images presented in companion sections. 3 - Videos of the Regenerative Futures Exhibition. Here you will find short videos documenting the set-up of the exhibition and the exhibition itself. 4 - Images of the Regenerative Futures Exhibition. This section documents the Exhibition in images. 5 - Images of Studio Life. This section documents in images, the co-creation studio sessions with experts and the studio development of the show exhibits. 6 - Exhibition guides for each individual World View. These guides take you through each individual ‘Future World’; Health (Global + Local), Economies (Global + Local) and Citizenship (Global + Local)

The ER-membrane transport system is critical for intercellular trafficking of the NSm movement protein and Tomato Spotted Wilt Tospovirus

Plant viruses move through plasmodesmata to infect new cells. The plant endoplasmic reticulum (ER) is interconnected among cells via the ER desmotubule in the plasmodesma across the cell wall, forming a continuous ER network throughout the entire plant. This ER continuity is unique to plants and has been postulated to serve as a platform for the intercellular trafficking of macromolecules. In the present study, the contribution of the plant ER membrane transport system to the intercellular trafficking of the NSm movement protein and Tomato spotted wilt tospovirus (TSWV) is investigated. We showed that TSWV NSm is physically associated with the ER membrane in Nicotiana benthamiana plants. An NSm-GFP fusion protein transiently expressed in single leaf cells was trafficked into neighboring cells. Mutations in NSm that impaired its association with the ER or caused its mis-localization to other subcellular sites inhibited cell-to-cell trafficking. Pharmacological disruption of the ER network severely inhibited NSm-GFP trafficking but not GFP diffusion. In the Arabidopsis thaliana mutant rhd3 with an impaired ER network, NSm-GFP trafficking was significantly reduced, whereas GFP diffusion was not affected. We also showed that the ER-to-Golgi secretion pathway and the cytoskeleton transport systems were not involved in the intercellular trafficking of TSWV NSm. Importantly, TSWV cell-to-cell spread was delayed in the ER-defective rhd3 mutant, and this reduced viral infection was not due to reduced replication. On the basis of robust biochemical, cellular and genetic analysis, we established that the ER membrane transport system serves as an important direct route for intercellular trafficking of NSm and TSWV

Chemoproteomics, A Broad Avenue to Target Deconvolution

Abstract As a vital project of forward chemical genetic research, target deconvolution aims to identify the molecular targets of an active hit compound. Chemoproteomics, either with chemical probe‐facilitated target enrichment or probe‐free, provides a straightforward and effective approach to profile the target landscape and unravel the mechanisms of action. Canonical methods rely on chemical probes to enable target engagement, enrichment, and identification, whereas click chemistry and photoaffinity labeling techniques improve the efficiency, sensitivity, and spatial accuracy of target recognition. In comparison, recently developed probe‐free methods detect protein‐ligand interactions without the need to modify the ligand molecule. This review provides a comprehensive overview of different approaches and recent advancements for target identification and highlights the significance of chemoproteomics in investigating biological processes and advancing drug discovery processes

Investigation on Flowback Behavior of Imbibition Fracturing Fluid in Gas–Shale Multiscale Pore Structure

To investigate the influence of flowback time and flowback difference on flowback behavior of shale fracturing fluid, we carried out the permeability test experiment of Longmaxi Formation shale under different flowback pressure gradients and analyzed the retention characteristics of water phase in shale pores and fractures after flowback by nuclear magnetic resonance (NMR) instrument. The results indicate that after flowback under the pressure gradient ranges of 0.06~0.18 MPa/cm, the content of retained water phase in shale samples ranges from 9.68% to 16.97% and the retention of fracturing fluid in shale does not decrease with the increase of flowback pressure difference. Additionally, increasing the flowback pressure difference will reduce the shale permeability damage rate, but the permeability damage rate is still above 80%. After the flowback, the water phase mainly stays in the pore space with D D < 100 nm to flow back out. The experimental results show that the critical flowback pressure gradient for particle migration of rock powder in shale fracture surface is 0.09 MPa/cm. The research results have important guiding significance for shale gas well flowback

Fine-grained task-level parallel and low power H.264 decoding in multi-core systems

In the past few years, the extinction of Moore's Law makes people reconsider the solutions for dealing with the low computing resource utilization of applications on multicore processor systems. However, making good use of computing resources in multi-core processors systems is not easy due to the differences between single-core and multi-core architecture. Nowadays short video apps like Instagram and Tik Tok have successfully caught people's eyes by fascinating short videos, typically just 10 to 30 seconds long, uploaded by the users of apps. And almost all of these videos are recorded by their mobile devices, which are typically HD (High Definition) or FHD (Full High Definition) videos, which prefer to be encoded/decoded by H.264/AVC rather then HEVC (High Efficiency Video Coding) on mobile devices in view of the energy consumption and decoding speed. How to dive the huge potential of the computing resource on multi-core mobile devices to speed up decoding these videos while consuming low energy, is a big challenge. In our previous work [1], a relatively simple parallel framework was proposed to implement a parallel H.264/ AV C decoder. This work further proposes a more detailed systematic task-level parallel framework, together with an energy saving strategy based on this framework, to research a new H.264/AVC decoder on multi-core processor systems. The proposed parallel method is composed of a set of rules to guide parallel software programming (PSPR) and a software parallelization framework (SPF). The PSPR is applied in pre-processing steps to address the potential issues limiting the inherent parallelism, and the SPF is applied to parallelize the original serial programs. After the parallelization is successfully deployed, DVFS technique would be applied to decrease the power dissipation based on the SPF. Results show that proposed solutions make a significant improvement in decoding speed of 32% at 720p, 27% at 1080p and 29% at 2160p, and in energy savings o...Nanyang Technological UniversityThis work is partially supported by NAP M4082282 and SUG M4082087 from NTU Singapore, and NSFC 61772094, Chongqing High-Tech Program cstc2017jcyjA1430, the Fundamental Research Funds for the Central Universities 106112017CDJQJ188829, China, and China Scholarship Council No. 201706050117

MicroRNA-221-3p inhibits the inflammatory response of keratinocytes by regulating the DYRK1A/STAT3 signaling pathway to promote wound healing in diabetes

Abstract Diabetic foot ulcer (DFU), a serious complication of diabetes, remains a clinical challenge. MicroRNAs affect inflammation and may have therapeutic value in DFU. Here, we find that an miR-221-3p mimic reduces the inflammatory response and increases skin wound healing rates in a mouse model of diabetes, whereas miR-221-3p knockout produced the opposite result. In human keratinocytes cells, miR-221-3p suppresses the inflammatory response induced by high glucose. The gene encoding DYRK1A is a target of miR-221-3p. High glucose increases the expression of DYRK1A, but silencing DYRK1A expression decreases high glucose–induced inflammatory cytokine release via dephosphorylation of STAT3, a substrate of DYRK1A. Application of miR-221-3p mimic to human keratinocytes cells not only decreases DYRK1A expression but also inhibits high glucose–induced production of inflammatory cytokines to promote wound healing. This molecular mechanism whereby miR-221-3p regulates inflammation through the DYRK1A/STAT3 signaling pathway suggests targets and therapeutic approaches for treating DFU