Nectin-4 is a new histological and serological tumor associated marker for breast cancer

Abstract Introduction Breast cancer is a complex and heterogeneous disease at the molecular level. Evolution is difficult to predict according to classical histoclinical prognostic factors. Different studies highlight the importance of large-scale molecular expression analyses to improve taxonomy of breast cancer and prognostic classification. Identification of new molecular markers that refine this taxonomy and improve patient management is a priority in the field of breast cancer research. Nectins are cell adhesion molecules involved in the regulation of epithelial physiology. We present here Nectin-4/PVRL4 as a new histological and serological tumor associated marker for breast carcinoma. Methods Expression of Nectin-4 protein was measured on a panel of 78 primary cells and cell lines from different origins and 57 breast tumors by FACS analysis and immunohistochemistry (IHC), respectively. mRNA expression was measured by quantitative PCR. Serum Nectin-4 was detected by ELISA and compared with CEA and CA15.3 markers, on panels of 45 sera from healthy donors, 53 sera from patients with non-metastatic breast carcinoma (MBC) at diagnosis, and 182 sera from patients with MBC. Distribution of histological/serological molecular markers and histoclinical parameters were compared using the standard Chi-2 test. Results Nectin-4 was not detected in normal breast epithelium. By contrast, Nectin-4 was expressed in 61% of ductal breast carcinoma vs 6% in lobular type. Expression of Nectin-4 strongly correlated with the basal-like markers EGFR, P53, and P-cadherin, and negatively correlated with the luminal-like markers ER, PR and GATA3. All but one ER/PR-negative tumors expressed Nectin-4. The detection of Nectin-4 in serum improves the follow-up of patients with MBC: the association CEA/CA15.3/Nectin-4 allowed to monitor 74% of these patients compared to 67% with the association CEA/CA15.3. Serum Nectin-4 is a marker of disease progression, and levels correlate with the number of metastases (P = 0.038). Serum Nectin-4 is also a marker of therapeutic efficiency and correlates, in 90% of cases, with clinical evolution. Conclusion Nectin-4 is a new tumor-associated antigen for breast carcinoma. Nectin-4 is a new bio-marker whose use could help refine breast cancer taxonomy and improve patients' follow-up. Nectin-4 emerges as a potential target for breast cancer immunotherapy.http://deepblue.lib.umich.edu/bitstream/2027.42/112418/1/12885_2007_Article_723.pd

Climatic Risk and Distribution Atlas of European Bumblebees

Bumble bees represent one of the most important groups of pollinators. In addition to their ecological and economic relevance, they are also a highly charismatic group which can help to increase the interest of people in realizing, enjoying and conserving natural systems. However, like most animals, bum- ble bees are sensitive to climate. In this atlas, maps depicting potential risks of climate change for bumble bees are shown together with informative summary statistics, ecological back- ground information and a picture of each European species. Thanks to the EU FP7 project STEP, the authors gathered over one million bumblebee records from all over Europe. Based on these data, they modelled the current climatic niche for almost all European species (56 species) and projected future climatically suitable conditions using three climate change scenarios for the years 2050 and 2100. While under a moderate change scenario only 3 species are projected to be at the verge of extinction by 2100, 14 species are at high risk under an intermediate change scenario. Under a most severe change scenario as many as 25 species are projected to lose almost all of their climatically suitable area, while a total of 53 species (77% of the 69 European species) would lose the main part of their suitable area. Climatic risks for bumblebees can be extremely high, depending on the future development of human society, and the corresponding effects on the climate. Strong mitigation strategies are needed to preserve this important species group and to ensure the sustainable provision of pollination services, to which they considerably contribute

Liaison sans fils à 60 GHz et réseau domestique multi-gigabit/s basé sur une infrastructure radio sur fibre bas coût

National audienceLe projet FUI8 ORIGIN (Optical Radio Infrastructure for Gigabit/s Indoor Network) s'adresse au marché du Réseau Local Domestique (RLD) en proposant une infrastructure bas coût qui combine l'efficacité de la fibre optique pour la diffusion radio avec les avantages d'une transmission sans fils. Les premières réalisations et les tests réussis sont présentés dans ce papier

Copernicus Ocean State Report, issue 6

The 6th issue of the Copernicus OSR incorporates a large range of topics for the blue, white and green ocean for all European regional seas, and the global ocean over 1993–2020 with a special focus on 2020

Quelle est la vertu du droit pénal dans le monde des affaires :un impératif sociétal ou l'inadéquation d'un remède facile ?

Cours-conférence à l'académie royale de Belgiqueinfo:eu-repo/semantics/nonPublishe

NB-IoT High Linear Doherty Amplifier with Active Balun

This paper presents a Doherty power amplifier with an enhanced power back-off efficiency and a high linearity using an adaptive bias circuit. The silicon area reduction is achieved with an active balun driver topology. The operating frequency range is 1.49GHz to 2.17GHz for NB-IoT applications. The post layout simulations (PLS) show a maximum output power of 31.6dBm with a peak PAE of 35.3% at 1.85GHz. The efficiency drops to 28% at 6dB back-off. The robustness to the 2:1 SWR achieves a variation in Gain and P sat of 3dB and 0.8dB, respectively

Code pénal de l'entreprise

Bruxelles, Bruylantinfo:eu-repo/semantics/published