Health Coaching Case Report: Optimizing Employee Health and Wellbeing in Organizations

Abstract Health and wellbeing of employees has a direct correlation to organizational performance. It is essential that organizations and successful leaders prioritize the health and wellbeing of all employees – from the C-suite to entry level positions. As rates of stress, chronic illness, and unhealthy lifestyle choices continue to increase, it is imperative that organizations discover strategies that cultivate employee wellbeing. Employees with high wellbeing are more engaged, productive, and energized and directly affect a company’s bottom line; it is in the best interest of employers to invest in human capital and wellbeing of employees. Health and wellness coaching demonstrates encouraging potential as a cost-effective catalyst to optimize employee wellbeing. Rooted in science-based research with the foundation in relationships, communication, and connection, health coaches partner with employees as they build self-awareness around a holistic view of health. As employees build self-awareness, they increasingly recognize the importance of managing stress and self-care, connecting to their vision and values, taking active steps towards change, and addressing barriers and obstacles. With these strategies, individuals build resilience as they gain energy, empowerment, and work towards positive growth. This paper outlines the challenges that leaders and employees are facing, describes the intervention of health and wellness coaching, and provides a group coaching case study that demonstrates how health and wellness coaching can foster employee wellbeing. This case study provides evidence that health coaching shows promise as an intervention to optimize employee health and wellbeing. Keywords: employee health and wellbeing, wellness, stress management, health and wellness coaching, group coaching, leader wellbeing, self-awareness, case repor

Targeted magnetic nanoparticle hyperthermia for the treatment of oral cancer

INTRODUCTION: Patients with oral squamous cell carcinoma currently experience a five year survival rate of approximately 60% with conventional surgical, chemotherapy and radiotherapy treatments. Magnetic hyperthermia offers an alternative treatment method by utilising the heating properties of magnetic nanoparticles to produce thermo-ablation of the tumour site when exposed to an alternating magnetic field. In this study we investigate in vitro if targeted magnetic hyperthermia offers a potential treatment for oral squamous cell carcinoma. MATERIALS AND METHODS: Magnetic iron oxide nanoparticles, with a biocompatible silica coating, were produced and conjugated with antibodies to target integrin αvβ6, a well-characterised oral squamous cell carcinoma biomarker. Utilising the heating properties of the magnetic nanoparticles we exposed them to an alternating magnetic field to produce thermo-ablation of tumour cells either negative for or over-expressing integrin αvβ6. RESULTS: The cell surface biomarker, αvβ6 integrin, was upregulated in tissue biopsies from oral squamous cell carcinoma patients compared to normal tissue. Functionalisation of the silica coating with anti-αvβ6 antibodies enabled direct targeting of the nanoparticles to αvβ6-overexpressing cells and applying thermal therapy significantly increased killing of the targeted tumour cells compared to control cells. CONCLUSION: Combining antibody-targeting magnetic nanoparticles with thermal-ablation offers a promising therapy for the targeted treatment of oral squamous cell carcinoma

A prelimnary study of diet in the juvenile gorean snapper, Lutjanus goreensis (Valenciennes, 1830) from Five Cowrie Creek, Lagos, Nigeria

Diet of the juvenile Gorean snapper, Lutjanus goreensis from Five Cowrie Creek was investigated between April 2008 and January 2009. Analyses of 184 specimens by numerical (NO), frequency of occurrence (FO) and geometric index of importance (GII) methods, respectively revealed a moderately high proportion (47.83%) of stomachs with food or prey. Shrimps and crabs constituted more than 80 % of total prey items. Other dietary components included lobsters, stomatopods, whole fish and fish parts. Similarly, analysis of diet composition by size - groups also indicated a predominance of the shrimps and crabs over all other prey items. In conclusion, L. goreensis can be described as a top-level carnivore feeding almost exclusively on epibenthic crustaceans in the juvenile stage

New agents in the Treatment of Myeloma Bone Disease

Patients with multiple myeloma develop a devastating bone disease driven by the uncoupling of bone remodelling, excess osteoclastic bone resorption and diminished osteoblastic bone formation. The bone phenotype is typified by focal osteolytic lesions leading to pathological fractures, hypercalcaemia and other catastrophic bone events such as spinal cord compression. This causes bone pain, impaired functional status, decreased quality of life and increased mortality. Early in the disease, malignant plasma cells occupy a niche environment that encompasses their interaction with other key cellular components of the bone marrow microenvironment. Through these interactions, osteoclast-activating factors and osteoblast inhibitory factors are produced, which together uncouple the dynamic process of bone remodelling, leading to net bone loss and focal osteolytic lesions. Current management includes antiresorptive therapies, i.e. bisphosphonates, palliative support and orthopaedic interventions. Bisphosphonates are the mainstay of treatment for myeloma bone disease (MBD), but are only partially effective and do have some significant disadvantages; for example, they do not lead to the repair of existing bone destruction. Thus, newer agents to prevent bone destruction and also promote bone formation and repair existing lesions are warranted. This review summarises novel ways that MBD is being therapeutically targeted

Advances in murine models of breast cancer bone disease

Bone is the most prevalent metastatic site for breast cancer affecting ~70% of patients with late-stage disease. Treatments for this condition currently focus on controlling disease progression and limiting tumour-induced damage to bone, thereby playing a valuable role in increasing quality of life. However, limited understanding of the interplay between tumour cells and their environment during bone metastasis has impeded the development of curative treatments. To unravel the complex genetic and phenotypic alterations that occur during this process, it would be helpful to have a model in which tumours develop spontaneously at the primary site, spread to bone, undergo a dormancy phase and then, after a fixed timeframe, become re-activated to form osteolytic/mixed lesions in the skeleton. Unlike humans, spontaneous metastasis of primary mammary tumours to bone is rare in mice and no syngeneic models of oestrogen receptor positive disease have been reported. As there is no single model that authentically reproduces all of the genetic and phenotypic changes representative of human bone metastasis, this review discusses the traditional and novel mouse models that are used to study bone metastasis from breast cancer. Additionally, this review focuses on advances that have been made towards making these models more closely related to human disease in an attempt to help researchers select the correct model(s) for their experimental needs with the aim of improving translational efficacy between the laboratory and the clinic

Health Coaching Case Report: Optimizing Employee Health and Wellbeing in Organizations

Abstract Health and wellbeing of employees has a direct correlation to organizational performance. It is essential that organizations and successful leaders prioritize the health and wellbeing of all employees – from the C-suite to entry level positions. As rates of stress, chronic illness, and unhealthy lifestyle choices continue to increase, it is imperative that organizations discover strategies that cultivate employee wellbeing. Employees with high wellbeing are more engaged, productive, and energized and directly affect a company’s bottom line; it is in the best interest of employers to invest in human capital and wellbeing of employees. Health and wellness coaching demonstrates encouraging potential as a cost-effective catalyst to optimize employee wellbeing. Rooted in science-based research with the foundation in relationships, communication, and connection, health coaches partner with employees as they build self-awareness around a holistic view of health. As employees build self-awareness, they increasingly recognize the importance of managing stress and self-care, connecting to their vision and values, taking active steps towards change, and addressing barriers and obstacles. With these strategies, individuals build resilience as they gain energy, empowerment, and work towards positive growth. This paper outlines the challenges that leaders and employees are facing, describes the intervention of health and wellness coaching, and provides a group coaching case study that demonstrates how health and wellness coaching can foster employee wellbeing. This case study provides evidence that health coaching shows promise as an intervention to optimize employee health and wellbeing. Keywords: employee health and wellbeing, wellness, stress management, health and wellness coaching, group coaching, leader wellbeing, self-awareness, case repor

Gravity coupled with matter and foundation of non-commutative geometry

We first exhibit in the commutative case the simple algebraic relations between the algebra of functions on a manifold and its infinitesimal length element $ds$. Its unitary representations correspond to Riemannian metrics and Spin structure while $ds$ is the Dirac propagator ds = \ts \!\!---\!\! \ts = D^{-1} where $D$ is the Dirac operator. We extend these simple relations to the non commutative case using Tomita's involution $J$. We then write a spectral action, the trace of a function of the length element in Planck units, which when applied to the non commutative geometry of the Standard Model will be shown (in a joint work with Ali Chamseddine) to give the SM Lagrangian coupled to gravity. The internal fluctuations of the non commutative geometry are trivial in the commutative case but yield the full bosonic sector of SM with all correct quantum numbers in the slightly non commutative case. The group of local gauge transformations appears spontaneously as a normal subgroup of the diffeomorphism group.Comment: 30 pages, Plain Te

Anticonvulsant, antiamnesic and anxiolytic activities of methanol leaf extract of Bambusa vulgaris (Poaceae) in mice

Background: Previous findings have shown that epilepsy can precipitate amnesia and anxiety, among other neuropsychiatric disorders. Bambusa vulgaris is used in African traditional medicine against convulsion, amnesia and anxiety but there is scanty scientific basis for these ethnomedicinal claims. Hence, this study investigated the anticonvulsant, antiamnesic and anti-anxiety effects of Bambusa vulgaris in mice. Methods: The acute oral ingestion of Bambusa vulgaris (100, 200 and 400 mg/kg) was investigated using pentylenetetrazole-, and strychnine-induced convulsion; antiamnesic using scopolamine-, and diazepam-induced amnesic models while the anxiolytic effect was assessed using elevated plus maze models. The phytochemical analysis was carried out using standard methods. Results: The extract at all the doses used significantly (p<0.05) elongated the death latency while at 400 mg/kg the onset of clonic and tonic convulsions were significantly (p<0.05) prolonged in pentylenetetrazole-induced convulsion model. The extract at 100, 200 and 400 mg/kg offered 60, 80 and 100% protection respectively in pentylenetetrazole-induced convulsion test. The extract showed no significant (p>0.05) effect on strychnine-induced convulsion model ruling out the involvement of strychnine-sensitive glycine receptor in the anticonvulsant effect of the extract. The extract at all the tested doses significantly (p<0.05) in a dose dependent fashion ameliorated the amnesia induced by scopolamine and diazepam suggesting antiamnesic effect. Bambusa vulgaris at all the tested doses significantly (p<0.05) in a dose dependent pattern increased the percentage open arm entries and percentage open arm duration on the open arm of the elevated plus maze as well as reduced the anxiety indices of the experimental mice consistent with anxiolytic effect. The phytochemical quantification of the extract showed abundance of tannins and corroborated by the findings from the Fourier transform infrared spectra of the extract. Conclusion: This study therefore concluded that Bambusa vulgaris may possess anticonvulsant, antiamnesic and anxiolytic effects and provided scientific proof for its traditional use. Keywords: Bambusa vulgaris, anticonvulsant, antiamnesic, anxiolytic, tannin, Fourier Transform-Infra Red spectr

ARQ-197, a small-molecule inhibitor of c-Met, reduces tumour burden and prevents myeloma-induced bone disease in vivo

The receptor tyrosine kinase c-Met, its ligand HGF, and components of the downstream signalling pathway, have all been implicated in the pathogenesis of myeloma, both as modulators of plasma cell proliferation and as agents driving osteoclast differentiation and osteoblast inhibition thus, all these contribute substantially to the bone destruction typically caused by myeloma. Patients with elevated levels of HGF have a poor prognosis, therefore, targeting these entities in such patients may be of substantial benefit. We hypothesized that ARQ-197 (Tivantinib), a small molecule c-Met inhibitor, would reduce myeloma cell growth and prevent myeloma-associated bone disease in a murine model. In vitro we assessed the effects of ARQ-197 on myeloma cell proliferation, cytotoxicity and c-Met protein expression in human myeloma cell lines. In vivo we injected NOD/SCID-γ mice with PBS (non-tumour bearing) or JJN3 cells and treated them with either ARQ-197 or vehicle. In vitro exposure of JJN3, U266 or NCI-H929 cells to ARQ-197 resulted in a significant inhibition of cell proliferation and an induction of cell death by necrosis, probably caused by significantly reduced levels of phosphorylated c-Met. In vivo ARQ-197 treatment of JJN3 tumour-bearing mice resulted in a significant reduction in tumour burden, tumour cell proliferation, bone lesion number, trabecular bone loss and prevented significant decreases in the bone formation rate on the cortico-endosteal bone surface compared to the vehicle group. However, no significant differences on bone parameters were observed in non-tumour mice treated with ARQ-197 compared to vehicle, implying that in tumour-bearing mice the effects of ARQ-197 on bone cells was indirect. In summary, these res ults suggest that ARQ-197 could be a promising therapeutic in myeloma patients, leading to both a reduction in tumour burden and an inhibition of myeloma-induced bone disease

Measurement of transmitted power in untapered multifibre unions oscillatory spectral behaviour

Shows a new structure, the untapered multifibre union, with similar oscillation behaviour to that of tapered single-mode fibres. As a consequences conical regions are not relevant to the final results. This oscillatory behaviour opens the way to low-cost all-fibre devices such as optical filter