A Study of Integrating the Security Engineering Process into the Software Lifecycle Process Standard (IEEE/EIA 12207)

In developing an information systems (IS), most organizations have preferred a traditional add-on approach that adds commercial security products after an IS development project is finished. However, a number of recent incidents with regard to IS security indicate that this approach does not guarantee IS security because commercial products are not designed for the specific organizational IS environments. As an alternative solution, previous studies suggested that organizations integrate both the security engineering (SE) process and software development lifecycle (SDLC) process standards. Unfortunately, a few studies tried to suggest the limited integration models. In this paper, as a practical way for the development of secure IS, we suggest two SE process models. First, we develop the generalized SE model that includes all SE activities through the whole SDLC. Secondly, we suggest the process integration model that interweaves SE with IEEE/EIA 12207 through Delphi analysis

An Implementation of the IT Fundamentals Knowledge Area in an Introductory IT Course

The recently promulgated IT model curriculum contains IT fundamentals (ITF) as one of its knowledge areas. It is intended to give students a broad understanding of (1) the IT profession and the skills that students must develop to become successful IT professionals and (2) the academic discipline of IT and its relationship to other disciplines. The model curriculum recommends 33 lecture hours to complete the IT fundamentals knowledge. The model curriculum also recommends that the material relevant to the IT fundamentals knowledge area be offered early in the curriculum, for example in an Introduction to IT course; however, many institutions will have to include additional material in an introductory IT course. For example, the Introduction to IT course at Georgia Southern University is used to introduce students to the available second disciplines (an important part of the Georgia Southern IT curriculum aimed at providing students with in-depth knowledge of an IT application domain), some productivity tools, and SQL in addition to an introduction to the discipline of IT. For many programs there may be too much material in an introductory IT course. This paper describes how Georgia Southern University resolved this problem by describing the structure of the introductory course at Georgia Southern, its assessment methods, and the relationship between the course and the ITF knowledge area and how those aspects of the ITF knowledge area that are not covered in the introductory course are covered elsewhere in the program

Abalone visceral extract inhibit tumor growth and metastasis by modulating Cox-2 levels and CD8+ T cell activity

<p>Abstract</p> <p>Background</p> <p>Abalone has long been used as a valuable food source in East Asian countries. Although the nutritional importance of abalone has been reported through <it>in vitro </it>and <it>in vivo </it>studies, there is little evidence about the potential anti-tumor effects of abalone visceral extract. The aim of the present study is to examine anti-tumor efficacy of abalone visceral extract and to elucidate its working mechanism.</p> <p>Methods</p> <p>In the present study, we used breast cancer model using BALB/c mouse-derived 4T1 mammary carcinoma and investigated the effect of abalone visceral extract on tumor development. Inhibitory effect against tumor metastasis was assessed by histopathology of lungs. Cox-2 productions by primary and secondary tumor were measured by real-time RT-PCR and immunoblotting (IB). Proliferation assay based on [³H]-thymidine incorporation and measurement of cytokines and effector molecules by RT-PCR were used to confirm tumor suppression efficacy of abalone visceral extract by modulating cytolytic CD8+ T cells. The cytotoxicity of CD8⁺T cell was compared by JAM test.</p> <p>Results</p> <p>Oral administration of abalone visceral extract reduced tumor growth (tumor volume and weight) and showed reduced metastasis as confirmed by decreased level of splenomegaly (spleen size and weight) and histological analysis of the lung metastasis (gross analysis and histological staining). Reduced expression of Cox-2 (mRNA and protein) from primary tumor and metastasized lung was also detected. In addition, treatment of abalone visceral extract increased anti-tumor activities of CD8⁺T cells by increasing the proliferation capacity and their cytolytic activity.</p> <p>Conclusions</p> <p>Our results suggest that abalone visceral extract has anti-tumor effects by suppressing tumor growth and lung metastasis through decreasing Cox-2 expression level as well as promoting proliferation and cytolytic function of CD8⁺T cells.</p

Recurrent Bilateral Branch Retinal Artery Occlusion with Hearing Loss and Encephalopathy: The First Case Report of Susac Syndrome in Korea

We report the first case of Susac syndrome in Koreans, in a 23-yr-old female patient who presented with sudden visual loss and associated neurological symptoms. Ophthalmic examination and fluorescein angiography showed multiple areas of branch retinal artery occlusion, which tended to recur in both eyes. Magnetic resonance imaging showed dot-like, diffusion-restricted lesions in the corpus callosum and left fornix, and audiometry showed low-frequency sensory hearing loss, compatible with Susac syndrome. She received immunosuppressive therapy with oral steroid and azathioprine. Three months later all the symptoms disappeared but obstructive vasculitis have been relapsing. This patient demonstrated the entire clinical triad of Susac syndrome, which tends to occur in young females. Although this disorder has rarely been reported in Asian populations, a high index of suspicion is warranted for early diagnosis and timely treatment

The Prevalence of Chronic Diseases among Migrants in Korea According to Their Length of Stay and Residential Status

Background: Migrant health is becoming public health issues, as the migrant populations are increasing and their length of stayis prolonged. This study aims to analyze the differences in prevalence of chronic diseases among migrants according to length ofstay and residential status.Methods: An initial population pool were 3,024 who were assessed with health screening programs by Migrant Health Association.2,459 migrants were selected for final analysis. Via Stata 10 we conducted univariate logistic regression analysis to examine theeffects of their length of stay and residential status on the prevalence of hypertension, diabetes, dyslipidemia, and obesity. In thefinal analysis, the result of each sex was adjusted for age, nationality, length of stay, and residential status via multiple logisticregression analysis.Results: Longer length of stay tends to increase the prevalence of hypertension in male; 4-6 year stay-duration groupdemonstrated statistically significant excess compared to 1 year or less stay-duration group (adjusted odds ratio [OR], 1.39;confidence interval [CI], 1.01 to 1.92). After adjustment, male migrants stayed more than 7 year showed considerably higherdyslipidemia than male migrants stayed less than 1 year (adjusted OR, 1.95; CI, 1.05 to 3.64). Compared to the group with 1 yearor less stay-duration, the prevalence of obesity in male was significantly higher among 4-6 year (adjusted OR, 1.65; CI, 1.17 to 2.32)and 7 year or more stay-duration group (adjusted OR, 1.65; CI, 1.11 to 2.45).Conclusion: Longer length of stay correlated to higher prevalence of hypertension, dyslipidemia, and obesity among somepopulation of migrants. So more researches and new developing policies are needed for this problem.OAIID:oai:osos.snu.ac.kr:snu2012-01/102/0000052039/7SEQ:7PERF_CD:SNU2012-01EVAL_ITEM_CD:102USER_ID:0000052039ADJUST_YN:YEMP_ID:A077862DEPT_CD:801CITE_RATE:0FILENAME:52 The Prevalence of Chronic Diseases among Migrants in Korea According.pdfDEPT_NM:의학과EMAIL:[email protected]_YN:NCONFIRM:

Cinnamon extract induces tumor cell death through inhibition of NFκB and AP1

<p>Abstract</p> <p>Background</p> <p><it>Cinnamomum cassia </it>bark is the outer skin of an evergreen tall tree belonging to the family Lauraceae containing several active components such as essential oils (cinnamic aldehyde and cinnamyl aldehyde), tannin, mucus and carbohydrate. They have various biological functions including anti-oxidant, anti-microbial, anti-inflammation, anti-diabetic and anti-tumor activity. Previously, we have reported that anti-cancer effect of cinnamon extracts is associated with modulation of angiogenesis and effector function of CD8⁺T cells. In this study, we further identified that anti-tumor effect of cinnamon extracts is also link with enhanced pro-apoptotic activity by inhibiting the activities NFκB and AP1 in mouse melanoma model.</p> <p>Methods</p> <p>Water soluble cinnamon extract was obtained and quality of cinnamon extract was evaluated by HPLC (High Performance Liquid Chromatography) analysis. In this study, we tested anti-tumor activity and elucidated action mechanism of cinnamon extract using various types of tumor cell lines including lymphoma, melanoma, cervix cancer and colorectal cancer <it>in vitro </it>and <it>in vivo </it>mouse melanoma model.</p> <p>Results</p> <p>Cinnamon extract strongly inhibited tumor cell proliferation <it>in vitro </it>and induced active cell death of tumor cells by up-regulating pro-apoptotic molecules while inhibiting NFκB and AP1 activity and their target genes such as <it>Bcl-2</it>, <it>BcL-xL </it>and <it>survivin</it>. Oral administration of cinnamon extract in melanoma transplantation model significantly inhibited tumor growth with the same mechanism of action observed <it>in vitro</it>.</p> <p>Conclusion</p> <p>Our study suggests that anti-tumor effect of cinnamon extracts is directly linked with enhanced pro-apoptotic activity and inhibition of NFκB and AP1 activities and their target genes <it>in vitro </it>and <it>in vivo </it>mouse melanoma model. Hence, further elucidation of active components of cinnamon extract could lead to development of potent anti-tumor agent or complementary and alternative medicine for the treatment of diverse cancers.</p