An Exploration of the Occupational Needs of College Students

This paper analyzes the barriers and supports for Dominican University of California students in meeting their occupational needs and what services might be beneficial to them. To be able to answer this question, we conducted a survey using convenience sampling with twenty-seven Dominican undergraduate students, interviewed staff, and conducted a focus group with the students who participated in the survey. Our results indicated four main themes which include: occupational needs, barriers to meeting occupational needs, supports to meeting occupational needs, and services recommended. For the implications for occupational therapy, we found that OTs are beneficial in several aspects of students’ lives and can be implemented on and around the campus

3D non-linear MHD simulation of the MHD response and density increase as a result of shattered pellet injection

The MHD response and the penetration of a deuterium shattered pellet into a JET plasma is investigated via the non-linear reduced MHD code JOREK with the neutral gas shielding (NGS) ablation model. The dominant MHD destabilizing mechanism by the injection is identified as the local helical cooling at each rational surface, as opposed to the global current profile contraction. Thus the injected fragments destabilize each rational surface as they pass through them. The injection penetration is found to be much better compared to MGI, with the convective transport caused by core MHD instabilities (e.g. 1/1 kink) contributing significantly to the core penetration. Moreover, the injection with realistic JET SPI system configurations is simulated in order to provide some insights into future operations, and the impact on the total assimilation and penetration depth of varying injection parameters such as the injection velocity or fineness of shattering is assessed. Further, the effect of changing the target equilibrium temperature or q profile on the assimilation and penetration is also investigated. Such analysis will form the basis of further investigation into a desirable configuration for the future SPI system in ITER.EURATOM 63305

In vitro Efficacy of a Novel Guanosine-Analog Phosphonate

Actinic keratosis, a frequent carcinoma in situ of non-melanoma skin cancer (NMSC), can transform into life-threatening cutaneous squamous cell carcinoma. Current treatment is limited due to low complete clearance rates and asks for novel therapeutic concepts; the novel purine nucleotide analogue OxBu may be an option. In order to enhance skin penetration, solid lipid nanoparticles (SLN, 136-156 nm) were produced with an OxBu entrapment efficiency of 96.5 ± 0.1%. For improved preclinical evaluation, we combined tissue engineering with clinically used keratin-18 quantification. Three doses of 10-3 mol/l OxBu, dissolved in phosphate-buffered saline as well as loaded to SLN, were effective on reconstructed NMSC. Tumour response and apoptosis induction were evaluated by an increase in caspase-cleaved fragment of keratin-18, caspase-7 activation as well as by reduced expression of matrix metallopeptidase-2 and Ki-67. OxBu efficacy was superior to equimolar 5-fluorouracil solution, and thus the drug should be subjected to the next step in preclinical evaluation