96 research outputs found

    Platón, la República, y el anarquismo. Sobre el significado político del símil de la línea (Rep. 509 d-511e)

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    This paper tries to undertake one more time the well-know image of the divided line to take out its political meaning by situating it in its context: a dialogue in which the justice is inquired. But it has at once the intention to intepret the question: what is justice? Not only as a moral or political question, but also as ontological, the question for that that makes posible every delimitation and every discernment. The place where both topics converge is the pólis, the place where the absence of principle, of arkhé, rest alive

    Platón, la República, y el anarquismo. Sobre el significado político del símil de la línea (Rep. 509 d-511e)

    Get PDF
    This paper tries to undertake one more time the well-know image of the divided line to take out its political meaning by situating it in its context: a dialogue in which the justice is inquired. But it has at once the intention to intepret the question: what is justice? Not only as a moral or political question, but also as ontological, the question for that that makes posible every delimitation and every discernment. The place where both topics converge is the pólis, the place where the absence of principle, of arkhé, rest alive

    Platón, la "República" y el anarquismo: Sobre el significado político del símil de la línea (Rep.509 d-511e)

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    Este ensayo pretende abordar de nuevo el conocido símil de la línea para extraer de él su significado político, situándolo en su contexto: un diálogo en que se pregunta por la justicia. Pero trata a la vez de interpretar la pregunta por la justicia como una cuestión que no es meramente moral o política, sino decididamente ontológica: la pregunta por aquello que hace posible toda delimitación y todo discernimiento. El lugar en que confluyen ambos asuntos no es otro que la pólis, el lugar en que se mantiene viva la ausencia de principio, la ausencia de arkhé

    Co-evolution of the bacterial pheromone ComS and sensor ComR fine-tunes natural transformation in streptococci.

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    Competence for natural transformation extensively contributes to genome evolution and the rapid adaptability of bacteria dwelling in challenging environments. In most streptococci, this process is tightly controlled by the ComRS signaling system, which is activated through the direct interaction between the (R)RNPP-type ComR sensor and XIP pheromone (mature ComS). The overall mechanism of activation and the basis of pheromone selectivity have been previously reported in Gram-positive salivarius streptococci; however, detailed 3D-remodeling of ComR leading up to its activation remains only partially understood. Here, we identified using a semi-rational mutagenesis approach two residues in the pheromone XIP that bolster ComR sensor activation by interacting with two aromatic residues of its XIP-binding pocket. Random and targeted mutagenesis of ComR revealed that the interplay between these four residues remodel a network of aromatic-aromatic interactions involved in relaxing the sequestration of the DNA-binding domain. Based on these data, we propose a comprehensive model for ComR activation based on two major conformational changes of the XIP-binding domain. Notably, the stimulation of this newly identified trigger point by a single XIP substitution resulted in higher competence and enhanced transformability, suggesting that pheromone-sensor co-evolution counter-selects for hyperactive systems in order to maintain a trade-off between competence and bacterial fitness. Overall, this study sheds new light on the ComRS activation mechanism and how it could be exploited for biotechnological and biomedical purposes

    Promotion of the dissertation as a methodological tool in the teaching of philosophy

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    Este proyecto de innovación docente propone un conjunto de iniciativas dirigidas a fomentar y difundir el uso de la disertación filosófica como herramienta metodológica con el objetivo de mejorar la formación del profesorado universitario y de enseñanza media. Es continuación del proyecto innova-docencia 2021/2022 "La filosofía entre el Bachillerato y la Universidad (III): perspectivas docentes para la educación en el siglo XXI".Universidad Complutense de Madrid - Innova DocenciaDepto. de Lógica y Filosofía TeóricaFac. de FilosofíaFALSEsubmitte

    Extracting the speed of sound in the strongly interacting matter created in ultrarelativistic lead-lead collisions at the LHC

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    International audienceUltrarelativistic nuclear collisions create a strongly interacting state of hot and dense quark-gluon matter that exhibits a remarkable collective flow behavior with minimal viscous dissipation. To gain deeper insights into its intrinsic nature and fundamental degrees of freedom, we extracted the speed of sound in this medium created using lead-lead (PbPb) collisions at a center-of-mass energy per nucleon pair of 5.02 TeV. The data were recorded by the CMS experiment at the CERN LHC and correspond to an integrated luminosity of 0.607 nb1^{-1}. The measurement is performed by studying the multiplicity dependence of the average transverse momentum of charged particles emitted in head-on PbPb collisions. Our findings reveal that the speed of sound in this matter is nearly half the speed of light, with a squared value of 0.241 ±\pm 0.002 (stat) ±\pm 0.016 (syst) in natural units. The effective medium temperature, estimated using the mean transverse momentum, is 219 ±\pm 8 (syst) MeV. The measured squared speed of sound at this temperature aligns precisely with predictions from lattice quantum chromodynamic (QCD) calculations. This result provides a stringent constraint on the equation of state of the created medium and direct evidence for a deconfined QCD phase being attained in relativistic nuclear collisions

    Elliptic anisotropy measurement of the f0_0(980) hadron in proton-lead collisions and evidence for its quark-antiquark composition

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    International audienceDespite the f0_0(980) hadron having been discovered half a century ago, the question about its quark content has not been settled: it might be an ordinary quark-antiquark (qqˉ\mathrm{q\bar{q}}) meson, a tetraquark (qqˉqqˉ\mathrm{q\bar{q}q\bar{q}}) exotic state, a kaon-antikaon (KKˉ\mathrm{K\bar{K}}) molecule, or a quark-antiquark-gluon (qqˉg\mathrm{q\bar{q}g}) hybrid. This paper reports strong evidence that the f0_0(980) state is an ordinary qqˉ\mathrm{q\bar{q}} meson, inferred from the scaling of elliptic anisotropies (v2v_2) with the number of constituent quarks (nqn_\mathrm{q}), as empirically established using conventional hadrons in relativistic heavy ion collisions. The f0_0(980) state is reconstructed via its dominant decay channel f0_0(980) \toπ+π\pi^+\pi^-, in proton-lead collisions recorded by the CMS experiment at the LHC, and its v2v_2 is measured as a function of transverse momentum (pTp_\mathrm{T}). It is found that the nqn_q = 2 (qqˉ\mathrm{q\bar{q}} state) hypothesis is favored over nqn_q = 4 (qqˉqqˉ\mathrm{q\bar{q}q\bar{q}} or KKˉ\mathrm{K\bar{K}} states) by 7.7, 6.3, or 3.1 standard deviations in the pTp_\mathrm{T}<\lt 10, 8, or 6 GeV/cc ranges, respectively, and over nqn_\mathrm{q} = 3 (qqˉg\mathrm{q\bar{q}g} hybrid state) by 3.5 standard deviations in the pTp_\mathrm{T}<\lt 8 GeV/cc range. This result represents the first determination of the quark content of the f0_0(980) state, made possible by using a novel approach, and paves the way for similar studies of other exotic hadron candidates
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