Making white spots disappear! Do minimally invasive treatments improve incisor opacities in children with molar incisor hypomineralisation?

acceptedVersio

Dogs and the criminology of control: A case study of contemporary policy making in England and Wales

This thesis explores the nexus of criminology and public policy analysis in order to better understand and explain the policy making processes in relation to the control of dogs in society. It does this through an empirical study of policy responses to the phenomenon of ‘status’ and ‘dangerous’ dogs in England and Wales, primarily during the past three decades. An influential body of work has suggested an expanding trend in punitiveness within Western societies over the past few decades. At the forefront of sociological thinking in this field is David Garland’s Culture of Control that theorises that the advent of late-modernity, with its adjusted macro-social conditions, has ushered in this new approach to law and order. As a theoretical scaffold, grand theories such as these can be useful, but this case study also seeks to go further into the empirical particulars of policy making in order to understand how a culture of control unfolds in relation to the lesser-explored arena of dangerous dogs. The methodological elements employed were two-fold and included both an extensive documentary analysis (including academic work, policy documents and legislation) recounted via a history of the present, and a thematic analysis produced from the empirical data of key policy actors' accounts (involving a programme of semi-structured elite interviews, n=25) gained via my unique insider-researcher access as a professional member of the dog policy network. Findings suggest that widespread anxieties regarding the threat to public safety posed by dangerous dogs, have been addressed via draconian legislative measures, most notably breed specific legislation (BSL) designed to manipulate and control the dog population. Evidence that BSL and other control measures are not working, and that substitute harms are befalling dog owners and their pets, have been obscured by competition and ‘white noise’ within a chaotic policy network. Public debate, fuelled by high profile and disproportionate media stories, has intrinsically linked dangerous dogs with other risky, criminal and anti-social behaviours. This ‘othering’, coupled with expressive, symbolic and politicised policy making, has resulted in an overly-punitive culture of control for dogs and their owners in society

Poor sleep quality and progression of gait impairment in an incident Parkinson’s disease cohort

Abnormal sleep may associate with cognitive decline in Parkinson's disease (PD). Furthermore, sleep dysfunction may associate with worse motor outcome. We hypothesised that PD patients with poor quality sleep would have greater progression in gait dysfunction, due to structural and functional overlap in networks subserving sleep and gait regulation. 12 PD patients and 12 age-matched controls completed longitudinal follow-up over 36 months. Poor sleep efficiency and greater sleep fragmentation correlated significantly with progression of step-width variability, a gait characteristic mediated by postural control, providing evidence that poor sleep in PD is associated with a more rapid deterioration in gait

Health empowerment scripts : simplifying social/green prescriptions

Social prescriptions are one term commonly used to describe non-pharmaceutical approaches to healthcare and are gaining popularity in the community, with evidence highlighting psychological benefits of reduced anxiety, depression and improved mood and physiological benefits of reduced risk of cardiovascular disease and reduced hypertension. The relationship between human health benefits and planetary health benefits is also noted. There are, however, numerous barriers, such as duration and frequencies to participate in activities, access, suitability, volition and a range of unpredictable variables (such as inclement weather, shifting interests and relocating home amongst others) impeding a comprehensive approach to their use on a wider scale. From a multidisciplinary perspective, this commentary incorporates a salutogenic and nature-based approach to health, we also provide a range of recommendations that can be undertaken at the patient level to assist in shifting the acknowledged systemic barriers currently occurring. These include using simple language to explain the purpose of health empowerment scripts, ensuing personal commitment to a minimum timeframe, enabling ease of access, co-designing a script program, providing ongoing motivational support and incorporating mindfulness to counter unexpected disruptions. Copyright © 2022 Lawson, Wissing, Henderson-Wilson, Snell, Chambers, McNeil and Nuttman

Spatial Environmental Modeling of Autoantibody Outcomes among an African American Population

In this study of autoimmunity among a population of Gullah African Americans in South Carolina, the links between environmental exposures and autoimmunity (presence of antinuclear antibodies (ANA)) have been assessed. The study population included patients with systemic lupus erythematosus (n = 10), their first degree relatives (n = 61), and unrelated controls (n = 9) where 47.5% (n = 38) were ANA positive. This paper presents the methodology used to model ANA status as a function of individual environmental influences, both self-reported and measured, while controlling for known autoimmunity risk factors. We have examined variable dimension reduction and selection methods in our approach. Following the dimension reduction and selection methods, we fit logistic spatial Bayesian models to explore the relationship between our outcome of interest and environmental exposures adjusting for personal variables. Our analysis also includes a validation “strip” where we have interpolated information from a specific geographic area for a subset of the study population that lives in that vicinity. Our results demonstrate that residential proximity to exposure site is important in this form of analysis. The use of a validation strip network demonstrated that even with small sample numbers some significant exposure-outcome relationships can be detected

The effect of increasing temperature on crop photosynthesis: From enzymes to ecosystems

As global land surface temperature continues to rise and heatwave events increase in frequency, duration, and/or intensity, our key food and fuel cropping systems will likely face increased heat-related stress. A large volume of literature exists on exploring measured and modelled impacts of rising temperature on crop photosynthesis, from enzymatic responses within the leaf up to larger ecosystem-scale responses that reflect seasonal and interannual crop responses to heat. This review discusses (i) how crop photosynthesis changes with temperature at the enzymatic scale within the leaf; (ii) how stomata and plant transport systems are affected by temperature; (iii) what features make a plant susceptible or tolerant to elevated temperature and heat stress; and (iv) how these temperature and heat effects compound at the ecosystem scale to affect crop yields. Throughout the review, we identify current advancements and future research trajectories that are needed to make our cropping systems more resilient to rising temperature and heat stress, which are both projected to occur due to current global fossil fuel emissions