13,764 research outputs found
Visible-light promoted atom transfer radical addition-elimination (ATRE) reaction for the synthesis of fluoroalkylated alkenes using DMA as electron-donor
Here, we describe a mild, catalyst-free and operationally-simple strategy for the direct fluoroalkylation of olefins driven by the photochemical activity of an electron donor-acceptor (EDA) complex between DMA and fluoroalkyl iodides. The significant advantages of this photochemical transformation are high efficiency, excellent functional group tolerance, and synthetic simplicity, thus providing a facile route for further application in pharmaceuticals and life sciences
(1R*,2S*)-2-Nitro-1-(4-nitrophenyl)propanol
The title compound, C9H10N2O5, presents a racemic mixture of two enantiomeric diastereomers. In the crystal, molecules assemble into zigzag chains parallel to the b axis [C(6) motif] due to the formation of elongated O—H⋯O(N) hydrogen bonds. Of interest is the fact that only the aliphatic nitro group is involved in hydrogen bonding and it adopts a gauche conformation with respect to the OH group
An adaptive scheduling scheme for fair bandwidth allocation
Class-based service differentiation is provided in DiffServ networks. However, this differentiation will be disordered under dynamic traffic loads due to the fixed weighted scheduling. An adaptive weighted scheduling scheme is proposed in this paper to achieve fair bandwidth allocation among different service classes. In this scheme, the number of active flows and the subscribed bandwidth are estimated based on the measurement of local queue metrics, then the scheduling weights of each service class are adjusted for the per-flow fairness of excess bandwidth allocation. This adaptive scheme can be combined with any weighted scheduling algorithm. Simulation results show that, comparing with fixed weighted scheduling, it effectively improve the fairness of excess bandwidth allocation
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MTR4 drives liver tumorigenesis by promoting cancer metabolic switch through alternative splicing.
The metabolic switch from oxidative phosphorylation to glycolysis is required for tumorigenesis in order to provide cancer cells with energy and substrates of biosynthesis. Therefore, it is important to elucidate mechanisms controlling the cancer metabolic switch. MTR4 is a RNA helicase associated with a nuclear exosome that plays key roles in RNA processing and surveillance. We demonstrate that MTR4 is frequently overexpressed in hepatocellular carcinoma (HCC) and is an independent diagnostic marker predicting the poor prognosis of HCC patients. MTR4 drives cancer metabolism by ensuring correct alternative splicing of pre-mRNAs of critical glycolytic genes such as GLUT1 and PKM2. c-Myc binds to the promoter of the MTR4 gene and is important for MTR4 expression in HCC cells, indicating that MTR4 is a mediator of the functions of c-Myc in cancer metabolism. These findings reveal important roles of MTR4 in the cancer metabolic switch and present MTR4 as a promising therapeutic target for treating HCC
5-Fluoroisophthalic acid
In the crystal structure of the title compound, C8H5FO4, the complete molecule is generated by crystallographic twofold symmetry with two C atoms and the F atom lying on the axis. The molecule is almost planar with the carboxyl group twisted with respect to the mean plane of the benzene ring by a dihedral angle of 2.01 (1)°. In the crystal, intermolecular O—H⋯O hydrogen bonds and C—H⋯F interactions connect the molecules into a two-dimensional supramolecular array
Charge order driven by Fermi-arc instability in Bi2201
The understanding of the origin of superconductivity in cuprates has been
hindered by the apparent diversity of intertwining electronic orders in these
materials. We combined resonant x-ray scattering (REXS), scanning-tunneling
microscopy (STM), and angle-resolved photoemission spectroscopy (ARPES) to
observe a charge order that appears consistently in surface and bulk, and in
momentum and real space within one cuprate family, Bi2201. The observed wave
vectors rule out simple antinodal nesting in the single-particle limit but
match well with a phenomenological model of a many-body instability of the
Fermi arcs. Combined with earlier observations of electronic order in other
cuprate families, these findings suggest the existence of a generic
charge-ordered state in underdoped cuprates and uncover its intimate connection
to the pseudogap regime.Comment: A high resolution version can be found at
http://www.phas.ubc.ca/~quantmat/ARPES/PUBLICATIONS/Articles/Bi2201_CDW_REXS_STM.pdf
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