Coupling of the meshless SPH-ALE method with a finite volume method

This paper presents a novel coupling algorithm for a Smoothed Particle Hydrodynamics-Arbitrary Lagrange Euler (SPH-ALE) and a mesh-based Finite Volume (FV) method where information is transferred in two ways. On the one hand, we use the FV calculation points as SPH neighbors in the regions where the mesh is overlapping the SPH-ALE particles. On the other hand, the boundary conditions for the FV domain are interpolated from the SPH-ALE particles, similar to what is done in the CHIMERA method of overlapping meshes. In contrast to the CHIMERA method, interpolation is not performed on a structured grid but on a set of unstructured points. Hence, an interpolation technique for scattered data is used. The approach is carefully validated by means of well-known academic testcases that show very encouraging results. Our final aim is the simulation of transient flows in hydraulic machines

Simulation des écoulements à surface libre dans les turbines Pelton par une méthode hybride SPH-ALE

International audienceAn Arbitrary Lagrange Euler (ALE) description of fluid flows is used together with the meshless numerical method Smoothed Particle Hydrodynamics (SPH) to simulate free surface flows. The ALE description leads to an hybrid method that can be closely connected to the finite volume approach. It is then possible to adapt some common techniques like upwind schemes and preconditioning to remedy some of the well known drawbacks of SPH like stability and accuracy. An efficient boundary treatment based on a proper upwinding of fluid information at the boundary surface is settled. The resulting SPH-ALE numerical method is applied to simulate free surface flows encountered in Pelton turbines.La méthode numérique sans maillage Smoothed Particle Hydrodynamics (SPH) est modifiée par l'adoption d'une description Arbitrary Lagrange Euler (ALE) des écoulements fluides, dans le but de simuler des écoulements à surface libre. Le formalisme ALE conduit à une méthode numérique hybride s'apparentant sur de nombreux points à une approche volumes finis. Il est alors possible d'adapter des techniques numériques courantes comme les schémas décentrés et le préconditionnement pour résoudre certains défauts majeurs de la méthode SPH, comme la stabilité numérique ou le manque de précision. Par ailleurs, le traitement des conditions limites est réalisé par un décentrement approprié des informations fluides sur les surfaces frontières. La méthode numérique SPH-ALE résultante est appliquée à la simulation d'écoulements à surface libre tels que ceux rencontrés dans les turbines Pelton

Skin Microvascular Thrombosis in Fusarium Infection in Two Early Biopsied Cases

Fusarium species cause rare and severe infections. Their incidence is increasing in immunocompromised patients but they are also observed in healthy hosts. Because of the rapid dissemination of infection and the frequent resistance of Fusarium species to antifungal drugs, histopathologic evidence of hyphae is very helpful to obtain the diagnosis rapidly. We report the clinical and pathological features of two patients with initial cutaneous lesions. Cutaneous early biopsies showed microvessel involvement with hyphae and thrombosis. Fusarium infection was confirmed by skin culture. Hyphae within a microvessel thrombus in the skin were highly suggestive of disseminated fungal infection. These pathological features enabled to establish an early diagnosis and to start efficient antifungal treatment. In early cutaneous biopsies of immunocompromised patients, the presence of cutaneous vessel thrombosis can suggest a fungal infection and may help to start specific therapy without delay for these life-threatening infections

Simulation des écoulements à surface libre dans les turbines Pelton par une méthode hybride SPH-ALE

International audienceAn Arbitrary Lagrange Euler (ALE) description of fluid flows is used together with the meshless numerical method Smoothed Particle Hydrodynamics (SPH) to simulate free surface flows. The ALE description leads to an hybrid method that can be closely connected to the finite volume approach. It is then possible to adapt some common techniques like upwind schemes and preconditioning to remedy some of the well known drawbacks of SPH like stability and accuracy. An efficient boundary treatment based on a proper upwinding of fluid information at the boundary surface is settled. The resulting SPH-ALE numerical method is applied to simulate free surface flows encountered in Pelton turbines.La méthode numérique sans maillage Smoothed Particle Hydrodynamics (SPH) est modifiée par l'adoption d'une description Arbitrary Lagrange Euler (ALE) des écoulements fluides, dans le but de simuler des écoulements à surface libre. Le formalisme ALE conduit à une méthode numérique hybride s'apparentant sur de nombreux points à une approche volumes finis. Il est alors possible d'adapter des techniques numériques courantes comme les schémas décentrés et le préconditionnement pour résoudre certains défauts majeurs de la méthode SPH, comme la stabilité numérique ou le manque de précision. Par ailleurs, le traitement des conditions limites est réalisé par un décentrement approprié des informations fluides sur les surfaces frontières. La méthode numérique SPH-ALE résultante est appliquée à la simulation d'écoulements à surface libre tels que ceux rencontrés dans les turbines Pelton

Statistics of resonances and of delay times in quasiperiodic Schr"odinger equations

We study the statistical distributions of the resonance widths ${\cal P} (\Gamma)$, and of delay times ${\cal P} (\tau)$ in one dimensional quasi-periodic tight-binding systems with one open channel. Both quantities are found to decay algebraically as $\Gamma^{-\alpha}$, and $\tau^{-\gamma}$ on small and large scales respectively. The exponents $\alpha$, and $\gamma$ are related to the fractal dimension $D_0^E$ of the spectrum of the closed system as $\alpha=1+D_0^E$ and $\gamma=2-D_0^E$. Our results are verified for the Harper model at the metal-insulator transition and for Fibonacci lattices.Comment: 4 pages, 3 figures, submitted to Phys. Rev. Let

Pretreatment Liver Injury Predicts Poor Prognosis of DLBCL Patients

Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of lymphoma, with different clinical manifestation and prognosis. The International Prognostic Index (IPI), an index designed during the prerituximab era for aggressive lymphoma, showed variable values in the prediction of patient clinical outcomes. The aim of this study was to analyze the prognostic value and causes of pretreatment liver injury in 363 de novo DLBCL patients in our institution. Pretreatment liver impairment, commonly detected in lymphoma patients, showed significant association with poor outcomes and increased serum inflammatory cytokines in DLBCL patients but had no relation to hepatitis B virus replication nor lymphomatous hepatic infiltration. Multivariate analysis revealed that liver dysfunction, advanced Ann Arbor stage, and elevated lactate dehydrogenase (LDH) were independent adverse prognostic factors of both PFS and OS. Accordingly, a new liver-IPI prognostic model was designed by adding liver injury as an important factor in determining IPI score. Based on Kaplan-Meier curves for PFS and OS, the liver-IPI showed better stratification in DLBCL patients than either the IPI or the revised IPI in survival prediction

Mitapivat, a pyruvate kinase activator, improves transfusion burden and reduces iron overload in M-thalassemic mice

Not available

BCL-2 Inhibitor ABT-737 effectively targets leukemia-initiating cells with differential regulation of relevant genes leading to extended survival in a NRAS/BCL-2 mouse model of high risk-myelodysplastic syndrome

During transformation, myelodysplastic syndromes (MDS) are characterized by reducing apoptosis of bone marrow (BM) precursors. Mouse models of high risk (HR)-MDS and acute myelogenous leukemia (AML) post-MDS using mutant NRAS and overexpression of human BCL-2, known to be poor prognostic indicators of the human diseases, were created. We have reported the efficacy of the BCL-2 inhibitor, ABT-737, on the AML post-MDS model; here, we report that this BCL-2 inhibitor also significantly extended survival of the HR-MDS mouse model, with reductions of BM blasts and lineage negative/Sca1+/KIT+ (LSK) cells. Secondary transplants showed increased survival in treated compared to untreated mice. Unlike the AML model, BCL-2 expression and RAS activity decreased following treatment and the RAS:BCL-2 complex remained in the plasma membrane. Exon-specific gene expression profiling (GEP) of HR-MDS mice showed 1952 differentially regulated genes upon treatment, including genes important for the regulation of stem cells, differentiation, proliferation, oxidative phosphorylation, mitochondrial function, and apoptosis; relevant in human disease. Spliceosome genes, found to be abnormal in MDS patients and downregulated in our HR-MDS model, such as Rsrc1 and Wbp4, were upregulated by the treatment, as were genes involved in epigenetic regulation, such as DNMT3A and B, upregulated upon disease progression and downregulated upon treatment

Etude tissulaire et moléculaire de la progression tumorale dans les lymphomes humains agressifs

PARIS7-Bibliothèque centrale (751132105) / SudocSudocFranceF