10 Years of Object-Oriented Analysis on H1

Over a decade ago, the H1 Collaboration decided to embrace the object-oriented paradigm and completely redesign its data analysis model and data storage format. The event data model, based on the RooT framework, consists of three layers - tracks and calorimeter clusters, identified particles and finally event summary data - with a singleton class providing unified access. This original solution was then augmented with a fourth layer containing user-defined objects. This contribution will summarise the history of the solutions used, from modifications to the original design, to the evolution of the high-level end-user analysis object framework which is used by H1 today. Several important issues are addressed - the portability of expert knowledge to increase the efficiency of data analysis, the flexibility of the framework to incorporate new analyses, the performance and ease of use, and lessons learned for future projects.Comment: 14th International Workshop on Advanced Computing and Analysis Techniques in Physics Researc

The separation of malic dehydrogenase isoenzymes of Neurospora crassa by polyacrylamide gel electrophoresis

The separation of malic dehydrogenase isoenzymes of Neurospora crassa by polyacrylamide gel electrophoresi

The clinical and cost-effectiveness of a Victim Improvement Package (VIP) for the reduction of chronic symptoms of depression or anxiety in older victims of common crime (the VIP trial): study protocol for a randomised controlled trial.

BACKGROUND: Older people are vulnerable to sustained high levels of psychosocial distress following a crime. A cognitive behavioural therapy (CBT)-informed psychological therapy, the Victim Improvement Package (VIP) may aid recovery. The VIP trial aims to test the clinical and cost-effectiveness of the VIP for alleviating depressive and anxiety symptoms in older victims of crime. METHODS/DESIGN: People aged 65 years or more who report being a victim of crime will be screened by Metropolitan Police Service Safer Neighbourhood Teams within a month of the crime for distress using the Patient Health Questionnaire-2 and the Generalised Anxiety Disorder-2. Those who screen positive will be signposted to their GP for assistance, and re-screened at 3 months. Participants who screen positive for depression and/or anxiety at re-screening are randomised to a CBT informed VIP added to treatment as usual (TAU) compared to TAU alone. The intervention consists of 10 individual 1-h sessions, delivered weekly by therapists from the mental health charity Mind. The primary outcome measure is the Beck Depression Inventory-II (BDI-II) and the Beck Anxiety Inventory (BAI), used as a composite measure, assessed at 6 months after the crime (post therapy) with a 9-month post-crime follow-up. Secondary outcome measures include the EQ-5D, and a modified Client Service Receipt Inventory. A total of 226 participants will be randomised VIP:TAU with a ratio 1:1, in order to detect a standardised difference of at least 0.5 between groups, using a mixed-effects linear-regression model with 90% power and a 5% significance level (adjusting for therapist clustering and potential drop-out). A cost-effectiveness analysis will incorporate intervention costs to compare overall health care costs and quality of life years between treatment arms. An embedded study will examine the impact of past trauma and engagement in safety behaviours and distress on the main outcomes. DISCUSSION: This trial should provide data on the clinical and cost-effectiveness of a CBT-informed psychological therapy for older victims of crime with anxiety and/or depressive symptoms and should demonstrate a model of integrated cross-agency working. Our findings should provide evidence for policy-makers, commissioners and clinicians responding to the needs of older victims of crime. TRIAL REGISTRATION: International Standard Randomised Controlled Trials Number, ID: ISRCTN16929670. Registered on 3 August 2016

The binary period and outburst behaviour of the SMC X-ray binary pulsar system SXP504

A probable binary period has been detected in the optical counterpart to the X-ray source CXOU J005455.6-724510 = RX J0054.9-7245 = AXJ0054.8-7244 = SXP504 in the Small Magellanic Cloud. This source was detected by Chandra on 04 Jul 2002 and subsequently observed by XMM-Newton on 18 Dec 2003. The source is coincident with an Optical Gravitational Lensing (OGLE) object in the lightcurves of which several optical outburst peaks are visible at ~ 268 day intervals. Timing analysis shows a period of 268.6 +/- 0.1 days at > 99% significance. Archival Rossi X-ray Timing Explorer (RXTE) data for the 504s pulse-period has revealed detections which correspond closely with predicted or actual peaks in the optical data. The relationship between this orbital period and the pulse period of 504s is within the normal variance found in the Corbet diagram.Comment: Accepted by MNRAS. 1 LATEX page. 4 figure

Chronic pain and chronic opioid use after intensive care discharge - Is it time to change practice?

Almost half of patients treated on intensive care unit (ICU) experience moderate to severe pain. Managing pain in the critically ill patient is challenging, as their pain is complex with multiple causes. Pharmacological treatment often focuses on opioids, and over a prolonged admission this can represent high cumulative doses which risk opioid dependence at discharge. Despite analgesia the incidence of chronic pain after treatment on ICU is high ranging from 33–73%. Measures need to be taken to prevent the transition from acute to chronic pain, whilst avoiding opioid overuse. This narrative review discusses preventive measures for the development of chronic pain in ICU patients. It considers a number of strategies that can be employed including non-opioid analgesics, regional analgesia, and non-pharmacological methods. We reason that individualized pain management plans should become the cornerstone for critically ill patients to facilitate physical and psychological well being after discharge from critical care and hospital

Orbital Period Determinations for Four SMC Be/X-ray Binaries

We present an optical and X-ray study of four Be/X-ray binaries located in the Small Magellanic Cloud (SMC). OGLE I-band data of up to 11 years of semi-continuous monitoring has been analysed for SMC X-2, SXP172 and SXP202B, providing both a measurement of the orbital period (Porb = 18.62, 68.90, and 229.9 days for the pulsars respectively) and a detailed optical orbital profile for each pulsar. For SXP172 this has allowed a direct comparison of the optical and X-ray emission seen through regular RXTE monitoring, revealing that the X-ray outbursts precede the optical by around 7 days. Recent X-ray studies by XMM-Newton have identified a new source in the vicinity of SXP15.3 raising doubt on the identification of the optical counterpart to this X-ray pulsar. Here we present a discussion of the observations that led to the proposal of the original counterpart and a detailed optical analysis of the counterpart to the new X-ray source, identifying a 21.7 d periodicity in the OGLE I-band data. The optical characteristics of this star are consistent with that of a SMC Be/X-ray binary. However, this star was rejected as the counterpart to SXP15.3 in previous studies due to the lack of H{\alpha} emission.Comment: Accepted for publication in MNRAS, 11 pages, 17 figure