Dialkylbiaryl phosphines in Pd-catalyzed amination: a user's guide

Dialkylbiaryl phosphines are a valuable class of ligand for Pd-catalyzed amination reactions and have been applied in a range of contexts. This perspective attempts to aid the reader in the selection of the best choice of reaction conditions and ligand of this class for the most commonly encountered and practically important substrate combinations.National Institutes of Health (U.S.) (Grant GM-58160

Camp Mabry Archaeological Survey and Testing, Travis County, Texas

In October 2001, the Center for Archaeological Studies (CAS) was contracted by the Adjutant General’s Department of the Texas Army National Guard (AGTX) to perform a 100% systematic archaeological survey on the grounds of Camp Mabry, in Austin. The project was comprised of a pedestrian survey, extensive shovel testing, and the excavation of two backhoe trenches. The survey resulted in the discovery of an 8 x 8-meter prehistoric site, 41TV1954. In addition, two previously recorded archaeological sites (41TV1667 and 41TV1722) were revisited, and shovel tests were excavated in order to reevaluate and document cultural resources and site boundaries. Based on data generated during the pedestrian survey and shovel testing, CAS has determined that 41TV1722 and 41TV1954 are not archaeologically significant and thus do not qualify for National Register consideration. After analyzing the results gathered from both shovel test and backhoe trench excavations on 41TV1667, CAS has concluded that the site does pose a moderate to high research potential. CAS thus recommends that further testing is needed on 41TV1667 in order to determine the site’s eligibility for nomination to the National Register of Historic Places

Diamine ligands in copper-catalyzed reactions

The utility of copper-mediated cross-coupling reactions has been significantly increased by the development of mild reaction conditions and the ability to employ catalytic amounts of copper. The use of diamine-based ligands has been important in these advances and in this perspective we discuss these systems, including the choice of reaction conditions and applications in the synthesis of pharmaceuticals, natural products and designed materials.National Institutes of Health (U.S.) (Grant GM-58160

The boundary cap: a source of neural crest stem cells that generate multiple sensory neuron subtypes

The boundary cap (BC) is a transient neural crest-derived group of cells located at the dorsal root entry zone (DREZ) that have been shown to differentiate into sensory neurons and glia in vivo. We find that when placed in culture, BC cells self-renew, show multipotency in clonal cultures and express neural crest stem cell (NCSCs) markers. Unlike sciatic nerve NCSCs, the BC-NCSC (bNCSCs) generates sensory neurons upon differentiation. The bNCSCs constitute a common source of cells for functionally diverse types of neurons, as a single bNCSC can give rise to several types of nociceptive and thermoreceptive sensory neurons. Our data suggests that BC cells comprise a source of multipotent sensory specified stem cells that persist throughout embryogenesis

A compendium of NASA Aerobee sounding rocket launchings for 1966

Compendium of Aerobee sounding rocket launchings for 196

E-Smart System for In-Situ Detection of Environmental Contaminants

A team of industrial, academic, and government organizations participated in the development of the Environmental Systems Management, Analysis and Reporting Network (E-SMART). E-SMART integrates diverse monitoring and control technologies by means of a modular, ''building block'' design approach to allow for flexible system configuration. The E-SMART network treats each smart device-whether a sensor, sampler, or actuator- as a black box that obeys the standard communication protocols and electrical interfaces for the network. This approach allows multiple vendors to produce different sensors which meet the same functional specification and which can be interchanged on the network without affecting operation. The project further developed and advanced the E-SMART standardized network protocol to include new sensors, sampling systems, and graphical user interfaces. Specifically, the E-SMART team developed the following three system elements: (1) Base technology for a new class of smart , highly sensitive, chemically-specific, in-situ, multichannel microsensors utilizing integrated optical interferometry technology, (2) A set of additional E-SMART-compatible sensors adapted from commercial off-the-shelf technologies, and (3) A Data Management and Analysis System (DMAS), including network management components and the user-friendly graphical user interface (GUI) for data evaluation and visualization

Pd-Catalyzed Synthesis of Ar-SCF3 Compounds under Mild Conditions

Good to excellent yields of aryl trifluoromethyl sulfides, which are an important class of compounds in both the pharmaceutical and agrochemical areas, can be achieved under mild conditions by the Pd-catalyzed reaction of aryl bromides with a trifluoromethylthiolate nucleophile (see scheme).National Institutes of Health (U.S.) (GM-58160)American Society for Engineering Education. National Defense Science and Engineering Graduate Fellowship (32 CFR 168a)National Science Foundation (U.S.) (CHE-980861

Prevalence and factors predictive of intraocular fungal infection in patients with fungemia at an academic urban tertiary care center

Objective To report the prevalence and to identify factors predictive of intraocular infection in patients with fungemia receiving prophylactic antifungal therapy. Methods A retrospective review of patients who received prophylactic antifungal therapy and a dilated fundus examination at an academic urban tertiary care center from 2000 to 2007. Basic demographic information, fungal species grown, antifungal agent(s) used, number of positive blood culture specimens, visual acuity, visual symptoms, and known risks of disseminated candidiasis were noted. Logistic regression analysis was used to determine the factors significantly associated with intraocular fungal infection. Results A total of 132 patients with positive fungemia culture were requested to have ophthalmology consults. The prevalence of ocular infection was 6.9% (N=9). All nine patients were infected with Candida species. Undergoing gastrointestinal (GI) surgery within the prior 6 months was significantly related to developing intraocular infection, with an odds ratio of 18.5 (95% confidence interval, 15.1–24.3; P=0.002). Having ≥3 positive fungal blood cultures was also a significant risk factor, with an odds ratio of 2.6 (95% confidence interval, 1.8–3.7; P=0.03). Among 40 patients having GI surgery, eight (20.0%) had intraocular fungal disease, compared with one of 92 patients (1.1%) not having GI surgery. Among 125 patients with a negative baseline examination result, two of 32 patients (6.3%), who had recent GI surgery, subsequently developed fungal ocular disease, compared with 0 of 93 patients (0%), who did not have recent GI surgery. Conclusion Recent GI surgery and higher numbers of positive fungal blood culture specimens may be predictive ofcandida ocular infections. Normal baseline fundoscopy examination results in patients with such risks may require repeat evaluations to detect delayed manifestations

Changing Kindergarten Readiness Perceptions in the Rural South

This qualitative study examined the perceptions and understandings of various stakeholders in the early childhood sector of the Southeastern United States about kindergarten readiness in response to the implementation of more rigorous academic standards in kindergarten. The study combined interviews, observations, and documents to assess experiences, expectations, and challenges in meeting the strong accountability standards imposed by accountability measures and the implementation of new standards. The qualitative analysis showed that as more rigorous standards are implemented in kindergarten, all stakeholder groups are experiencing high levels of pressure related to the testing and accountability requirements related to the standards. The study further revealed that the stakeholder groups did not share a common understanding of the level of school readiness necessary for the children to reach by first grade and that early communication with parents is necessary for a successful transition of children into the school environment. The results of the study provide insight into the perceptions and understandings of the participants as they experience the readiness process from preschool through participation in kindergarten