369 research outputs found
ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠΉ ΠΌΠ°ΡΡΡ Π»ΠΈΠ³Π½ΠΎΡΡΠ»ΡΡΠΎΠ½Π°ΡΠ° Π½Π°ΡΡΠΈΡ Π½Π° ΡΠ΅ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° Π²ΡΡΠΎΠΊΠΎΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ ΡΡΡΠΏΠ΅Π½Π·ΠΈΠΉ Π±ΡΡΠΎΠ³ΠΎ ΡΠ³Π»Ρ
ΠΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½ΠΎ Π²ΠΏΠ»ΠΈΠ² ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΡ ΠΌΠ°ΡΠΈ Π»ΡΠ³Π½ΠΎΡΡΠ»ΡΡΠΎΠ½Π°ΡΡ Π½Π°ΡΡΡΡ Π½Π° ΡΠ΅ΠΎΠ»ΠΎΠ³ΡΡΠ½Ρ Π²Π»Π°ΡΡΠΈΠ²ΠΎΡΡΡ Π²ΠΈΡΠΎΠΊΠΎΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠΎΠ²Π°Π½ΠΈΡ
Π²ΠΎΠ΄ΠΎΠ²ΡΠ³ΡΠ»ΡΠ½ΠΈΡ
ΡΡΡΠΏΠ΅Π½Π·ΡΠΉ Π½Π° ΠΎΡΠ½ΠΎΠ²Ρ Π±ΡΡΠΎΠ³ΠΎ Π²ΡΠ³ΡΠ»Π»Ρ ΠΠ»Π΅ΠΊΡΠ°Π½Π΄ΡΡΠΉΡΡΠΊΠΎΠ³ΠΎ ΡΠΎΠ΄ΠΎΠ²ΠΈΡΠ°. ΠΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΠΎ Π½ΠΈΠ·ΡΠΊΠΎΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½Ρ ΡΡΠ°ΠΊΡΡΡ ΡΠΏΡΠΈΡΡΡΡ ΡΠΎΠ·ΡΡΠ΄ΠΆΠ΅Π½Π½Ρ Π²ΠΎΠ΄ΠΎΠ²ΡΠ³Ρ-Π»ΡΠ½ΠΈΡ
ΡΡΡΠΏΠ΅Π½Π·ΡΠΉ Π° Π²ΠΈΡΠΎΠΊΠΎΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½Ρ Π²ΠΈΡΡΡΠΏΠ°ΡΡΡ Π² ΡΠΎΠ»Ρ ΡΡΠ°Π±ΡΠ»ΡΠ·Π°ΡΠΎΡΡΠ².ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠΉ ΠΌΠ°ΡΡΡ Π»ΠΈΠ³Π½ΠΎΡΡΠ»ΡΡΠΎΠ½Π°ΡΠΎΠ² Π½Π°ΡΡΠΈΡ Π½Π° ΡΠ΅ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° Π²ΡΡΠΎΠΊΠΎΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
Π²ΠΎΠ΄ΠΎΡΠ³ΠΎΠ»ΡΠ½ΡΡ
ΡΡΡΠΏΠ΅Π½Π·ΠΈΠΉ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ Π±ΡΡΠΎΠ³ΠΎ ΡΠ³Π»Ρ ΠΠ»Π΅ΠΊΡΠ°Π½Π΄ΡΠΈΠΉΡΠΊΠΎΠ³ΠΎ ΠΌΠ΅ΡΡΠΎΡΠΎΠΆΠ΄Π΅Π½ΠΈΡ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ Π½ΠΈΠ·ΠΊΠΎΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠ΅ ΡΡΠ°ΠΊΡΠΈΠΈ ΡΠΎΠΏΡΡΡΡΠ²ΡΡΡ ΡΠ°Π·ΠΆΠΈΠΆΠ΅Π½ΠΈΡ Π²ΠΎΠ΄ΠΎΡΠ³ΠΎΠ»ΡΠ½ΡΡ
ΡΡΡΠΏΠ΅Π½Π·ΠΈΠΉ Π° Π²ΡΡΠΎΠΊΠΎΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠ΅ Π²ΡΡΡΡΠΏΠ°ΡΡ Π² ΡΠΎΠ»ΠΈ ΡΡΠ°Π±ΠΈΠ»ΠΈΠ·Π°ΡΠΎΡΠΎΠ²
The identification of critical facilities from the position of cybersecurity violation by the example of energy
The article describes methods for identification of critical facilities, being a significant trend in researching critical infrastructures, particularly in the energy sector. The proposed methods are focused on the investigation of the energy object state in relation to the violation of cybersecurity of its information infrastructure. The cyber threats are believed to be important contemporary threats to energy security in Russia. The proposed methods formed the basis of development information-analytical system used for monitoring of cybersecurity violations in energy sector
Π Π΅Π³ΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠ΅ ΡΡΠ΄ΠΎΠΊΠΎΠ½ΡΡΠΎΠ»ΠΈΡΡΡΡΠΈΠ΅ ΡΡΡΡΠΊΡΡΡΡ Π£ΡΠ°Π»Π°
One of the most challenging requirements for the next generation EUV lithography is an extremely low amount of critically sized defects on mask blanks. Fast and reliable inspection of mask blanks is still a challenge. Here we present the current status of the development of our actinic Schwarzschild objective based microscope operating in dark field with EUV discharge produced plasma source. For characterization of the microscope performance, several programmed defect structures - artificial pits and bumps were created on top of multilayer mirror (ML) surfaces and investigated both with EUV microscope and atomic force microscope (AFM). Defect size sensitivity of actinic inspection in dark field mode without resolving the defects is under study. The dependency between defect shape, size and position in relation to the ML surface and its scattering signal will be discussed. Furthermore, first results of a defect mapping algorithm are presented
ΠΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ Π°ΠΏΠΏΠ°ΡΠ°ΡΠ½ΠΎΠΉ ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ Π°Π»Π³ΠΎΡΠΈΡΠΌΠΎΠ² Π²ΡΡΠΈΡΠ»Π΅Π½ΠΈΡ ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΎΠΉ ΡΡΠΌΠΌΡ CRC32
ΠΡΠΈΠ²Π΅Π΄Π΅Π½ΠΎ ΠΎΠΏΠΈΡΠ°Π½ΠΈΠ΅ Π°ΠΏΠΏΠ°ΡΠ°ΡΠ½ΡΡ
ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΠΉ ΠΌΠ°ΡΡΠΈΡΠ½ΠΎΠ³ΠΎ ΠΈ ΡΠ°Π±Π»ΠΈΡΠ½ΠΎΠ³ΠΎ Π°Π»Π³ΠΎΡΠΈΡΠΌΠΎΠ² Π²ΡΡΠΈΡΠ»Π΅Π½ΠΈΡ ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΎΠΉ ΡΡΠΌΠΌΡ CRC32 Π½Π° ΠΠΠΠ‘ Cyclone ΡΠΈΡΠΌΡ Altera ΠΌΠ°ΠΊΠ΅ΡΠ° SDK-6.1. ΠΠΎΠΊΠ°Π·Π°Π½Ρ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ Π°ΠΏΠΏΠ°ΡΠ°ΡΠ½ΠΎΠΉ ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ Π½Π° ΠΏΡΠΈΠΌΠ΅ΡΠ΅ ΠΎΠΏΠΈΡΠ°Π½ΠΈΡ Π±Π»ΠΎΠΊΠΎΠ² Π²ΡΡΠΈΡΠ»Π΅Π½ΠΈΡ CRC32 ΠΈ ΡΠ°Π±ΠΎΡΠΎΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡ ΡΠΏΡΠΎΠ΅ΠΊΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΡΡΡΡΠΎΠΉΡΡΠ² Π½Π° ΠΊΠΎΠ½ΠΊΡΠ΅ΡΠ½ΡΡ
ΠΏΡΠΈΠΌΠ΅ΡΠ°Ρ
ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠΈΡΡΠ΅ΠΌΡ Π ΠΠ (OH)3βNH4Cl ΠΏΡΠΈ Π½Π°Π³ΡΠ΅Π²Π°Π½ΠΈΠΈ
The temporal evolution of neon pinch plasmas, generated in a 2kJ plasma focus device, has been investigated by x-ray spectroscopic methods for two sets of device parameters. These two sets lead to characteristic differences of the K-shell emission. Stationary models are shown to fail to explain the experimental observations even qualitatively. Transient spectra analysis shows that the characteristic differences observed can be referred to different transient modes of plasma dynamics. The spectra analysis includes beside resonance lines also dielectronic satellites and recombination continua. The results concerning the development of the plasma parameters achieved by the spectra modeling are supported by independent measurements of the time resolved K-shell emission and by optical streak images of the pinch plasma dynamics, which confirms the reliability of the transient spectroscopic analysis presented
\u3ci\u3e Glioblastoma derived exosomes contribute to tumor immune evasion \u3c/i\u3e
Glioblastoma multiforme (GBM) is the most frequent and lethal primary brain tumor in adults. Despite intense biomedical research, the median survival after diagnosis is 15 months. One factor contributing to this poor prognosis is the immune protection afforded by the tumor microenvironment. Tumors have a diverse repertoire of immune-evasive techniques. One method of evasion not well explored is the release of tumor-derived exosomes. Exosomes are tiny membrane-bound vesicles of endocytic origin that contain viable mRNA and functional proteins that can affect the physiology of recipient cells. Exosome release has been reported for numerous cancer types, including GBM. Exosomes from colon cancer have been shown to carry Fas ligand (FasL) and to induce apoptosis of activated T cells. The aim of this study was to elucidate whether the same immune-evasive technique is used in GBM. GBM exosomes were isolated from the serum-free culture medium of U87 MG and U138 MG cells by using differential ultracentrifugation and were then resuspended in phosphate-buffered saline. The protein concentration of the resulting exosome pellet was determined, and subsequent exosome treatments were based on protein concentration. A3T T cells were plated at a concentration of 10,000 cells per well in 96-well plates and were treated with quantified exosome fractions or with recombinant FasL, and T cell proliferation was determined. Our data demonstrated that tumor-derived exosomes significantly inhibited the proliferation of T cells and that the cellular inhibition resulting from the exosomes was comparable to that seen with the recombinant FasL. These results suggest that targeting FasL in GBM could greatly decrease the amount of immune suppression that occurs at the tumor site
ΠΡΠΊΠ°Π·ΠΎΡΡΡΠΎΠΉΡΠΈΠ²ΡΠΉ ΠΌΠ½ΠΎΠ³ΠΎΡΠ°Π·Π½ΡΠΉ Π°ΡΠΈΠ½Ρ ΡΠΎΠ½Π½ΡΠΉ ΡΠ»Π΅ΠΊΡΡΠΎΠΏΡΠΈΠ²ΠΎΠ΄ Ρ Π½Π΅ΡΠΈΠ½ΡΡΠΎΠΈΠ΄Π°Π»ΡΠ½ΡΠΌΠΈ ΡΠΎΠΊΠ°ΠΌΠΈ
Π Π°ΡΡΠΌΠΎΡΡΠ΅Π½ ΠΏΡΠΈΠ½ΡΠΈΠΏ ΠΏΠΎΡΡΡΠΎΠ΅Π½ΠΈΡ ΠΌΠ½ΠΎΠ³ΠΎΡΠ°Π·Π½ΠΎΠ³ΠΎ Π°ΡΠΈΠ½Ρ
ΡΠΎΠ½Π½ΠΎΠ³ΠΎ ΡΠ»Π΅ΠΊΡΡΠΎΠΏΡΠΈΠ²ΠΎΠ΄Π°, ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡΠ΅Π³ΠΎ ΠΏΡΠΈ Π½Π΅ΠΎΠ΄Π½ΠΎΠΊΡΠ°ΡΠ½ΡΡ
ΠΎΡΠΊΠ°Π·Π°Ρ
ΠΏΡΠ΅ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»Ρ ΡΠ°ΡΡΠΎΡΡ ΠΈ Π΄Π²ΠΈΠ³Π°ΡΠ΅Π»Ρ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΡΡ ΠΎΡΠΊΠ°Π·ΠΎΡΡΡΠΎΠΉΡΠΈΠ²ΠΎΠ΅ ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠ΅, Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΠΈΡΡΠ΅ΠΌΡΡ
Π½Π΅ΡΠΈΠ½ΡΡΠΎΠΈΠ΄Π°Π»ΡΠ½ΡΡ
ΡΠΎΠΊΠΎΠ² Ρ Π²ΠΎΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ΠΌ ΡΠ°Π±ΠΎΡΠΎΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΠΈ Π·Π° ΡΡΠ΅Ρ Π°ΠΊΡΠΈΠ²ΠΈΠ·Π°ΡΠΈΠΈ Π°Π»Π³ΠΎΡΠΈΡΠΌΠ° Π²ΠΎΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΡ Π² ΡΠΏΡΠ°Π²Π»ΡΡΡΠ΅ΠΌ ΠΌΠΈΠΊΡΠΎΠΊΠΎΠ½ΡΡΠΎΠ»Π»Π΅ΡΠ΅. ΠΡΠΈΠ²Π΅Π΄Π΅Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π΄Π»Ρ Π°Π²Π°ΡΠΈΠΉΠ½ΠΎΠΉ ΡΠΈΡΡΠ°ΡΠΈΠΈ ΡΠΈΠΏΠ° "ΠΎΠ±ΡΡΠ² ΡΠ°Π·Ρ" Π΄Π»Ρ ΡΠ»ΡΡΠ°Ρ ΡΡΠ΅Ρ
ΡΠ°Π·Π½ΠΎΠ³ΠΎ Π΄Π²ΠΈΠ³Π°ΡΠ΅Π»Ρ Ρ ΡΠ°ΡΡΠΈΡΠ½ΡΠΌ Π²ΠΎΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ΠΌ ΡΠ°Π±ΠΎΡΠΎΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΠΈ Π°ΡΠΈΠ½Ρ
ΡΠΎΠ½Π½ΠΎΠ³ΠΎ Π΄Π²ΠΈΠ³Π°ΡΠ΅Π»Ρ
Π Π°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΡΠ΅ΠΏΠ»ΠΎΠΎΠ±ΠΌΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΎΡΡΠ΄ΠΎΠ²Π°Π½ΠΈΡ ΡΡΠ°ΡΡΠΊΠ° ΡΠ»ΠΈΠ²Π°-Π½Π°Π»ΠΈΠ²Π° Π½Π΅ΡΡΠ΅ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠ² Π―ΠΉΡΠΊΠΎΠ³ΠΎ ΠΠΠ
Π Π΄ΠΈΠΏΠ»ΠΎΠΌΠ½ΠΎΠΌ ΠΏΡΠΎΠ΅ΠΊΡΠ΅ ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½Π° ΡΡΡΠ°Π½ΠΎΠ²ΠΊΠ° ΡΠ»ΠΈΠ²Π°-Π½Π°Π»ΠΈΠ²Π° Π½Π΅ΡΡΠ΅ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠ² Π² ΠΆΠ΅Π»Π΅Π·Π½ΠΎΠ΄ΠΎΡΠΎΠΆΠ½ΡΠ΅ Π²Π°Π³ΠΎΠ½Ρ-ΡΠΈΡΡΠ΅ΡΠ½Ρ Ρ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠΎΠΉ ΡΠ΅ΠΏΠ»ΠΎΠΎΠ±ΠΌΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΎΡΡΠ΄ΠΎΠ²Π°Π½ΠΈΡ. Π Π΄ΠΈΠΏΠ»ΠΎΠΌΠ½ΠΎΠΌ ΠΏΡΠΎΠ΅ΠΊΡΠ΅ ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠ΅ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠΈ ΡΠ΅ΠΏΠ»ΠΎΠΎΠ±ΠΌΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΎΡΡΠ΄ΠΎΠ²Π°Π½ΠΈΡ. ΠΡΠΈΠ²Π΅Π΄Π΅Π½Ρ ΡΠ°ΡΡΠ΅ΡΡ ΠΎΡΠ½ΠΎΠ²Π½ΡΡ
ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
, ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠ²Π½ΡΡ
ΠΈ ΠΏΡΠΎΡΠ½ΠΎΡΡΠ½ΡΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ Π°ΠΏΠΏΠ°ΡΠ°ΡΠ°. ΠΡΠΈΠ²Π΅Π΄Π΅Π½Ρ ΡΠ°ΡΡΠ΅ΡΡ ΠΎΡΠ½ΠΎΠ²Π½ΡΡ
ΡΠ΅Ρ
Π½ΠΈΠΊΠΎ-ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ, Π²ΡΠΏΠΎΠ»Π½Π΅Π½ Π³ΠΎΠ΄ΠΎΠ²ΠΎΠΉ Π³ΡΠ°ΡΠΈΠΊ ΠΠ»Π°Π½ΠΎΠ²ΠΎ-ΠΏΡΠ΅Π΄ΡΠΏΡΠ΅Π΄ΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΡΠ°Π±ΠΎΡ, ΠΏΠΎ ΠΊΠΎΡΠΎΡΡΠΌ Π²ΠΈΠ΄Π½ΠΎ, ΡΡΠΎ ΡΠ°Π±ΠΎΡΠ° ΡΡΠ°ΡΡΠΊΠ° ΡΠ»ΠΈΠ²Π°-Π½Π°Π»ΠΈΠ²Π° Π½Π΅ΡΡΠ΅ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠ² ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½Π° ΠΈ ΡΠ΅Π½ΡΠ°Π±Π΅Π»ΡΠ½Π°.The setting of oil drain loading into railroad tanks with the development of heat transfer equipment and different constructions of the heat transfer equipment are considered in the diploma project. There are the calculations of the basic design, structural properties, technical and economic indicators in the diploma. The annual schedule of scheduled and preventative work is performed. It shows that the work of oil drain loading sector is effective and profitable. The diploma project contains the estimated explanatory note
Π Π΅ΠΈΠ½ΠΆΠΈΠ½ΠΈΡΠΈΠ½Π³ ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² Π² ΠΎΡΠ΄Π΅Π»Π΅ ΡΠΊΠΎΠ½ΠΎΠΌΠΈΠΊΠΈ ΠΈ ΡΠΈΠ½Π°Π½ΡΠΎΠ² ΠΡΠ°ΡΠ½ΠΎΡΡΡΠΊΠΎΠ³ΠΎ Π¦Π€Π’Π Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ BestPractices
The development of new types of sophisticated soft x-ray sources requires the knowledge of their emission characteristics such as photon flux, spectral distribution, and size of the radiation source. Calibrated spectrographs for the soft x-ray region are needed to determine these properties. The components of a soft x-ray spectrograph consisting of a pinhole gold transmission grating and a charge coupled device (CCD) camera are calibrated at the radiometry laboratory of the Physikalisch-Technische Bundesanstalt using the synchrotron radiation facility BESSY. Two different kinds of CCD-based photon detectors (one thinned and back illuminated, one coated with a phosphorous layer) are compared with regard to their sensitivities in the spectral range between 50 eV and 1.7 keV. The results obtained for the thinned CCD are compared with theoretical calculations of the sensitivity
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