113 research outputs found

    Risk aversion in the use of complex kidneys in paired exchange programs: Opportunities for even more transplants?

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    This retrospective review of the largest United States kidney exchange reports characteristics, utilization, and recipient outcomes of kidneys with simple compared to complex anatomy and extrapolates reluctance to accept these kidneys. Of 3105 transplants performed, only 12.8% were right kidneys and 23.1% had multiple renal arteries. 59.3% of centers used fewer right kidneys than expected and 12.1% transplanted zero right kidneys or kidneys with more than 1 artery. Five centers transplanted a third of these kidneys (35.8% of right kidneys and 36.7% of kidneys with multiple renal arteries). 22.5% and 25.5% of centers currently will not entertain a match offer for a left or right kidney with more than one artery, respectively. There were no significant differences in all-cause graft failure or death-censored graft loss for kidneys with multiple arteries, and a very small increased risk of graft failure for right kidneys versus left of limited clinical relevance for most recipients. Kidneys with complex anatomy can be used with excellent outcomes at many centers. Variation in use (lack of demand) for these kidneys reduces the number of transplants, so systems to facilitate use could increase demand. We cannot know how many donors are turned away because perceived demand is limited.Wiley Read-and-Publish Agreemen

    Global cities and cultural diversity: challenges and opportunities for young people’s nutrition.

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    Childhood obesity is a common concern across global cities and threatens sustainable urban development. Initiatives to improve nutrition and encourage physical exercise are promising but are yet to exert significant influence on prevention. Childhood obesity in London is associated with distinct ethnic and socio-economic patterns. Ethnic inequalities in health-related behaviour endure, underpinned by inequalities in employment, housing, access to welfare services, and discrimination. Addressing these growing concerns requires a clearer understanding of the socio-cultural, environmental and economic contexts of urban living that promote obesity. We explore opportunities for prevention using asset based-approaches to nutritional health and well-being, with a particular focus on adolescents from diverse ethnic backgrounds living in London. We focus on the important role that community engagement and multi-sectoral partnership play in improving the nutritional outcomes of London's children. London's children and adolescents grow up in the rich cultural mix of a global city where local streets are characterised by diversity in ethnicities, languages, religions, foods, and customs, creating complex and fluid identities. Growing up with such everyday diversity we argue can enhance the quality of life for London's children and strengthen their social capital. The Determinants of young Adult Social well-being and Health longitudinal study of about 6500 of London's young people demonstrated the positive impact of cultural diversity. Born to parents from over a hundred countries and exposed to multi-lingual households and religious practices, they demonstrated strong psychological resilience and sense of pride from cultural straddling, despite material disadvantage and discrimination. Supporting the potential contribution of such socio-cultural assets is in keeping with the values of social justice and equitable and sustainable development. Our work signals the importance of community engagement and multisectoral partnerships, involving, for example, schools and faith-based organisations, to improve the nutrition of London's children

    Erratum to: High level synthesis and generation FPGAs with the BEDROC system

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    Exploiting Reconfigurability for Effective Detection of Delay Faults in LUT-Based FPGAs

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    Implementing a RAKE Receiver for Wireless Communications on an FPGA-based Computer System

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    RAKE receivers are widely used in the wireless communications industry. Currently, custom VLSI is the most popular implementation. Programmable and reconfigurable logic implementations are becoming more attractive because of their flexibility and due to technology advancements. We have implemented a RAKE receiver on an Annapolis Wildforce board with four Xilinx 4000 family chips for a total of 100,000 gate equivalents. Our system is able to implement a RAKE receiver for underwater data communication systems that works in real time. We also investigate mapping a RAKE receiver to a Virtex chip for real-time atmospheric wireless communication

    Formally Verified Synthesis of Combinational {CMOS} Circuits

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    We present a system for simultaneously synthesizing and proving correct CMOS implementations of combinational circuits. Our system, developed within the Nuprl proof development system, is based on a set of transformation rules that generate CMOS implementations from their logical specifications. Our research differs from previous work in three important ways: our rules are rigorously proven with respect to a formal transistor model, our transformation rules admit the synthesis of both pass transistor and series/parallel networks, and our implementation produces a human readable proof along with each circuit it synthesizes
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