PIN69 Cost Utility Analysis of 13-Valent Pneumococcal Conjugate Vaccine in Malaysia

Farrando Sicilia, Jordi; Lecea, Ignasi de; Fuente Fuente, Carlos; Ribas Seix, Anna; Masana Padrós, Judit; Delgado, José L

Structures for Interacting Composite Fermions: Stripes, Bubbles, and Fractional Quantum Hall Effect

Much of the present day qualitative phenomenology of the fractional quantum Hall effect can be understood by neglecting the interactions between composite fermions altogether. For example the fractional quantum Hall effect at $\nu=n/(2pn\pm 1)$ corresponds to filled composite-fermion Landau levels,and the compressible state at $\nu=1/2p$ to the Fermi sea of composite fermions. Away from these filling factors, the residual interactions between composite fermions will determine the nature of the ground state. In this article, a model is constructed for the residual interaction between composite fermions, and various possible states are considered in a variational approach. Our study suggests formation of composite-fermion stripes, bubble crystals, as well as fractional quantum Hall states for appropriate situations.Comment: 16 pages, 7 figure

Fermion Chern Simons Theory of Hierarchical Fractional Quantum Hall States

We present an effective Chern-Simons theory for the bulk fully polarized fractional quantum Hall (FQH) hierarchical states constructed as daughters of general states of the Jain series, {\it i. e.} as FQH states of the quasi-particles or quasi-holes of Jain states. We discuss the stability of these new states and present two reasonable stability criteria. We discuss the theory of their edge states which follows naturally from this bulk theory. We construct the operators that create elementary excitations, and discuss the scaling behavior of the tunneling conductance in different situations. Under the assumption that the edge states of these fully polarized hierarchical states are unreconstructed and unresolved, we find that the differential conductance $G$ for tunneling of electrons from a Fermi liquid into {\em any} hierarchical Jain FQH states has the scaling behavior $G\sim V^\alpha$ with the universal exponent $\alpha=1/\nu$, where $\nu$ is the filling fraction of the hierarchical state. Finally, we explore alternative ways of constructing FQH states with the same filling fractions as partially polarized states, and conclude that this is not possible within our approach.Comment: 10 pages, 50 references, no figures; formerly known as "Composite Fermions: The Next Generation(s)" (title changed by the PRB thought police). This version has more references and a discussion of the stability of the new states. Published version. One erroneous reference is correcte

Fractional Quantum Hall States of Clustered Composite Fermions

The energy spectra and wavefunctions of up to 14 interacting quasielectrons (QE's) in the Laughlin nu=1/3 fractional quantum Hall (FQH) state are investigated using exact numerical diagonalization. It is shown that at sufficiently high density the QE's form pairs or larger clusters. This behavior, opposite to Laughlin correlations, invalidates the (sometimes invoked) reapplication of the composite fermion picture to the individual QE's. The series of finite-size incompressible ground states are identified at the QE filling factors nu_QE=1/2, 1/3, 2/3, corresponding to the electron fillings nu=3/8, 4/11, 5/13. The equivalent quasihole (QH) states occur at nu_QH=1/4, 1/5, 2/7, corresponding to nu=3/10, 4/13, 5/17. All these six novel FQH states were recently discovered experimentally. Detailed analysis indicates that QE or QH correlations in these states are different from those of well-known FQH electron states (e.g., Laughlin or Moore-Read states), leaving the origin of their incompressibility uncertain. Halperin's idea of Laughlin states of QP pairs is also explored, but is does not seem adequate.Comment: 14 pages, 9 figures; revision: 1 new figure, some new references, some new data, title chang

Characterisation of secondary metabolites associated with neutrophil apoptosis

We studied changes in secondary metabolites in human neutrophils undergoing constitutive or tumour necrosis factor (TNFalpha) stimulated apoptosis by a combination of high-performance liquid chromatography (HPLC) and NMR spectroscopy. Our results show that in contrast to freshly isolated neutrophils, neutrophil cells aged for 20 h in vitro had marked differences in the levels of a number of endogenous metabolites including lactate, amino acids and phosphocholine (PCho). There was no change in the concentration of taurine or glutamate and the ATP/ADP ratio was not affected. Levels of glutamine and lactate actually decreased. Identical changes were also observed in neutrophils stimulated to undergo apoptosis over a shorter time period (6 h) in the presence of TNFalpha and the phosphatidylinositol-3-kinase inhibitor wortmannin (WM). The changes in the concentration of PCho suggest possible activation of phospholipase associated with apoptosis or a selective failure of phosphatidycholine synthesis. The increased levels of apoptosis obtained with WM+TNFalpha, compared to TNFalpha by itself, suggest a synergistic effect by these compounds. The acceleration in rate of apoptosis probably arises from suppression by WM of pathway(s) that normally delay the onset of apoptosis. Changes in PCho and other endogenous metabolites, if proven to be characteristic of apoptosis in other cell systems, may permit non-invasive quantification of apoptosis.

CPT, T, and Lorentz Violation in Neutral-Meson Oscillations

Tests of CPT and Lorentz symmetry using neutral-meson oscillations are studied within a formalism that allows for indirect CPT and T violation of arbitrary size and is independent of phase conventions. The analysis is particularly appropriate for studies of CPT and T violation in oscillations of the heavy neutral mesons D, B_d, and B_s. The general Lorentz- and CPT-breaking standard-model extension is used to derive an expression for the parameter for CPT violation. It varies in a prescribed way with the magnitude and orientation of the meson momentum and consequently also with sidereal time. Decay probabilities are presented for both uncorrelated and correlated mesons, and some implications for experiments are discussed.Comment: 11 pages, references added, accepted in Physical Review

News from the Muon (g-2) Experiment at BNL

The magnetic moment anomaly a_mu = (g_mu - 2) / 2 of the positive muon has been measured at the Brookhaven Alternating Gradient Synchrotron with an uncertainty of 0.7 ppm. The new result, based on data taken in 2000, agrees well with previous measurements. Standard Model evaluations currently differ from the experimental result by 1.6 to 3.0 standard deviations.Comment: Talk presented at RADCOR - Loops and Legs 2002, Kloster Banz, Germany, September 8-13 2002, to be published in Nuclear Physics B (Proc. Suppl.); 5 pages, 3 figure

Improved Measurement of the Positive Muon Anomalous Magnetic Moment

A new measurement of the positive muon's anomalous magnetic moment has been made at the Brookhaven Alternating Gradient Synchrotron using the direct injection of polarized muons into the superferric storage ring. The angular frequency difference omega_{a} between the angular spin precession frequency omega_{s} and the angular orbital frequency omega_{c} is measured as well as the free proton NMR frequency omega_{p}. These determine R = omega_{a} / omega_{p} = 3.707~201(19) times 10^{-3}. With mu_{mu} / mu_{p} = 3.183~345~39(10) this gives a_{mu^+} = 11~659~191(59) times 10^{-10} (pm 5 ppm), in good agreement with the previous CERN and BNL measurements for mu^+ and mu^-, and with the standard model prediction.Comment: 4 pages, 4 figures. accepted for publication in Phys. Rev. D62 Rapid Communication

Energy determinants GAPDH and NDPK act as genetic modifiers for hepatocyte inclusion formation

Differential expression and activity of the cellular energy regulators GAPDH and NDPK underlie reactive oxygen species–induced damage in the mouse liver and may contribute to human liver disease progression