557 research outputs found
The cytotoxic domain of colicin E9 is a channel-forming endonuclease
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2002
- Field of study
Bacterial toxins commonly translocate cytotoxic enzymes into cells using dedicated channelforming subunits or domains as conduits. We demonstrate that the small cytotoxic endonuclease domain from the bacterial toxin colicin E9 (the E9 DNase) exhibits nonvoltage- gated, channel-forming activity in planar lipid bilayers and that this activity is linked to toxin translocation into cells. A disulfide bond engineered into the DNase abolished channel activity and colicin toxicity but left endonuclease activity unaffected, with NMR experiments suggesting decreased conformational flexibility as the likely reason for these alterations. Concomitant with the reduction of the disulfide bond was the restoration of conformational flexibility, DNase channel activity and colicin toxicity. Our data suggest that endonuclease domains of colicins may mediate their own translocation across the bacterial inner membrane through an intrinsic channel activity that is dependent on structural plasticity in the protein
Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study
- Author
- Abel K
- Adamali H.
- Adeloye D
- Adeyemi Oluwaseun
- Adrego Rita
- Aguilar Jimenez Laura A.
- Ahmad Haider N
- Ahmad Shanaz
- Ahmed R
- Ahwireng Nyarko
- Ainsworth Mark
- Al-Sheklly B.
- Alamoudi Asma
- Alfaro-Almagro Fidel
- Ali Mariam
- Aljaroof M
- Allan L
- Allen R J
- Allerton Lisa
- Allsop Lynne
- Allt Ann Marie
- Almeida Paula
- Altmann Danny
- Alvarez Corral Maria
- Amoils S.
- Anderson David
- Antoniades C
- Arbane Gill
- Arias Ava Maria
- Armour C.
- Armstrong Lisa
- Armstrong Natalie
- Arnold David
- Arnold H
- Ashish A
- Ashworth Andrew
- Ashworth M
- Aslani S
- Assefa-Kebede Hosanna
- Atkin C
- Atkin Paul
- Aul Raminder
- Aung H
- Austin Liam
- Avram Cristina
- Ayoub A.
- Babores M.
- Baggott R
- Bagshaw J
- Baguley D
- Bailey L
- Baillie J.K.
- Bain S
- Bakali M
- Bakau M
- Baldry E
- Baldwin D
- Baldwin M
- Ballard C
- Bandula Steven
- Banerjee A
- Bang Dongchun
- Barker R E
- Barman L
- Barratt Shaney
- Barrett Fiona
- Basire Donna
- Basu N.
- Bates A
- Bates M
- Batterham R
- Baxendale H
- Bayes Hannah
- Beadsworth M.
- Beckett P
- Beggs Mark
- Begum M
- Beirne Paul
- Bell Murdina
- Bell R
- Bennett Kaytie
- Beranova Eva
- Bermperi Areti
- Berridge Anthony
- Berry C.
- Betts Sarah
- Bevan Emily
- Bhui K
- Bingham Michelle
- Birchall K
- Bishop L.
- Bisnauthsing Karen
- Blaikely J.
- Bloss Angela
- Bolger A.
- Bolton Charlotte E.
- Bonnington J.
- Botkai A
- Bourne Charlotte
- Bourne Michelle
- Bramham K.
- Brear Lucy
- Breen G
- Breeze Jonathon
- Briggs A.
- Bright E
- Brightling Christopher E
- Brill Simon
- Brindle K
- Broad Lauren
- Broadley A
- Brookes C
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- Brown Ammani
- Brown Angela
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- Brown Jeremy S
- Brown Jo
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- Brugha Terry
- Brunskill Nigel
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- Chalder Trudie
- Chalmers James D.
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- Chan Flora
- Channon K M
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- Charalambou A
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- Checkley A
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- Cheng Yutung
- Chetham Luke
- Childs C
- Chilvers Edwin R
- Chinoy H
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- Chong-James K.
- Choudhury Gourab
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- Chowienczyk P
- Christie C
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- Gupta Ayushman
- Gurram Sambasivarao
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- Weir-McCall Jonathan R
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- Wyles J.
- Wynter Inez
- Xie Cheng
- Xu M
- Yasmin Najira
- Yasmin S
- Yates Tom
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- Young Susan
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- Zawia Amira
- Zeidan Lisa
- Zhao Bang
- Zheng Bang
- Zongo O.
- Publication venue
- Elsevier
- Publication date
- 22/09/2023
- Field of study
Introduction:
The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan abnormalities after hospitalisation with COVID-19, evaluate their determinants, and explore associations with patient-related outcome measures.
Methods:
In a prospective, UK-wide, multicentre MRI follow-up study (C-MORE), adults (aged ≥18 years) discharged from hospital following COVID-19 who were included in Tier 2 of the Post-hospitalisation COVID-19 study (PHOSP-COVID) and contemporary controls with no evidence of previous COVID-19 (SARS-CoV-2 nucleocapsid antibody negative) underwent multiorgan MRI (lungs, heart, brain, liver, and kidneys) with quantitative and qualitative assessment of images and clinical adjudication when relevant. Individuals with end-stage renal failure or contraindications to MRI were excluded. Participants also underwent detailed recording of symptoms, and physiological and biochemical tests. The primary outcome was the excess burden of multiorgan abnormalities (two or more organs) relative to controls, with further adjustments for potential confounders. The C-MORE study is ongoing and is registered with ClinicalTrials.gov, NCT04510025.
Findings:
Of 2710 participants in Tier 2 of PHOSP-COVID, 531 were recruited across 13 UK-wide C-MORE sites. After exclusions, 259 C-MORE patients (mean age 57 years [SD 12]; 158 [61%] male and 101 [39%] female) who were discharged from hospital with PCR-confirmed or clinically diagnosed COVID-19 between March 1, 2020, and Nov 1, 2021, and 52 non-COVID-19 controls from the community (mean age 49 years [SD 14]; 30 [58%] male and 22 [42%] female) were included in the analysis. Patients were assessed at a median of 5·0 months (IQR 4·2–6·3) after hospital discharge. Compared with non-COVID-19 controls, patients were older, living with more obesity, and had more comorbidities. Multiorgan abnormalities on MRI were more frequent in patients than in controls (157 [61%] of 259 vs 14 [27%] of 52; p<0·0001) and independently associated with COVID-19 status (odds ratio [OR] 2·9 [95% CI 1·5–5·8]; padjusted=0·0023) after adjusting for relevant confounders. Compared with controls, patients were more likely to have MRI evidence of lung abnormalities (p=0·0001; parenchymal abnormalities), brain abnormalities (p<0·0001; more white matter hyperintensities and regional brain volume reduction), and kidney abnormalities (p=0·014; lower medullary T1 and loss of corticomedullary differentiation), whereas cardiac and liver MRI abnormalities were similar between patients and controls. Patients with multiorgan abnormalities were older (difference in mean age 7 years [95% CI 4–10]; mean age of 59·8 years [SD 11·7] with multiorgan abnormalities vs mean age of 52·8 years [11·9] without multiorgan abnormalities; p<0·0001), more likely to have three or more comorbidities (OR 2·47 [1·32–4·82]; padjusted=0·0059), and more likely to have a more severe acute infection (acute CRP >5mg/L, OR 3·55 [1·23–11·88]; padjusted=0·025) than those without multiorgan abnormalities. Presence of lung MRI abnormalities was associated with a two-fold higher risk of chest tightness, and multiorgan MRI abnormalities were associated with severe and very severe persistent physical and mental health impairment (PHOSP-COVID symptom clusters) after hospitalisation.
Interpretation:
After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification
Modulation of type-1 Ins(1,4,5)P3 receptor channels by the FK506-binding protein, FKBP12
- Publication venue
- 'Portland Press Ltd.'
- Publication date
- Field of study
Voltage-gating of Escherichia coli porin: a cystine-scanning mutagenesis study of loop 3 1 1Edited by I. B. Holland
- Author
- Berrier
- Bjorksten
- Buehler
- Chothia
- Cowan
- Dargent
- Dela Vega
- Derman
- Duché
- Edward J.A. Lea
- Geoffrey A. Armstrong
- Graeme Bainbridge
- Hamid Mobasheri
- Hazes
- Hirsch
- Jeanteur
- Jeanteur
- Jeremy H. Lakey
- Karshikoff
- Kreusch
- Lakey
- Lakey
- Lakey
- Lea
- Misra
- Misra
- Phale
- Przybylski
- Rudel
- Saint
- Saint
- Sarkar
- Schindler
- Schindler
- Schirmer
- Sen
- Soares
- Soares
- Strack
- Van Gelder
- Watanabe
- Weiss
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Correction to: An autosomal dominant neurological disorder caused by de novo variants in FAR1 resulting in uncontrolled synthesis of ether lipids (Genetics in Medicine, (2021), 23, 4, (740-750), 10.1038/s41436-020-01027-3)
- Author
- Acosta Maria T.
- Adam Margaret
- Adams David R.
- Agrawal Pankaj B.
- Alejandro Mercedes E.
- Alvey Justin
- Amendola Laura
- Andrews Ashley
- Ashley Euan A.
- Azamian Mahshid S.
- Bacino Carlos A.
- Bademci Guney
- Baker Eva
- Bakhtiari Somayeh
- Balasubramanyam Ashok
- Baldridge Dustin
- Bale Jim
- Bamshad Michael
- Barbouth Deborah
- Barth Magalie
- Bayrak-Toydemir Pinar
- Beck Anita
- Beggs Alan H.
- Begtrup Amber
- Behrens Edward
- Bejerano Gill
- Bennett Jimmy
- Berg-Rood Beverly
- Bernstein Jonathan A.
- Berry Gerard T.
- Bican Anna
- Bivona Stephanie
- Blue Elizabeth
- Bohnsack John
- Bonnenmann Carsten
- Bonner Devon
- Botto Lorenzo
- Boyd Brenna
- Brady Lauren
- Brault Jennifer
- Briere Lauren C.
- Brokamp Elly
- Brokamp Elly
- Brown Gabrielle
- Burke Elizabeth A.
- Burrage Lindsay C.
- Butte Manish J.
- Byers Peter
- Byrd William E.
- Carey John
- Carrasquillo Olveen
- Cassiman David
- Chang Ta Chen Peter
- Chanprasert Sirisak
- Chao Hsiao Tuan
- Chong Karen
- Clark Gary D.
- Coakley Terra R.
- Cobban Laurel A.
- Cogan Joy D.
- Coggins Matthew
- Cole F. Sessions
- Colley Heather A.
- Cooper Cynthia M.
- Cope Heidi
- Craigen William J.
- Crouse Andrew B.
- Cunningham Michael
- Dai Hongzheng
- Dasari Surendra
- Davis Joie
- Dayal Jyoti G.
- Deardorff Matthew
- Dell’Angelica Esteban C.
- Dhar Shweta U.
- Dipple Katrina
- Doherty Daniel
- Dorrani Naghmeh
- Doss Argenia L.
- Douglas Jessica
- Douine Emilie D.
- Drack Arlene V.
- Draper David D.
- Duncan Laura
- D’Souza Precilla
- Earl Dawn
- Eckstein David J.
- Ellingwood Sara
- Emrick Lisa T.
- Eng Christine M.
- Esteves Cecilia
- Falk Marni
- Ferdinandusse Sacha
- Fernandez Liliana
- Ferreira Carlos
- Fieg Elizabeth L.
- Findley Laurie C.
- Fisher Paul G.
- Fogel Brent L.
- Forghani Irman
- Fresard Laure
- Gaebler-Spira Deborah
- Gahl William A.
- Gahl William A.
- Glass Ian
- Gochuico Bernadette
- Godfrey Rena A.
- Golden-Grant Katie
- Goldman Alica M.
- Goldrich Madison P.
- Goldstein David B.
- Grajewski Alana
- Groden Catherine A.
- Guillen Sacoto Maria J.
- Gutierrez Irma
- Hahn Sihoun
- Hamid Rizwan
- Hanchard Neil A.
- Hassey Kelly
- Hayes Nichole
- High Frances
- Hing Anne
- Hisama Fuki M.
- Holm Ingrid A.
- Hom Jason
- Horike-Pyne Martha
- Huang Alden
- Huang Yong
- Huryn Laryssa
- IJlst Lodewijk
- Isasi Rosario
- Jamal Fariha
- Jarvik Gail P.
- Jarvik Jeffrey
- Jayadev Suman
- Karaviti Lefkothea
- Kelley Emily G.
- Kennedy Jennifer
- Kiley Dana
- Kohane Isaac S.
- Kohler Jennefer N.
- Korrick Susan
- Kozuira Mary
- Krakow Deborah
- Krasnewich Donna M.
- Kravets Elijah
- Krier Joel B.
- Kruer Michael C.
- Ladda Roger L.
- Lalani Seema R.
- Lam Byron
- Lam Christina
- LaMoure Grace L.
- Lanpher Brendan C.
- Lanza Ian R.
- Latham Lea
- LeBlanc Kimberly
- Lee Brendan H.
- Lee Hane
- Levitt Roy
- Lewis Richard A.
- Lincoln Sharyn A.
- Liu Pengfei
- Liu Xue Zhong
- Longo Nicola
- Loo Sandra K.
- Loscalzo Joseph
- Maas Richard L.
- MacDowall John
- Macnamara Ellen F.
- Macnamara Ellen F.
- MacRae Calum A.
- Maduro Valerie V.
- Majcherska Marta M.
- Mak Bryan C.
- Malicdan May Christine V.
- Mamounas Laura A.
- Manolio Teri A.
- Mao Rong
- Maravilla Kenneth
- Markello Thomas C.
- Marom Ronit
- Marth Gabor
- Martin Beth A.
- Martin Martin G.
- Martin Nicole
- Martínez-Agosto Julian A.
- Marwaha Shruti
- McCauley Jacob
- McConkie-Rosell Allyn
- McCormack Colleen E.
- McCray Alexa T.
- McGee Elisabeth
- McWalter Kirsty
- Mefford Heather
- Merritt J. Lawrence
- Might Matthew
- Millan Francisca
- Mirzaa Ghayda
- Mooijer Petra M.
- Morava Eva
- Moretti Paolo
- Moretti Paolo
- Mosbrook-Davis Deborah
- Mulvihill John J.
- Murdock David R.
- Nagy Anna
- Nakano-Okuno Mariko
- Nath Avi
- Nelson Stanley F.
- Newman John H.
- Nicholas Sarah K.
- Nickerson Deborah
- Nieves-Rodriguez Shirley
- Novacic Donna
- Nowak Catherine B.
- Oglesbee Devin
- Orengo James P.
- Pace Laura
- Pak Stephen
- Pallais J. Carl
- Palmer Christina G.S.
- Papp Jeanette C.
- Parker Neil H.
- Perlman Seth
- Perry Katherine Wesseling
- Phillips John A.
- Posey Jennifer E.
- Potocki Lorraine
- Power Bradley
- Pras-Raves Mia
- Pusey Barbara N.
- Quinlan Aaron
- Raja Archana N.
- Rao Deepak A.
- Raskind Wendy
- Renteria Genecee
- Reuter Chloe M.
- Rives Lynette
- Robertson Amy K.
- Rodan Lance H.
- Rosenfeld Jill A.
- Rosenwasser Natalie
- Rossignol Francis
- Ruiter Jos P.N.
- Ruzhnikov Maura
- Sacco Ralph
- Sampson Jacinda B.
- Samson Susan L.
- Saporta Mario
- Schaechter Judy
- Schedl Timothy
- Schoch Kelly
- Scott C. Ron
- Scott Daryl A.
- Sell Susan L.
- Shashi Vandana
- Shin Jimann
- Signer Rebecca H.
- Silverman Edwin K.
- Sinsheimer Janet S.
- Sisco Kathy
- Smith Edward C.
- Smith Kevin S.
- Smith Rosemarie
- Solem Emily
- Solnica-Krezel Lilianna
- Solomon Ben
- Spillmann Rebecca C.
- Stoler Joan M.
- Sullivan Jennifer A.
- Sullivan Kathleen
- Sun Angela
- Sutton Shirley
- Sweetser David A.
- Sybert Virginia
- Tabor Holly K.
- Tan Queenie K.G.
- Tarnopolsky Mark
- te Brinke Heleen
- Tekin Mustafa
- Telischi Fred
- Thorson Willa
- Thurm Audrey
- Tian Cuixia
- Tifft Cynthia J.
- Toro Camilo
- Toro Camilo
- Tran Alyssa A.
- Tucker Brianna M.
- Ulm Elizabeth
- Urv Tiina K.
- van Kampen Antoine H.C.
- van Lint Alida E.M.
- Vanderver Adeline
- Vaz Frédéric M.
- Velinder Matt
- Viskochil Dave
- Vogel Tiphanie P.
- Wahl Colleen E.
- Waisfisz Quinten
- Walker Melissa
- Wallace Stephanie
- Walley Nicole M.
- Walsh Chris A.
- Wambach Jennifer
- Wan Jijun
- Wanders Ronald J.A.
- Wang Lee kai
- Wangler Michael F.
- Ward Patricia A.
- Waterham Hans R.
- Wegner Daniel
- Wener Mark
- Wenger Tara
- Westerfield Monte
- Wever Eric
- Wheeler Matthew T.
- Whitlock Jordan
- Wolfe Lynne A.
- Wolfe Lynne A.
- Woods Jeremy D.
- Yamamoto Shinya
- Yang John
- Yousef Muhammad
- Zastrow Diane B.
- Zein Wadih
- Zhao Chunli
- Ziegler Alban
- Zuchner Stephan
- Zwijnenburg Petra J.G.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
In the original author list, Seth Perlman’s degrees were listed as MD, PhD. Dr Perlman’s degree is MD. The original version has been corrected
An autosomal dominant neurological disorder caused by de novo variants in FAR1 resulting in uncontrolled synthesis of ether lipids
- Author
- Acosta Maria T.
- Adam Margaret
- Adams David R.
- Agrawal Pankaj B.
- Alejandro Mercedes E.
- Alvey Justin
- Amendola Laura
- Andrews Ashley
- Ashley Euan A.
- Azamian Mahshid S.
- Bacino Carlos A.
- Bademci Guney
- Baker Eva
- Bakhtiari Somayeh
- Balasubramanyam Ashok
- Baldridge Dustin
- Bale Jim
- Bamshad Michael
- Barbouth Deborah
- Barth Magalie
- Bayrak-Toydemir Pinar
- Beck Anita
- Beggs Alan H.
- Begtrup Amber
- Behrens Edward
- Bejerano Gill
- Bennett Jimmy
- Berg-Rood Beverly
- Bernstein Jonathan A.
- Berry Gerard T.
- Bican Anna
- Bivona Stephanie
- Blue Elizabeth
- Bohnsack John
- Bonnenmann Carsten
- Bonner Devon
- Botto Lorenzo
- Boyd Brenna
- Brady Lauren
- Brault Jennifer
- Briere Lauren C.
- Brokamp Elly
- Brokamp Elly
- Brown Gabrielle
- Burke Elizabeth A.
- Burrage Lindsay C.
- Butte Manish J.
- Byers Peter
- Byrd William E.
- Carey John
- Carrasquillo Olveen
- Cassiman David
- Chang Ta Chen Peter
- Chanprasert Sirisak
- Chao Hsiao Tuan
- Chong Karen
- Clark Gary D.
- Coakley Terra R.
- Cobban Laurel A.
- Cogan Joy D.
- Coggins Matthew
- Cole F. Sessions
- Colley Heather A.
- Cooper Cynthia M.
- Cope Heidi
- Craigen William J.
- Crouse Andrew B.
- Cunningham Michael
- Dai Hongzheng
- Dasari Surendra
- Davis Joie
- Dayal Jyoti G.
- Deardorff Matthew
- Dell’Angelica Esteban C.
- Dhar Shweta U.
- Dipple Katrina
- Doherty Daniel
- Dorrani Naghmeh
- Doss Argenia L.
- Douglas Jessica
- Douine Emilie D.
- Drack Arlene V.
- Draper David D.
- Duncan Laura
- D’Souza Precilla
- Earl Dawn
- Eckstein David J.
- Ellingwood Sara
- Emrick Lisa T.
- Eng Christine M.
- Esteves Cecilia
- Falk Marni
- Ferdinandusse Sacha
- Fernandez Liliana
- Ferreira Carlos
- Fieg Elizabeth L.
- Findley Laurie C.
- Fisher Paul G.
- Fogel Brent L.
- Forghani Irman
- Fresard Laure
- Gaebler-Spira Deborah
- Gahl William A.
- Gahl William A.
- Glass Ian
- Gochuico Bernadette
- Godfrey Rena A.
- Golden-Grant Katie
- Goldman Alica M.
- Goldrich Madison P.
- Goldstein David B.
- Grajewski Alana
- Groden Catherine A.
- Guillen Sacoto Maria J.
- Gutierrez Irma
- Hahn Sihoun
- Hamid Rizwan
- Hanchard Neil A.
- Hassey Kelly
- Hayes Nichole
- High Frances
- Hing Anne
- Hisama Fuki M.
- Holm Ingrid A.
- Hom Jason
- Horike-Pyne Martha
- Huang Alden
- Huang Yong
- Huryn Laryssa
- IJlst Lodewijk
- Isasi Rosario
- Jamal Fariha
- Jarvik Gail P.
- Jarvik Jeffrey
- Jayadev Suman
- Karaviti Lefkothea
- Kelley Emily G.
- Kennedy Jennifer
- Kiley Dana
- Kohane Isaac S.
- Kohler Jennefer N.
- Korrick Susan
- Kozuira Mary
- Krakow Deborah
- Krasnewich Donna M.
- Kravets Elijah
- Krier Joel B.
- Kruer Michael C.
- Ladda Roger L.
- Lalani Seema R.
- Lam Byron
- Lam Christina
- LaMoure Grace L.
- Lanpher Brendan C.
- Lanza Ian R.
- Latham Lea
- LeBlanc Kimberly
- Lee Brendan H.
- Lee Hane
- Levitt Roy
- Lewis Richard A.
- Lincoln Sharyn A.
- Liu Pengfei
- Liu Xue Zhong
- Longo Nicola
- Loo Sandra K.
- Loscalzo Joseph
- Maas Richard L.
- MacDowall John
- Macnamara Ellen F.
- Macnamara Ellen F.
- MacRae Calum A.
- Maduro Valerie V.
- Majcherska Marta M.
- Mak Bryan C.
- Malicdan May Christine V.
- Mamounas Laura A.
- Manolio Teri A.
- Mao Rong
- Maravilla Kenneth
- Markello Thomas C.
- Marom Ronit
- Marth Gabor
- Martin Beth A.
- Martin Martin G.
- Martin Nicole
- Martínez-Agosto Julian A.
- Marwaha Shruti
- McCauley Jacob
- McConkie-Rosell Allyn
- McCormack Colleen E.
- McCray Alexa T.
- McGee Elisabeth
- McWalter Kirsty
- Mefford Heather
- Merritt J. Lawrence
- Might Matthew
- Millan Francisca
- Mirzaa Ghayda
- Mooijer Petra M.
- Morava Eva
- Moretti Paolo
- Moretti Paolo
- Mosbrook-Davis Deborah
- Mulvihill John J.
- Murdock David R.
- Nagy Anna
- Nakano-Okuno Mariko
- Nath Avi
- Nelson Stanley F.
- Newman John H.
- Nicholas Sarah K.
- Nickerson Deborah
- Nieves-Rodriguez Shirley
- Novacic Donna
- Nowak Catherine B.
- Oglesbee Devin
- Orengo James P.
- Pace Laura
- Pak Stephen
- Pallais J. Carl
- Palmer Christina G.S.
- Papp Jeanette C.
- Parker Neil H.
- Perlman Seth
- Perry Katherine Wesseling
- Phillips John A.
- Posey Jennifer E.
- Potocki Lorraine
- Power Bradley
- Pras-Raves Mia
- Pusey Barbara N.
- Quinlan Aaron
- Raja Archana N.
- Rao Deepak A.
- Raskind Wendy
- Renteria Genecee
- Reuter Chloe M.
- Rives Lynette
- Robertson Amy K.
- Rodan Lance H.
- Rosenfeld Jill A.
- Rosenwasser Natalie
- Rossignol Francis
- Ruiter Jos P.N.
- Ruzhnikov Maura
- Sacco Ralph
- Sampson Jacinda B.
- Samson Susan L.
- Saporta Mario
- Schaechter Judy
- Schedl Timothy
- Schoch Kelly
- Scott C. Ron
- Scott Daryl A.
- Sell Susan L.
- Shashi Vandana
- Shin Jimann
- Signer Rebecca H.
- Silverman Edwin K.
- Sinsheimer Janet S.
- Sisco Kathy
- Smith Edward C.
- Smith Kevin S.
- Smith Rosemarie
- Solem Emily
- Solnica-Krezel Lilianna
- Solomon Ben
- Spillmann Rebecca C.
- Stoler Joan M.
- Sullivan Jennifer A.
- Sullivan Kathleen
- Sun Angela
- Sutton Shirley
- Sweetser David A.
- Sybert Virginia
- Tabor Holly K.
- Tan Queenie K.G.
- Tarnopolsky Mark
- te Brinke Heleen
- Tekin Mustafa
- Telischi Fred
- Thorson Willa
- Thurm Audrey
- Tian Cuixia
- Tifft Cynthia J.
- Toro Camilo
- Toro Camilo
- Tran Alyssa A.
- Tucker Brianna M.
- Ulm Elizabeth
- Urv Tiina K.
- van Kampen Antoine H.C.
- van Lint Alida E.M.
- Vanderver Adeline
- Vaz Frédéric M.
- Velinder Matt
- Viskochil Dave
- Vogel Tiphanie P.
- Wahl Colleen E.
- Waisfisz Quinten
- Walker Melissa
- Wallace Stephanie
- Walley Nicole M.
- Walsh Chris A.
- Wambach Jennifer
- Wan Jijun
- Wanders Ronald J.A.
- Wang Lee kai
- Wangler Michael F.
- Ward Patricia A.
- Waterham Hans R.
- Wegner Daniel
- Wener Mark
- Wenger Tara
- Westerfield Monte
- Wever Eric
- Wheeler Matthew T.
- Whitlock Jordan
- Wolfe Lynne A.
- Wolfe Lynne A.
- Woods Jeremy D.
- Yamamoto Shinya
- Yang John
- Yousef Muhammad
- Zastrow Diane B.
- Zein Wadih
- Zhao Chunli
- Ziegler Alban
- Zuchner Stephan
- Zwijnenburg Petra J.G.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/04/2021
- Field of study
Purpose: In this study we investigate the disease etiology in 12 patients with de novo variants in FAR1 all resulting in an amino acid change at position 480 (p.Arg480Cys/His/Leu). Methods: Following next-generation sequencing and clinical phenotyping, functional characterization was performed in patients’ fibroblasts using FAR1 enzyme analysis, FAR1 immunoblotting/immunofluorescence, and lipidomics. Results: All patients had spastic paraparesis and bilateral congenital/juvenile cataracts, in most combined with speech and gross motor developmental delay and truncal hypotonia. FAR1 deficiency caused by biallelic variants results in defective ether lipid synthesis and plasmalogen deficiency. In contrast, patients’ fibroblasts with the de novo FAR1 variants showed elevated plasmalogen levels. Further functional studies in fibroblasts showed that these variants cause a disruption of the plasmalogen-dependent feedback regulation of FAR1 protein levels leading to uncontrolled ether lipid production. Conclusion: Heterozygous de novo variants affecting the Arg480 residue of FAR1 lead to an autosomal dominant disorder with a different disease mechanism than that of recessive FAR1 deficiency and a diametrically opposed biochemical phenotype. Our findings show that for patients with spastic paraparesis and bilateral cataracts, FAR1 should be considered as a candidate gene and added to gene panels for hereditary spastic paraplegia, cerebral palsy, and juvenile cataracts
Multiplicity dependence of inclusive J/ψ production at midrapidity in pp collisions at √s=13 TeV
- Author
- Acharya Shreyasi
- Adamová Dagmar
- Adler Alexander
- Adolfsson Jonatan
- Aggarwal Madan Mohan
- Aglieri Rinella Gianluca
- Agnello Michelangelo
- Agrawal Neelima
- Ahammed Zubayer
- Ahmad Shakeel
- Ahn Sang Un
- Akbar Zaenal
- Akindinov Alexander
- Al-Turany Mohammad
- Alam Sk Noor
- Albuquerque Danilo Silva de
- Aleksandrov Dmitry
- Alessandro Bruno
- Alfanda Haidar Mas’ud
- Alfaro Molina Jose Ruben
- Ali B.
- Ali Y.
- Alici Andrea
- Alizadehvandchali N.
- Alkin Anton
- Alme Johan
- Alt Torsten
- Altenkämper Lucas
- Altsybeev Igor
- Anaam M.N.
- Andrei Cristian
- Andreou D.
- Andronic Anton
- Angeletti M.
- Anguelov Venelin
- Anson Christopher Daniel
- Antinori Federico
- Antičić Tome
- Antonioli Pietro
- Apadula N.
- Aphecetche Laurent Bernard
- Appelshäuser Harald
- Arcelli Silvia
- Arnaldi Roberta
- Arratia M.
- Arsene Ionut Cristian
- Arslandok Mesut
- Arteche Díaz Raúl
- Augustinus Andre
- Averbeck Ralf Peter
- Aziz S.
- Azmi Mohd Danish
- Badalà A.
- Baek Y.W.
- Bagnasco S.
- Bai X.
- Bailhache R.
- Bala Renu
- Balbino A.
- Baldisseri Alberto
- Ball Markus
- Balouza S.
- Banerjee D.
- Barbera Roberto
- Barioglio L.
- Barnaföldi G.G.
- Barnby Lee Stuart
- Barret V.
- Bartalini P.
- Bartels C.
- Barth K.
- Bartsch Esther
- Baruffaldi F.
- Bastid Nicole
- Basu S.
- Batigne G.
- Batyunya B.
- Bauri D.
- Bazo Alba J.L.
- Bearden Ian Gardner
- Beattie C.
- Bedda C.
- Behera N.K.
- Belikov I.
- Bell Hechavarria A.D.C.
- Bellini F.
- Bellwied Rene
- Belyaev V.
- Bencedi G.
- Beole S.
- Bercuci A.
- Berdnikov Y.
- Berdnikova A.
- Berenyi D.
- Bertens Redmer Alexander
- Berzano D.
- Besoiu M.G.
- Betev Latchezar
- Bhasin Anju
- Bhat I.R.
- Bhat M.A.
- Bhatt H.
- Bhattacharjee Buddhadeb
- Bianchi A.
- Bianchi L.
- Bianchi N.
- Bielčík Jaroslav
- Bielčíková Jana
- Bilandzic A.
- Biro Gabor
- Biswas R.
- Biswas S.
- Blair J.T.
- Blau Dmitry S.
- Blume Christoph
- Boca G.
- Bock Friederike
- Bogdanov A.
- Boi S.
- Bok J.
- Boldizsár László
- Bolozdynya Alexander I.
- Bombara Marek
- Bonomi G.
- Borel Hervé
- Borissov Alexander
- Bossi H.
- Botta Elena
- Bratrud L.
- Braun-Munzinger Peter
- Bregant Marco
- Broz Michal
- Bruna Elena
- Bruno Giuseppe Eugenio
- Buckland M.D.
- Budnikov Dmitry
- Bufalino Stefania
- Bugnon O.
- Buncic Predrag
- Buthelezi Edith Zinhle
- Butt J.B.
- Bysiak S.A.
- Bühler Paul
- Büsching Henner
- Caffarri D.
- Caliva Alberto
- Calvo Villar Ernesto
- Camacho J.M.M.
- Camacho R.S.
- Camerini Paolo
- Canedo F.D.M.
- Capon A.A.
- Carnesecchi F.
- Caron R.
- Castro A.J.
- Casula Ester Anna Rita
- Catalano F.
- Ceballos Sanchez C.
- Chakraborty Pritam
- Chandra S.
- Chang W.
- Chapeland S.
- Chartier Marielle
- Chattopadhyay S.
- Chattopadhyay S.
- Chauvin A.
- Cheshkov C.
- Cheynis Brigitte
- Chibante Barroso V.
- Chinellato D.D.
- Cho S.
- Chochula P.
- Chowdhury T.
- Christakoglou Panagiotis
- Christensen C.H.
- Christiansen P.
- Chujo T.
- Cicalo C.
- Cifarelli L.
- Cilladi L.D.
- Cindolo F.
- Ciupek M.R.
- Clai G.
- Cleymans J.
- Colamaria F.
- Colella D.
- Collu Alberto
- Colocci M.
- Concas M.
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- Suaide Alexandre Alarcon do Passo
- Sugitate Toru
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- Vértesi R.
- Völkl Martin Andreas
- Wagner Boris
- Weber Michael
- Weber Steffen Georg
- Wegrzynek A.
- Wenzel Sandro Christian
- Wessels Johannes P.
- Wiechula Jens
- Wikne J.
- Wilk G.
- Wilkinson J.
- Willems G.A.
- Willsher E.
- Windelband Bernd
- Winn M.
- Witt William Edward
- Wright J.R.
- Wu Y.
- Xu R.
- Yalcin S.
- Yamaguchi Y.
- Yamakawa K.
- Yang S.
- Yano S.
- Yin Z.
- Yokoyama H.
- Yoo In-Kwon
- Yoon Jin-Hee
- Yuan S.
- Yuncu A.
- Yurchenko V.
- Zaccolo Valentina
- Zaman A.
- Zampolli Chiara
- Zanoli Henrique Jose Correia
- Zardoshti Nima
- Zarochentsev Andrey
- Zaviyalov Nikolaj
- Zbroszczyk Hanna Paulina
- Zhalov M.
- Zhang S.
- Zhang X.
- Zhang Z.
- Zherebchevskii V.
- Zhi Y.
- Zhou D.
- Zhou Y.
- Zhou Z.
- Zhu J.
- Zhu Y.
- Zichichi Antonino
- Zinovjev Gennady M.
- Zurlo Nicola
- Závada Petr
- Šafařík K.
- Šuljić Miljenko
- Šumbera Michal
- Publication venue
- 'Elsevier BV'
- Publication date
- 10/11/2020
- Field of study
Measurements of the inclusive J/ψ yield as a function of charged-particle pseudorapidity density dNch/dη in pp collisions at √s = 13 TeV with ALICE at the LHC are reported. The J/ψ meson yield is measured at midrapidity (|y| < 0.9) in the dielectron channel, for events selected based on the charged-particle multiplicity at midrapidity (|η| < 1) and at forward rapidity (−3.7 < η < −1.7 and 2.8 < η < 5.1); both observables are normalized to their corresponding averages in minimum bias events. The increase of the normalized J/ψ yield with normalized dNch/dη is significantly stronger than linear and dependent on the transverse momentum. The data are compared to theoretical predictions, which describe the observed trends well, albeit not always quantitatively
Deep Underground Neutrino Experiment (DUNE) Near Detector Conceptual Design Report
- Author
- Abed Abud Adam
- Abi Babak
- Acciarri Roberto
- Acero Mario
- Adamov Giorge
- Adams David
- Adinolfi Marco
- Aduszkiewicz Antoni
- Ahmad Zubayer
- Ahmed Jhanzeb
- Alion Tyler
- Alonso Monsalve Saul
- Alrashed Munerah
- Alt Christoph
- Alton Andrew
- Amedo Pablo
- Anderson John
- Andreopoulos Costas
- Andrews Michael P
- Andrianala Fenompanirina
- Andringa Sofia
- Anfimov Nikolay
- Ankowski Artur
- Antonova Maria
- Antusch Stefan
- Aranda-Fernandez Alfredo
- Ariga Akitaka
- Arnold Lukas
- Arroyave Manuel
- Asaadi Jonathan
- Aurisano Adam
- Aushev Vladimir
- Autiero Dario
- Ayala-Torres Marco Alberto
- Azfar Farrukh
- Back A.
- Back Henning
- Back John
- Backhouse Chris
- Baesso Paolo
- Bagaturia Iuri
- Bagby Linda
- Balasubramanian Supraja
- Baldi Pierre
- Baller Bruce
- Bambah Bindu
- Barao Fernando
- Barenboim Gabriela
- Barker Gary J
- Barkhouse Wayne
- Barnes Christopher
- Barr Giles
- Barranco Monarca Juan
- Barros Nuno
- Barrow Joshua
- Basharina-Freshville Anastasia
- Bashyal Amit
- Basque Vincent
- Batista das Chagas Ewerton
- Battat J.B. R.
- Battisti Federico
- Bay Fatih
- Bazo Alba José Luis
- Beacom John
- Bechetoille Edouard
- Behera Biswaranjan
- Belchior E.
- Bellantoni Leo
- Bellettini Giorgio
- Bellini Vincenzo
- Beltramello Olga
- Belver Daniel
- Benekos Nektarios
- Bento Neves Francisco
- Berkman Sophie
- Bernardini Paolo
- Berner Roman
- Berns Hans-Gerd
- Bertolucci Sergio
- Betancourt Minerba
- Betancur Rodríguez Amalia
- Bhattacharjee Maharnab
- Bhuller Shyam
- Bhuyan Bipul
- Biagi Simone
- Bian Jianming
- Biassoni Matteo
- Biery Kurt
- Bilki Burak
- Bishai Mary
- Bitadze Alexander
- Blake Andrew
- Blaszczyk Flor de Maria
- Blazey Gerald C
- Blucher Edward
- Boissevain Jan
- Bolognesi Sara
- Bolton Timothy
- Bomben Luca
- Bonesini Maurizio
- Bongrand Mathieu
- Bonini Filiberto
- Booth Alexander
- Booth Chris
- Bordoni Stefania
- Borkum Aran
- Boschi Tommaso
- Bostan Nilay
- Bour Petr
- Bourgeois Christian
- Boyd Steve B
- Boyden Daniel
- Bracinik Juraj
- Braga Davide
- Brailsford Dominic
- Brandt Andrew
- Bremer Johan
- Brew Christopher
- Brianne Eldwan
- Brice Stephen
- Brizzolari Claudia
- Bromberg Carl
- Brooijmans Gustaaf
- Brooke Jim
- Bross Alan
- Brunetti Giulia
- Brunetti Maria
- Buchanan Norman
- Budd Howard
- Cagnoli I.
- Caiulo Davide
- Calafiura Paolo
- Calcutt Jacob
- Calin Marius
- Calvez Steven
- Calvo Enrique
- Caminata Alessio
- Campanelli Mario
- Cankocak Kerem
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- de Almeida Rogerio
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- Dyshkant Alexandre S
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- Li Lingge
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- Spitz Joshua
- Spooner N.J. C.
- Spurgeon Kyle
- Staley Richard
- Stancari Michelle
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- Stein Raul
- Steiner Herbert M
- Stewart James
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- Teklu Abraham Meles
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- Terao Kazuhiro
- Ternes Christoph
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- Thea Alessandro
- Thompson Joshua
- Thorn Craig
- Timm Steven C
- Todd Jacob
- Tonazzo Alessandra
- Torbunov Dmitri
- Torti Marta
- Tortola Mariam
- Tortorici Francesco
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- Totani Dante
- Toups Matthew
- Touramanis Christos
- Travaglini R.
- Trevor Jason
- Trilov Stoyan
- Trzaska Wladyslaw
- Tsai Yun-Tse
- Tsamalaidze Zviadi
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- Tsverava Nikolozi
- Tufanli Serhan
- Tull Craig
- Tyley E.
- Tzanov Martin
- Uchida Melissa
- Urheim Jon
- Usher Tracy
- Uzunyan Sergey
- Vagins Mark
- Vahle Patricia
- Valdiviesso Gustavo
- Valencia Edgar
- Valerio P.
- Vallari Zoya
- Valle J.W. F.
- Vallecorsa Sofia
- Van Berg Rick
- Van de Water Richard
- Varanini Filippo
- Vargas Danaisis
- Varner Gary
- Vasel Justin
- Vasina Svetlana
- Vasseur Georges
- Vaughan Noah
- Vaziri Kamran
- Ventura Sandro
- Verdugo Antonio
- Vergani Stefano
- Vermeulen Milo
- Verzocchi Marco
- Vicenzi Matteo
- Vieira de Souza Henrique
- Vignoli Chiara
- Vilela Cristovao
- Viren Brett
- Vrba Tomas
- Wachala Tomasz
- Waldron Abigail
- Wallbank Michael
- Wang Hanguo
- Wang Jingbo
- Wang L.
- Wang M.H. L.S.
- Wang Yi
- Wang Yue
- Warburton Karl
- Warner David
- Wascko Morgan
- Waters David
- Watson Alan
- Weatherly Pierce
- Weber Alfons
- Weber Michele
- Wei Hanyu
- Weinstein Amanda
- Wenman Dan
- Wetstein Matthew
- White Andy
- Whitehead Leigh
- Whittington Denver
- Wilking Michael
- Wilkinson Callum
- Williams Zachary
- Wilson Fergus
- Wilson Robert
- Wolcott Jeremy
- Wongjirad Taritree
- Wood Anthony
- Wood Kevin
- Worcester Elizabeth
- Worcester Matthew
- Wret Clarence
- Wu Wanwei
- Wu Wenjie
- Xiao Yiwen
- Yandel Erin
- Yang Guang
- Yang Kang
- Yang Shaokai
- Yang Tingjun
- Yankelevich Alejandro
- Yershov Nikolai
- Yonehara Katsuya
- Young Tim
- Yu Bo
- Yu Haiwang
- Yu Jae
- Yuan Wenlong
- Zaki Rowan
- Zalesak Jaroslav
- Zambelli Laura
- Zamorano Bruno
- Zani Andrea
- Zazueta Luis
- Zeit Grace
- Zeller G.P.
- Zeller Geralyn
- Zennamo Joseph
- Zeug Kyle
- Zhang Chao
- Zhao Manhong
- Zhivun Elena
- Zhu Guanying
- Zilberman Perri
- Zimmerman Eric
- Zito Marco
- Zucchelli Stefano
- Zuklin Josef
- Zutshi Vishnu
- Zwaska Robert
- Publication venue
- 'MDPI AG'
- Publication date
- 01/01/2021
- Field of study
International audienceThe Deep Underground Neutrino Experiment (DUNE) is an international, world-class experiment aimed at exploring fundamental questions about the universe that are at the forefront of astrophysics and particle physics research. DUNE will study questions pertaining to the preponderance of matter over antimatter in the early universe, the dynamics of supernovae, the subtleties of neutrino interaction physics, and a number of beyond the Standard Model topics accessible in a powerful neutrino beam. A critical component of the DUNE physics program involves the study of changes in a powerful beam of neutrinos, i.e., neutrino oscillations, as the neutrinos propagate a long distance. The experiment consists of a near detector, sited close to the source of the beam, and a far detector, sited along the beam at a large distance. This document, the DUNE Near Detector Conceptual Design Report (CDR), describes the design of the DUNE near detector and the science program that drives the design and technology choices. The goals and requirements underlying the design, along with projected performance are given. It serves as a starting point for a more detailed design that will be described in future documents
Scintillation light detection in the 6-m drift-length ProtoDUNE Dual Phase liquid argon TPC
- Author
- Abed Abud Adam
- Abi Babak
- Acciarri Roberto
- Acero Mario
- Adames Marcio
- Adamov George
- Adamowski Mark
- Adams David
- Adinolfi Marco
- Aduszkiewicz Antoni
- Aguilar Jessica
- Ahmad Zubayer
- Ahmed Jhanzeb
- Aimard Benjamin
- Ali-Mohammadzadeh Behnam
- Alion Tyler
- Allison Kyle
- Alonso Monsalve Saul
- AlRashed Munera
- Alt Christoph
- Alton Andrew
- Alvarez Rodrigo
- Amedo Pablo
- Anderson John
- Andreopoulos Costas
- Andreotti Mirco
- Andrews Michael P.
- Andrianala Fenompanirina
- Andringa Sofia
- Anfimov Nikolay
- Ankowski Artur
- Antoniassi Marcelo
- Antonova Maria
- Antoshkin Alexander
- Antusch Stefan
- Aranda-Fernandez Alfredo
- Arellano Luciano
- Arnold Lukas
- Arroyave Manuel
- Asaadi Jonathan
- Asquith Lily
- Aurisano Adam
- Aushev Vladimir
- Autiero Dario
- Ayala Lara Victor
- Ayala-Torres Marco Alberto
- Azfar Farrukh
- Back Ashley
- Back Henning
- Back John
- Backhouse Chris
- Bagaturia Iuri
- Bagby Linda
- Balashov Nikita
- Balasubramanian Supraja
- Baldi Pierre
- Baller Bruce
- Bambah Bindu
- Barao Fernando
- Barenboim Gabriela
- Barham Alzas Pablo
- Barker Gary J.
- Barkhouse Wayne
- Barnes Christopher
- Barr Giles
- Barranco Monarca Juan
- Barros Adilson
- Barros Nuno
- Barrow Joshua
- Basharina-Freshville Anastasia
- Bashyal Amit
- Basque Vincent
- Batchelor Charlie
- Batista das Chagas Ewerton
- Battat J.B. R.
- Battisti Federico
- Bay Fatih
- Bazetto Maria Cecilia
- Bazo Alba José Luis
- Beacom John
- Bechetoille Edouard
- Behera Biswaranjan
- Beigbeder Christophe
- Bellantoni Leo
- Bellettini Giorgio
- Bellini Vincenzo
- Beltramello Olga
- Benekos Nektarios
- Benitez Montiel Carlos
- Bento Neves Francisco
- Berger Joshua
- Berkman Sophie
- Bernardini Paolo
- Berner Roman
- Bersani Andrea
- Bertolucci Sergio
- Betancourt Minerba
- Betancur Rodríguez Amalia
- Bevan Adrian
- Bezawada Yashwanth
- Bezerra T.J. C.
- Bhardwaj Akhil
- Bhatnagar Vipin
- Bhattacharjee Maharnab
- Bhattarai Devesh
- Bhuller Shyam
- Bhuyan Bipul
- Biagi Simone
- Bian Jianming
- Biassoni Matteo
- Biery Kurt
- Bilki Burak
- Bishai Mary
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- Coelho J.A. B.
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- de Mello Neto J.R. T.
- de Oliveira M.A. Leigui
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- Pec Viktor
- Peeters S.J. M.
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- Penzo Aldo
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- Pugnere Denis
- Qian Xin
- Raaf Jennifer L.
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- Spooner N.J. C.
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- Zazueta Luis
- Zeller Geralyn
- Zennamo Joseph
- Zetina L.M. Montañno
- Zeug Kyle
- Zhang Chao
- Zhang Shuaixiang
- Zhang Yuze
- Zhao Manhong
- Zhivun Elena
- Zhu Guanying
- Zimmerman Eric
- Zucchelli Stefano
- Zuklin Josef
- Zutshi Vishnu
- Zwaska Robert
- Publication venue
- Publication date
- 30/03/2022
- Field of study
DUNE is a dual-site experiment for long-baseline neutrino oscillation studies, neutrino astrophysics and nucleon decay searches. ProtoDUNE Dual Phase (DP) is a 6 × 6 × 6 m3 liquid argon time-projection-chamber (LArTPC) that recorded cosmic-muon data at the CERN Neutrino Platform in 2019–2020 as a prototype of the DUNE Far Detector. Charged particles propagating through the LArTPC produce ionization and scintillation light. The scintillation light signal in these detectors can provide the trigger for non-beam events. In addition, it adds precise timing capabilities and improves the calorimetry measurements. In ProtoDUNE-DP, scintillation and electroluminescence light produced by cosmic muons in the LArTPC is collected by photomultiplier tubes placed up to 7 m away from the ionizing track. In this paper, the ProtoDUNE-DP photon detection system performance is evaluated with a particular focus on the different wavelength shifters, such as PEN and TPB, and the use of Xe-doped LAr, considering its future use in giant LArTPCs. The scintillation light production and propagation processes are analyzed and a comparison of simulation to data is performed, improving understanding of the liquid argon properties.DUNE is a dual-site experiment for long-baseline neutrino oscillation studies, neutrino astrophysics and nucleon decay searches. ProtoDUNE Dual Phase (DP) is a 6x6x6m3 liquid argon time-projection-chamber (LArTPC) that recorded cosmic-muon data at the CERN Neutrino Platform in 2019-2020 as a prototype of the DUNE Far Detector. Charged particles propagating through the LArTPC produce ionization and scintillation light. The scintillation light signal in these detectors can provide the trigger for non-beam events. In addition, it adds precise timing capabilities and improves the calorimetry measurements. In ProtoDUNE-DP, scintillation and electroluminescence light produced by cosmic muons in the LArTPC is collected by photomultiplier tubes placed up to 7 m away from the ionizing track. In this paper, the ProtoDUNE-DP photon detection system performance is evaluated with a particular focus on the different wavelength shifters, such as PEN and TPB, and the use of Xe-doped LAr, considering its future use in giant LArTPCs. The scintillation light production and propagation processes are analyzed and a comparison of simulation to data is performed, improving understanding of the liquid argon properties
Measurement of electrons from semileptonic heavy-flavour hadron decays at midrapidity in pp and Pb–Pb collisions at √sNN = 5.02 TeV
- Author
- Acharya Shreyasi
- Adamová Dagmar
- Adhya S.P.
- Adler Alexander
- Adolfsson Jonatan
- Aggarwal Madan Mohan
- Aglieri Rinella Gianluca
- Agnello Michelangelo
- Agrawal Neelima
- Ahammed Zubayer
- Ahmad Shakeel
- Ahn Sang Un
- Akindinov Alexander
- Al-Turany Mohammad
- Alam Sk Noor
- Albuquerque Danilo Silva de
- Aleksandrov Dmitry
- Alessandro Bruno
- Alfanda Haidar Mas’ud
- Alfaro Molina Jose Ruben
- Ali B.
- Ali Y.
- Alici Andrea
- Alkin Anton
- Alme Johan
- Alt Torsten
- Altenkämper Lucas
- Altsybeev Igor
- Anaam M.N.
- Andrei Cristian
- Andreou D.
- Andrews Harry Arthur
- Andronic Anton
- Angeletti M.
- Anguelov Venelin
- Anson Christopher Daniel
- Antinori Federico
- Antičić Tome
- Antonioli Pietro
- Anwar Rafay
- Apadula N.
- Aphecetche Laurent Bernard
- Appelshäuser Harald
- Arcelli Silvia
- Arnaldi Roberta
- Arratia M.
- Arsene Ionut Cristian
- Arslandok Mesut
- Arteche Díaz Raúl
- Augustinus Andre
- Averbeck Ralf Peter
- Aziz S.
- Azmi Mohd Danish
- Badalà A.
- Baek Y.W.
- Bagnasco S.
- Bai X.
- Bailhache R.
- Bala Renu
- Baldisseri Alberto
- Ball Markus
- Balouza S.
- Baral R.C.
- Barbera Roberto
- Barioglio L.
- Barnaföldi Gergely Gábor
- Barnby Lee Stuart
- Barret V.
- Bartalini P.
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- Baruffaldi F.
- Bastid Nicole
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- Batigne G.
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- Botta Elena
- Bratrud L.
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- Broker T.A.
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- Buthelezi Edith Zinhle
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- Suaide Alexandre Alarcon do Passo
- Sugitate Toru
- Suire Christophe Pierre
- Suleymanov Mais Kazim Oglu
- Sultanov Rishat
- Sumowidagdo Suharyo
- Suzuki Ken
- Swain Sagarika
- Szabo Alexander
- Szarka Imrich
- Tabassam Uzma
- Taillepied G.
- Takahashi Jun
- Tambave Ganesh Jagannath
- Tang S.
- Tarhini Mohamad
- Tarzila Madalina-Gabriela
- Tauro Arturo
- Tejeda Muñoz Guillermo
- Telesca Adriana
- Terrevoli Cristina
- Thakur Dhananjaya
- Thakur Sanchari
- Thomas Deepa
- Thoresen Freja
- Tieulent Raphael Noel
- Tikhonov Anatoly
- Timmins Anthony Robert
- Toia Alberica
- Topilskaya Nataliya
- Toppi Marco
- Torales Acosta Fernando
- Trifiro A.
- Tripathy Sushanta
- Tripathy Tulika
- Trogolo Stefano
- Trombetta Giuseppe
- Tropp Lukas
- Trubnikov Victor
- Trzaska Wladyslaw Henryk
- Trzcinski Tomasz Piotr
- Trzeciak Barbara Antonina
- Tsuji Tomoya
- Tumkin Alexandr
- Turrisi Rosario
- Tveter Trine Spedstad
- Ullaland Kjetil
- Umaka Ejiro Naomi
- Uras Antonio
- Usai Gianluca
- Utrobicic Antonija
- Vala Martin
- Valle N.
- Vallero S.
- van der Kolk N.
- van Doremalen L.V.R.
- Varga Dezsö
- Varga Z.
- Varga-Kofarago Monika
- Vargas A.
- Vargyas Márton
- Varma Raghava
- Vasileiou Maria
- Vasiliev Andrey
- Vazquez Rueda Omar
- Vechernin Vladimir
- Veen Annelies Marianne
- Vercellin Ermanno
- Vergara Limón Sergio
- Vermunt L.
- Vernet Renaud
- Vicencio M.G.D.L.C.
- Vicković Linda
- Viinikainen Jussi Samuli
- Vilakazi Zabulon
- Villalobos Baillie Orlando
- Villatoro Tello Abraham
- Vino G.
- Vinogradov Alexander A.
- Virgili Tiziano
- Vislavicius Vytautas
- Vodopyanov Alexander
- Volkel Benedikt
- Voloshin Kirill
- Voloshin Sergei
- Volpe Giacomo
- Vorobyev Ivan
- Voscek Dominik
- Vrláková Janka
- Vyvre Pierre vande
- Vázquez Doce Oton
- Vértesi Róbert
- Völkl Martin Andreas
- Wagner Boris
- Watanabe Yosuke
- Weber Michael
- Weber Steffen Georg
- Wegrzynek Adam Tadeusz
- Weiser Dennis
- Wenzel Sandro Christian
- Wessels Johannes P.
- Widmann E.
- Wiechula Jens
- Wikne Jon
- Wilk Grzegorz Andrzej
- Wilkinson Jeremy
- Willems Guido Alexander
- Willsher Emily Jade
- Windelband Bernd
- Witt William Edward
- Wu Y.
- Xu R.
- Yalcin Serpil
- Yamakawa Kosei
- Yang S.
- Yano Satoshi
- Yin Zhongbao
- Yokoyama Hiroki
- Yoo In-Kwon
- Yoon Jin-Hee
- Yuan S.
- Yurchenko Volodymyr
- Yüncü Alperen
- Zaccolo Valentina
- Zaman Ali
- Zampolli Chiara
- Zanoli Henrique Jose Correia
- Zardoshti Nima
- Zarochentsev Andrey
- Zaviyalov Nikolaj
- Zbroszczyk Hanna Paulina
- Zhalov Mikhail
- Zhang Xiaoming
- Zhang Z.
- Zhao C.
- Zherebchevskii V.
- Zhigareva Natalia
- Zhou Daicui
- Zhou You
- Zhou Zhuo
- Zhu Jianhui
- Zhu Y.
- Zichichi Antonino
- Zimmermann Markus Bernhard
- Zinovjev Gennady M.
- Zurlo Nicola
- Závada Petr
- Šafařík Karel
- Šefčík Michal
- Šuljić Miljenko
- Šumbera Michal
- Publication venue
- 'Elsevier BV'
- Publication date
- 20/03/2020
- Field of study
The differential invariant yield as a function of transverse momentum (pT) of electrons from semileptonic heavy-flavour hadron decays was measured at midrapidity in central (0–10%), semi-central (30–50%) and peripheral (60–80%) lead–lead (Pb–Pb) collisions at √sNN = 5.02 TeV in the pT intervals 0.5–26 GeV/c (0–10% and 30–50%) and 0.5–10 GeV/c (60–80%). The production cross section in proton–proton (pp) collisions at √s = 5.02 TeV was measured as well in 0.5 < pT < 10 GeV/c and it lies close to the upper band of perturbative QCD calculation uncertainties up to pT = 5 GeV/c and close to the mean value for larger pT. The modification of the electron yield with respect to what is expected for an incoherent superposition of nucleon–nucleon collisions is evaluated by measuring the nuclear modification factor RAA. The measurement of the RAA in different centrality classes allows in-medium energy loss of charm and beauty quarks to be investigated. The RAA shows a suppression with respect to unity at intermediate pT, which increases while moving towards more central collisions. Moreover, the measured RAA is sensitive to the modification of the parton distribution functions (PDF) in nuclei, like nuclear shadowing, which causes a suppression of the heavy-quark production at low pT in heavy-ion collisions at LHC
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