The Eect of Mechanical Loading on the Frequency of an Oscillator Circuit

We investigate the effect of mechanical strain on the frequency of an electronic oscillator embedded in an integrated circuit. This analysis is aimed at explaining a 1% inaccuracy in the oscillator frequency under test conditions prescribed by a leading supplier of semi-conductor devices. During the test the package containing the oscillator was clamped to a circuit board by mechanical pressure. By considering the nature of the oscillator we show that tensile strains of the order of 10^-4 could explain the observations via the piezoresistance effect. Both a simple one-dimensional analysis based on the beam equation and an elastic finite element simulation show that strains of this magnitude can be generated during the test

Comment on "Role of heavy meson exchange in near threshold N N --> d pi"

In a recent paper by C. J. Horowitz (Phys. Rev. C {\bf 48}, 2920 (1993)) a heavy meson exchange is incorporated into threshold NN --> d pi to enhance the grossly underestimated cross section. However, that calculation uses an unjustified assumption on the initial and final momenta, which causes an overestimate of this effect by a factor of 3--4. I point out that the inclusion of the Delta(1232) isobar increases the cross section significantly even at threshold.Comment: 7 pages, figures by fax or mail from [email protected]

The angiotensin-converting enzyme (ACE) gene family of Anopheles gambiae

Background Members of the M2 family of peptidases, related to mammalian angiotensin converting enzyme (ACE), play important roles in regulating a number of physiological processes. As more invertebrate genomes are sequenced, there is increasing evidence of a variety of M2 peptidase genes, even within a single species. The function of these ACE-like proteins is largely unknown. Sequencing of the A. gambiae genome has revealed a number of ACE-like genes but probable errors in the Ensembl annotation have left the number of ACE-like genes, and their structure, unclear. Results TBLASTN and sequence analysis of cDNAs revealed that the A. gambiae genome contains nine genes (AnoACE genes) which code for proteins with similarity to mammalian ACE. Eight of these genes code for putative single domain enzymes similar to other insect ACEs described so far. AnoACE9, however, has several features in common with mammalian somatic ACE such as a two domain structure and a hydrophobic C terminus. Four of the AnoACE genes (2, 3, 7 and 9) were shown to be expressed at a variety of developmental stages. Expression of AnoACE3, AnoACE7 and AnoACE9 is induced by a blood meal, with AnoACE7 showing the largest (approximately 10-fold) induction. Conclusion Genes coding for two-domain ACEs have arisen several times during the course of evolution suggesting a common selective advantage to having an ACE with two active-sites in tandem in a single protein. AnoACE7 belongs to a sub-group of insect ACEs which are likely to be membrane-bound and which have an unusual, conserved gene structure

Localized tachyon condensation and G-parity conservation

We study the condensation of localized tachyon in non-supersymmetric orbifold {\C^2/\Z_n}. We first show that the G-parities of chiral primaries are preserved under the condensation of localized tachyon(CLT) given by the chiral primaries. Using this, we finalize the proof of the conjecture that the lowest-tachyon-mass-squared increases under CLT at the level of type II string with full consideration of GSO projection. We also show the equivalence between the $G$-parity given by $G=[jk_1/n]+ [jk_2/n]$ coming from partition function and that given by $G=\{jk_1/n\}k_2 -\{jk_2/n\}k_1$ coming from the monomial construction for the chiral primaires in the dual mirror picture.Comment: 12 pages, 2 figures, final form to appear in JHE

Gauged Fermionic Q-balls

We present a new model for a non-topological soliton (NTS) that contains interacting fermions, scalar particles and a gauge field. Using a variational approach, we estimate the energy of the localized configuration, showing that it can be the lowest energy state of the system for a wide range of parameters.Comment: 5 pages, 2 figures; revised version to appear in Phys. Rev.

Generational Mass Splitting of Neutrinos in High Temperature SU(2)L⊗U(1)SU(2)_{\scriptscriptstyle{L}}\otimes U(1) Gauge Theory

We calculate the generational mass splitting of neutrinos in high temperature $SU(2)_{\scriptscriptstyle{L}}\otimes U(1)$ gauge theory when the temperature is above $250$ GeV and the gauge symmetry is restored. We consider the case of neutrinos that are massless at tree level as well as the case of neutrinos with tree-level mass and large mixing.Comment: 12 Pages, JHU-TIPAC-940008/INFNCA-TH-94-

Resting respiratory tract dendritic cells preferentially stimulate T helper cell Type 2(Th2) responses and require obligatory cytokine signals for induction of Th1 immunity

Consistent with their role in host defense, mature dendritic cells (DCs) from central lymphoid organs preferentially prime for T helper cell type 1 (Th1)-polarized immunity. However, the “default” T helper response at mucosal surfaces demonstrates Th2 polarity, which is reflected in the cytokine profiles of activated T cells from mucosal lymph nodes. This study on rat respiratory tract DCs (RTDCs) provides an explanation for this paradox. We demonstrate that freshly isolated RTDCs are functionally immature as defined in vitro, being surface major histocompatibility complex (MHC) II lo, endocytosishi, and mixed lymphocyte reactionlo, and these cells produce mRNA encoding interleukin (IL)-10. After ovalbumin (OVA)-pulsing and adoptive transfer, freshly isolated RTDCs preferentially stimulated Th2-dependent OVA-specific immunoglobulin (Ig)G1 responses, and antigen-stimulated splenocytes from recipient animals produced IL-4 in vitro. However, preculture with granulocyte/macrophage colony stimulating factor increased their in vivo IgG priming capacity by 2–3 logs, inducing production of both Th1- and Th2-dependent IgG subclasses and high levels of IFN-γ by antigen-stimulated splenocytes. Associated phenotypic changes included upregulation of surface MHC II and B7 expression and IL-12 p35 mRNA, and downregulation of endocytosis, MHC II processing– associated genes, and IL-10 mRNA expression. Full expression of IL-12 p40 required additional signals, such as tumor necrosis factor α or CD40 ligand. These results suggest that the observed Th2 polarity of the resting mucosal immune system may be an inherent property of the resident DC population, and furthermore that mobilization of Th1 immunity relies absolutely on the provision of appropriate microenvironmental costimuli

Southern Hemisphere Observations of a 101810^{18}eV Cosmic Ray Source Near the Direction of the Galactic Centre

We report on an analysis of data from the southern hemisphere SUGAR cosmic ray detector. We confirm the existence of an excess of $10^{18}$eV cosmic rays from a direction close to the Galactic Centre, first reported by the AGASA group. We find that the signal is consistent with that from a point source, and we find no evidence for an excess of cosmic rays coming from the direction of the Galactic Centre itself.Comment: 14 pages including 5 postscript figures, corrected the title (replaced "Cosmic Ray Source" instead of "Cosmic Ray"