Thyroid hormones correlate with field metabolic rate in ponies, Equus ferus caballus

Acknowledgments The authors thank Jürgen Dörl for technical help and for taking care of the animals and Peter Thompson for technical assistance with the doubly labelled water analysis. Funding The study was supported by a grant from the German Research Foundation (DFG;GE 704/13-1).Peer reviewedPublisher PD

Chief Digital Officers and Environmental Performance in Complex Settings

This paper studies the impact of a chief digital officer (CDO) on corporate environmental performance. Drawing on the upper echelons theory and the attention-based view, we examine whether and under what environmental contingencies the presence of a CDO affects a firm’s environmental performance. To test our theory, we use a dataset of 514 publicly-traded U.S. firms and analyze their greenhouse gas (GHG) emissions from 2005 to 2021. Our results show that the presence of a CDO is negatively associated with GHG emissions and that environmental complexity moderates this relationship. Thereby, we extend the understanding of the outcomes of new functional top management team members and contribute by bringing the industry environmental level into the analysis. In addition, the results encourage managers to consider corporate environmental performance outcomes and environmental contingencies when deciding whether to implement a CDO role

Too Drained from Being Agile? The Self-Regulatory Effects of the Use of Agile ISD Practices and their Consequences on Turnover Intention

While much is known about the beneficial effects of agile information systems development (ISD), scholars have largely neglected to address its potential downsides. Specifically, research on this topic has thus far overlooked the ambivalent implications of the specific demands placed on developers working in agile ISD teams, including potentially depleting effects. Drawing on ego depletion theory and the associated literature, we provide a more balanced view and introduce self-regulatory resource depletion triggered by using agile ISD practices—encompassing software development (SD) and project management (PM) practices—as a theoretical perspective on why agile developers experience different levels of work-related fatigue that lead to stronger or weaker turnover intentions. Furthermore, we propose that due to the specific way in which agile ISD methods organize ISD project work, developers’ perceived workload influences the intensity by which agile ISD practices affect self-regulatory resources and developers’ feelings of fatigue. We examined our research model using a multimethod approach including quantitative and qualitative data. We found that the use of agile SD practices enhances developers’ self-regulatory resources and reduces fatigue and turnover intention. Our results also show that perceived workload strengthens the energizing effects of the use of agile SD practices and reveals a depleting effect of the use of agile PM practices, with countervailing implications for turnover intention. This study contributes to agile ISD literature by drawing a more nuanced and balanced picture with both resource-enhancing and resource-draining effects of the use of agile ISD practices. Finally, we give managerial advice regarding factors to consider when designing and managing agile ISD projects

The expression of stlA in Photorhabdus luminescens is controlled by nutrient limitation

Photorhabdus is a genus of Gram-negative entomopathogenic bacteria that also maintain a mutualistic association with nematodes from the family Heterorhabditis. Photorhabdus has an extensive secondary metabolism that is required for the interaction between the bacteria and the nematode. A major component of this secondary metabolism is a stilbene molecule, called ST. The first step in ST biosynthesis is the non-oxidative deamination of phenylalanine resulting in the production of cinnamic acid. This reaction is catalyzed by phenylalanine-ammonium lyase, an enzyme encoded by the stlA gene. In this study we show, using a stlA-gfp transcriptional fusion, that the expression of stlA is regulated by nutrient limitation through a regulatory network that involves at least 3 regulators. We show that TyrR, a LysR-type transcriptional regulator that regulates gene expression in response to aromatic amino acids in E. coli, is absolutely required for stlA expression. We also show that stlA expression is modulated by σS and Lrp, regulators that are implicated in the regulation of the response to nutrient limitation in other bacteria. This work is the first that describes pathway-specific regulation of secondary metabolism in Photorhabdus and, therefore, our study provides an initial insight into the complex regulatory network that controls secondary metabolism, and therefore mutualism, in this model organism

Ties That No Longer Bind? Effects and Responsiveness of Party Attachments in a Period of Crises

Party attachments shape perceptions of the political context, but neither are they fixed nor do they completely blind supporters to the political reality. When severe societal challenges such as the European debt or refugee crises force parties to change their policies or make formerly inconsequential positions salient and thus relevant, party identifiers may find their policy preferences at odds with their party identification. This may lead party supporters to adopt their party’s position. However, if the inconsistent position is sufficiently important, party identifiers may also loosen the ties to their party. We use individual-level data from the GLES campaign panels 2009-2017 to show how these crises have prompted identifiers to follow the party line in some cases, but have even more often weakened or even eroded party attachments among supporters who hold strong positions. In effect, the European debt crisis and particularly the European refugee crisis appear to have contributed to an issue-based reshuffling of the partisan balance in German politics

Seasonal changes in energy expenditure, body temperature and activity patterns in llamas (Lama glama)

The authors thank Knut Salzmann und Arne Oppermann for technical help and for taking care of the animals and Anna Stölzl for help with the administering of the ruminal unit of the telemetry system. The study was supported by a grant from the German Research Foundation (DFG) to A.R. (RI 1796/3-1).Peer reviewedPublisher PD

Mechanisms of toxicity mediated by neutrophil and eosinophil granule proteins.

Neutrophils and eosinophils are granulocytes which are characterized by the presence of granules in the cytoplasm. Granules provide a safe storage site for granule proteins that play important roles in the immune function of granulocytes. Upon granulocytes activation, diverse proteins are released from the granules into the extracellular space and contribute to the fight against infections. In this article, we describe granule proteins of both neutrophils and eosinophils able to kill pathogens and review their anticipated mechanism of antimicrobial toxicity. It should be noted that an excess of granules protein release can lead to tissue damage of the host resulting in chronic inflammation and organ dysfunction

THE CIRCULAR MODEL OF SOME PADA PENGELOLAAN MEDIA SOSIAL INSTAGRAM FORUM HUMAN CAPITAL INDONESIA

Keberadaan media sosial digunakan oleh perusahaan atau organisasi untuk melakukan kegiatan komunikasi, seperti sarana publikasi, sarana kehumasan, promosi, dan lain-lain, salah satunya yaitu Forum Human Capital Indonesia. Tujuan dari penelitian ini adalah melihat bagaimana pengelolaan Instagram @fhci.bumn oleh tim komunikasi Forum Human Capital Indonesia yang dikaji melalui The Circular Model of Some. The Circular Model of Some merupakan salah satu model yang terdiri dari empat tahap, yaitu share, optimize, manage, dan engage. Pada tahap share, dibagi menjadi tiga bagian, yaitu participate, connect, dan build trust. Tahap optimize, ada dua bagian, yaitu listen and learn dan take part in authentic communication. Tahap manage memiliki tiga bagian, diantaranya media monitoring, quick responses, dan real-time interaction. Terakhir, adalah tahap engage, dimana pada tahap ini terdiri atas dua bagian, yaitu influencer dan interactivity. Penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian deskriptif dengan paradigma konstruktivisme. Penelitian ini menggunakan teknik pengumpulan data wawancara mendalam terhadap tiga narasumber, observasi dilokasi penelitian, dan dokumentasi peneliti seperti berkas, foto kegiatan, dan lainnya. Hasil penelitian ini menyatakan bahwa pengelolaan media sosial Instagram Forum Human Capital Indonesia dilakukan dalam empat tahap. Pada tahapan share, penggunaan Instagram oleh Forum Human Capital Indonesia dilatar belakangi kemudahan akses, mereka memiliki target dari Instagram yaitu para penggiat human capital dan pencari kerja, dan dalam membangun kepercayaan publik, mereka menampilkan informasi perusahaan di profil mereka dan berkolaborasi dengan Kementerian Badan Usaha Milik Negara di konten mereka. Pada tahap optimize, konten dibuat berdasarkan apa yang sedang trending namun tetap mempertimbangkan keinginan audiens, membuka ruang diskusi bagi followers dan menjaga komunikasi dengan followers. Pada tahap manage, pemantauan media dilakukan secara manual dan hanya memanfaatkan fitur Instagram, respon cepat dan interaksi real-time yang optimal karena tim komunikasi merespon secepat mungkin. Dalam proses engage, Forum Human Capital Indonesia memiliki brand influencer, yaitu Erick Thohir dan Alexandra Askandar, dan mereka memiliki konten interaktif, seperti teka-teki silang dan tebak logo BUMN. Pada penelitian ini, dapat disimpulkan bahwa tim komunikasi Forum Human Capital Indonesia melaksanakan pengelolaan Instagram mereka yang terbagi kedalam beberapa tahapan sesuai dengan The Circular Model of Some. ***** The existence of social media is used by companies or organizations to carry out communication activities, such as means of publication, public relations facilities, promotions, and others, one of which is the Indonesian Human Capital Forum. The Instagram Human Capital Forum Indonesia has the most followers among other social media owned and managed properly in 2021. The purpose of this research is to see how Forum Human Capital Indonesia’s Instagram is managed by communication team of Forum Human Capital Indonesia which is reviewed through The Circular Models of Some. The Circular Model of Some is a model that consists of four stages, namely share, optimize, manage, and engage. In the share stage, there are three parts that support this stage, namely participate, connect, and build trust. In the optimize stage, there are two parts, namely listen and learn and take part in authentic communication. The manage stage has three parts, including media monitoring, quick responses, and real-time interaction. Lastly, is the engage stage, which at this stage consists of two parts, namely influencer and interactivity. This study uses a qualitative approach with descriptive research type with constructivism paradigm. This study uses in-depth interview data collection techniques to three sources, observations at the research location, and researcher documentation such as files, photos of activities, and others. The results of this study state that the management of social media Instagram Forum Human Capital Indonesia is carried out in four stages. At the share stage, the use of Instagram by Forum Human Capital Indonesia is based on ease of access, they have Instagram's target of human capital activists and job seekers, and in building public trust, they display company information on their profiles and collaborate with the Ministry of Owned Enterprises. Country in their content. At the optimize stage, content is created based on what is trending but still considers the wishes of the audience, opens discussion space for followers and maintains communication with followers. In the manage stage, media monitoring is done manually and only utilizes Instagram features, fast response and optimal real-time interaction because the communication team responds as quickly as possible. In the process of engagement, the Indonesian Human Capital Forum has brand influencers, namely Erick Thohir and Alexandra Askandar, and they have interactive content, such as crossword puzzles and guessing the logo of BUMN. In this study, it can be concluded that Forum Human Capital Indonesia’s communication team carries out their Instagram management which is divided into several stages according to The Circular Model of Some