Highly Abundant Proteins Favor More Stable 3D Structures in Yeast

AbstractTo understand the variation of protein sequences in nature, we need to reckon with evolutionary constraints that are biophysical, cellular, and ecological. Here, we show that under the global selection against protein misfolding, there exists a scaling among protein folding stability, protein cellular abundance, and effective population size. The specific scaling implies that the several-orders-of-magnitude range of protein abundances in the cell should leave imprints on extant protein structures, a prediction that is supported by our structural analysis of the yeast proteome

A luminous blue kilonova and an off-axis jet from a compact binary merger at z=0.1341

The recent discovery of a faint gamma-ray burst (GRB) coincident with the gravitational wave (GW) event GW 170817 revealed the existence of a population of low-luminosity short duration gamma-ray transients produced by neutron star mergers in the nearby Universe. These events could be routinely detected by existing gamma-ray monitors, yet previous observations failed to identify them without the aid of GW triggers. Here we show that GRB150101B was an analogue of GRB170817A located at a cosmological distance. GRB 150101B was a faint short duration GRB characterized by a bright optical counterpart and a long-lived X-ray afterglow. These properties are unusual for standard short GRBs and are instead consistent with an explosion viewed off-axis: the optical light is produced by a luminous kilonova component, while the observed X-rays trace the GRB afterglow viewed at an angle of ~13 degrees. Our findings suggest that these properties could be common among future electromagnetic counterparts of GW sources.Comment: 28 pages, 8 figures, 2 tables. Accepted for publicatio

Gravitational Waves from a Compact Star in a Circular, Inspiral Orbit, in the Equatorial Plane of a Massive, Spinning Black Hole, as Observed by LISA

Results are presented from high-precision computations of the orbital evolution and emitted gravitational waves for a stellar-mass object spiraling into a massive black hole in a slowly shrinking, circular, equatorial orbit. The focus of these computations is inspiral near the innermost stable circular orbit (isco)---more particularly, on orbits for which the angular velocity Omega is 0.03 < Omega/Omega_{isco} < 1. The computations are based on the Teukolsky-Sasaki-Nakamura formalism, and the results are tabulated in a set of functions that are of order unity and represent relativistic corrections to low-orbital-velocity formulas. These tables can form a foundation for future design studies for the LISA space-based gravitational-wave mission. A first survey of applications to LISA is presented: Signal to noise ratios S/N are computed and graphed as functions of the time-evolving gravitational-wave frequency for representative values of the hole's mass M and spin a and the inspiraling object's mass \mu, with the distance to Earth chosen to be r_o = 1 Gpc. These S/N's show a very strong dependence on the black-hole spin, as well as on M and \mu. A comparison with predicted event rates shows strong promise for detecting these waves, but not beyond about 1Gpc if the inspiraling object is a white dwarf or neutron star. This argues for a modest lowering of LISA's noise floor. A brief discussion is given of the prospects for extracting information from the observed wavesComment: Physical Review D, in press; 21 pages, 9 figures, 10 tables it is present in the RevTeX fil

Animal Welfare Worldwide, the Opinion of Practicing Veterinarians

The objective of this study was to investigate the animal welfare issues considered the most important by companion animal veterinarians worldwide. For this purpose, a global survey of several potential animal welfare issues was distributed via SurveyMonkey® in multiple languages. The distribution of survey responses differed by region. The main animal welfare concern reported worldwide was obesity, although there were differences across regions, possibly due to cultural and socioeconomic factors. Anthropomorphism (attributing human qualities or characteristics to an animal) was an issue in western countries but less so in Asia, Africa, and Oceania. There were significant differences between Asia and Europe, Africa, and Oceania in the importance and prevalence of convenience euthanasia. There were also age and sex differences in participant responses, with older veterinarians reporting fewer welfare problems than younger veterinarians, and female veterinarians reporting more welfare issues than their male counterparts

Increased Biodiversity in the Environment Improves the Humoral Response of Rats

Previous studies have compared the immune systems of wild and of laboratory rodents in an effort to determine how laboratory rodents differ from their naturally occurring relatives. This comparison serves as an indicator of what sorts of changes might exist between modern humans living in Western culture compared to our hunter-gatherer ancestors. However, immunological experiments on wild-caught animals are difficult and potentially confounded by increased levels of stress in the captive animals. In this study, the humoral immune responses of laboratory rats in a traditional laboratory environment and in an environment with enriched biodiversity were examined following immunization with a panel of antigens. Biodiversity enrichment included colonization of the laboratory animals with helminths and co-housing the laboratory animals with wild-caught rats. Increased biodiversity did not apparently affect the IgE response to peanut antigens following immunization with those antigens. However, animals housed in the enriched biodiversity setting demonstrated an increased mean humoral response to T-independent and T-dependent antigens and increased levels of “natural” antibodies directed at a xenogeneic protein and at an autologous tissue extract that were not used as immunogens

On rotational excitations and axial deformations of BPS monopoles and Julia-Zee dyons

It is shown that Julia-Zee dyons do not admit slowly rotating excitations. This is achieved by investigating the complete set of stationary excitations which can give rise to non-vanishing angular momentum. The relevant zero modes are parametrized in a gauge invariant way and analyzed by means of a harmonic decomposition. Since general arguments show that the solutions to the linearized Bogomol'nyi equations cannot contribute to the angular momentum, the relevant modes are governed by a set of electric and a set of non self-dual magnetic perturbation equations. The absence of axial dipole deformations is also established.Comment: 22 pages, Revtex, no figure

Future non-linear stability for reflection symmetric solutions of the Einstein-Vlasov system of Bianchi types II and VI0_0

Using the methods developed for the Bianchi I case we have shown that a boostrap argument is also suitable to treat the future non-linear stability for reflection symmetric solutions of the Einstein-Vlasov system of Bianchi types II and VI$_0$. These solutions are asymptotic to the Collins-Stewart solution with dust and the Ellis-MacCallum solution respectively. We have thus generalized the results obtained by Rendall and Uggla in the case of locally rotationally symmetric Bianchi II spacetimes to the reflection symmetric case. However we needed to assume small data. For Bianchi VI$_0$ there is no analogous previous result.Comment: 30 page

The stellar content of the Hamburg/ESO survey VI. The metallicity distribution of main-sequence turnoff stars in the Galactic halo

We determine the metallicity distribution function (MDF) of the Galactic halo based on metal-poor main-sequence turnoff-stars (MSTO) which were selected from the Hamburg/ESO objective-prism survey (HES) database. Corresponding follow-up moderateresolution observations (R ~ 2000) of some 682 stars (among which 617 were accepted program stars) were carried out with the 2.3m telescope at the Siding Spring Observatory (SSO). Corrections for the survey volume covered by the sample stars were quantitatively estimated and applied to the observed MDF. The corrections are quite small, when compared with those for a previously studied sample of metal-poor giants. The corrected observational MDF of the turnoff sample was then compared with that of the giants, as well as with a number of theoretical predictions of Galactic chemical evolution, including the mass-loss modified Simple Model. Although the survey-volume corrected MDFs of the metal-poor turnoff and the halo giants notably differ in the region of [Fe/H] > -2.0, below [Fe/H] ~ -2.0, (the region we scientifically focus on most) both MDFs show a sharp drop at [Fe/H] ~ -3.6 and present rather similar distributions in the low-metallicity tail. Theoretical models can fit some parts of the observed MDF, but none is found to simultaneously reproduce the peak as well as the features in the metal-poor region with [Fe/H] between -2.0 to -3.6. Among the tested models only the GAMETE model, when normalized to the tail of the observed MDF below [Fe/H] ~ -3.0, and with Z_{cr} = 10^{-3.4}Z_{\odot}, is able to predict the sharp drop at [Fe/H] ~ -3.6.Comment: 10 pages, 11 figures, accepted for publication in A&

Nitrogen Production in Starburst Galaxies Detected by GALEX

We investigate the production of nitrogen in star-forming galaxies with ultraviolet (UV) radiation detected by the Galaxy Evolution Explorer Satellite (GALEX). We use a sample of 8745 GALEX emission-line galaxies matched to the Sloan Digital Sky Survey (SDSS) spectroscopic sample. We derive both gas-phase oxygen and nitrogen abundances for the sample and apply stellar population synthesis models to derive stellar masses and star formation histories of the galaxies. We compare oxygen abundances derived using three different diagnostics. We derive the specific star formation rates of the galaxies by modeling the seven-band GALEX+SDSS photometry. We find that galaxies that have log (SFR/M_*) ≳ − 10.0 typically have values of log (N/O) ~ 0.05 dex less than galaxies with log (SFR/M_*) ≾ − 10.0 and similar oxygen abundances