The role of the lateral amygdala in the retrieval and maintenance of fear-memories formed by repeated probabilistic reinforcement

The lateral nucleus of the amygdala (LA) is a key element in the neural circuit subserving Pavlovian fear-conditioning, an animal model of fear and anxiety. Most studies have focused on the role of the LA in fear acquisition and extinction, i.e., how neural plasticity results from changing contingencies between a neutral conditioned stimulus (CS) (e.g., a tone) and an aversive unconditioned stimulus (US) (e.g., a shock). However, outside of the lab, fear-memories are often the result of repeated and unpredictable experiences. Examples include domestic violence, child abuse or combat. To better understand the role of the LA in the expression of fear resulting from repeated and uncertain reinforcement, rats experienced a 30% partial reinforcement (PR) fear-conditioning schedule four days a week for four weeks. Rats reached asymptotic levels of conditioned-fear expression after the first week. We then manipulated LA activity with drug (or vehicle) (VEH) infusions once a week, for the next three weeks, before the training session. LA infusions of muscimol (MUSC), a GABA-A agonist that inhibits neural activity, reduced CS evoked fear-behavior to pre-conditioning levels. LA infusions of pentagastrin (PENT), a cholecystokinin-2 (CCK) agonist that increases neural excitability, resulted in CS-evoked fear-behavior that continued past the offset of the CS. This suggests that neural activity in the LA is required for the retrieval of fear memories that stem from repeated and uncertain reinforcement, and that CCK signaling in the LA plays a role in the recovery from fear after the removal of the fear-evoking stimulus

Monsters, black holes and the statistical mechanics of gravity

We review the construction of monsters in classical general relativity. Monsters have finite ADM mass and surface area, but potentially unbounded entropy. From the curved space perspective they are objects with large proper volume that can be glued on to an asymptotically flat space. At no point is the curvature or energy density required to be large in Planck units, and quantum gravitational effects are, in the conventional effective field theory framework, small everywhere. Since they can have more entropy than a black hole of equal mass, monsters are problematic for certain interpretations of black hole entropy and the AdS/CFT duality. In the second part of the paper we review recent developments in the foundations of statistical mechanics which make use of properties of high-dimensional (Hilbert) spaces. These results primarily depend on kinematics -- essentially, the geometry of Hilbert space -- and are relatively insensitive to dynamics. We discuss how this approach might be adopted as a basis for the statistical mechanics of gravity. Interestingly, monsters and other highly entropic configurations play an important role.Comment: 9 pages, 4 figures, revtex; invited Brief Review to be published in Modern Physics Letters

Simulations of Damped Lyman-Alpha and Lyman Limit Absorbers in Different Cosmologies: Implications for Structure Formation at High Redshift

We use hydrodynamic cosmological simulations to study damped Lyman-alpha (DLA) and Lyman limit (LL) absorption at redshifts z=2-4 in five variants of the cold dark matter scenario. Our standard simulations resolve the formation of dense concentrations of neutral gas in halos with circular velocity v_c roughly 140 km/s for Omega_m=1 and 90 km/s for Omega_m=0.4, at z=2; an additional LCDM simulation resolves halos down to v_c approximately 50 km/s at z=3. We find a clear relation between HI column density and projected distance to the center of the nearest galaxy, with DLA absorption usually confined to galactocentric radii less than 10-15 kpc and LL absorption arising out to projected separations of 30 kpc or more. Detailed examination provides evidence of non-equilibrium effects on absorption cross-section. If we consider only absorption in the halos resolved by our standard simulations, then all five models fall short of reproducing the observed abundance of DLA and LL systems at these redshifts. If we extrapolate to lower halo masses, we find all four models are consistent with the observed abundance of DLA systems if the the extrapolated behavior extends to circular velocities roughly 50-80 km/s, and they may produce too much absorption if the relation continues to 40 km/s. Our results suggest that LL absorption is closely akin to DLA absorption, arising in less massive halos or at larger galactocentric radii but not caused by processes acting on a radically different mass scale.Comment: 33 pages with 10 embedded EPS figures. Substantially revised and updated from original version. Includes new high-resolution simulations. Accepted for publication in the Ap

Dust Emission Features in NGC 7023 between 0.35 and 2.5 micron: Extended Red Emission (0.7 micron) and Two New Emission Features (1.15 and 1.5 micron)

We present 0.35 to 2.5 micron spectra of the south and northwest filaments in the reflection nebula NGC 7023. These spectra were used to test the theory of Seahra & Duley that carbon nanoparticles are responsible for Extended Red Emission (ERE). Our spectra fail to show their predicted second emission band at 1.0 micron even though both filaments exhibit strong emission in the familiar 0.7 micron ERE band. The northwest filament spectrum does show one, and possibly two, new dust emission features in the near-infrared. We clearly detect a strong emission band at 1.5 micron which we tentatively attribute to beta-FeSi_2 grains. We tentatively detect a weaker emission band at 1.15 micron which coincides with the location expected for transitions from the conduction band to mid-gap defect states of silicon nanoparticles. This is added evidence that silicon nanoparticles are responsible for ERE as they already can explain the observed behavior of the main visible ERE band.Comment: 9 pages, color figures, accepted to the ApJ, color and b/w versions available at http://dirty.as.arizona.edu/~kgordon/papers/ere_1um.htm

Measuring the Halo Mass of z=3 Damped Ly-alpha Absorbers from the Absorber-Galaxy Cross-correlation

[Abridged] We test the reliability of a method to measure the mean halo mass of Damped Ly-alpha absorbers (DLAs). The method is based on measuring the ratio of the cross-correlation between DLAs and galaxies to the auto-correlation of the galaxies themselves ($w_{\rm dg}/w_{\rm gg}$), which is (in linear theory) the ratio of their bias factor. This is shown to be true irrespective of the galaxy redshift distribution, provided that one uses the same galaxies for the two correlation functions. The method is applicable to all redshifts. Here, we focus on z=3 DLAs and we demonstrate that the method robustly constrains the mean DLA halo mass using smoothed particle hydrodynamics (SPH) cosmological simulations. If we use the bias formalism of Mo & White with the DLA and galaxy mass distributions of these simulations, we predict a bias ratio of 0.771. Direct measurement from the simulations of $w_{\rm dg}/w_{\rm gg}$ st yields a ratio of 0.73+/-0.08, in excellent agreement with that prediction. Equivalently, inverting the measured correlation ratio to infer a mean DLA halo mass yields (log. averaging, in solar units) =11.13+/-013, in excellent agreement with the true value in the simulations: 11.16. The cross- correlation method thus appears to yield a robust estimate of the average host halo mass even though the DLAs and the galaxies occupy a broad mass spectrum of halos, and massive halos contain multiple galaxies with DLAs. We show that the inferred mean DLA halo mass is independent of the galaxy sub-sample used, i.e. the cross-correlation technique is also reliable. Our results imply that the cross-correlation length between DLAs and LBGs is predicted to be, at most, 2.85 Mpc. Future observations will soon distinguish models in which DLAs are in low mass halos from those in which DLAs are in massive halos.Comment: 15 pages, 7 figures, to be published in ApJ 2005 July 20th (Full resolution of Fig.2 at http://www.mpe.mpg.de/~nbouche/papers/Xcorr/f2-orig.eps); minor changes to match the published tex

Effects of Aflatoxin B1 and Fumonisin B1 on Blood Biochemical Parameters in Broilers

The individual and combined effects of dietary aflatoxin B1 (AFB1) and fumonisin B1 (FB1) on liver pathology, serum levels of aspartate amino-transferase (AST) and plasma total protein (TP) of broilers were evaluated from 8 to 41 days of age. Dietary treatments included a 3 × 3 factorial arrangement with three levels of AFB1 (0, 50 and 200 μg AFB1/kg), and three levels of FB1 (0, 50 and 200 mg FB1/kg). At 33 days post feeding, with the exception of birds fed 50 mg FB1 only, concentrations of AST were higher (p < 0.05) in all other treatment groups when compared with controls. Plasma TP was lower (p < 0.05) at six days post feeding in groups fed 200 μg AFB1/kg alone or in combination with FB1. At day 33 days post feeding, with the exception of birds fed the highest combination of AFB1 and FB1 which had higher plasma TP than control birds, plasma TP of birds fed other dietary treatments were similar to controls. Broilers receiving the highest levels of AFB1 and FB1 had bile duct proliferation and trabecular disorder in liver samples. AFB1 singly or in combination with FB at the levels studied, caused liver damage and an increase in serum levels of AST

Digital Signal Processing

Contains reports on twelve research projects.U. S. Navy - Office of Naval Research (Contract N00014-75-C-0951)National Science Foundation (Grant ENG76-24117)National Aeronautics and Space Administration (Grant NSG-5157)Joint Services Electronics Program (Contract DAABO7-76-C-1400)U.S. Navy-Office of Naval Research (Contract N00014-77-C-0196)Woods Hole Oceanographic InstitutionU. S. Navy - Office of Naval Research (Contract N00014-75-C-0852)Department of Ocean Engineering, M.I.T.National Science Foundation subcontract to Grant GX 41962 to Woods Hole Oceanographic Institutio

Digital Signal Processing

Contains a research summary and reports on fifteen research projects.National Science Foundation FellowshipJoint Services Electronics Program (Contract DAAG29-78-C-0020)National Science Foundation (Grant ENG76-24117)U.S. Navy - Office of Naval Research (Contract N00014-75-C-0951)National Science Foundation (Grant ENG76-24117)Schlumberger-Doll Research Center FellowshipHertz Foundation FellowshipNational Aeronautics and Space Administration (Grant NSG-5157)U.S. Navy - Office of Naval Research (Contract N00014-77-C-0196

F.A.R.O.G. FORUM, Vol. 5 No. 8

https://digitalcommons.library.umaine.edu/francoamericain_forum/1064/thumbnail.jp

Is There Such a Thing as Psychological Pain? and Why It Matters

Medicine regards pain as a signal of physical injury to the body despite evidence contradicting the linkage and despite the exclusion of vast numbers of sufferers who experience psychological pain. By broadening our concept of pain and making it more inclusive, we would not only better accommodate the basic science of pain but also would recognize what is already appreciated by the layperson—that pain from diverse sources, physical and psychological, share an underlying felt structure