Challenges and opportunities for a South America Waterway System

South America has been developed from its coast to its hinterlands since the beginning of its Western colonization. However, to this point, no significant effort has been made to integrate its interior. Waterways transportation can be considered the most sustainable inland mode of transportation due to its low CO2 emissions per ton of cargo transport. With this in mind, this paper investigates the history, challenges and opportunities of the past proposals for the construction of the South America Waterway System (SAWS) connecting the La Plata, Amazon, and Orinoco river basins. It focuses on particular challenges of the proposed waterway. (i) a comparison between the deforestation surrounding existing road and waterway infrastructure in the Amazon, (ii) the large water level variation in the Amazon basin, (iii) and the alternatives for storing water to reduce the impacts of floods and droughts in the proposed waterway. We conclude that deforestation surrounding existing waterways is practically zero and that groundwater storage has an important role in storing water for the basin and reservoirs, a limited one. The SAWS can significantly foster South American integration, encourage sustainable extraction of natural resources in the region and help the conservation of the Amazon forest

IFNL4 ss469415590 polymorphism is associated with unfavourable clinical and immunological status in HIV-infected individuals

AbstractThe IFNL4 ss469415590 polymorphism, in high linkage disequilibrium with the IL28B rs12979860 variant, has been associated with hepatitis C virus clearance. We evaluated whether ss469415590 is associated with clinical and immunovirological parameters in human immunodeficiency virus-infected subjects. We found an independent association of the IFNL4 ss469415590 polymorphism with higher prevalence of AIDS-defining illnesses and lower CD4 T cell numbers. These results suggest the existence of common host defence mechanisms against different viral infections