201 research outputs found
A Practical Tool to Generate Complex Energy System Configuration Based on the SYNTHSEP Methodology
Traditional fossil fueledpower plants are commonly based on steam Rankine cycle or Brayton Joule cycle. Using water or air as working fluid is obviously the most obvious choice for the wide availability of these substances in nature. However, the scarcity of natural energy sources and the strong need of reducing environmental impact have necessarily drawn the research to new energy systems configurations operating with other working fluids, which are able to recover lower temperature sources, such as Sun or industrial wasted heat. The variety of new working fluids (refrigerants or organic fluids) widens the choice to a variety of configurations that can be tailored to the specific source characteristics and boundary constraints. It is not always easy or even possible to conceive the best configuration for given specifications withthe mere experience of a common designer. To design a new system configuration, the designer normally uses some \u201cnon-codified rules\u201d deriving from his knowledge of basic thermodynamics and energy engineering. This paper aims instead at showing a practicaltool that is based on a new methodology, named SYNTHSEP, to generate new energy system configurations. This methodology starts from the simple thermodynamic cycles operated by a given fluid made up of the four fundamental processes (compression, heating, expansion and cooling) and uses a rigorous set of codified rules to build the final system configuration. The paper presents the basics of the new methodology and how it has been implemented in a practical tool that simply requires the information about the elementary cycles and their shared processes as input data
Riduzione delle perdite al camino e delle emissioni nocive grazie ai nuovi bruciatori recuperativi a canali suddivisi e rigenerativi
La riduzione delle perdite di calore al camino, spesso, rappresentala via più efficace e conveniente peraumentare il rendimento dei forni industriali. I bruciatoririgenerativi offrono un rendimento termico superiore,a fronte di una spesa maggiore in termini di cicli di accensionee di aspirazione dei fumi; i nuovi bruciatori conrecuperatore di calore integrato a canali suddivisi offrono in un sistema recuperativo lo stesso rendimentotermico dei bruciatori rigenerativi. Entrambi i modelli di bruciatore utilizzano la tecnologia della combustionesenza fiamma per la riduzione delle emissioni di NOx
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The potential of the natural gas grid to accommodate hydrogen as an energy vector in transition towards a fully renewable energy system
The temporal and geographical availability of renewable energy sources is highly variable, which imposes the importance of correct choices for energy storage and energy transport systems. This paper presents a smart strategy to utilize the natural gas distribution grid to transport and store the hydrogen. The goal is twofold: evaluating the capacity limits of the grid to accommodate “green hydrogen” for preset increasing shares of renewable energy sources (RESs) and determining at the same time the optimal mix of wind, photovoltaic (PV), biomethane and power-to-gas systems that minimizes the investment and operation costs. To this end, the energy supply system of an entire country is modelled and optimized considering the real characteristics and pressure levels of the gas grid, which is assumed to be the only storage mechanism of green hydrogen. The operational concept is to fill up the gas grid with hydrogen during the day and with natural gas during the night while always consuming the natural gas-hydrogen blend. Green hydrogen is generated by electrolysers powered by PVs, wind turbines and biomethane power systems. Results of the optimizations showed that: i) as long as the share of RES does not exceed 20%, there is no need to use the gas grid as RES storage system, ii) from 20 to 50% of RES share the gas grid receives the surplus of electricity in the peaks that would be necessary to “complete” the dispatchability of RES electricity, iii) above 50%, the excess of electricity in the peaks has to be used to generate the thermal energy required by the consumers. The gas grid can be used as unique renewable energy carrier and storage system up to 65% of RES share
Synthesis and parameter optimization of a combined sugar and ethanol production process integrated with a CHP system
The combined sugar and ethanol production process from sugar cane is a paradigmatic application for energy integration strategies because of the high number of hot and cold streams involved, the external hot utility requirement at two temperature levels for juice evaporation and crystallization, and the electricity demand for juice extraction by milling. These conditions make it convenient to combine the sugar-cane process with a CHP system fuelled by bagasse, the main by-product from juice extraction. The strategies, tools and expertise on energy integration developed separately by the research teams authoring this paper are applied here jointly to optimize the synthesis and the design parameters of the process and of the total site starting from the basic idea of dissociating the heat exchanger network design problem from the total site synthesis problem. At first the minimization of the external heat requirement for the process alone is pursued and results show that a one third reduction can be achieved by optimal heat integration. Then the use of the by-product bagasse for on-site power generation is considered and two bagasse-fuelled CHP systems are optimized along with some parts of the sugar and ethanol production process in order to obtain maximum total site net power. Results show a variety of interesting scenarios of combined sugar, ethanol and electricity production plants with considerably high electricity output
Quizartinib, an FLT3 inhibitor, as monotherapy in patients with relapsed or refractory acute myeloid leukaemia: an open-label, multicentre, single-arm, phase 2 trial
BACKGROUND: Old age and FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) mutations in patients with acute myeloid leukaemia are associated with early relapse and poor survival. Quizartinib is an oral, highly potent, and selective next-generation FLT3 inhibitor with clinical antileukaemic activity in relapsed or refractory acute myeloid leukaemia. We aimed to assess the efficacy and safety of single-agent quizartinib in patients with relapsed or refractory acute myeloid leukaemia.
METHODS: We did an open-label, multicentre, single-arm, phase 2 trial at 76 hospitals and cancer centres in the USA, Europe, and Canada. We enrolled patients with morphologically documented primary acute myeloid leukaemia or acute myeloid leukaemia secondary to myelodysplastic syndromes and an Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 into two predefined, independent cohorts: patients who were aged 60 years or older with relapsed or refractory acute myeloid leukaemia within 1 year after first-line therapy (cohort 1), and those who were 18 years or older with relapsed or refractory disease following salvage chemotherapy or haemopoietic stem cell transplantation (cohort 2). Patients with an FLT3-ITD allelic frequency of more than 10% were considered as FLT3-ITD positive, whereas all other patients were considered as FLT3-ITD negative. Patients received quizartinib once daily as an oral solution; the initial 17 patients received 200 mg per day but the QTcF interval was prolonged for more than 60 ms above baseline in some of these patients. Subsequently, doses were amended for all patients to 135 mg per day for men and 90 mg per day for women. The co-primary endpoints were the proportion of patients who achieved a composite complete remission (defined as complete remission + complete remission with incomplete platelet recovery + complete remission with incomplete haematological recovery) and the proportion of patients who achieved a complete remission. Efficacy and safety analyses included all patients who received at least one dose of quizartinib (ie, the intention-to-treat population). Patients with a locally assessed post-treatment bone marrow aspirate or biopsy were included in efficacy analyses by response; all other patients were considered to have an unknown response. This study is registered with ClinicalTrials.gov, number NCT00989261, and with the European Clinical Trials Database, EudraCT 2009-013093-41, and is completed.
FINDINGS: Between Nov 19, 2009, and Oct 31, 2011, a total of 333 patients were enrolled (157 in cohort 1 and 176 in cohort 2). In cohort 1, 63 (56%) of 112 FLT3-ITD-positive patients and 16 (36%) of 44 FLT3-ITD-negative patients achieved composite complete remission, with three (3%) FLT3-ITD-positive patients and two (5%) FLT3-ITD-negative patients achieving complete remission. In cohort 2, 62 (46%) of 136 FLT3-ITD-positive patients achieved composite complete remission with five (4%) achieving complete remission, whereas 12 (30%) of 40 FLT3-ITD-negative patients achieved composite complete remission with one (3%) achieving complete remission. Across both cohorts (ie, the intention-to-treat population of 333 patients), grade 3 or worse treatment-related treatment-emergent adverse events in 5% or more of patients were febrile neutropenia (76 [23%] of 333), anaemia (75 [23%]), thrombocytopenia (39 [12%]), QT interval corrected using Fridericia\u27s formula (QTcF) prolongation (33 [10%]), neutropenia (31 [9%]), leucopenia (22 [7%]), decreased platelet count (20 [6%]), and pneumonia (17 [5%]). Serious adverse events occurring in 5% or more of patients were febrile neutropenia (126 [38%] of 333; 76 treatment related), acute myeloid leukaemia progression (73 [22%]), pneumonia (40 [12%]; 14 treatment related), QTcF prolongation (33 [10%]; 32 treatment related), sepsis (25 [8%]; eight treatment related), and pyrexia (18 [5%]; nine treatment related). Notable serious adverse events occurring in less than 5% of patients were torsades de pointes (one [<1%]) and hepatic failure (two [1%]). In total, 125 (38%) of 333 patients died within the study treatment period, including the 30-day follow-up. 18 (5%) patients died because of an adverse event considered by the investigator to be treatment related (ten [6%] of 157 patients in cohort 1 and eight [5%] of 176 in cohort 2.
INTERPRETATION: Single-agent quizartinib was shown to be highly active and generally well tolerated in patients with relapsed or refractory acute myeloid leukaemia, particularly those with FLT3-ITD mutations. These findings confirm that targeting the FLT3-ITD driver mutation with a highly potent and selective FLT3 inhibitor is a promising clinical strategy to help improve clinical outcomes in patients with very few options. Phase 3 studies (NCT02039726; NCT02668653) will examine quizartinib at lower starting doses.
FUNDING: Ambit Biosciences/Daiichi Sankyo
A Practical Tool to Generate Complex Energy System Configuration Based on the SYNTHSEP Methodology
Optimum Choice of Energy System Configuration and Storages for a Proper Match between Energy Conversion and Demands
This Special Issue addresses the general problem of a proper match between the demands of energy users and the units for energy conversion and storage, by means of proper design and operation of the overall energy system configuration. The focus is either on systems including single plants or groups of plants, connected or not to one or more energy distribution networks. In both cases, the optimum design and operation involve decisions about thermodynamic processes, about the type, number, design parameters of components/plants, and storage capacities, and about mutual interconnections and the interconnections with the distribution grids. The problem is very wide, can be tackled with dierent methodologies and may have several, more or less valuable and complicated solutions. The twelve accepted papers certainly represent a good contribution to perceive its dicult
A practical tool to generate complex energy system configurations based on the SYNTHSEP methodology
Traditional fossil fuelled power plants are commonly based on steam Rankine cycle or Brayton Joule cycle. Using water or air as working fluid is obviously the most obvious choice for the wide availability of these substances in nature. However, the scarcity of natural energy sources and the strong need of reducing environmental impact have necessarily drawn the research to new energy systems configurations operating with other working fluids, which are able to recover lower temperature sources, such as Sun or industrial wasted heat. The variety of new working fluids (refrigerants or organic fluids) widens the choice to a variety of configurations that can be tailored to the specific source characteristics and boundary constraints. It is not always easy or even possible to conceive the best configuration for given specifications with the mere experience of a common designer. To design a new system configuration, the designer normally uses some \u201cnon-codified rules\u201d deriving from his knowledge of basic thermodynamics and energy engineering. This paper aims instead at showing a practical tool that is based on a new methodology, named SYNTHSEP, to generate new energy system configurations. This methodology starts from the simple thermodynamic cycles operated by a given fluid made up of the four fundamental processes (compression, heating, expansion and cooling) and uses a rigorous set of codified rules to build the final system configuration. The paper presents the basics of the new methodology and how it has been implemented in a practical tool that simply requires the information about the elementary cycles and their shared processes as input data
A Critical Review of the Thermoeconomic Diagnosis Methodologies for the Location of Causes of Malfunctions in Energy Systems
Thermoeconomic diagnosis procedures in the literature rely on the assumption that specific
consumptions of resources in the components are the key to interpret the effects of
malfunctions and then to trace a path towards the sources of anomalies. The main
obstacle to a successful application of these approaches is represented by the actual
interactions existing among components which cause a propagation of the alteration of
component specific consumptions and therefore mask those effects that would allow a
direct identification of the origin of malfunction. This paper presents an extensive discussion
of potentialities and limits of diagnosis procedures proposed in the literature in
distinguishing the effects induced by component interactions from those that are intrinsically
generated by the anomaly, which is considered here as the main task to locate
effectively causes of malfunctions in energy systems. 10.1115/1.235814
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