CHEMICAL CHARACTERIZATION BY GC-MS FROM THE AERIAL PARTS OF FAGONIA LONGISPINA (ZYGOPHYLLACEAE)

Objective: The objective was to characterize the phytochemical constituents in ethyl acetate (EtOAc) extract from the aerial parts of Fagonia longispina(zygophyllaceae) by gas chromatography-mass spectrometry (GC-MS).Methods: The dried powder of the aerial parts of F. lonjispina was extracted exhaustively with ethanol. The extract was concentrated, diluted withwater and partitioned with EtOAc. The residue of the EtOAc extract was performed using a GC-MS.Results: Chemical constituents of the EtOAcextract of F. Longispina Family (Zygophylaceae) were identified by GC-MS and their relative concentrationswere determined. F. Longispina extract contained 12 compounds: Cis-4-(4 -T-butylcyclohexyl)-4-methyl-2-pentanone (33.33%), 4beta-(tert-butyl)1alpha-(1methylvinyl)cyclohexanemethanol (09.52%), cyclohexyl-2-methylenebutanylketone(14.28%),trans-4-(–t-butylcyclohexyl)-4-methyl2-pentanone(9.52%),2,6,10-trimetyl,14-Ethylne-14pentadecene (6.66%), 2-decen-1-ol(cas) (4.76%), 3,7,11,15-tetramethyl-2-hexadecen-1-ol(2.85%),2-nonen-1-ol (4.76%), citronellylacetate(2.85%), tetratetracontane(3.38%), hexatriacontane(cas) (3.38%), and phytolacetate(4.76%).'Conclusions: This GC-MS study helps to predict the formula and structure of phytoconstituents which can be used as drugs, and further investigationmay leads to the development of drug formulation. These compounds are probably the major players in the antioxidant responses evoked by the plant.Keywords: Etyl acetate extract, Gas chromatography-mass spectrometry analysis, Fagonia longispina

Valeurs nutritives et toxicité du foenicululm vulgare miller

Food values and toxicity of the foenicululm vulgare millerFoeniculum vulagre Mill. plant aromatic, spontaneous and wides pread in algeria is used by the population for its medicinal virtues. Our samples, coming from the Algerian west, showed that the contents of the principal compounds resulting from the primary metabolism and for each part of the plant (soed, stem and roots) are interesting for proteins (17,5 %) and lipids (12 %) and relatively  weak for glucids (13 %). The presence of toxic components coming from the secondary metabolism in particular the coumarins and tanins, made up recognized like inhibiting the digestibility of proteins, influential on the evolution of the ponderal mass of the animal (rat "Wistar"). The saponosides, flavonoïdes, sterols and steroïdes, tanins, coumarins, alcaloïdes, anthracenosides, anthocyanosides and emodols with little or no presence, have only little influence on the digestibility qualities of the plant. The output of 2,7 % in essential oil from the flowering plant is interesting and is in conformity with those obtained by the literature

Etude physicochimique et microbiologique de l’huile essentielle de Thymus fontanesii Boiss & Reut

Thymus fontanesii (thym) est une plante aromatique, répandue en Algérie et très utilisée par les populations locales pour ses vertus médicinales. L’huile essentielle de cette plante originaire de l’ouest algérien, fait l’objet dans cet article d’une étude physicochimique et microbiologique. L’extraction de l’huile essentielle a été effectuée par entraînement à la vapeur d’eau. Le rendement obtenu à partir des feuilles (2%) est intéressant pour l’exploitation industrielle. La densité spécifique (0.9219), l’indice de réfraction à 20° (1.4999), le pouvoir rotatoire (+3.4313), la miscibilité à l’éthanol (0.6V/1V), le point de congélation

Étude phytochimique et évaluation de l’activité anti-oxydante de Thymus CIliatus ssp. Coloratus

Thymus ciliatus ssp. Coloratus, plante aromatique, spontanée et répandue en régions méditerranéennes et dans le nord de l’Algérie est très utilisée par les populations locales pour ses vertus médicinales. Les tests phytochimiques appliqués au Thymus ciliatus ssp coloratus ont montré la présence de quelques familles de composés chimiques et notamment les flavonoïdes. L'activité antioxydante in vitro de l’extrait de flavonoïdes a été évaluée par la technique de réduction du fer « FRAP » (ferric reducing antioxydant power) et par le test de DPPH. La première méthode a montré que la fraction acétate d’éthyle de la partie aérienne a une capacité à réduire le fer plus marquée que celles de l’acide ascorbique et le BHA et que celle des racines, est nettement inférieure. Quant aux fractions butanoliques des flavonoïdes de la partie aérienne et des racines, elles ont une capacité à réduire le fer largement inférieure à celles de l’acide ascorbique et le BHA. L’activité antioxydante, obtenue par la second procédé et relative à la fraction acétate d’éthyle des flavonoïdes de la partie aérienne de la plante est plus importante (I.C₅₀=0,85 mg/mL) que celles obtenues à partir d’antioxydants utilisés dans les industries alimentaire et pharmaceutique en l’occurrence l’acide ascorbique (I.C₅₀ = 1,12 mg/mL) et le BHA (I.C₅₀=1,61 mg/mL).Mots-clés : Thymus coloratus, activité antioxydant, flavonoïde, FRAP, DPPH.Phytochemical study and evaluation of the antioxidant activity of thymus ciliatus ssp. Coloratus Thymus ciliatus ssp. coloratus, aromatic plant, spontaneous and widespread in the Mediterranean and in northern Algeria is widely used by local people for its medicinal properties. Phytochemical tests applied for Thymus sciliatus ssp coloratus showed the presence of several families of chemical compounds including flavonoïds. The in vitro antioxidant activity of flavonoïds extract was evaluated by the iron reduction technique "FRAP" (ferric reducing antioxidant power) and DPPH test. The first method showed that the ethyl acetate fraction of the aerial part has an ability to reduce the iron greater than ascorbic acid and BHA and the roots, is significantly lower. As for butanol fractions of flavonoïds from the aerial part and roots, they have an ability to reduce iron significantly lower than those of ascorbic acid and BHA. The antioxidant activity obtained by the second method and on the ethyl acetate fraction of flavonoïds from the aerial part of the plant is more important (I.C₅₀ = 0.85 mg / mL) than those obtained from 'antioxidants used in food and pharmaceutical industries namely ascorbic acid (I.C₅₀ = 1.12 mg / mL) and BHA (I.C₅₀ = 1.61 mg / mL).Keywords : Thymus coloratus, antioxidant activity, flavonoïd, FRAP, DPPH

Aberrometry from Astronomy to Vision Science

Aberrometry is a branch from optical metrology and more directly from astronomy. Applied to the science of vision, it allows for dramatic improvements in human vision research, such as refining the visual capabilities of healthy and diseased subjects beyond physiological limits. In retinal imaging, it permits observing with very high resolution, photoreceptors allowing glimpsing an earlier diagnosis of some retinal pathologies as well as the observation and assessment of more effective treatments. They rely on the ocular wave front collection with the help of an aberrometer which allows establishing the precise and quantitative record of the various optical aberrations of the human eye, whether low or high degree. In this work, we draw our approach to apply these concepts to refractive surgery and contact lenses adaptation, to relate the changes in higher-order aberrations (HOAs) following wavefront-guided femtosecond laser-assisted (WFG FS-LASIK), and to explore the correlations between preoperative spherical equivalence (SE) and mechanisms of HOAs affecting the visual quality

Civil Society Advocacy For Human Rights and Environmental Corporate Accountability: The case of the EU Corporate Sustainability Due Diligence Directive

Since the endorsement of the UN Guiding Principles on Business and Human Rights (UNGPs) by the UN Human Rights Council in 2011, several legislative processes have been initiated to make corporate human rights and environmental due diligence mandatory. One of the most recent and significant examples of this is the EU Corporate Sustainability Due Diligence Directive (CSDDD), a framework which aims to create legally binding obligations for companies based or active in the EU regarding the impact of their activities throughout their value chains. This legislative process was formally initiated in February 2022, when the European Commission published a proposal for a Directive. In parallel to advocating with EU institutions and representatives to ensure the highest possible level of human rights and environmental protection. This Coalition has expressed concerns roach for and the Coalition approach as two different approaches to EU due diligence legislation. It aims to answer the following research question: which of these two approaches constitutes a stronger framework for corporate accountability? This thesis is based on the experience of a traineeship at the European Center for Constitutional and Human Rights (ECCHR), a member of the aforementioned civil society coalition. It builds on the concept of corporate accountability, which is conceptualised into an analytical framework, based on an existing framework by Bernaz (2020). The concept is broken down into seven dimensions - personal scope, beneficiaries, material scope, legal force, due diligence obligation, enforcement, and reparations. By analysing each approach through the prism of this analytical framework and proceeding to a comparative analysis, this thesis outlines key differences between the two approaches and situates them on a spectrum of corporate accountability. As a background for these analyses, this thesis presents a literature review on the concept of corporate accountability, as well as a state of the evolving policy field of due diligence.</p

Synthesis and characterization of peptidomimetics containing oxazolidin-2-one and oxazolidine scaffolds

International audienceIn this paper, we report the synthesis of peptidomimetics containing oxazolidin-2-one and oxazolidine rings. The two of these heterocyclic peptidomimetics novel series were obtained from serine as starting material through an efficient intramolecular cyclization. In the case of oxazolidine, the formation of only one diastereoisomer was observed

FLAVONOID FROM METHANOLIC EXTRACT OF LIMONIASTRUM FEEI (GIRARD) BATT (PLUMBAGINACEAE)

According to the biological screening results of several extracts from three parts (leaves, stems and twigs) of Limoniastrum feei (plumbagenaceae)against fungi (Candida albican, sacharomyce), and bacteria (Escherechia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Klebseilla entercoccus)realized by disc diffusion method, we interested to isolate the natural products responsible of these activities. Our investigation led to the isolation ofthree phytochemical constituents by the liquid chromatography method, the compounds were identified by spectroscopic analysis as flavonoids. Theisolated compounds were identified as Quercetin 1, kaempferol-3-o-β-d-glucopyranoside (astragalin) 2 and quercetin-7-o-β-d-glucopyranoside 3.The presence of different types of bioactive constituents in the L. feei extract may explain it wide use by the local population.Keywords: Limoniastrum feei, Bioactive extract, Phytochemical screening, Flavonoid

A new decision support model for preanesthetic evaluation

International audienceBackground and objective: The principal challenges in the field of anesthesia and intensive care consist of reducing both anesthetic risks and mortality rate. The ASA score plays an important role in patients’ preanesthetic evaluation. In this paper, we propose a methodology to derive simple rules which classify patients in a category of the ASA scale on the basis of their medical characteristics.Methods: This diagnosis system is based on MR-Sort, a multiple criteria decision analysis model. The proposed method intends to support two steps in this process. The first is the assignment of an ASA score to the patient; the second concerns the decision to accept—or not—the patient for surgery.Results: In order to learn the model parameters and assess its effectiveness, we use a database containing the parameters of 898 patients who underwent preanesthesia evaluation. The accuracy of the learned models for predicting the ASA score and the decision of accepting the patient for surgery is assessed and proves to be better than that of other machine learning methods. Furthermore, simple decision rules can be explicitly derived from the learned model. These are easily interpretable by doctors, and their consistency with medical knowledge can be checked.Conclusions: The proposed model for assessing the ASA score produces accurate predictionson the basis of the (limited) set of patient attributes in the database available for the tests. Moreover, the learned MR-Sort model allows for easy interpretation by providing humanreadable classification rules