Genetic Variation in the HSD17B1 Gene and Risk of Prostate Cancer

Steroid hormones are believed to play an important role in prostate carcinogenesis, but epidemiological evidence linking prostate cancer and steroid hormone genes has been inconclusive, in part due to small sample sizes or incomplete characterization of genetic variation at the locus of interest. Here we report on the results of a comprehensive study of the association between HSD17B1 and prostate cancer by the Breast and Prostate Cancer Cohort Consortium, a large collaborative study. HSD17B1 encodes 17β-hydroxysteroid dehydrogenase 1, an enzyme that converts dihydroepiandrosterone to the testosterone precursor Δ5-androsterone-3β,17β-diol and converts estrone to estradiol. The Breast and Prostate Cancer Cohort Consortium researchers systematically characterized variation in HSD17B1 by targeted resequencing and dense genotyping; selected haplotype-tagging single nucleotide polymorphisms (htSNPs) that efficiently predict common variants in U.S. and European whites, Latinos, Japanese Americans, and Native Hawaiians; and genotyped these htSNPs in 8,290 prostate cancer cases and 9,367 study-, age-, and ethnicity-matched controls. We found no evidence that HSD17B1 htSNPs (including the nonsynonymous coding SNP S312G) or htSNP haplotypes were associated with risk of prostate cancer or tumor stage in the pooled multiethnic sample or in U.S. and European whites. Analyses stratified by age, body mass index, and family history of disease found no subgroup-specific associations between these HSD17B1 htSNPs and prostate cancer. We found significant evidence of heterogeneity in associations between HSD17B1 haplotypes and prostate cancer across ethnicity: one haplotype had a significant (p < 0.002) inverse association with risk of prostate cancer in Latinos and Japanese Americans but showed no evidence of association in African Americans, Native Hawaiians, or whites. However, the smaller numbers of Latinos and Japanese Americans in this study makes these subgroup analyses less reliable. These results suggest that the germline variants in HSD17B1 characterized by these htSNPs do not substantially influence the risk of prostate cancer in U.S. and European whites

Les sols

Les sols sont le support de nos activités agricoles et sylvicoles et les garants de notre sécurité alimentaire. Ils assurent un grand nombre de services écosystémiques qui sont au coeur de grands enjeux planétaires. Pourtant ils restent encore largement méconnus, en particulier au niveau mondial. Les programmes du Groupement d&#8217;intérêt scientifique Sol ont permis de délivrer en 2011 le premier rapport sur L&#8217;état des sols de France. Ce rapport souligne les connaissances acquises ainsi que les inquiétudes et les incertitudes relatives à l&#8217;évolution de ces sols

Living with oropharyngeal dysphagia: effects of bolus modification on health-related quality of life—a systematic review

Purpose - Difficulty swallowing, oropharyngeal dysphagia, is widespread among many patient populations (such as stroke and cancer groups) and aged community-dwelling individuals. It is commonly managed with bolus modification: altering food (usually cutting, mashing or puréeing) or fluids (typically thickening) to make them easier or safer to swallow. Although this treatment is ubiquitous, anecdotal evidence suggests patients dislike this management, and this may affect compliance and well-being. This review aimed to examine the impact of bolus modification on health-related quality of life. Methods - A systematic review of the literature was conducted by speech pathologists with experience in oropharyngeal dysphagia. The literature search was completed with electronic databases, PubMed and Embase, and all available exclusion dates up to September 2012 were used. The search was limited to English-language publications which were full text and appeared in peer-reviewed journals. Results - Eight studies met the inclusion criteria. Generally, bolus modification was typically associated with worse quality of life. Modifications to foods appeared to be more detrimental than modifications to fluids, but this may be due to the increased severity of dysfunction that is implied by the necessity for significant alterations to foods. The number of studies retrieved was quite small. The diverse nature of methodologies, terminologies and assessment procedures found in the studies makes the results difficult to generalise. Conclusion - Overall, even though the severity of dysphagia may have been a confounding factor, the impact of bolus modification on health-related quality of life in patients with oropharyngeal dysphagia appears to be negative, with increased modification of food and fluids often correlating to a decreased quality of life. Further, associated disease factors, such as decreased life expectancy, may also have affected health-related quality of life. More research is needed

Oceanization starts at depth during continental rupturing in the Northern Red Sea

We present here 3D seismic reflection and gravity data obtained from an off-axis area of the NW Red Sea, as well as results of a study of gabbroic rocks recovered in the same area both from an oil well below a thick evaporitic-sedimentary sequence, and from a layered mafic complex exposed on the Brothers Islets. These new data provide constraints on the composition, depth of emplacement and age of early syn-rift magma intrusions into the deep crust. The Brothers are part of a series of sub-parallel NW-striking topographic highs associated with SW-dipping extensional fault blocks with significant footwall uplift during rifting that brought early syn-rift deep crustal rocks up to the seafloor. Assuming an important role played by magmatism in the evolution of narrow rifts helps to solve the controversy on the nature of the crust in the northern/central Red Sea (i.e., the crust outside the axial oceanic cells is either oceanic or it consists of melt-intruded extended continental crust). Gabbros show petrologic and geochemical signatures similar to those of MORB-type gabbroic cumulates and are compatible with their having been emplaced either in a continental or in an oceanic context. We explored the different hypotheses proposed to explain the lack of magnetic anomalies in the presence of oceanic crust in the northern Red Sea. Our results, combined with a review of all the geophysical and geological data in the area, suggest a stretched and thinned continental crust with few isolated sites of basaltic injections, in line with a model whereby asthenospheric melt intrusions contribute to weaken the lower crust enabling some decoupling between upper and lower crust, protracting upper crust extension and delaying crustal breakup. Our findings show that continental rupture in the northern Red Sea is preceded by intrusion of basaltic melts with MORB-type elemental and isotopic signature, that cooled forming gabbros at progressively shallower crustal depths as rifting progressed toward continental separation

A Scale Map of the 26 SNPs Genotyped in the MEC Screening Panel and a Plot of the Pattern of Linkage Disequilibrium among Them (in Whites)

<p>The four tag SNPs are markers with arrows, and the block of high linkage disequilibrium and limited haplotype diversity spanning <i>HSD17B1</i> is highlighted.</p

Emerging patterns of marine nitrogen fixation

Biological N2 fixation is an important part of the marine nitrogen cycle as it provides a source of new nitrogen that can support biological carbon export and sequestration. Research in the past decade has focused on determining the patterns of distribution and abundance of diazotrophs, defining the environmental features leading to these patterns and characterizing the factors that constrain marine N2 fixation overall. In this Review, we describe how variations in the deposition of iron from dust to different ocean basins affects the limiting nutrient for N2 fixation and the distribution of different diazotrophic species. However, many questions remain about marine N2 fixation, including the role of temperature, fixed nitrogen species, CO2 and physical forcing in controlling N2 fixation, as well as the potential for heterotrophic N2 fixation