Estimation of the Duration of the Turbidity Current in a Reservoir

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchive

Estimation of Sediment Yield and Transportation in a Watershed River Reach Due to Climate Change

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchive

Downstream Impact Investigation of Released Sediment from Reservoir Desilting Operation

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchive

Tamshui River Estuary Impact Investigation of Induced Topographic Changes from Discharge Changes

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchive

Long-Term Effects Of River Bed Variations Downstream Of The Shihmen Reservoir Due To Climate Change

Most rivers in Taiwan are suffered from serious sedimentation problems due to extreme weather in recent years. In order to decrease sediment trap in Shihmen Reservoir, the reservoir sediment was effluent into downstream river during flood period. The river sediment deposition and erosion would be thus more violent. The quasi-two dimensional model, NETSTARS, was applied to investigate hydraulic characteristics and corresponding river sedimentation behavior in Da-Han basin. The model was calibrated and verified with field survey data and then was utilized to predict the spatial and temporal variations of downstream suspended solid concentration. Through investigating the change of suspended solid concentration at Yuan-Shan Dam- which is one of the most important water supply facility in Taipei metropolitan area- the success of lowing the suspended solid concentration was certain. The water level and bed elevation movement in typhoon events were investigated via the numerical model at different river reaches. The joint operation of Shihmen sluice gate and Yuan-Shan weir was also discussed for Long-term effects due to climate change

Effect Of Sediment Releasing Operation From Reservoir Outlets On The Water Treatment Plant Downstream

With steep slope and strong rainfall intensity, landslide and debris flow could generate huge amount of sediment yield from the watershed, typically during typhoon floods in Taiwan. As such huge amount of sediment moved into a reservoir, serious sedimentation problem reduced storage of reservoir due to decrease of flow velocity and without sufficient sediment releasing bottom outlet. As a result, using flood discharge to release sediment during Typhoon or rain fall duration is very important. This study adopts the data of field observation from outlet structures of the Shihmen reservoir to establish the operational strategies of sediment releasing rule and keep water sustained supply at downstream river intake. Based on the numerical simulation by using 1-D and 2-D models, the relationship of sediment concentration between the Shihmen reservoir and downstream withdraw intake at the YuanShan weir can be established. The sediment concentration reduction ratio is calculated to be 89% from the Shihmen reservoir to the YuanShan weir. This study also focuses on the sediment concentration mitigation influence of tunnel spillway due to the high sediment concentration releasing from bottom outlet. From simulated results, when the extra discharge of tunnel spillway reaches 830m3/s for specific event, the influence of reducing sediment concentration to downstream river by tunnel spillway can maintain water supply of downstream withdraw intake at YuanShan weir. In practice, when using the extra discharge of tunnel spillway to reduce sediment concentration during Typhoon Haitang and Typhoon Wipha, the sediment concentration at YuanShan weir can reduce water turbidity lower than 6000NTU that water treatment plant can deal with

Characterisation of the biflavonoid hinokiflavone as a premRNA splicing modulator that inhibits SENP

We have identified the plant biflavonoid hinokiflavone as an inhibitor of splicing in vitro and modulator of alternative splicing in cells. Chemical synthesis confirms hinokiflavone is the active molecule. Hinokiflavone inhibits splicing in vitro by blocking spliceosome assembly, leading to accumulation of the A complex. Cells treated with hinokiflavone show altered subnuclear organization specifically of splicing factors required for A complex formation, which relocalize together with SUMO1 and SUMO2 into enlarged nuclear speckles. Hinokiflavone increases protein SUMOylation levels, both in in vitro splicing reactions and in cells. Hinokiflavone also inhibited a purified, E. coli expressed SUMO protease, SENP1, in vitro, indicating the increase in SUMOylated proteins results primarily from inhibition of de-SUMOylation. Using a quantitative proteomics assay we identified many SUMO2 sites whose levels increased in cells following hinokiflavone treatment, with the major targets including 6 proteins that are components of the U2 snRNP and required for A complex formation

Epigenetic polypharmacology: from combination therapy to multitargeted drugs

The modern drug discovery process has largely focused its attention in the so-called magic bullets, single chemical entities that exhibit high selectivity and potency for a particular target. This approach was based on the assumption that the deregulation of a protein was causally linked to a disease state, and the pharmacological intervention through inhibition of the deregulated target was able to restore normal cell function. However, the use of cocktails or multicomponent drugs to address several targets simultaneously is also popular to treat multifactorial diseases such as cancer and neurological disorders. We review the state of the art with such combinations that have an epigenetic target as one of their mechanisms of action. Epigenetic drug discovery is a rapidly advancing field, and drugs targeting epigenetic enzymes are in the clinic for the treatment of hematological cancers. Approved and experimental epigenetic drugs are undergoing clinical trials in combination with other therapeutic agents via fused or linked pharmacophores in order to benefit from synergistic effects of polypharmacology. In addition, ligands are being discovered which, as single chemical entities, are able to modulate multiple epigenetic targets simultaneously (multitarget epigenetic drugs). These multiple ligands should in principle have a lower risk of drug-drug interactions and drug resistance compared to cocktails or multicomponent drugs. This new generation may rival the so-called magic bullets in the treatment of diseases that arise as a consequence of the deregulation of multiple signaling pathways provided the challenge of optimization of the activities shown by the pharmacophores with the different targets is addressed