1,840 research outputs found
Satellite Power Systems (SPS) Space Transportation Workshop Summary
Space transportation requirements are major elements in the technical and economic realization of the entire SPS concept. First, steps in enhancing the shuttle include the Titan based liquid boost module (LBM) and liquid propellant boosters (LPB) to replace the present solid rocket boosters (SRB). The next choice between new ballistic or winged boosters must still be made; as well as the choice between series (staged) and parallel operation. Entirely new vehicles of large size are required before the economic and environmental problems of the prototype, or even demonstration, SPS can be resolved. Social impacts such as noise, and atmospheric pollution, locally and in the ionosphere, must be fully addressed. Although rather advanced technology and well developed operational management is required to properly target the average cost of gross cargo payloads into LEO at 30 (1979)/kg for all operational payloads require the use of very advanced, long lived vehicles with a sophisticated operational organization using off shore, equatorial launch sites
Jp24 transient pressure measuring methods research status report, 1 jan. - 31 mar. 1965
Transient pressure transducer evaluation and improvement of laboratory electric equipment and technique
Solar electric space mission analysis Progress report, 1 Jun. - 31 Dec. 1966
Characteristics and trajectory analysis of solar electric propulsion space missions - Mars orbiter and Jupiter flyb
Aerospace systems and mission analysis research Status report, 1 Apr. - 31 Dec. 1966
Systems and mission analysis of solar electric propulsion for solar system exploratio
Aerospace systems and mission analysis research - Solar electric space mission analysis Final report
Mission analysis for solar electric propelled spacecraft on Mars Orbiter, Jupiter flyby, and asteroid belt exploration trajectorie
Special mount improves remote transducer accuracy
Transducer-mounting device allows measurement of transient pressure in a hostile environment. The device provides free passage areas and a controlled environment for the measuring instrument
Transient pressure measuring methods research Final summary technical report
Transient pressure measuring methods as applied to liquid propellant rocket thrust chambe
Assimilation to the Unmarked
Steel, JC ORCiD: 0000-0003-3608-7542Intravitreal injection of recombinant adeno-associated virus (AAV) might be an alternative approach for retinal gene therapy for certain applications. Although the jelly-like substance consists mainly of water, anti-viral antibodies against various viruses such as HIV or HSV have been observed in the human vitreous and anti-AAV neutralising antibodies (NAbs) in rhesus macaque vitreous have also been detected. In this study, the human vitreous humour was obtained from 70 post mortem unpaired eye cups and 10 paired eye cups from the Queensland Eye Bank. The transduction efficiency of 1-3 · 108 vcg of recombinant AAV-2, -5, -6 and -8 expressing secreted nanoluciferase was measured following transduction of ARPE-19 and Cos-7 cells at vitreous humour dilutions from 1:2 to 1:10
000. At vitreous humour dilution of 1:2, a reduction in transduction of over 50% was observed for AAV2 in 50.5% of samples and for AAV6 in 66.2% of samples. Only 23.2% of tested samples showed similar reduction in transduction efficiency for AAV5, and for AAV8 only 2.5% of samples inhibited transduction by 50% at 1:2 dilution. Differences in serum antibody levels have been previously observed in a similar Australian population, but low transduction inhibition at vitreous humour dilutions of 1:100 suggests that the concentration of NAbs within the vitreous humour is lower than in human serum. In addition, this study also reported an increase in transduction efficiency for AAV8 at highest vitreous humour concentrations, supporting previous reports that human albumin can increase AAV transduction but only in some serotypes
Micro-drive Array for Chronic in vivo Recording: Tetrode Assembly
The tetrode, a bundle of four electrodes, has proven to be a valuable tool for the simultaneous recording of multiple neurons in-vivo. The differential amplitude of action potential signatures over the channels of a tetrode allows for the isolation of single-unit activity from multi-unit signals. The ability to precisely control the stereotaxic location and depth of the tetrode is critical for studying coordinated neural activity across brain regions. In combination with a micro-drive array, it is possible to achieve precise placement and stable control of many tetrodes over the course of days to weeks. In this protocol, we demonstrate how to fabricate and condition tetrodes using basic tools and materials, install the tetrodes into a multi-drive tetrode array for chronic in-vivo recording in the rat, make ground wire connections to the micro-drive array, and attach a protective cone onto the micro-drive array in order to protect the tetrodes from physical contact with the environment
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