Why are the parts worth more than the sum? "Chop shop," a corporate valuation model

Stock market ; Corporations

Modern slavery in business: The sad and sorry state of a non-field

“Modern slavery,” a term used to describe severe forms of labor exploitation, is beginning to spark growing interest within business and society research. As a novel phenomenon, it offers potential for innovative theoretical and empirical pathways to a range of business and management research questions. And yet, development into what we might call a “field” of modern slavery research in business and management remains significantly, and disappointingly, underdeveloped. To explore this, we elaborate on the developments to date, the potential drawbacks, and the possible future deviations that might evolve within six subdisciplinary areas of business and management. We also examine the value that nonmanagement disciplines can bring to research on modern slavery and business, examining the connections, critiques, and catalysts evident in research from political science, law, and history. These, we suggest, offer significant potential for building toward a more substantial subfield of research

Proteome analysis of the UVB-resistant marine bacterium <i>Photobacterium angustum</i> S14

The proteome of the marine bacterium Photobacterium angustum S14 was exposed to UVB and analyzed by the implementation of both the post-digest ICPL labeling method and 2D-DIGE technique using exponentially growing cells. A total of 40 and 23 proteins were quantified in all replicates using either the ICPL or 2D-DIGE methods, respectively. By combining both datasets from 8 biological replicates (4 biological replicates for each proteomics technique), 55 proteins were found to respond significantly to UVB radiation in P. angustum. A total of 8 UVB biomarkers of P. angustum were quantified in all replicates using both methods. Among them, the protein found to present the highest increase in abundance (almost a 3-fold change) was RecA, which is known to play a crucial role in the so-called recombinational repair process. We also observed a high number of antioxidants, transport proteins, metabolism-related proteins, transcription/translation regulators, chaperonins and proteases. We also discuss and compare the UVB response and global protein expression profiles obtained for two different marine bacteria with trophic lifestyles: the copiotroph P. angustum and oligotroph Sphingopyxis alaskensis

Like a Prayer? Applying Conflicts with Religious Dimensions Theory to the Muezzin Law Conflict

What is the nature of the dispute around an Israeli law that proposes restricting how Muslim followers are called for prayer? And, why does the nature of this dispute hold any importance? LeBaron and Senbel have developed a theory differentiating conflicts with religious dimensions (CRDs) from other types of conflicts. The importance of this distinction stems from and highlights the unique role that religion plays in conflicts, which liberal, rational, and individualistic orientations to conflict management fail to address. This article offers a trial run of LeBaron and Senbel’s innovative theoretical framework. We apply CRD theory to conduct an analysis of a legislative attempt to amend an environmental law in Israel. The proposed amendment would limit the use of public address (PA) systems to amplify the Mouzins’ calls for prayer. Proposed limitations on this Islamic practice triggered a public outcry and a sharp societal dispute in Israel. The analysis in this article exposes the real conflict over the proposed amendment to be a CRD, rather than what it seemed on its face: an environmental regulation conflict. This article also contributes to further developing CRD theory. We elaborate on the combined effects of the conflict’s intensity, its duration, and the proximity of its subject to the core values of a religion. We suggest that identifying the unique amalgam of these aspects in a CRD is important to its effective management

Choreography, controversy and child sex abuse: Theoretical reflections on a cultural criminological analysis of dance in a pop music video

This article was inspired by the controversy over claims of ‘pedophilia!!!!’ undertones and the ‘triggering’ of memories of childhood sexual abuse in some viewers by the dance performance featured in the music video for Sia’s ‘Elastic Heart’ (2015). The case is presented for acknowledging the hidden and/or overlooked presence of dance in social scientific theory and cultural studies and how these can enhance and advance cultural criminological research. Examples of how these insights have been used within other disciplinary frameworks to analyse and address child sex crime and sexual trauma are provided, and the argument is made that popular cultural texts such as dance in pop music videos should be regarded as significant in analysing and tracing public perceptions and epistemologies of crimes such as child sex abuse

Capitalism and unfree labour : a review of Marxist perspectives on modern slavery

Contrary to the expectations of liberal and neoclassical economists, as well as many Marxists, the deepening and extension of capitalism appear to be heightening the prevalence of unfree labor. By most accounts, the forms of exploitation encapsulated within unfree labor – including those typically referred to as forced labor, human trafficking and modern slavery – are proliferating in the global economy, including in advanced capitalist societies. We evaluate these developments in light of the relationship between capitalism and unfree labor through the prism of Marxism, revealing a deep-seated divide between a neo-Smithian reading, according to which capitalism and unfree labor are incompatible, and a more faithful Marxist tradition that views forced labor as one possible form of labor control and exploitation under capitalism. Building on this second tradition, we argue that international political economy scholars who seek to shed light into the contemporary and historic dynamics of unfree labor must transcend the rigid theoretical binaries that have long characterized Marxist debates on capitalism and unfree labor

STAT5 regulation of BCL10 parallels constitutive NFkappaB activation in lymphoid tumor cells.

BACKGROUND: Signal Transducer and Activator of Transcription 5 A and B (STAT5) are key survival factors in cells of the lymphoid lineage. Identification of novel, tissue-specific STAT5 regulated genes would advance the ability to combat diseases due to aberrant STAT5 signaling. In the present work a library of human STAT5 bound genomic elements was created and validated. RESULTS: Of several STAT5 responsive genomic regulatory elements identified, one was located within the first intron of the human BCL10 gene. Chromatin immuno-precipitation reactions confirmed constitutive in vivo STAT5 binding to this intronic fragment in various human lymphoid tumor cell lines. Interestingly, non-phosphorylated STAT5 was found in the nuclei of Kit225 and YT cells in the absence of cytokine stimulation that paralleled constitutive NFkappaB activation. Inhibition of the hyperactive JAK3/STAT5 pathway in MT-2 cells via the Mannich-base, NC1153, diminished the constitutive in vivo occupancy of BCL10-SBR by STAT5, reduced NFkappaB activity and BCL10 protein expression in a dose dependent manner. Moreover, depletion of STAT5 via selective antisense oligonucleotide treatment similarly resulted in decreased BCL10 mRNA and protein expression, cellular viability and impaired NFkappaB activity independent of IL-2. CONCLUSION: These results suggest that the NFkappaB regulator BCL10 is an IL-2-independent STAT5 target gene. These findings proffer a model in which un-activated STAT5 can regulate pathways critical for lymphoid cell survival and inhibitors that disrupt STAT5 function independent of tyrosine phosphorylation may be therapeutically effective in treating certain leukemias/lymphomas

Musical preferences and technologies: Contemporary material and symbolic distinctions criticised

Today how individuals interact with various cultural items is not perfectly consistent with theoretical frameworks of influential scholars on cultural consumption, such as Bourdieu (1984), Gans (1999), and Peterson and Simkus (1992). One such variation is in the ever increasing variety of technological modes to acquire and listen to music (Pinch and Bijsterveld, 2004). However, as a consequence of digital divides (van Dijk, 2006), technological items may not be distributed equally among social groups. At present, the value of status-making through a preference for different genres of music extends itself to different forms of consumption and ways of experiencing music. We are yet to fully understand the power these practices have on generating status. This article is therefore motivated by the need to integrate within quantitative frameworks of taste and cultural consumption, an analysis of individuals’ technological engagement. These two dimensions, integrated as components of musical practices, enhance our understanding of cultural boundaries across different social groups.The objective is to bridge a gap detected in the literature, addressing the following questions: Are technological modes to listen to music related to musical tastes

STAT5 regulation of BCL10 parallels constitutive NFκB activation in lymphoid tumor cells

<p>Abstract</p> <p>Background</p> <p>Signal Transducer and Activator of Transcription 5 A and B (STAT5) are key survival factors in cells of the lymphoid lineage. Identification of novel, tissue-specific STAT5 regulated genes would advance the ability to combat diseases due to aberrant STAT5 signaling. In the present work a library of human STAT5 bound genomic elements was created and validated.</p> <p>Results</p> <p>Of several STAT5 responsive genomic regulatory elements identified, one was located within the first intron of the human <it>BCL10 </it>gene. Chromatin immuno-precipitation reactions confirmed constitutive <it>in vivo </it>STAT5 binding to this intronic fragment in various human lymphoid tumor cell lines. Interestingly, non-phosphorylated STAT5 was found in the nuclei of Kit225 and YT cells in the absence of cytokine stimulation that paralleled constitutive NFκB activation. Inhibition of the hyperactive JAK3/STAT5 pathway in MT-2 cells via the Mannich-base, NC1153, diminished the constitutive <it>in vivo </it>occupancy of BCL10-SBR by STAT5, reduced NFκB activity and BCL10 protein expression in a dose dependent manner. Moreover, depletion of STAT5 via selective antisense oligonucleotide treatment similarly resulted in decreased BCL10 mRNA and protein expression, cellular viability and impaired NFκB activity independent of IL-2.</p> <p>Conclusion</p> <p>These results suggest that the NFκB regulator BCL10 is an IL-2-independent STAT5 target gene. These findings proffer a model in which un-activated STAT5 can regulate pathways critical for lymphoid cell survival and inhibitors that disrupt STAT5 function independent of tyrosine phosphorylation may be therapeutically effective in treating certain leukemias/lymphomas.</p