An Extremal Chiral Primary Three-Point Function at Two-loops in ABJ(M)

archiveprefix: arXiv primaryclass: hep-th reportnumber: QMUL-PH-14-23 slaccitation: %%CITATION = ARXIV:1411.0626;%%archiveprefix: arXiv primaryclass: hep-th reportnumber: QMUL-PH-14-23 slaccitation: %%CITATION = ARXIV:1411.0626;%%archiveprefix: arXiv primaryclass: hep-th reportnumber: QMUL-PH-14-23 slaccitation: %%CITATION = ARXIV:1411.0626;%

Real-Time Monitoring of Nitric Oxide Dynamics in the Myocardium: Biomedical Application of Nitric Oxide Sensor

Nitric oxide (NO) is an important physiological mediator that regulates a wide range of cellular processes in many tissues. Therefore, the accurate and reliable measurement of physiological NO concentration is essential to the understanding of NO signaling and its biological role. Most methods used for NO detection are indirect including spectroscopic approaches such as the Griess assay for nitrite and detection of methemoglobin after NO reaction with oxyhemoglobin. These methods cannot accurately reflect the changes in NO concentration in vivo and in real time. Therefore, direct methods are necessary for investigating biological process and diseases related to NO in biological conditions. There is a growing interest in the development of electrochemically based sensors for direct, in vivo, and real-time monitoring of NO. Electrochemical methods offer simplicity, good sensitivity, high selectivity, fast response times, and long-term calibration stability compared to other techniques including electron paramagnetic resonance, chemiluminescence, and fluorescence. In this article, we present real-time NO dynamics in the myocardium during myocardial ischemia-reperfusion (IR) utilizing electrochemical NO microsensor. And applications of electrochemical NO sensor for the evaluation of cardioprotective effects of therapeutic treatments such as drug administration and ischemic preconditioning are reviewed

15-Keto prostaglandin E2 induces heme oxygenase-1 expression through activation of Nrf2 in human colon epithelial CCD 841 CoN cells

Prostaglandin E-2 (PGE(2)) plays a key role in inflammation-associated carcinogenesis. NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes the oxidation of the 15(S)-hydroxyl group of PGE(2) to generate 15-keto PGE(2). 15-PGDH has been known as a tumor suppressor in various malignancies including colon cancer. However, the molecular mechanisms underlying the tumor-suppressive function of 15-PGDH remain largely unresolved. In this study, we found that 15-keto PGE(2) upregulated the expression of heme oxygenase-1 (HO-1), a representative antioxidative and anti-inflammatory enzyme, at both transcriptional and translational levels, in human colon epithelial CCD 841 CoN cells. A redox-sensitive transcription factor, NF-E2-related factor (Nrf2) plays a critical role in the regulation of HO-1 and other cytoprotective proteins. 15-Keto PGE(2) induced translocation of Nrf2 into the nucleus and antioxidant response element-driven luciferase activity. Furthermore, the silencing of the Nrf2 gene abolished 15-keto PGE(2)-induced HO-1 expression in CCD 841 CoN cells. 15-Keto PGE(2) activated AKT signaling, and the pharmacological AKT inhibitor, LY294002 suppressed the 15-keto PGE(2)-induced HO-1 expression. 15-Keto PGE(2) generates the reactive oxygen species which is suppressed by the general antioxidant N-acetyl-L-cysteine. N-acetyl-L-cysteine treatment attenuated the 15-keto PGE(2)-induced phosphorylation of GSK3 beta, transcriptional activity of Nrf2, and subsequently HO-1 expression. However, 13,14-dihydro-15-keto PGE(2) lacking the alpha,beta-unsaturated carbonyl moiety failed to induce intracellular production of reactive oxygen species, HO-1 expression and nuclear translocation of Nrf2. In conclusion, 15-keto PGE(2) induces HO-1 expression through Nrf2 activation in human colon epithelial cells.

The Jury as a Door-Opener to Race in O.J. Simpsons Criminal Trial

The purpose of this paper is to analyze O.J. Simpsons criminal trial to provide an understanding of how Americas jury system works to introduce race-relations in court. The focus thus lies on how the jury system worked to shift a question of guilt and innocence into a question that inevitably included a racial aspect. In a review of the jury as a political organ, the paper attempts to point out that the workings of Americas jury, unlike those of judge-made law, include a decision-making process that is more politically influenced than judicially shaped. Especially highlighted is the fact that the jury serves to decide upon the majority will concerning a defendants guilt, but that in doing so, the differences among by Americas racial majorities and minorities are inevitably called into question. This is further exemplified at the stage of deciding the venue of the trial, the jury selection process, and the juror dismissals. At the stage of relocating the venue of the trial, O.J. Simpsons lawyers decided to waive their right to a change of venue. This is contrasted with the case of Rodney King and explained by the fact that the venue directly relates to the racial build-up of the jury. Similarly, the jury selection process further is analyzed to indicate that the jury system is expressly being used as a tool to introduce race. Lastly, the frequent dismissals that occurred during the O.J. Simpson trial are further interpreted to relate to racial interests

Expression of PD-L1 in triple-negative breast cancer based on different immunohistochemical antibodies

Additional file 1. Additional Tables, Tables S1–S4

Generalizations of -Subalgebras in BCK/BCI-Algebras Based on Point -Structures

The aim of this article is to obtain more general forms than the papers of (Jun et al. (2010); Jun et al. (in press)). The notions of -subalgebras of types , and are introduced, and the concepts of -support and -support are also introduced. Several related properties are investigated. Characterizations of -subalgebra of type are discussed, and conditions for an -subalgebra of type to be an -subalgebra of type are considered

Coderivations of Ranked Bigroupoids

The notion of (co)derivations of ranked bigroupoids is discussed by Alshehri et al. (in press), and their generalized version is studied by Jun et al. (under review press). In particular, Jun et al. (under review press) studied coderivations of ranked bigroupoids. In this paper, the generalization of coderivations of ranked bigroupoids is discussed. The notion of generalized coderivations in ranked bigroupoids is introduced, and new generalized coderivations of ranked bigroupoids are obtained by combining a generalized self-coderivation with a rankomorphism. From the notion of (X,∗,&)-derivation, the existence of a rankomorphism of ranked bigroupoids is established

Soft p-ideals of soft BCI-algebras

AbstractMolodtsov [D. Molodtsov, Soft set theory–First results, Comput. Math. Appl. 37 (1999) 19–31] introduced the concept of soft set as a new mathematical tool for dealing with uncertainties that is free from the difficulties that have troubled the usual theoretical approaches. Jun [Y. B. Jun, Soft BCK/BCI-algebras, Comput. Math. Appl. 56 (2008) 1408–1413] applied first the notion of soft sets by Molodtsov to the theory of BCK/BCI-algebras. In this paper we introduce the notion of soft p-ideals and p-idealistic soft BCI-algebras, and then investigate their basic properties. Using soft sets, we give characterizations of (fuzzy) p-ideals in BCI-algebras. We provide relations between fuzzy p-ideals and p-idealistic soft BCI-algebras